GLOBAL ESTIMATES OF THE IMPACT OF A COLLAPSE OF THE WEST ANTARCTIC ICE SHEET: AN APPLICATION OF FUND

The threat of an abrupt and extreme rise in sea level is widely discussed in the media, but little understood in practise, including the likely impacts of such a rise. This paper explores for the first time the global impacts of extreme sea-level rise, triggered by a hypothetical collapse of the West Antarctic Ice Sheet (WAIS). As the potential contributions remain uncertain, a wide range of scenarios are explored: WAIS contributions to sea-level rise of between 0.5m/century up to 5m/century. Together with other business-as-usual sea-level contributions, in the worst case this gives an approximately 6-m rise of global-mean sea level from 2030 to 2130. Global exposure to extreme sea-level rise is significant: roughly 400 million people (or about 8% of global population) are threatened by a 5-m rise in sea level, just based on 1995 data. The coastal module within the FUND model is tuned with global data on coastal zone characteristics concerning population, land areas and land use, and then used for impact analysis under the extreme sea-level rise scenarios. The model considers the interaction of (dry)land loss, wetland loss, protection costs and human displacement, assuming perfect adaptation based on cost-benefit analysis. Unlike earlier analyses, response costs are represented in a non-linear manner, including a sensitivity analysis based on response costs. It is found that much of the world’s coast would be abandoned given these extreme scenarios, although according to the global model, significant lengths of the world’s coast are worth defending even in the most extreme case. Hence, this suggests that actual population displacement would be a small fraction of the potential population displacement. This result is consistent with the present distribution of coastal population, which is heavily concentrated in specific areas. Hence a partial defence can protect most of the world’s coastal population. However, protection costs rise substantially diverting large amounts of investment from other sectors, and large areas of (dry)land and coastal wetlands are still predicted to be lost. While some observations of response to abrupt relative sea-level rise due to subsidence support the global model results, detailed case studies of the WAIS collapse in the Netherlands, Thames Estuary and the Rhone delta suggest a greater potential for abandonment than shown by the global model. This probably reflects a range of issues, including: (1) economic criteria such as the cost-benefit ratio is not the only factor which drives response decisions, with wider perceptions of risk driving the actual response; (2) the inefficiencies of adaptation in the real world, including indecision and competition for limited resources; and (3) the possible loss of confidence under the scenario of abrupt climate change. Collectively, these results illustrate an area where there are potential limits to adaptation, even when economic analysis suggests that adaptation will occur. The significant impacts found in the global model together with the potential for greater impacts as found in the detailed case studies shows that the response to abrupt sea-level rise is worthy of further research, including exploring the differing impact results by scale.Abrupt climate change, sea-level rise, coastal impacts, adaptation, adaptation limits

The cholesterol-raising diterpenes from coffee beans increase serum lipid transfer protein activity levels in humans

Cafestol and kahweol–diterpenes present in unfiltered coffee— strongly raise serum VLDL and LDL cholesterol and slightly reduce HDL cholesterol in humans. The mechanism of action is unknown. We determined whether the coffee diterpenes may affect lipoprotein metabolism via effects on lipid transfer proteins and lecithin:cholesterol acyltransferase in a randomized, double-blind cross-over study with 10 healthy male volunteers. Either cafestol (61–64 mg/day) or a mixture of cafestol (60 mg/day) and kahweol (48–54 mg/day) was given for 28 days. Serum activity levels of cholesterylester transfer protein, phospholipid transfer protein and lecithin:cholesterol acyltransferase were measured using exogenous substrate assays. Relative to baseline values, cafestol raised the mean (±S.D.) activity of cholesterylester transfer protein by 18±12% and of phospholipid transfer protein by 21±14% (both P<0.001). Relative to cafestol alone, kahweol had no significant additional effects. Lecithin:cholesterol acyltransferase activity was reduced by 11±12% by cafestol plus kahweol (P=0.02). It is concluded that the effects of coffee diterpenes on plasma lipoproteins may be connected with changes in serum activity levels of lipid transfer proteins

