7,466 research outputs found
Resolving the Formation of Protogalaxies. I. Virialization
(Abridged) Galaxies form in hierarchically assembling dark matter halos. With
cosmological three dimensional adaptive mesh refinement simulations, we explore
in detail the virialization of baryons in the concordance cosmology, including
optically thin primordial gas cooling. We focus on early protogalaxies with
virial temperatures of 10^4 K and their progenitors. Without cooling, virial
heating occurs in shocks close to the virial radius for material falling in
from voids. Material in dense filaments penetrates deeper to about half that
radius. With cooling the virial shock position shrinks and also the filaments
reach scales as small as a third the virial radius. The temperatures in
protogalaxies found in adiabatic simulations decrease by a factor of two from
the center and show flat entropy cores. In cooling halos the gas reaches virial
equilibrium with the dark matter potential through its turbulent velocities. We
observe turbulent Mach numbers ranging from one to three in the cooling cases.
This turbulence is driven by the large scale merging and interestingly remains
supersonic in the centers of these early galaxies even in the absence of any
feedback processes. The virial theorem is shown to approximately hold over 3
orders of magnitude in length scale with the turbulent pressure prevailing over
the thermal energy. The turbulent velocity distributions are Maxwellian and by
far dominate the small rotation velocities associated with the total angular
momentum of the galaxies. Decomposing the velocity field using the
Cauchy-Stokes theorem, we show that ample amounts of vorticity are present
around shocks even at the very centers of these objects.Comment: 13 pages, 6 figures. Submitted to ApJ on 8 March 2007. Revised
manuscript. Comments welcom
Resolving the Formation of Protogalaxies. III. Feedback from the First Stars
The first stars form in dark matter halos of masses ~10^6 M_sun as suggested
by an increasing number of numerical simulations. Radiation feedback from these
stars expels most of the gas from their shallow potential well of their
surrounding dark matter halos. We use cosmological adaptive mesh refinement
simulations that include self-consistent Population III star formation and
feedback to examine the properties of assembling early dwarf galaxies. Accurate
radiative transport is modeled with adaptive ray tracing. We include supernova
explosions and follow the metal enrichment of the intergalactic medium. The
calculations focus on the formation of several dwarf galaxies and their
progenitors. In these halos, baryon fractions in 10^8 solar mass halos decrease
by a factor of 2 with stellar feedback and by a factor of 3 with supernova
explosions. We find that radiation feedback and supernova explosions increase
gaseous spin parameters up to a factor of 4 and vary with time. Stellar
feedback, supernova explosions, and H_2 cooling create a complex, multi-phase
interstellar medium whose densities and temperatures can span up to 6 orders of
magnitude at a given radius. The pair-instability supernovae of Population III
stars alone enrich the halos with virial temperatures of 10^4 K to
approximately 10^{-3} of solar metallicity. We find that 40% of the heavy
elements resides in the intergalactic medium (IGM) at the end of our
calculations. The highest metallicity gas exists in supernova remnants and very
dilute regions of the IGM.Comment: 15 pages, 16 figures, accepted to ApJ. Many changes, including
estimates of metal line cooling. High resolution images and movies available
at http://www.slac.stanford.edu/~jwise/research/PGalaxies3
Coarse-grained model of entropic allostery
Many signaling functions in molecular biology require proteins to bind to substrates such as DNA in response to environmental signals such as the simultaneous binding to a small molecule. Examples are repressor proteins which may transmit information via a conformational change in response to the ligand binding. An alternative entropic mechanism of "allostery" suggests that the inducer ligand changes the intramolecular vibrational entropy, not just the mean static structure. We present a quantitative, coarse-grained model of entropic allostery, which suggests design rules for internal cohesive potentials in proteins employing this effect. It also addresses the issue of how the signal information to bind or unbind is transmitted through the protein. The model may be applicable to a wide range of repressors and also to signaling in trans-membrane proteins
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Measles vaccination and antibody response in autism spectrum disorder
OBJECTIVE: To test the hypothesis that measles vaccination was involved in the pathogenesis of autism spectrum disorders (ASD) as evidenced by signs of a persistent measles infection or abnormally persistent immune response shown by circulating measles virus or raised antibody titres in children with ASD who had been vaccinated against measles, mumps and rubella (MMR) compared with controls. DESIGN: Case-control study, community based. METHODS: A community sample of vaccinated children aged 10-12 years in the UK with ASD (n = 98) and two control groups of similar age, one with special educational needs but no ASD (n = 52) and one typically developing group (n = 90), were tested for measles virus and antibody response to measles in the serum. RESULTS: No difference was found between cases and controls for measles antibody response. There was no dose-response relationship between autism symptoms and antibody concentrations. Measles virus nucleic acid was amplified by reverse transcriptase-PCR in peripheral blood mononuclear cells from one patient with autism and two typically developing children. There was no evidence of a differential response to measles virus or the measles component of the MMR in children with ASD, with or without regression, and controls who had either one or two doses of MMR. Only one child from the control group had clinical symptoms of possible enterocolitis. CONCLUSION: No association between measles vaccination and ASD was shown
An interacting spin flip model for one-dimensional proton conduction
A discrete asymmetric exclusion process (ASEP) is developed to model proton
conduction along one-dimensional water wires. Each lattice site represents a
water molecule that can be in only one of three states; protonated,
left-pointing, and right-pointing. Only a right(left)-pointing water can accept
a proton from its left(right). Results of asymptotic mean field analysis and
Monte-Carlo simulations for the three-species, open boundary exclusion model
are presented and compared. The mean field results for the steady-state proton
current suggest a number of regimes analogous to the low and maximal current
phases found in the single species ASEP [B. Derrida, Physics Reports, {\bf
301}, 65-83, (1998)]. We find that the mean field results are accurate
(compared with lattice Monte-Carlo simulations) only in the certain regimes.
