Different long-term trends of the oxygen red 630.0 nm line nightglow intensity as the result of lowering the ionosphere F2 layer

Long-term observations of total nightglow intensity of the atomic oxygen red 630.0 nm line at Abastumani (41.75° N, 42.82° E) in 1957–1993 and measurements of the ionosphere F2 layer parameters from the Tbilisi ionosphere station (41.65° N, 44.75° E) in 1963–1986 have been analyzed. It is shown that a decrease in the long-term trend of the mean annual red 630.0 nm line intensity from the pre-midnight value (+0.770±1.045 R/year) to its minimum negative value (−1.080±0.670 R/year) at the midnight/after midnight is a possible result of the observed lowering of the peak height of the ionosphere F2 layer electron density <I>hm</I>F2 (−0.455±0.343 km/year). A theoretical simulation is carried out using a simple Chapman-type layer (damping in time) for the height distribution of the F2 layer electron density. The estimated values of the lowering in the <I>hm</I>F2, the increase in the red line intensity at pre-midnight and its decrease at midnight/after midnight are close to their observational ones, when a negative trend in the total neutral density of the upper atmosphere and an increase in the mean northward wind (or its possible consequence – a decrease in the southward one) are assumed

Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications

Superparamagnetic iron oxide nanoparticles can providemultiple benefits for biomedical applications in aqueous environments such asmagnetic separation or magnetic resonance imaging. To increase the colloidal stability and allow subsequent reactions, the introduction of hydrophilic functional groups onto the particles’ surface is essential. During this process, the original coating is exchanged by preferably covalently bonded ligands such as trialkoxysilanes. The duration of the silane exchange reaction, which commonly takes more than 24 h, is an important drawback for this approach. In this paper, we present a novel method, which introduces ultrasonication as an energy source to dramatically accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove the generic character, different functional groups were introduced on the surface including polyethylene glycol chains, carboxylic acid, amine, and thiol groups. Their colloidal stability in various aqueous buffer solutions as well as human plasma and serum was investigated to allow implementation in biomedical and sensing applications.status: publishe

Cohort profile. the ESC-EORP chronic ischemic cardiovascular disease long-term (CICD LT) registry

The European Society of cardiology (ESC) EURObservational Research Programme (EORP) Chronic Ischemic Cardiovascular Disease registry Long Term (CICD) aims to study the clinical profile, treatment modalities and outcomes of patients diagnosed with CICD in a contemporary environment in order to assess whether these patients at high cardiovascular risk are treated according to ESC guidelines on prevention or on stable coronary disease and to determine mid and long term outcomes and their determinants in this population