Oxidation of AlInAs for current blocking in a photonic crystal laser

To make an electrically pumped photonic crystal membrane laser is a challenging task. One of the problems is how to avoid short circuiting between the p- and n-doped parts of the laser diode, when the membrane thickness is limited to 200-300nm. We propose to use the oxide of AlInAs to realize a current blocking function. In this way, based on submicron selective area re-growth, we aim for electrically injected photonic crystal lasers with high output power, small threshold currents and low power consumption. Here results are presented on the oxidation of AlInAs. The results show that it is feasible to use the oxide of AlInAs for current blocking in an InP-based membrane photonic crystal laser

Terra sigillata in southern Latium:The evidence from the Pontine Region Project (1987-2014)

This contribution is the first of a series of publications by the authors to systematically disclose the wealth of material evidence collected during some 30 years of fieldwork in the Pontine region by the Pontine Region Project. This project has, since its inception in the mid-1980s, investigated more than 36 km2 of terrain across all major geomorphological units of the region, largely by means of systematic surface investigations. During these investigations, close to 200 000 artefacts were collected for further study, including c. 1 660 fragments of (Italian) terra sigillata, the emblematic, shiny red fine table ware of the Early Imperial period. In this article, we present a detailed spatial and contextual analysis of the terra sigillata fragments that have been gathered within the Pontine Region Project and discuss the results in light of economic issues (market integration, economic growth). We then supplement this evidence by published evidence of name stamps from surrounding areas to further expose to what extent, and in what ways, the different parts of southern Latium were embedded in the long-distance economic networks of the period

Characterization of human high-density lipoprotein subclasses LP A-I and LP A-I/A-II and binding to HepG2 cells

Abstract Plasma HDL can be classified according to their apolipoprotein content into at least two types of lipoprotein particles: lipoproteins containing both apo A-I and apo A-II (LP A-I/A-II) and lipoproteins with apo A-I but without apo A-II (LP A-I). LP A-I and LP A-I/A-II were isolated by immuno-affinity chromatography. LP A-I has a higher cholesterol content and less protein compared to LP A-I/A-II. The average particle mass of LP A-I is higher (379 kDa) than the average particle weight of LP A-I/A-II (269 kDa). The binding of 125I-LP A-I to HepG2 cells at 4°C, as well as the uptake of [3H]cholesteryl ether-labelled LP A-I by HepG2 cells at 37° C, was significantly higher than the binding and uptake of LP A-I/A-II. It is likely that both binding and uptake are mediated by apo A-I. Our results do not provide evidence in favor of a specific role for apo A-II in the binding and uptake of HDL by HepG2 cells

A Large Atom Number Metastable Helium Bose-Einstein Condensate

We have produced a Bose-Einstein condensate of metastable helium (4He*) containing over 1.5x10^7 atoms, which is a factor of 25 higher than previously achieved. The improved starting conditions for evaporative cooling are obtained by applying one-dimensional Doppler cooling inside a magnetic trap. The same technique is successfully used to cool the spin-polarized fermionic isotope (3He*), for which thermalizing collisions are highly suppressed. Our detection techniques include absorption imaging, time-of-flight measurements on a microchannel plate detector and ion counting to monitor the formation and decay of the condensate.Comment: 4 pages, 3 figures (changed content

Transmission of pillar-based photonic crystal waveguides in InP technology

Waveguides based on line defects in pillar photonic crystals have been fabricated in InP/InGaAsP/InP technology. Transmission measurements of different line defects are reported. The results can be explained by comparison with two-dimensional band diagram simulations. The losses increase substantially at mode crossings and in the slow light regime. The agreement with the band diagrams implies a good control on the dimensions of the fabricated features, which is an important step in the actual application of these devices in photonic integrated circuit

Расстройства сексуального здоровья при воспалительных заболеваниях внутренних гениталий у женщин

При обследовании гинекологических больных выявлены развивающиеся у них разные варианты и формы сексуальной дезадаптации супружеской пары. Показаны их причины, механизмы формирования и клинические проявления.The investigation of gynecological patients revealed development of different variants and forms of sexual dysadaptation of the married couple. Their causes, formation mechanisms and clinical manifestations are shown