Herschel/PACS Imaging of Protostars in the HH 1-2 Outflow Complex

We present 70 and 160 micron Herschel science demonstration images of a field in the Orion A molecular cloud that contains the prototypical Herbig-Haro objects HH 1 and 2, obtained with the Photodetector Array Camera and Spectrometer (PACS). These observations demonstrate Herschel's unprecedented ability to study the rich population of protostars in the Orion molecular clouds at the wavelengths where they emit most of their luminosity. The four protostars previously identified by Spitzer 3.6-40 micron imaging and spectroscopy are detected in the 70 micron band, and three are clearly detected at 160 microns. We measure photometry of the protostars in the PACS bands and assemble their spectral energy distributions (SEDs) from 1 to 870 microns with these data, Spitzer spectra and photometry, 2MASS data, and APEX sub-mm data. The SEDs are fit to models generated with radiative transfer codes. From these fits we can constrain the fundamental properties of the protostars. We find luminosities in the range 12-84 L_sun and envelope densities spanning over two orders of magnitude. This implies that the four protostars have a wide range of envelope infall rates and evolutionary states: two have dense, infalling envelopes, while the other two have only residual envelopes. We also show the highly irregular and filamentary structure of the cold dust and gas surrounding the protostars as traced at 160 microns.Comment: 6 pages, 4 figures, accepted for publication in the A&A Herschel special issu

Hier ist wahrhaftig ein Loch im Himmel - The NGC 1999 dark globule is not a globule

The NGC 1999 reflection nebula features a dark patch with a size of ~10,000 AU, which has been interpreted as a small, dense foreground globule and possible site of imminent star formation. We present Herschel PACS far-infrared 70 and 160mum maps, which reveal a flux deficit at the location of the globule. We estimate the globule mass needed to produce such an absorption feature to be a few tenths to a few Msun. Inspired by this Herschel observation, we obtained APEX LABOCA and SABOCA submillimeter continuum maps, and Magellan PANIC near-infrared images of the region. We do not detect a submillimer source at the location of the Herschel flux decrement; furthermore our observations place an upper limit on the mass of the globule of ~2.4x10^-2 Msun. Indeed, the submillimeter maps appear to show a flux depression as well. Furthermore, the near-infrared images detect faint background stars that are less affected by extinction inside the dark patch than in its surroundings. We suggest that the dark patch is in fact a hole or cavity in the material producing the NGC 1999 reflection nebula, excavated by protostellar jets from the V 380 Ori multiple system.Comment: accepted for the A&A Herschel issue; 7 page

Polymer-Supported Photosensitizers for Oxidative Organic Transformations in Flow and under Visible Light Irradiation

A 2,1,3-benzothiadiazole (BTZ)–based vinyl crosslinker was synthesized and copolymerized with large excesses of styrene using free radical polymerization to deliver heterogeneous triplet photosensitizers in three distinct physical formats: gels, beads and monoliths. These photosensitizers were employed for the production of singlet oxygen (1O2) and for the aerobic hydroxylation of aryl boronic acids via superoxide radical anion (O2˙-) whereby the materials demonstrated good chemical and photo stability. BTZ-containing beads and monoliths were exploited as photosensitizers in a commercial flow reactor, and 1O2 production was also demonstrated using direct sunlight irradiation, with a conversion rate comparable to the rates achieved when using a 420 nm LED module as the source of photons

Effect of Ethanoic Extract of Treculia Africana Seeds on Total Cholesterol, Total Protein, and Nitric Oxide

Treculia africana is well known and eaten by the people of South-South and South-East region of Nigeria. T. africana can be eaten alone or process and combine it with other fruits. It is nutritious and provide natural bioactive substance to the body. This study was aim to evaluate the Effect of Ethanoic Extract of Treculia africana Seeds on Total Cholesterol, Total Protein, and Nitric Oxide. It was an experimental research. 20 male rats were randomly selected into four groups (control, low dose, moderate dose and high dose groups) with five animals per group.  Group A served as control and received only water and pellet feed, Group B (low dose) received 250mg/kg, group C (moderate dose) received 300mg/kgand group D (high dose) received 350mg/kg of aqueous extract of Treculia africana seed respectively. The extract was administered orally to the rats once a day for a period of 10days. On the 11th day, the animals were anaesthetized with chloroform soaked in cotton wool and blood tissues were collected. The results revealed that,there is significantly increase in the serum levels of total protein in all the treated groups when compared with control (Total protein control 51.40±0.51, low dose 61.60±0.51* medium dose 71.60±0.51*, and 71.80±1.07*). Total cholesterol significantly decreased when both medium and high dose were administered when compared with control (Total cholesterol control 2.34±0.05, medium dose 1.90±0.07*, high dose 1.96±0.19*). Also, nitric oxide significantly increases serum levels in the groups treated with T. africana when compared with control (Nitric oxide control 7.16±0.14, low dose 8.98±0.09*, medium dose 8.50±0.15* and high dose 8.02±0.11*)

