Foreign Tourists in World Heritage Sites: A Motivation-Based Segmentation

The inclusion on the lists published by the United Nations Educational, Scientific, and Cultural Organization (UNESCO)—World Heritage Site (WHS), Intangible Cultural Heritage (ICH), and World Heritage Sites in Danger—suggests, first of all, the acknowledgement of something worth protecting and, secondly, an increase in the strength of tourist attraction to the affected destination, especially among specific visitors. The identification and classification of tourists that are seen to be more interested in heritage is the stated aim of this work, based on models already proposed in the scientific literature. For this purpose, a survey was conducted that interviewed a representative sample of international tourists visiting the city of Córdoba. A multi-variant technique of case-cluster was applied. In addition, a discriminant analysis was used to validate the clusters of the cases obtained. For analyzing the differences between the different groups obtained, some non-parametrical statistical procedures were applied. The results obtained allowed for the visualization of a model that shows the empirical evidence regarding the presence of four types of foreign tourists that are considered valid for segmentation in the city of Córdoba as a WHS tourist destination: the alternative tourist, emotional tourist, cultural tourist, and heritage tourist. These results allow public and private managers to design specific strategies to increase visitor satisfaction

Peer-to-Peer Tourism: Tourists’ Profile Estimation through Artificial Neural Networks

Peer-to-peer tourism is one of the great global trends that is transforming the tourism sector, introducing several changes in many aspects of tourism, such as the way of travelling, staying or living the experience in the destination. This research aims to determine the relationship between the sociodemographic characteristics of tourists interested in peer-to-peer accommodation and the importance they give to various motivational factors about this type of tourism in a “culturaltourism” city. The methodology used in this research is an artificial neural network of the multilayer perceptron type to estimate a sociodemographic profile of the peer-to-peer accommodation tourist user based on predetermined input values consisting of the answers to the Likert-type questions previously carried out using a questionnaire. Thus, the model developed, through a customized set of answers to these questions, allows the presentation of a “composite picture” of a peer-to-peer tourist based on sociodemographic characteristics. This function is especially interesting for adapting the peer-to-peer hosting offer according to the preferences of potential users

Segmentation and sociodemographic profile of heritage tourist

Purpose – Heritage tourism has been greatly developed in recent years, especially in cities declared the World Heritage Sites. This kind of research comes from the need of understanding the demands of tourists in destinations. Design – This research studies the sociodemographic profile of tourists and their perceptions about the attributes of the city of Sucre, which has been declared the World Heritage Site. This research is based on two previous theoretical models. Methodology – The fieldwork consisted of conducting 529 personal surveys. The field work was carried out via personal interviews with the tourists in Sucre. The conducted period was between November 2017 and March 2018. Approach – A high cultural level and a medium-high income level characterise most tourists. The attributes that a patrimonial tourist destination must have were analysed in order to make it a sustainable site, where both culture and tourism come together. Findings – The main results of the investigation show a segmentation of the tourists that visit this city into four types: alternative, cultural, emotional, and patrimonial tourists. Originality of the research – The results of this research determine the most highly valued attributes of the city and those that should be improved

Collegii Sancti Thomae Complutensis Dialecticae institutiones sive Logica parva

Sign.: [parágrafo]4, A-O8, P3Portada con esc. xil.Esc. episcopal xil. en p. [3] (r[parágrafo]2

Relevance of gastrointestinal manifestations in a large Spanish cohort of patients with systemic lupus erythematosus: what do we know?

SLE can affect any part of the gastrointestinal (GI) tract. GI symptoms are reported to occur in >50% of SLE patients. To describe the GI manifestations of SLE in the RELESSER (Registry of SLE Patients of the Spanish Society of Rheumatology) cohort and to determine whether these are associated with a more severe disease, damage accrual and a worse prognosis. METHODS: We conducted a nationwide, retrospective, multicentre, cross-sectional cohort study of 3658 SLE patients who fulfil =4 ACR-97 criteria. Data on demographics, disease characteristics, activity (SLEDAI-2K or BILAG), damage (SLICC/ACR/DI) and therapies were collected. Demographic and clinical characteristics were compared between lupus patients with and without GI damage to establish whether GI damage is associated with a more severe disease. RESULTS: From 3654 lupus patients, 3.7% developed GI damage. Patients in this group (group 1) were older, they had longer disease duration, and were more likely to have vasculitis, renal disease and serositis than patients without GI damage (group 2). Hospitalizations and mortality were significantly higher in group 1. Patients in group 1 had higher modified SDI (SLICC Damage Index). The presence of oral ulcers reduced the risk of developing damage in 33% of patients. CONCLUSION: Having GI damage is associated with a worse prognosis. Patients on a high dose of glucocorticoids are at higher risk of developing GI damage which reinforces the strategy of minimizing glucocorticoids. Oral ulcers appear to decrease the risk of GI damage. © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology

Systematic assessment of long-read RNA-seq methods for transcript identification and quantification

