2-Diphenylphosphinomethyl-3-methylpyrazine

The lateral metalation-electrophilic trapping reaction of alkyl-substituted pyrazines has always been challenging and poorly regioselective, with the corresponding derivatives often being isolated in moderate yield. In this contribution, we first report on the preparation of an unsymmetrically-substituted pyrazine, that is 2-diphenylphosphinomethyl-3-methylpyrazine, by subjecting to metalation with n-BuLi the commercially available 2,3-dimethylpyrazine, followed by interception of the putative lithiated benzyl-type intermediate with Ph2PCl. Such a functionalization has been successfully carried out in the absence of additional ligands, working either in THF at −78 °C or in a more environmentally friendly solvent like cyclopentyl methyl ether at 0 °C, with the desired phosphine derivative being isolated in 70–85% yield. The newly synthesized adduct has been fully characterized by means of multinuclear magnetic resonance spectroscopic techniques, and also by preparing a selenium derivative, which furnished single crystals that were suitable for X-ray analysis

Exploring the Historical Context of Graphic Symbols: the NOTAE Knowledge Graph and its Visual Interface

Graphic symbols i.e. graphic entities drawn as a visual unit in a written text and representing something other or something more than a word of that text are the research object of the NOTAE project, which investigates them in the documentary practice of the late Roman State and Post-Roman Kingdoms (400-800 AD). While research results from the project are stored by filling forms resulting from the analysis of ancient documents, we argue that the availability of a navigable knowledge graph can ease the work of researchers at finding non trivial implications in data. In this paper, we propose a first version of the NOTAE Knowledge Graph, and we outline future works and possible synergies

A Qualitative Exploration of the Use of Contraband Cell Phones in Secured Facilities

Offenders accepting contraband cell phones in secured facilities violate state corrections law, and the possession of these cell phones is a form of risk taking behavior. When offenders continue this risky behavior, it affects their decision making in other domains where they are challenging authorities; and may impact the length of their incarceration. This qualitative phenomenological study examined the lived experience of ex-offenders who had contraband cell phones in secured correctional facilities in order to better understand their reasons for taking risks with contraband cell phones. The theoretical foundation for this study was Trimpop\u27s risk-homeostasis and risk-motivation theories that suggest an individual\u27s behaviors adapt to negotiate between perceived risk and desired risk in order to achieve satisfaction. The research question explored beliefs and perceptions of ex-offenders who chose to accept the risk of using contraband cell phones during their time in secured facilities. Data were collected anonymously through recorded telephone interviews with 8 male adult ex-offenders and analyzed using thematic content analysis. Findings indicated participants felt empowered by possession of cell phones in prison, and it was an acceptable risk to stay connected to family out of concern for loved ones. The study contributes to social change by providing those justice system administrators, and prison managers responsible for prison cell phone policies with more detailed information about the motivations and perspectives of offenders in respect to using contraband cell phones while imprisoned in secured facilities

Chapter Identifying, Classifying and Searching Graphic Symbols in the NOTAE System

The use of graphic symbols in documentary records from the 5th to the 9th century has so far received scant attention. What we mean by graphic symbols are graphic signs (including alphabetical ones) drawn as a visual unit in a written text and representing something other or something more than a word of that text. The Project NOTAE represents the first attempt to investigate these graphic entities as a historical phenomenon from Late Antiquity to early medieval Europe in any written sources containing texts generated for pragmatic purposes (contracts, petitions, official and private letters, lists etc.). Identifying and classifying graphic symbols on such documents is a task that requires experience and knowledge of the field, but software applications may come in help by learning to recognize symbols from previously annotated documents and suggesting experts potential symbols and likely classification in newly acquired documents to be validated, thus easing the task. This contribution introduces the NOTAE system that, in addition to the aforementioned task, provides non expert users with tools to explore the documents annotated by experts

Chapter Identifying, Classifying and Searching Graphic Symbols in the NOTAE System

The use of graphic symbols in documentary records from the 5th to the 9th century has so far received scant attention. What we mean by graphic symbols are graphic signs (including alphabetical ones) drawn as a visual unit in a written text and representing something other or something more than a word of that text. The Project NOTAE represents the first attempt to investigate these graphic entities as a historical phenomenon from Late Antiquity to early medieval Europe in any written sources containing texts generated for pragmatic purposes (contracts, petitions, official and private letters, lists etc.). Identifying and classifying graphic symbols on such documents is a task that requires experience and knowledge of the field, but software applications may come in help by learning to recognize symbols from previously annotated documents and suggesting experts potential symbols and likely classification in newly acquired documents to be validated, thus easing the task. This contribution introduces the NOTAE system that, in addition to the aforementioned task, provides non expert users with tools to explore the documents annotated by experts

Exploring the Historical Context of Graphic Symbols: the NOTAE Knowledge Graph and its Visual Interface

Graphic symbols i.e. graphic entities drawn as a visual unit in a written text and representing something other or something more than a word of that text are the research object of the NOTAE project, which investigates them in the documentary practice of the late Roman State and Post-Roman Kingdoms (400-800 AD). While research results from the project are stored by filling forms resulting from the analysis of ancient documents, we argue that the availability of a navigable knowledge graph can ease the work of researchers at finding non trivial implications in data. In this paper, we propose a first version of the NOTAE Knowledge Graph, and we outline future works and possible synergies

NOTAE: NOT A writtEn word but graphic symbols.

Late antique and early medieval documents often include graphic symbols, i.e., graphic entities drawn as a visual unit whithin a written text, but communicating something other than a word of that text. The Project NOTAE aims to investigate them, in order to capture all the possible historical implications by studying their execution, models, cross influences, historical context and transmission. The project involves two approaches working in close collaboration: the historical, papyrological and palaeographical investigation and the IT research activity, which has developed the NOTAE System (fundamental tool, to fulfil the humanistic approach itself) and the NOTAE Knowledge Graph, testing also the possibility of identifying graphic symbols through software applications

Catheterization laboratory activity before and during COVID-19 spread: A comparative analysis in Piedmont, Italy, by the Italian Society of Interventional Cardiology (GISE)

COronaVIrus Disease 19 (COVID-19) led to the reorganization of Cardiology Units in terms of working spaces and healthcare personnel. In this scenario, both outpatient visits and elective interventional cardiology procedures were suspended and/or postponed. We aimed to report the impact of COVID-19 on interventional coronary and structural procedures in Piedmont, Italy. Methods The number of coronary angiographies (CAG), percutaneous coronary interventions (PCI), primary PCI (pPCI), transcatheter aortic valve replacements (TAVR) and Mitraclip performed in Piedmont between March 1st and April 20th, 2020 (CoV-time) were collected from each catheterization laboratory and compared to the number of procedures performed the year before in the same months (NoCoV-time)