IRAS4A1: Multi-wavelength continuum analysis of a very flared Class 0 disk

Understanding the formation of substructures in protoplanetary disks is vital for gaining insights into dust growth and the process of planet formation. Studying these substructures in highly embedded Class 0 objects using the Atacama Large Millimeter/submillimeter Array (ALMA), however, poses significant challenges. Nonetheless, it is imperative to do so to unravel the mechanisms and timing behind the formation of these substructures. In this study, we present high-resolution ALMA data at Bands 6 and 4 of the NGC1333 IRAS4A Class 0 protobinary system. This system consists of two components, A1 and A2, separated by 1.8" and located in the Perseus molecular cloud at $\sim$293 pc distance. To gain a comprehensive understanding of the dust properties and formation of substructures in the early stages, we conducted a multi-wavelength analysis of IRAS4A1. Additionally, we sought to address whether the lack of observed substructures in very young disks, could be attributed to factors such as high degrees of disk flaring and large scale heights. To explore this phenomenon, we employed radiative transfer models using RADMC-3D. Our multi-wavelength analysis of A1 discovered characteristics such as high dust surface density, substantial dust mass within the disk, and elevated dust temperatures. These findings suggest the presence of large dust grains compared to the ones in the interstellar medium (ISM), greater than 100 microns in size within the region. Furthermore, while there's no direct detection of any substructure, our models indicate that some, such as a small gap, must be present. In summary, this result implies that disk substructures may be masked or obscured by a large scale height in combination with a high degree of flaring in Class 0 disks. [Abridged]Comment: Accepted for publication in A&A, 13 pages, 7 figure

Increased platelet counts and platelet activation in early symptomatic versus asymptomatic carotid stenosis and relationship with microembolic status: Results from the Platelets And Carotid Stenosis (PACS) Study

Background: Cerebral microembolic signals (MES) may predict increased stroke risk in carotid stenosis. However, the relationship between platelet counts or platelet activation status and MES in symptomatic versus asymptomatic carotid stenosis has not been comprehensively assessed. Setting: University teaching hospitals. Methods: This prospective, pilot observational study assessed platelet counts and platelet activation status, and the relationship between platelet activation and MES in asymptomatic versus early (≤4 weeks after TIA/stroke) and late phase (≥3 months) symptomatic moderate or severe (≥50%) carotid stenosis patients. Full blood count measurements were performed, and whole blood flow cytometry was used to quantify platelet surface activation marker expression (CD62P and CD63) and circulating leucocyte-platelet complexes. Bilateral simultaneous transcranial Doppler ultrasound monitoring of the middle cerebral arteries was performed for 1 hour to classify patients as MES-positive or MES-negative. Results: Data from 31 asymptomatic patients were compared with 46 symptomatic patients in the early phase, and 35 of these patients followed up to the late phase after symptom onset. The median platelet count (211 vs. 200 x 109/L; p=0.03) and the median % lymphocyte-platelet complexes were higher in early symptomatic than asymptomatic patients (2.8 vs. 2.4%, p=0.001). The % lymphocyte-platelet complexes was higher in early symptomatic than asymptomatic patients with ≥70% carotid stenosis (p=0.0005), and in symptomatic patients recruited within 7 days of symptom onset (p=0.028). Complete TCD data were available in 25 asymptomatic and 31 early phase symptomatic, and 27 late phase symptomatic patients. 12% of asymptomatic versus 32% of early phase symptomatic (p=0.02) and 19% of late phase symptomatic patients (p=0.2) were MES-positive. Early symptomatic MES-negative patients had ahigher % lymphocyte-platelet complexes than asymptomatic MES-negative patients (2.8 vs. 2.3%; p=0.0085). Discussion: Recently symptomatic carotid stenosis patients have higher platelet counts (potentially reflecting increased platelet production, mobilisation or reduced clearance) and platelet activation status than asymptomatic patients. MES were more frequently detected in early symptomatic than asymptomatic patients, but the differences between late symptomatic and asymptomatic groups were not significant. Increased lymphocyte-platelet complex formation in recently symptomatic vs. asymptomatic MES-negative patients indicates enhanced platelet activation in this early symptomatic subgroup. Platelet biomarkers, in combination with TCD, have the potential to aid risk-stratification in asymptomatic and symptomatic carotid stenosis patients

