Impressive clinical course of diabetic patient with various medical problems and remarkable improvement by insulin degludec and liraglutide (Xultophy)

Diabetes mellitus causes macrovascular, microvascular angiopathy, and increased cancer risk. Authors et al. have continued clinical practice and research on diabetes cases. Current case is impressive 79-year-old female with various diseases. They include asthma and COPD, steroid intake for years, sleep apnea syndrome (SAS), Continuous Positive Airway Pressure (CPAP) therapy, tongue cancer, arteriosclerosis, bone complications, Carpal tunnel syndrome (CTS), and so on. When she developed hyperglycemia with 9.0% of HbA1c, Xultophy® was started. It contains insulin degludec and liraglutide which is Glucagon-like peptide-1 receptor agonist (GLP-1 RA). HbA1c values decreased as 7.9%, 7.3%, 6.9%, 6.5% in 1-4 months, with remarkable effect. The satisfactory efficacy may be from double agents of Xultophy® or probable secondary diabetes due to continuation of steroid of the case. This report will be expected to be some reference in the future diabetic research development

Seasonal changes in HbA1c values from young to elderly diabetic patients

Background: Current research has focused on the seasonal changes in HbA1c at the age of 21-90 years old. Subjects and methods: Subjects were 96 patients with type 2 diabetes mellitus (T2DM). Methods include the classification of group A, B, C by the age with 21-50, 51-70, 71-90 years old. HbA1c values in median were calculated for five consecutive seasons from December 2017 to February 2019. Results: BMI value in 3 group A, B, C was 29.7, 24.7, 25.3, respectively. Basal HbA1c was 7.0%, 7.1%, 7.1%, in 3 groups, respectively. Seasonal changes in HbA1c are as follows: group A showed highest in the summer, group B showed highest in the spring and gradually decreased to the winter, and group C showed gradual decrease and lowest in autumn. Discussion and conclusion: Seasonal changes would be probably from i) working generation with fatigue for persistent hot climate in group A, ii) rather stable daily life with balanced work and rest for the home in group B and C, iii) hot climate from spring to summer may be involved in the changes. Current investigation does not include multiple related factors. Further research will be expected for clarifying various factors

6-shogaolおよび6-paradolの体内動態および薬理作用の検討

13301甲第4071号博士（薬学）金沢大学博士論文要旨Abstrac

6-shogaolおよび6-paradolの体内動態および薬理作用の検討

13301甲第4071号博士（薬学）金沢大学博士論文本文Ful

Preventive Effect of Pine Bark Extract (Flavangenol) on Metabolic Disease in Western Diet-Loaded Tsumura Suzuki Obese Diabetes Mice

It is known that the metabolic syndrome has a multi-factorial basis involving both genetic and environmental risk factors. In this study, Tsumura Suzuki Obese Diabetes (TSOD) mice, a mouse model of multi-factorial, hereditary, obese type II diabetes, were given a Western diet (WTD) as an environmental factor to prepare a disease model (TSOD-WTD) and to investigate the preventive effects of Pine bark extract (Flavangenol) against obesity and various features of metabolic disease appearing in this animal model. In contrast to control Tsumura Suzuki Non-obesity (TSNO) mice, TSOD mice were obese and suffered from other metabolic complications. WTD-fed TSOD mice developed additional features such as hyperinsulinemia, abnormal glucose/lipid metabolism and fatty liver. The treatment with Flavangenol had a suppressive effect on increase in body weight and accumulation of visceral and subcutaneous fat, and also showed preventive effects on symptoms related to insulin resistance, abnormal glucose/lipid metabolism and hypertension. Flavangenol also increased the plasma concentration of adiponectin and decreased the plasma concentration of TNF-α. We next investigated the effect of Flavangenol on absorption of meal-derived lipids. Flavangenol suppressed absorption of neutral fat in an olive-oil-loading test (in vivo) and showed an inhibitory effect on pancreatic lipase (in vitro). The above results suggest that Flavangenol has a preventive effect on severe metabolic disease due to multiple causes that involve both genetic and environmental risk factors. The mechanism of action might involve a partial suppressive effect of meal-derived lipids on absorption

Updating the role of matrix metalloproteinases in mineralized tissue and related diseases

Bone development and healing processes involve a complex cascade of biological events requiring well-orchestrated synergism with bone cells, growth factors, and other trophic signaling molecules and cellular structures. Beyond health processes, MMPs play several key roles in the installation of heart and blood vessel related diseases and cancer, ranging from accelerating metastatic cells to ectopic vascular mineralization by smooth muscle cells in complementary manner. The tissue inhibitors of MMPs (TIMPs) have an important role in controlling proteolysis. Paired with the post-transcriptional efficiency of specific miRNAs, they modulate MMP performance. If druggable, these molecules are suggested to be a platform for development of “smart” medications and further clinical trials. Thus, considering the pleiotropic effect of MMPs on mammals, the purpose of this review is to update the role of those multifaceted proteases in mineralized tissues in health, such as bone, and pathophysiological disorders, such as ectopic vascular calcification and cancer

The biochemistry of mineralizing extracellular vesicles. Part I: The role of phosphatases

In this chapter, we will review some of the information regarding the functional significance of the inorganic phosphate (Pi)/pyrophosphate (PPi) ratio for physiological mineralization of hard tissues. We will recount the structure and function of the phosphatases involved in the regulation of this ratio: Tissue-nonspecific alkaline phosphatase (TNAP); Nucleotide Pyrophosphatases/Phosphodiesterase 1 (ENPP1); Na,K-ATPase; Nucleoside triphosphate diphosphohydrolase 1 (CD39); ecto-5′-nucleotidase (CD73) and orphan phosphatase 1 (PHOSPHO1); and how this knowledge has guided the development of protein therapeutics and of small molecule inhibitors to affect the Pi/PPi ratio in pathological conditions ranging from soft bones to ectopic calcification disorders

Avaliação da capacidade discriminante de distribuições da proeminência do pico cepstral para identificar nódulos vocais

Este trabalho tem como objetivo avaliar as distribuições de CPP e CPPS para a vogal sustentada /a/ e suas estatísticas descritivas como discriminantes entre vozes saudáveis e vozes de pacientes diagnosticados com n´módulos vocais. Além de calcular essas medidas na escala decibel como normalmente realizado na literatura, este trabalho também as calculou na escala linear. Após avaliar 9 estatísticas da distribuição de 4 medidas de CPP e 4 medidas de CPPS para 35 voluntários, o 95-ésimo percentil do CPP, calculado a cada 2ms e na escala decibel, apresentou a maior capacidade discriminante, alcançando um valor-p de 3,58e-05, uma sensibilidade de 88,67%, especificidade de 85% e precisão de classificação igual a 85,71%.info:eu-repo/semantics/publishedVersio