The effect of chromosome structure upon meiotic homologous and homoeologous recombinations in Triticeae

The tribe Triticeae contains about 500 diploid and polyploid taxa, among which are important crops, such as wheat, barley and rye. The phylogenetic relationships, genome compo-sition and chromosomal architecture, were already reported in the pioneer genetic studies on these species, given their implications in breeding-related programs. Hexaploid wheat, driven by its high capacity to develop cytogenetic stocks, has always been at the forefront of these studies. Cytogenetic stocks have been widely used in the identification of homoeologous relationships between the chromosomes of wheat and related species, which has provided valuable information on genome evolution with implications in the transfer of useful agronomical traits into crops. Meiotic recombination is non-randomly distributed in the Triticeae species, and crossovers are formed in the distal half of the chromosomes. Also of interest for crops improvement is the possibility of being able to modulate the intraspecific and interspecific recombination landscape to increase its frequency in crossover-poor regions. Structural changes may help in this task. In fact, chromosome truncation increases the recombination frequency in the adjacent intercalary region. However, structural changes also have a negative effect upon recombination. Gross chromosome rearrangements produced in the evolution usually suppress meiotic recombination between non-syntenic homoeologs. Thus, the chromosome structural organization of related genomes is of great interest in designing strategies of the introgression of useful genes into crops

Macrodistrofia lipomatosa en el pie: A propósito de un caso y revisión de la literatura

La macrofistrofia lipomatosa es una forma de gigantismo localizado poco frecuente y de causa desconocida, se caracteriza por un gran aumento del crecimiento de todos los elementos mesenquimales, en particular el tejido fibroadiposo de uno o varios dedos del pie o de la mano. Nosotros presentamos un paciente con una deformidad estática en el primer dedo del pie derecho, con una discusión de los hallazgos clínicos, patológicos y radiológicos, así como una revisión de la bibliografía.Macrodystrophia Lipomatosa, a rare form of localized gigantism of unknown cause, is characterized by a dramatic overgrowth of all the mesenchymal elements, paricularly the fibroadipose tissue, of one or more digits of the foot or hand. We report the case of an patient, who had a static deformity of the first toe of the right food. The clinical, pathologic, and roentgenographic findings are discussed and review of the literature is provided

Sistema de gestión de activos fijos tangibles del instituto de suelos de Granma

In the Department of Economy of the Institute of Floors of Granma the control of the fixed tangible assets is taken with those that it counts the institution, all the information corresponding to the same ones it was taken in a manual way and by means of Microsoft Excel, that which caused that the information was dispersed, was required of a great number of hours to be upgraded, it was sensitive to losses and deterioration. For that outlined previously, it is that in the present investigation a system of environment web is developed with new potentialities, to facilitate the management from the concerning information to the fixed tangible assets of the Institute of Floors of Granma, allowing a bigger consistency and security of the stored information, facilitating the handling and the quick access to the same one. In this document it is exposed the theoretical foundation, the used tools, the characteristics of the system, design, implementation and the carried out tests. The development of this work is based on technologies multiplatform; it was made use of programming languages like HTML, JavaScript and PHP, as well as Leaves of Styles (CSS). As servant web the Apache was used and I eat agent of databases MySQL, for create and publish the pages it was appealed Dreamweaver CS5, also as development methodology Extreme Programming (XP).En el Departamento de Economía del Instituto de Suelos de Granma se lleva el control de los activos fijos tangibles con los que cuenta la institución, toda la información correspondiente a los mismos se gestiona de forma manual y mediante el tabulador electrónico de Microsoft Excel, lo cual ocasiona que la información se encuentra dispersa, se requiere de un gran número de horas de trabajo para su actualización, es sensible a pérdidas y deterioro. Por lo planteado anteriormente, en la presente investigación se desarrolla un sistema de entorno web con nuevas potencialidades, para facilitar la gestión de la información concerniente a los activos fijos tangibles del Instituto de Suelos de Granma, permitiendo una mayor consistencia y seguridad de la información almacenada, facilitando el manejo y el rápido acceso a la misma. En este documento se expone la fundamentación teórica, las herramientas utilizadas, las características del sistema, diseño, implementación y las pruebas realizadas. El desarrollo de este trabajo está basado en tecnologías multiplataforma; mediante el uso de lenguajes de programación como el HTML, JavaScript y PHP, así como Hojas de Estilos (CSS). Como servidor web se utilizó el Apache y como gestor de bases de datos el MySQL, para el crear y editar las páginas se recurrió al Dreamweaver CS5, además como metodología de desarrollo Extreme Programming (XP)