Nucleation and Growth of the Superconducting Phase in the Presence of a Current

We study the localized stationary solutions of the one-dimensional time-dependent Ginzburg-Landau equations in the presence of a current. These threshold perturbations separate undercritical perturbations which return to the normal phase from overcritical perturbations which lead to the superconducting phase. Careful numerical work in the small-current limit shows that the amplitude of these solutions is exponentially small in the current; we provide an approximate analysis which captures this behavior. As the current is increased toward the stall current J*, the width of these solutions diverges resulting in widely separated normal-superconducting interfaces. We map out numerically the dependence of J* on u (a parameter characterizing the material) and use asymptotic analysis to derive the behaviors for large u (J* ~ u^-1/4) and small u (J -> J_c, the critical deparing current), which agree with the numerical work in these regimes. For currents other than J* the interface moves, and in this case we study the interface velocity as a function of u and J. We find that the velocities are bounded both as J -> 0 and as J -> J_c, contrary to previous claims.Comment: 13 pages, 10 figures, Revte

A Closed-Form Solution of the Multi-Period Portfolio Choice Problem for a Quadratic Utility Function

In the present paper, we derive a closed-form solution of the multi-period portfolio choice problem for a quadratic utility function with and without a riskless asset. All results are derived under weak conditions on the asset returns. No assumption on the correlation structure between different time points is needed and no assumption on the distribution is imposed. All expressions are presented in terms of the conditional mean vectors and the conditional covariance matrices. If the multivariate process of the asset returns is independent it is shown that in the case without a riskless asset the solution is presented as a sequence of optimal portfolio weights obtained by solving the single-period Markowitz optimization problem. The process dynamics are included only in the shape parameter of the utility function. If a riskless asset is present then the multi-period optimal portfolio weights are proportional to the single-period solutions multiplied by time-varying constants which are depending on the process dynamics. Remarkably, in the case of a portfolio selection with the tangency portfolio the multi-period solution coincides with the sequence of the simple-period solutions. Finally, we compare the suggested strategies with existing multi-period portfolio allocation methods for real data.Comment: 38 pages, 9 figures, 3 tables, changes: VAR(1)-CCC-GARCH(1,1) process dynamics and the analysis of increasing horizon are included in the simulation study, under revision in Annals of Operations Researc

Performance of the LHCb vertex locator

The Vertex Locator (VELO) is a silicon microstrip detector that surrounds the proton-proton interaction region in the LHCb experiment. The performance of the detector during the first years of its physics operation is reviewed. The system is operated in vacuum, uses a bi-phase CO2 cooling system, and the sensors are moved to 7 mm from the LHC beam for physics data taking. The performance and stability of these characteristic features of the detector are described, and details of the material budget are given. The calibration of the timing and the data processing algorithms that are implemented in FPGAs are described. The system performance is fully characterised. The sensors have a signal to noise ratio of approximately 20 and a best hit resolution of 4 μm is achieved at the optimal track angle. The typical detector occupancy for minimum bias events in standard operating conditions in 2011 is around 0.5%, and the detector has less than 1% of faulty strips. The proximity of the detector to the beam means that the inner regions of the n+-on-n sensors have undergone space-charge sign inversion due to radiation damage. The VELO performance parameters that drive the experiment's physics sensitivity are also given. The track finding efficiency of the VELO is typically above 98% and the modules have been aligned to a precision of 1 μm for translations in the plane transverse to the beam. A primary vertex resolution of 13 μm in the transverse plane and 71 μm along the beam axis is achieved for vertices with 25 tracks. An impact parameter resolution of less than 35 μm is achieved for particles with transverse momentum greater than 1 GeV/c