Refinements and extensions including more elaborate forces and pore defects are
also discussed.Comment: 13pp, 6 fig
No Longer Discrete:Modeling the Dynamics of Social Networks and Continuous Behavior
The dynamics of individual behavior are related to the dynamics of the social structures in which individuals are embedded. This implies that in order to study social mechanisms such as social selection or peer influence, we need to model the evolution of social networks and the attributes of network actors as interdependent processes. The stochastic actor-oriented model is a statistical approach to study network-attribute coevolution based on longitudinal data. In its standard specification, the coevolving actor attributes are assumed to be measured on an ordinal categorical scale. Continuous variables first need to be discretized to fit into such a modeling framework. This article presents an extension of the stochastic actor-oriented model that does away with this restriction by using a stochastic differential equation to model the evolution of a continuous attribute. We propose a measure for explained variance and give an interpretation of parameter sizes. The proposed method is illustrated by a study of the relationship between friendship, alcohol consumption, and self-esteem among adolescents
On certain other sets of integers
We show that if A is a subset of {1,...,N} containing no non-trivial
three-term arithmetic progressions then |A|=O(N/ log^{3/4-o(1)} N).Comment: 29 pp. Corrected typos. Added definitions for some non-standard
notation and remarks on lower bound
Resolving the Formation of Protogalaxies. II. Central Gravitational Collapse
Numerous cosmological hydrodynamic studies have addressed the formation of
galaxies. Here we choose to study the first stages of galaxy formation,
including non-equilibrium atomic primordial gas cooling, gravity and
hydrodynamics. Using initial conditions appropriate for the concordance
cosmological model of structure formation, we perform two adaptive mesh
refinement simulations of ~10^8 M_sun galaxies at high redshift. The
calculations resolve the Jeans length at all times with more than 16 cells and
capture over 14 orders of magnitude in length scales. In both cases, the dense,
10^5 solar mass, one parsec central regions are found to contract rapidly and
have turbulent Mach numbers up to 4. Despite the ever decreasing Jeans length
of the isothermal gas, we only find one site of fragmentation during the
collapse. However, rotational secular bar instabilities transport angular
momentum outwards in the central parsec as the gas continues to collapse and
lead to multiple nested unstable fragments with decreasing masses down to
sub-Jupiter mass scales. Although these numerical experiments neglect star
formation and feedback, they clearly highlight the physics of turbulence in
gravitationally collapsing gas. The angular momentum segregation seen in our
calculations plays an important role in theories that form supermassive black
holes from gaseous collapse.Comment: Replaced with accepted version. To appear in ApJ v681 (July 1
Living with multimorbidity? The lived experience of multiple chronic conditions in later life
Multimorbidity is defined biomedically as the co-existence of two or more long-term conditions in an individual. Globally, the number of people living with multiple conditions is increasing, posing stark challenges both to the clinical management of patients and the organisation of health systems. Qualitative literature has begun to address how concurrency affects the self-management of chronic conditions, and the concept of illness prioritisation predominates. In this article, we adopt a phenomenological lens to show how older people with multiple conditions experience illness. This UK study was qualitative and longitudinal in design. Sampling was purposive and drew upon an existing cohort study. In total, 15 older people living with multiple conditions took part in 27 in-depth interviews. The practical stages of analysis were guided by Constructivist Grounded Theory. We argue that the concept of multimorbidity as biomedically imagined has limited relevance to lived experience, while concurrency may also be erroneous. In response, we outline a lived experience of multiple chronic conditions in later life, which highlights differences between clinical and lay assumptions and makes the latter visible
Wakeful rest alleviates interference-based forgetting
Retroactive interference (RI)—the disruptive influence of events occurring after the formation of a new memory—is one of the primary causes of forgetting. Placing individuals within an environment that postpones interference should, therefore, greatly reduce the likelihood of information being lost from memory. For example, a short period of wakeful rest should diminish interference-based forgetting. To test this hypothesis, participants took part in a foreign language learning activity and were shown English translations of 20 Icelandic words for immediate recall. Half of the participants were then given an 8-min rest before completing a similar or dissimilar interfering distractor task. The other half did not receive a rest until after the distractor task, at which point interference had already taken place. All participants were then asked to translate the Icelandic words for a second time. Results revealed that retention was significantly worse at the second recall test, but being allowed a brief rest before completing the distractor task helped reduce the amount of forgetting. Taking a short, passive break can shield new memories from RI and alleviate forgetting.ERAS Scheme, University of Wolverhampto
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