Cumulative and Ratio Time Evaluations in Keystroke Dynamics To Improve the Password Security Mechanism

The password mechanism is widely adopted as a control security system to legitimate access to a database or a transaction content or computing resources. This is because of the low cost of the mechanism, the software routine simplicity, and the facility for the user. But the password mechanism can suffer from serious vulnerabilities, which have to be reduced in some way. An aid comes from the keystroke dynamic evaluation, which uses the rhythm in which an individual types characters on a keyboard. It has been demonstrated how the keystroke dynamics are unique biometric template of the users typing pattern. So, the dwell time (the time a key pressed) and the flight time (the time between “key up” and the next “key down”) are used to verify the real user’s identity. In this work we investigated the keystroke dynamic already reported in literature but with some differences, so to obtain additional benefits. Rather than the commonly adopted absolute times (dwell and fly times), we deal with cumulative and ratio ones (i.e. sum and ratio of dwell and fly times), taking into account that the latest are times which do not change even if the user’s typing style evolves with practic

The Human SLC25A33 and SLC25A36 Genes of Solute Carrier Family 25 Encode Two Mitochondrial Pyrimidine Nucleotide Transporters

The human genome encodes 53 members of the solute carrier family 25 (SLC25), also called the mitochondrial carrier family, many of which have been shown to transport inorganic anions, amino acids, carboxylates, nucleotides, and coenzymes across the inner mitochondrial membrane, thereby connecting cytosolic and matrix functions. Here two members of this family, SLC25A33 and SLC25A36, have been thoroughly characterized biochemically. These proteins were overexpressed in bacteria and reconstituted in phospholipid vesicles. Their transport properties and kinetic parameters demonstrate that SLC25A33 transports uracil, thymine, and cytosine (deoxy)nucleoside di- and triphosphates by an antiport mechanism and SLC25A36 cytosine and uracil (deoxy)nucleoside mono-, di-, and triphosphates by uniport and antiport. Both carriers also transported guanine but not adenine (deoxy)nucleotides. Transport catalyzed by both carriers was saturable and inhibited by mercurial compounds and other inhibitors of mitochondrial carriers to various degrees. In confirmation of their identity (i) SLC25A33 and SLC25A36 were found to be targeted to mitochondria and (ii) the phenotypes of Saccharomyces cerevisiae cells lacking RIM2, the gene encoding the well characterized yeast mitochondrial pyrimidine nucleotide carrier, were overcome by expressing SLC25A33 or SLC25A36 in these cells. The main physiological role of SLC25A33 and SLC25A36 is to import/export pyrimidine nucleotides into and from mitochondria, i.e. to accomplish transport steps essential for mitochondrial DNA and RNA synthesis and breakdown

Emovo Corpus: an Italian Emotional Speech Database

This article describes the first emotional corpus, named EMOVO, applicable to Italian language,. It is a database built from the voices of up to 6 actors who played 14 sentences simulating 6 emotional states (disgust, fear, anger, joy, surprise, sadness) plus the neutral state. These emotions are the well-known Big Six found in most of the literature related to emotional speech. The recordings were made with professional equipment in the Fondazione Ugo Bordoni laboratories. The paper also describes a subjective validation test of the corpus, based on emotion-discrimination of two sentences carried out by two different groups of 24 listeners. The test was successful because it yielded an overall recognition accuracy of 80%. It is observed that emotions less easy to recognize are joy and disgust, whereas the most easy to detect are anger, sadness and the neutral state

Phase separations, liquid crystal ordering and molecular partitioning in mixtures of PEG and DNA oligomers

Liquid crystals (LCs) ordering of DNA and RNA oligomers relies on the presence of inter-duplex end-to-end attraction, driving the formation of linear aggregates. Such interactions are gauged, at a macroscopic level, by the osmotic pressure at the isotropic-nematic and nematic-columnar phase transitions. We studied aqueous solutions of PEG and DNA duplex-forming oligomers, finding that there is a wide range of concentrations in which these mixtures phase separate into coexisting PEG-rich and DNA-rich phases, the latter being either in the isotropic state or ordered as a nematic or columnar LC. We determined the phase diagram in mixtures of PEG and DNA duplexes with different terminal motifs\u2013blunt ends, sticky overhangs, aggregation-preventing overhangs\u2013and measured the partitioning of the species in the coexisting phases. On this basis, we determined the osmotic pressure as a function of the DNA concentration across the phase diagram. We compared the equation of state obtained in this way with both the Carnahan\u2013Starling equation of state for hard spheres and with the pressure predicted by computer simulations of a system of aggregating cylinders. We obtain a good agreement between experiments and simulations, and end-to-end attraction energies of the order of 6 kcal/mol, a bit larger than expected, but still in agreement with the current models for DNA-DNA interactions