DRESS Syndrome Associated with Carbamazepine: A Case Report

DRESS Syndrome is a severe toxicity. Considered a rare, serious and multi-organ reaction, frequently associated with antiepileptic drugs (phenytoin, carbamazepine, lamotrigine). The objective of this article is to describe the clinical characteristics, complementary tests, their diagnosis, evolution and treatment. We present a 31‐year‐old patient who is admitted to the Clinic Service of the SOLCA Hospital in Riobamba with a history of sporadic seizures with no apparent cause treated with carbamazepine and lamotrigine. DRESS syndrome presents a clinical triad of fever, rash, and multi-organ disorder). DRESS syndrome begins late, slowly evolves and clinically similar to infectious processes, which is why it is frequently misdiagnosed. Its incidence is very low in individuals exposed to various medications. The correct diagnosis is difficult especially in professionals not trained in the skin specialty. A misdiagnosis or delay in it increases mortality by up to 30%. The fundamental basis in the treatment of DRESS syndrome is to immediately withdraw the triggering drug and use systemic corticosteroid pulses, which will undoubtedly save the patient's life. It is concluded that DRESS Syndrome can be fatal, so an early diagnosis is important. Due to its classic clinical triad of fever, rash and multi-organ involvement, there is difficulty in its diagnosis, especially when there is no evaluation by a skin specialist. However, once correctly diagnosed, it has a satisfactory evolution. Keywords: DRESS syndrome, carbamazepine, lamotrigine, rash, multiorgan involvement. RESUMEN El Síndrome de DRESS una toxicodermia grave. Considerada como una reacción rara, grave y compromete a varios órganos, asociada frecuentemente a medicamentos antiepilépticos (fenitoína, carbamazepina, lamotrigina). El objetivo de este artículo es describir las características clínicas, exámenes complementarios, su diagnóstico, evolución y tratamiento. Presentamos una paciente de 31 años que es ingresada al Servicio de Clínica del Hospital SOLCA de Riobamba con antecedentes de crisis convulsivas esporádicas sin causa aparente tratada con carbamazepina y lamotrigina. El síndrome de DRESS presenta una triada clínica de fiebre, exantema y alteración multiorgánica). El síndrome de DRESS inicia tardíamente, de evolución lenta y clínicamente similar a procesos infecciosos, por lo que frecuentemente es mal diagnosticado. Su incidencia es muy baja en individuos expuestos a diversos medicamentos. El diagnóstico acertado es difícil sobre todo en profesionales no entrenados en la especialidad de piel. Un mal diagnóstico o dilación del mismo aumenta la mortalidad de hasta un 30%. La base fundamental en el tratamiento del síndrome DRESS es retirar inmediatamente el medicamento desencadenante y usar pulsos de corticoide sistémico, salvara la vida del paciente sin duda. Se concluye que el Síndrome de DRESS puede ser mortal, por lo que es importante un diagnóstico temprano. A través de su triada clínica clásica de fiebre, exantema y afectación multiorgánica, existe dificultad en su diagnóstico sobre todo cuando no hay la valoración de un especialista en piel. Sin embargo, una vez diagnosticada correctamente, tiene una evolución satisfactoria. Palabras clave: síndrome de DRESS, carbamazepina, lamotrigina, exantema, afectación multiorgánica

