When your face doesn't fit: employment discrimination against people with facial disfigurements

This study aimed to investigate the recruitment prospects of people with facial disfigurement and a contrasting group of wheelchair users, representing a functional impairment with little aesthetic impact. Three applications were made to each of 144 vacancies using three CVs and cover letters rotated around conditions in which one applicant was described as a wheelchair user, another had a non-contagious facial disfigurement, and the third (control condition) had neither. There was evidence of discrimination against people with facial disfigurement in jobs requiring high (but not low) levels of customer contact, and against wheelchair users for jobs entailing high or low customer contact. Aesthetic considerations, social norms, and the possibility of stigma by association are discussed as potential underlying factors

Connexins and Diabetes

Cell-to-cell interactions via gap junctional communication and connexon hemichannels are involved in the pathogenesis of diabetes. Gap junctions are highly specialized transmembrane structures that are formed by connexon hemichannels, which are further assembled from proteins called “connexins.” In this paper, we discuss current knowledge about connexins in diabetes. We also discuss mechanisms of connexin influence and the role of individual connexins in various tissues and how these are affected in diabetes. Connexins may be a future target by both genetic and pharmacological approaches to develop treatments for the treatment of diabetes and its complications

Drought and root herbivory interact to alter the response of above-ground parasitoids to aphid infested plants and associated plant volatile signals

Multitrophic interactions are likely to be altered by climate change but there is little empirical evidence relating the responses of herbivores and parasitoids to abiotic factors. Here we investigated the effects of drought on an above/belowground system comprising a generalist and a specialist aphid species (foliar herbivores), their parasitoids, and a dipteran species (root herbivore).We tested the hypotheses that: (1) high levels of drought stress and below-ground herbivory interact to reduce the performance of parasitoids developing in aphids; (2) drought stress and root herbivory change the profile of volatile organic chemicals (VOCs) emitted by the host plant; (3) parasitoids avoid ovipositing in aphids feeding on plants under drought stress and root herbivory. We examined the effect of drought, with and without root herbivory, on the olfactory response of parasitoids (preference), plant volatile emissions, parasitism success (performance), and the effect of drought on root herbivory. Under drought, percentage parasitism of aphids was reduced by about 40–55% compared with well watered plants. There was a significant interaction between drought and root herbivory on the efficacy of the two parasitoid species, drought stress partially reversing the negative effect of root herbivory on percent parasitism. In the absence of drought, root herbivory significantly reduced the performance (e.g. fecundity) of both parasitoid species developing in foliar herbivores. Plant emissions of VOCs were reduced by drought and root herbivores, and in olfactometer experiments parasitoids preferred the odour from well-watered plants compared with other treatments. The present work demonstrates that drought stress can change the outcome of interactions between herbivores feeding above- and belowground and their parasitoids, mediated by changes in the chemical signals from plants to parasitoids. This provides a new insight into how the structure of terrestrial communities may be affected by drought

Accountability Work: Examining the Values, Technologies and Work Practices that Facilitate Transparency in Charities

Charities are subject to stringent transparency and accountability requirements from government and funders to ensure that they are conducting work and spending money appropriately. Charities are increasingly important to civic life and have unique characteristics as organisations. This provides a rich space in which HCI researchers may learn from and affect both held notions of transparency and accountability, and the relationships between these organisations and their stakeholders. We conducted ethnographic fieldwork and workshops over a seven month period at a charity. We aimed to understand how the transparency obligations of a charity manifest through work and how the workers of a charity reason about transparency and accountability as an everyday practice. Our findings highlight how organisations engage in presenting different accounts of their work; how workers view their legal transparency obligations in contrast with their accountability to their everyday community; and how their labour does not translate well to outcome measures or metrics. We discuss implications for the design of future systems that support organisations to produce accounts of their work as part of everyday practice

Prevalence of osteoarthritis in lower middle- and low-income countries: a systematic review and meta-analysis