3D #DigitalInvasions: a crowdsourcing project for mobile user generated content

This paper introduces the #InvasioniDigitali project which is an online crowdsourcing initiative started in Italy in 2013 with the aim to promote the value of and engagement with local heritage. The paper focuses on two case studies of pilot ‘invasions’ using 3D data capture by students at museums and heritage sites in Sicily

Risk of heat illness in men and women: a systematic review and meta-analysis

Background Heat illness (HI) is a growing global concern; its incidence has risen dramatically across the world in recent years. The individual factors whereby elevated core temperature produces HI are not well-understood. Given known physiological differences between men and women pertaining to temperature regulation, we hypothesized that women would be at increased risk of HI than men. Objectives We aimed to determine the relative risk of HI in women compared with men through an exhaustive literature review and meta-analysis. Methods We search PubMed and Ovid Medline databases from inception to Apr 2017. Search terms included all permutations of sex and heat illness (including heatstroke and exertional heat illness) with no language restrictions. We included adult or adolescent human data reporting comparable male and female HI rates. One reviewer identified and screened titles and abstracts. Two independent reviewers applied eligibility criteria. Disagreements were resolved with a third reviewer. Results Of 5888 articles identified by searches, 36 were included in the systematic review and 22 in the meta-analysis. The mean (standard deviation) quality score was 3.31(1.25)/5. Overall the rate among women was consistently lower than men across the lifespan. The male: female pooled IRR was 2.28 (p<0.001, 95% CI: 1.66-3.16). There was modest heterogeneity (between-studies variance (τ2) = 0.02). The rates did not differ significantly when corrected for severity or occupation. Discussion The rate of HI was significantly increased in men compared with women. Risk for HI might be conferred by psychological and behavioral factors rather than physiological ones. Further research is required to delineate which groups are at greatest risk, leading to the development of mitigation strategies against HI

stream temperature estimated in situ from thermal infrared images best estimate and uncertainty

The paper aims to show a technique to estimate in situ the stream temperature from thermal-infrared images deepening its best estimate and uncertainty. Stream temperature is an important indicator of water quality and nowadays its assessment is important particularly for thermal pollution monitoring in water bodies. Stream temperature changes are especially due to the anthropogenic heat input from urban wastewater and from water used as a coolant by power plants and industrial manufacturers. The stream temperatures assessment using ordinary techniques (e.g. appropriate thermometers) is limited by sparse sampling in space due to a spatial discretization necessarily punctual. Latest and most advanced techniques assess the stream temperature using thermal-infrared remote sensing based on thermal imagers placed usually on aircrafts or using satellite images. These techniques assess only the surface water temperature and they are suitable to detect the temperature of vast water bodies but do not allow a detailed and precise surface water temperature assessment in limited areas of the water body. The technique shown in this research is based on the assessment of thermal-infrared images obtained in situ via portable thermal imager. As in all thermographic techniques, also in this technique, it is possible to estimate only the surface water temperature. A stream with the presence of a discharge of urban wastewater is proposed as case study to validate the technique and to show its application limits. Since the technique analyzes limited areas in extension of the water body, it allows a detailed and precise assessment of the water temperature. In general, the punctual and average stream temperatures are respectively uncorrected and corrected. An appropriate statistical method that minimizes the errors in the average stream temperature is proposed. The correct measurement of this temperature through the assessment of thermal- infrared images obtained in situ via portable thermal imager is confirmed by the direct measurement of stream temperature using an ordinary technique based on an appropriate thermometer

The Saccharomyces cerevisiae gene YPR011c encodes a mitochondrial transporter of adenosine 5'-phosphosulfate and 3'-phospho-adenosine 5'-phosphosulfate

The genome of Saccharomyces cerevisiae contains 35 members of the mitochondrial carrier family, nearly all of which have been functionally characterized. In this study, the identification of the mitochondrial carrier for adenosine 5'-phosphosulfate (APS) is described. The corresponding gene (YPR011c) was overexpressed in bacteria. The purified protein was reconstituted into phospholipid vesicles and its transport properties and kinetic parameters were characterized. It transported APS, 3'-phospho-adenosine 5'-phosphosulfate, sulfate and phosphate almost exclusively by a counter-exchange mechanism. Transport was saturable and inhibited by bongkrekic acid and other inhibitors. To investigate the physiological significance of this carrier in S. cerevisiae, mutants were subjected to thermal shock at 45°C in the presence of sulfate and in the absence of methionine. At 45°C cells lacking YPR011c, engineered cells (in which APS is produced only in mitochondria) and more so the latter cells, in which the exit of mitochondrial APS is prevented by the absence of YPR011cp, were less thermotolerant. Moreover, at the same temperature all these cells contained less methionine and total glutathione than wild-type cells. Our results show that S. cerevisiae mitochondria are equipped with a transporter for APS and that YPR011cp-mediated mitochondrial transport of APS occurs in S. cerevisiae under thermal stress condition