Historia urbana y patrimonio urbano en los estudios de grado y doctorado

Enseñar y aprender urbanismo nunca ha sido tarea sencilla ni para un docente ni para unalumno, debido al gran número de disciplinas que engloba tan magna palabra. Tradicionalmente se han usado diversos métodos de aproximación al conocimiento de una ciudad, considerándola como un hecho “funcional”, “social y político”, “cultural” yen menor medida “históricos”. Este nos aportará las claves definitivas para elconocimiento de una ciudad porque analizará las piezas generadas por cada una de lasetapas históricas sucedidas en la misma y nos desvelará las directrices seguidas para su conformación urbana, y será el que guía su morfogénesis. La presencia de los estudiosacerca de la forma urbana, dentro de los diferentes planes de estudios de Historia del Arte, estuvieron siempre enfocados al campo de la urbanística. Pretendemos analizar elcontexto formativo en el que se ha desarrollado esta experiencia desde el primer plan deestudios (1994) hasta la actualidad. Constatamos un planteamiento basado enparadigmas del hecho urbano organizados en secuencia histórico-discursiva. Comprobamos que la enseñanza, fundamentada en una metodología docenteeminentemente formalista, influye de forma definitiva sobre el aprendizaje, cuyas competencias y habilidades están centradas en analizar el hecho urbano inserto en etapas y “estilos” artísticosTeach and learn urbanism never has been task simple for a teaching or a student, due tothe great number of disciplines that encompasses so magna Word. Traditionally are have used different methods of approach to the knowledge, considering it as a made"functional", "social and political", "cultural" and to a lesser extent "historic". However, It will give us keys to the knowledge of a city, it will analyze the parts generated by each of the historical stages occurred in the same and will reveal us the guidelines followed by its urban formation, ultimately will be the only one that guided their morphogenesis. The presence of studies about urban forms within the different curricula of history of art was always focused on the field of the urbanology. With this contribution is intended to an analysis of the context training in which it has developed this experience from the first plan of studies (1994) up to now. Is notes an approach based on the conception of paradigms of the urban form through which is organizes the historical-discursive sequence. Also verifies that teaching, based on a highly formalist teaching methodology focused on analyze the urban fact inserted in stages and artistic "styles

GASTRONOMIC PERCEPTION AND MOTIVATION OF A TOURISTIC DESTINATION: THE CITY OF QUITO, ECUADOR

The segmentation of intenational tourists who visit the city of Quito according to their perceptions with regard to the gastronomy. To achieve this objective, the methodology used in this investigation has been the application of a multivariate technique of item grouping and the realization of an univariate ANOVA post hoc analysis. The main conclusions that emanante from this research focus on the segmentation of international tourists into three different groups and in how the attraction to the gastronomy, considered by the travellers implies a greater satisfaction of the destination. The main practical implications are centred on a better understanding of key factors about how gastronomy can reinforce a touristic destination and achieve a greater satisfaction considered by the traveller

Diaphragmatic activation correlated with lumbar multifidus muscles and thoracolumbar fascia by B-mode and M-mode ultrasonography in subjects with and without non-specific low back pain: a pilot study.

Background and Objectives: The diaphragm, the lumbar multifidus muscles, and the thoracolumbar fascia (TLF) execute an important role in the stability of the lumbar spine and their morphology has been modified in subjects with non-specific low back pain (NS-LBP). While it is true that three structures correlate anatomically, the possible functional correlation between them has not been investigated previously in healthy subjects nor in subjects with NS-LBP. The aim of the present study was to examine this functional nexus by means of a comparison based on ultrasonographic parameters of the diaphragm, the lumbar multifidus muscles, and the TLF in subjects with and without NS-LBP. Materials and Methods: A sample of 54 (23 NS-LBP and 31 healthy) subjects were included in the study. The thickness and diaphragmatic excursion at tidal volume (TV) and force volume (FV), the lumbar multifidus muscles thickness at contraction and at rest, and the TLF thickness were evaluated using rehabilitative ultrasound imaging (RUSI) by B-mode and M-mode ultrasonography. The diaphragm thickening capacity was also calculated by thickening fraction (TF) at tidal volume and force volume. Results: There were no significant differences recorded between the activation of the diaphragm and the activation of the lumbar multifidus muscles and TLF for each variable, within both groups. However, there were significant differences recorded between both groups in diaphragm thickness and diaphragm thickening capacity at tidal volume and force volume. Conclusions: Diaphragmatic activation had no functional correlation with the activation of lumbar multifidus muscles and TLF for both groups. Nevertheless, subjects with NS-LBP showed a reduced diaphragm thickness and a lower diaphragm thickening capacity at tidal volume and force volume, compared to healthy subjects

Dynamics of Rye Chromosome 1R Regions with High or Low Crossover Frequency in Homology Search and Synapsis Development