Evidence from the Global Burden of Disease studies suggests that osteoarthritis (OA) is a significant cause of disability globally; however, it is less clear how much of this burden exists in low-income and lower middle-income countries. This study aims to determine the prevalence of OA in people living in low-income and lower middle-income countries. Four electronic databases (MEDLINE, EMBASE, CINAHL and Web of Science) were systematically searched from inception to October 2018 for population-based studies. We included studies reporting the prevalence of OA among people aged 15 years and over in low-income and lower middle-income countries. The prevalence estimates were pooled across studies using random effects meta-analysis. Our study was registered with PROSPERO, number CRD42018112870.The search identified 7414 articles, of which 356 articles were selected for full text assessment. 34 studies were eligible and included in the systematic review and meta-analysis. The pooled prevalence of OA was 16·05% (95% confidence interval (CI) 12·55–19·89), with studies demonstrating a substantial degree of heterogeneity (I2 = 99·50%). The pooled prevalence of OA was 16.4% (CI 11·60–21.78%) in South Asia, 15.7% (CI 5·31–30·25%) in East Asia and Pacific, and 14.2% (CI 7·95–21·89%) in Sub Saharan Africa. The meta-regression analysis showed that publication year, study sample size, risk of bias score and country-income categories were significantly associated with the variations in the prevalence estimates. The prevalence of OA is high in low-income and lower middle-income countries, with almost one in six of the study participants reported to have OA. With the changing population demographics and the shift to the emergence of non-communicable diseases, targeted public health strategies are urgently needed to address this growing epidemic in the aging population

In-channel 3D models of riverine environments for hydromorphological characterization

Recent legislative approaches to improve the quality of rivers have resulted in the design and implementation of extensive and intensive monitoring programmes that are costly and time consuming. An important component of assessing the ecological status of a water body as required by the Water Framework Directive is characterising the hydromorphology. Recent advances in autonomous operation and the spatial coverage of monitoring systems enables more rapid 3D models of the river environment to be produced. This study presents a Structure from Motion (SfM) semi-autonomous based framework for the estimation of key reach hydromorphological measures such as water surface area, wetted water width, bank height, bank slope and bank-full width, using in-channel stereo-imagery. The framework relies on a stereo-camera that could be positioned on an autonomous boat. The proposed approach is demonstrated along three 40 m long reaches with differing hydromorphological characteristics. Results indicated that optimal stereo-camera settings need to be selected based on the river appearance. Results also indicated that the characteristics of the reach have an impact on the estimation of the hydromorphological measures; densely vegetated banks, presence of debris and sinuosity along the reach increased the overall error in hydromorphological measure estimation. The results obtained highlight a potential way forward towards the autonomous monitoring of freshwater ecosystem

Quantitative GPCR and ion channel transcriptomics in primary alveolar macrophages and macrophage surrogates

Background: Alveolar macrophages are one of the first lines of defence against invading pathogens and play a central role in modulating both the innate and acquired immune systems. By responding to endogenous stimuli within the lung, alveolar macrophages contribute towards the regulation of the local inflammatory microenvironment, the initiation of wound healing and the pathogenesis of viral and bacterial infections. Despite the availability of protocols for isolating primary alveolar macrophages from the lung these cells remain recalcitrant to expansion in-vitro and therefore surrogate cell types, such as monocyte derived macrophages and phorbol ester-differentiated cell lines (e.g. U937, THP-1, HL60) are frequently used to model macrophage function.Methods: The availability of high throughput gene expression technologies for accurate quantification of transcript levels enables the re-evaluation of these surrogate cell types for use as cellular models of the alveolar macrophage. Utilising high-throughput TaqMan arrays and focussing on dynamically regulated families of integral membrane proteins, we explore the similarities and differences in G-protein coupled receptor (GPCR) and ion channel expression in alveolar macrophages and their widely used surrogates.Results: The complete non-sensory GPCR and ion channel transcriptome is described for primary alveolar macrophages and macrophage surrogates. The expression of numerous GPCRs and ion channels whose expression were hitherto not described in human alveolar macrophages are compared across primary macrophages and commonly used macrophage cell models. Several membrane proteins known to have critical roles in regulating macrophage function, including CXCR6, CCR8 and TRPV4, were found to be highly expressed in macrophages but not expressed in PMA-differentiated surrogates.Conclusions: The data described in this report provides insight into the appropriate choice of cell models for investigating macrophage biology and highlights the importance of confirming experimental data in primary alveolar macrophages. © 2012 Groot-Kormelink et al.; licensee BioMed Central Ltd

Better Workers, Better Elections? Electoral Management Body Workforces and Electoral Integrity Worldwide

Building better elections is a central task for the study of democracy and democratisation. Despite this, there have been no cross-national studies on the staff who manage and implement elections: electoral management body (EMB) workforces. This article provides the first macroscopic worldwide picture of workforce characteristics, human resource management practices and employee outcomes, and analyses the effects they have on electoral integrity, based on original international surveys of electoral management bodies (EMBs) (n = 51) and electoral officials (n = 2029). Drawing from the human resource management literature, a framework is developed to explain how these factors might interact with EMB performance. Analysis demonstrates them to be highly related. Adding data on human resource management practices and employee outcomes improves explanatory models designed to predict the performance of EMBs. Chiefly, EMBs that enable greater opportunities for employees to be involved in decision-making processes perform better. Recruitment practices, job satisfaction and levels of stress are also important