The Long-read RNA-Seq Genome Annotation Assessment Project (LRGASP) Consortium was formed to evaluate the effectiveness of long-read approaches for transcriptome analysis. The consortium generated over 427 million long-read sequences from cDNA and direct RNA datasets, encompassing human, mouse, and manatee species, using different protocols and sequencing platforms. These data were utilized by developers to address challenges in transcript isoform detection and quantification, as well as de novo transcript isoform identification. The study revealed that libraries with longer, more accurate sequences produce more accurate transcripts than those with increased read depth, whereas greater read depth improved quantification accuracy. In well-annotated genomes, tools based on reference sequences demonstrated the best performance. When aiming to detect rare and novel transcripts or when using reference-free approaches, incorporating additional orthogonal data and replicate samples are advised. This collaborative study offers a benchmark for current practices and provides direction for future method development in transcriptome analysis

Fluid challenges in intensive care: the FENICE study A global inception cohort study

Fluid challenges (FCs) are one of the most commonly used therapies in critically ill patients and represent the cornerstone of hemodynamic management in intensive care units. There are clear benefits and harms from fluid therapy. Limited data on the indication, type, amount and rate of an FC in critically ill patients exist in the literature. The primary aim was to evaluate how physicians conduct FCs in terms of type, volume, and rate of given fluid; the secondary aim was to evaluate variables used to trigger an FC and to compare the proportion of patients receiving further fluid administration based on the response to the FC.This was an observational study conducted in ICUs around the world. Each participating unit entered a maximum of 20 patients with one FC.2213 patients were enrolled and analyzed in the study. The median [interquartile range] amount of fluid given during an FC was 500 ml (500-1000). The median time was 24 min (40-60 min), and the median rate of FC was 1000 [500-1333] ml/h. The main indication for FC was hypotension in 1211 (59 %, CI 57-61 %). In 43 % (CI 41-45 %) of the cases no hemodynamic variable was used. Static markers of preload were used in 785 of 2213 cases (36 %, CI 34-37 %). Dynamic indices of preload responsiveness were used in 483 of 2213 cases (22 %, CI 20-24 %). No safety variable for the FC was used in 72 % (CI 70-74 %) of the cases. There was no statistically significant difference in the proportion of patients who received further fluids after the FC between those with a positive, with an uncertain or with a negatively judged response.The current practice and evaluation of FC in critically ill patients are highly variable. Prediction of fluid responsiveness is not used routinely, safety limits are rarely used, and information from previous failed FCs is not always taken into account

Caracterización analítica y funcional de extractos con actividad antimicrobiana obtenidos de plantas del género Cistus

La familia Cistaceae, conocida vulgarmente como “jaras”, comprende unas 150 especies que forman parte importante del ecosistema mediterráneo. En el presente trabajo se han estudiado cuatro de las especies más abundantes de esta familia localizadas en el territorio español (Cistus salviifolius, C. clusii, C. albidus y C. ladanifer), las cuales fueron recolectadas y utilizadas para la obtención de un total de catorce extractos a través de diversos métodos de extracción sólido-líquido, fraccionamiento mediante cromatografía líquida y métodos de secado. Tras un análisis de la actividad antimicrobiana frente a microorganismos modelo, E. coli y S. aureus, y del contenido polifenólico de los mismos se seleccionaron aquellos extractos que presentaron la máxima capacidad antimicrobiana, así como un alto contenido polifenólico y un buen rendimiento de extracción.Esta selección ha permitido identificar la potencialidad como antimicrobiano del extracto acuoso de C. salviifolius, el cual fue caracterizado por HPLC acoplado a espectrometría de masas identificando un total de 48 compuestos polifenólicos entre los que destacaron los elagitaninos y los flavonoles. Se realizó una selección de aquellos compuestos puros más abundantes en el extracto para abordar el estudio de los posibles efectos sinérgicos entre estos compuestos mediante la construcción del isobolograma a partir de las curvas dosisefecto de los compuestos individuales, encontrando, por primera vez, varias combinaciones sinérgicas entre ácido elágico, punicalagina y derivados de flavonoles, interacciones que podrían explicar la potente actividad antimicrobiana del extracto.Posteriormente, se realizó un análisis cinético de la evolución del crecimiento de E. coli, S. aureus y C. albicans en presencia de varios extractos vegetales con el objetivo de encontrar un agente antimicrobiano de amplio espectro. Los resultados muestran que la inhibición de S. aureus estaría asociada con la presencia de elagitaninos, ácido elágico y flavonoles, probablemente glicosilados, y la inhibición de E. coli se correspondería más con la presencia de flavonoles, no encontrando extractos eficaces contra el hongo levaduriforme C. albicans. Por último, mediante la utilización de membranas modelo de E. coli y de S. aureus, se ha encontrado que el ácido elágico y las punicalaginas tienen un efecto directo desestabilizador de las membranas bacterianas mientras el mecanismo de acción de los flavonoles parece estar menos relacionado con este aspecto.En conclusión, los resultados obtenidos en la presente memoria podrían sentar las bases para el diseño de nuevos agentes antisépticos para dermocosmética o incluso productos sanitarios frente a cepas clínicas hospitalarias patogénicas de S. aureus como MRSA

Collegij Sancti Thomae complutensis In universam Aristotelis logicam quaestiones

Octava editio denuo correcta[8], 556, [4] p. ; 4ºCatalina, 1491Palau, 57656Sign.: [calderón]4, A-Z8, 2A-2M8Texto a dos col.Portada con orla tip. y escudo xilográfico de la Orden de PredicadoresEsc. xil. de la Orden de Predicadores en r. de [calderón]2FA16COL(1737) -- Anot. mss. en port. y v. última p. (2M8) -- Enc. perg