In many organisms, homologous pairing and synapsis depend on the meiotic recombination machinery that repairs double-strand DNA breaks (DSBs) produced at the onset of meiosis. The culmination of recombination via crossover gives rise to chiasmata, which locate distally in many plant species such as rye, Secale cereale. Although, synapsis initiates close to the chromosome ends, a direct effect of regions with high crossover frequency on partner identification and synapsis initiation has not been demonstrated. Here, we analyze the dynamics of distal and proximal regions of a rye chromosome introgressed into wheat to define their role on meiotic homology search and synapsis. We have used lines with a pair of two-armed chromosome 1R of rye, or a pair of telocentrics of its long arm (1RL), which were homozygous for the standard 1RL structure, homozygous for an inversion of 1RL that changes chiasma location from distal to proximal, or heterozygous for the inversion. Physical mapping of recombination produced in the ditelocentric heterozygote (1RL/1RLinv) showed that 70% of crossovers in the arm were confined to a terminal segment representing 10% of the 1RL length. The dynamics of the arms 1RL and 1RLinv during zygotene demonstrates that crossover-rich regions are more active in recognizing the homologous partner and developing synapsis than crossover-poor regions. When the crossover-rich regions are positioned in the vicinity of chromosome ends, their association is facilitated by telomere clustering; when they are positioned centrally in one of the two-armed chromosomes and distally in the homolog, their association is probably derived from chromosome elongation. On the other hand, chromosome movements that disassemble the bouquet may facilitate chromosome pairing correction by dissolution of improper chromosome associations. Taken together, these data support that repair of DSBs via crossover is essential in both the search of the homologous partner and consolidation of homologous synapsis

Portal EduQTech sobre aplicación de normativa de calidad en las aulas universitarias

Como venimos señalando en diferentes trabajos previos desarrollados por nuestro grupo, la normativa que en los últimos años está configurando el entorno universitario apunta a la importancia de la calidad en la Educación Superior. Para conseguir esta calidad es necesario motivar, formar e implicar a los docentes en la utilización de los conceptos clave de esta filosofía, si bien su aplicación en la labor diaria puede resultar un poco ambigua o complicada. En respuesta a esta necesidad, desde el grupo EduQTech, se ha desarrollado un proyecto destinado a crear una red interdisciplinar sobre la aplicación de normativa sobre calidad en el aula, cuyo principal objetivo es dar a conocer, debatir y adaptar a la realidad universitaria diferentes estándares sobre calidad propios del entorno social. Se busca acercar la Universidad a la Sociedad, aprender de la experiencia de esta última y mejorar de forma continua nuestro trabajo como docentes, lo que repercutirá en beneficios para los alumnos – egresados y finalmente en la propia Sociedad. La concreción del trabajo se ha realizado a través de un portal en Internet basado en software libre.Postprint (author's final draft

Active fold system in the northern continental margin of the Alboran Sea (Western Mediterranean)

En el margen septentrional del Mar de Alborán, la deformación compresiva relacionada con la convergencia entre las placas de Eurasia y Nubia se resuelve mediante una intensa fracturación según dos grandes sistemas de fallas de dirección NNE-SSO con movimiento sinestro y NO-SE de desplazamiento dextral-normal. El análisis estructural de los elementos geomorfológicos presentes en el fondo marino permite establecer, además, una serie de elementos morfológicos generados por la actividad de pliegues anticlinales y sinclinales que conforman una serie de elevaciones de dirección N050-060ºE. Estos pliegues deforman a las unidades sedimentarias superficiales y han sido activos al menos durante el Cuaternario, como lo demuestra el patrón de espesores de las unidades sísmicas afectadas por el plegamiento y la deformación de la superficie erosiva asociada a una terraza contornítica. Este patrón de estructuras se interpreta como generado por la deformación existente sobre una falla de cabalgamiento, vergente hacia el norte, que asume parte de la deformación compresiva causada por la indentación del bloque de la Dorsal de Alborán.In the northern margin of the Alboran Sea, the compressive deformation related to the convergence between the Nubian and Eurasian plates is resolved by an intense fracturing along two large fault systems trending NNE-SSW with left-lateral movements and NW-SE with right-lateral normal components. The structural analysis of the geomorphological elements on the seafloor also allows us to establish a series of morphological elements generated by the activity of some anticline and syncline fold sets. It is basically a series of ridges heading N050-060ºE. These folds deform the shallow sedimentary units and have been active at least during the Quaternary, as evidenced by the thickness pattern of seismic units affected by the folding and the deformation of an erosive surface associated with a contouritic terrace. This pattern of structures is interpreted to be generated by the overlying deformation on a thrust fault, verging towards the north, which assumes part of the compressive deformation caused by the indentation of the Alborán Ridge block.Versión del edito