Mentalizing subtypes in eating disorders: A latent profile analysis

Background: Mentalizing, the mental capacity to understand oneself and others in terms of mental states, has been found to be reduced in several mental disorders. Some studies have suggested that eating disorders (EDs) may also be associated with impairments in mentalizing. The aim of this work is to investigate the possible presence of mentalizing subtypes in a sample of patients with EDs. Method: A sample of patients with eating disorders (N = 157) completed a battery of measures assessing mentalization and related variables, including the Reflective Functioning Questionnaire (RFQ), the Difficulties in Emotion Regulation Strategies (DERS), the Interpersonal Reactivity Index (IRI). Clinicians rated patients in relation to imbalances in different dimensions of mentalization to prementalizing modes and attachment style by using the Mentalization Imbalances Scale, the Modes of Mentalization Scale (MMS), and the Adult Attachment Questionnaire. A latent profile analysis was conducted to test the possible presence of different subgroups. MANOVA was used to test the possible differences between the four mentalizing profiles in relation to emotion dysregulation (DERS), empathy (IRI), and adequate and impairments in mentalizing (MMS and RFQ). Results: The latent profile analysis suggested the presence of four different profiles in relation to impairments in the dimensions of mentalization: (1) affective/self/automatic imbalances, (2) external imbalance, (3) cognitive/self/automatic imbalances, and (4) cognitive/other/automatic imbalances. Patients belonging to profile 1 are characterized by the prevalence of affective mentalization that overwhelms the capacity to reflect on mental states with an imbalance on the self-dimension; profile 2 patients are excessively focused on the external cues of mentalization; profile 3 patients are characterized by an over-involvement on the cognitive and self-facets of mentalization, with an impairment in adopting the other mind perspective; and profile 4 patients have similar impairments compared to profile 3 patients but with an excessive focus on others and deficits in self-reflection. These profiles were heterogeneous in terms of EDs represented in each group and presented significant differences on various variables such as attachment style, emotion dysregulation, empathy, interpersonal reactivity, and reflective function. This study represents, so far, the first work that confirms the presence of different mentalizing patterns in ED patients. Conclusions: ED patients can be classified in relation to impairments in different dimensions of mentalization above and beyond ED diagnosis

Effects of government expenditure, credit and tax policies on the economic development of Iran with special reference to the 1960-76 period

Iran is ons of the best case studies among the oil producing countries in which the effects of oil revenue can be examined. While it has some of the basic characteristics of developing countries, it is endowed with enormous wealth. A combination of these factors has increased the role of the government in economic development by granting a greater possibility of spending and menoeuverability with regard to its economic policies. Due to the importance of the state in the economic development of Iran, this thesis has been devoted to the economic role of the government in Iran. We have examined the determinants of government expenditure, in three parts, its effects and the importance of different channels of finance. In the first part, we have examined the determinants of government expenditure which indicate that on the one hand, the revenue constraint has determined the level of government expenditure at the aggregate level and changes in the pattern of expenditure have been produced by an exogenous factor mainly oil revenue. On the other hand, this exogenous factor which has granted the state a political independence from its social base, has affected the pattern of distribution of government expenditure. Due to the importance of political factors, social and economic expenditures have been undermined while defence expenditure has been over-emphasised. The effects of such a pattern of government expenditure which has been reinforced by other economic policies, have been the distortion of economic development. As the second part will show, the effects of government economic policies have been determined by the short-run nature of the determinants of government expenditure through which the government has tried to benefit the middle and upper classes in order to grasp some political support. In the main the majority of peasants have been ignored and have received no part of government expenditure. Also, by the emphasis on capital intensity, has created a maldistribution of Income which has appeared as an impediment to the growth of industrial production* In the service sector, while the long -run needs for human capital and infra-structural investment have been undermined, defence expenditure has resulted in the depletion of foreign exchange and the distortion of the pattern of development. As the third part shows, the above pattern has been affected by the structure of the Iranian fiscal system in which a relative independence of the state has been ensured through the external channel of finance which has reduced the importance of public opinion in the allocation of government spendings. Not only has it resluted in retarding the development of the fiscal system , but, has also reinforced the gearing of the Iranian economy to the exogenous determinant which in turn has been determined by the structure of the international oil market and the commitment of the Iranian government to its allies. Due to the existence of such dualistic determinants, the government has had to balance between internal and external factors. Because of the gradual rising of importance of oil revenue, the trade-off point has moved toward external factors which has caused . an increasing trend towards military expenditure. In this way, the gap between the state and its internal / social base has widened and the political system has no longer been able to reflect the long-run needs of the economy. Since economic decision making has been strongly affected by the political factors, a socio-political change may be inevitable at a time of economic crisis