Discovery of an unusual bright eclipsing binary with the longest known period: TYC 2505-672-1 / MASTER OT J095310.04+335352.8

We report on the MASTER Global Robotic Net discovery of an eclipsing binary, MASTER OT J095310.04+335352.8, previously known as unremarkable star TYC 2505-672-1, which displays extreme orbital parameters. The orbital period P=69.1 yr is more than 2.5 times longer than that of epsilon-Aurigae, which is the previous record holder. The light curve is characterized by an extremely deep total eclipse with a depth of more than 4.5 mag, which is symmetrically shaped and has a total duration of 3.5 yrs. The eclipse is essentially gray. The spectra acquired with the Russian 6 m BTA telescope both at minimum and maximum light mainly correspond to an M0-1III--type red giant, but the spectra taken at the bottom of eclipse show small traces of a sufficiently hot source. The observed properties of this system can be better explained as the red giant eclipsed by a large cloud (the disk) of small particles surrounding the invisible secondary companion.Comment: 8 figures, 9 pages, Astronomy and astrophysics in prin

АНАЛІЗ ФАРМАКОТЕРАПІЇ АРТЕРІАЛЬНОЇ ГІПЕРТЕНЗІЇ НА СТАЦІОНАРНОМУ ЕТАПІ

The aim of the work. To analyze the prescription of antihypertensive drugs of different groups in hospital conditions, the adherence of patients to treatment; to determine the role of the pharmacist in increasing the effectiveness of the treatment of people with arterial hypertension. Materials and Methods. A retrospective analysis of 34 medical records of inpatients who were treated in Ternopil City Communal Hospital No. 3 during 2022 with a diagnosis of "Arterial hypertension, II stage" was conducted as was also the analysis of questionnaires (supplemented Morisky-Green questionnaire (MMAS-8)). Results and Discussion. The analysis of pharmacotherapy showed that patients mostly received combined antihypertensive therapy (79.4 %), the share of patients who received ACE inhibitors was 61.8 %, diuretics – 53.0 %, calcium ion antagonists and beta-blockers – 20.6 %. As a result of the analysis of the questionnaires, it was found that the high level of compliance was in 17.6 %, average level in 14.7 % of patients, and the low one (67.6 %) prevailed, especially in the older age group. Conclusions. A low level of adherence to treatment was recorded in the vast majority of patients. Pharmacists within the framework of the current protocol need to work with patients with arterial hypertension to increase adherence to treatment.Мета роботи. Проаналізувати призначення антигіпертензивних препаратів різних груп в умовах стаціонару, прихильність хворих до лікування, визначити роль фармацевта у підвищенні ефективності лікування осіб з артеріальною гіпертензією. Матеріали і методи. Проведено ретроспективний аналіз 34 карт стаціонарних хворих, які перебували на лікуванні в Тернопільській міській комунальній лікарні № 3 впродовж 2022 р. з діагнозом артеріальної гіпертензії, ІІ ст. та аналіз анкет (доповнений опитувальник Моріски-Грін (MMAS-8). Результати й обговорення. Аналіз фармакотерапії продемонстрував, що хворі переважно отримували комбіновану антигіпертензивну терапію (79,4 %), частка хворих, які отримували інгібітори АПФ, становила 61,8 %, діуретики – 53,0 %, антагоністи іонів кальцію і бета-адреноблокатори по 20,6 %. В результаті аналізу анкет виявлено, що високий рівень комплаєнтності був у 17,6 %, середній – у 14,7% хворих, переважав низький (67,6 %), особливо в старшій віковій групі. Висновки. У більшості хворих реєстрували низький рівень прихильності до лікування. Фармацевтам в рамках діючого протоколу необхідно проводити роботу з хворими на артеріальну гіпертензію з підвищення прихильності до лікування

MASTER Optical Polarization Variability Detection in the Microquasar V404 Cyg/GS 2023+33

On 2015 June 15, the Swift space observatory discovered that the Galactic black hole candidate V404 Cyg was undergoing another active X-ray phase, after 25 years of inactivity. The 12 telescopes of the MASTER Global Robotic Net located at six sites across four continents were the first ground-based observatories to start optical monitoring of the microquasar after its gamma-ray wake up at 18h 34m 09s U.T. on 2015 June 15. In this paper, we report, for the first time, the discovery of variable optical linear polarization, changing by 4%-6% over a timescale of ∼1 hr, on two different epochs. We can conclude that the additional variable polarization arises from the relativistic jet generated by the black hole in V404 Cyg. The polarization variability correlates with optical brightness changes, increasing when the flux decreases.Fil: Lipunov, V.. M.V.Lomonosov Moscow State University. Physics Department; RusiaFil: Gorbovskoy, E.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Krushinskiy, V.. Kourovka Astronomical Observatory, Ural Federal University; RusiaFil: Vlasenko, D.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Tiurina, N.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Balanutsa, P.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Kuznetsov, A.. M.V.Lomonosov Moscow State University, Sternberg Astronomical Institute; RusiaFil: Budnev, N.. Applied Physics Institute. Irkutsk State University; RusiaFil: Gress, O.. Applied Physics Institute, Irkutsk State University; RusiaFil: Tlatov, A.. Kislovodsk Solar Station of the Main (Pulkovo) Observatory RAS; RusiaFil: Rebolo Lopez, L.. Instituto de Astrofsica de Canarias; EspañaFil: Serra-Ricart, M.. Instituto de Astrofsica de Canarias; EspañaFil: Buckley, D. A. H.. South African Astronomical Observatory; SudáfricaFil: Israelyan, G.. Instituto de Astrofsica de Canarias; EspañaFil: Lodieu, N.. Instituto de Astrofisica de Canarias; EspañaFil: Ivanov, K.. Applied Physics Institute. Irkutsk State University; RusiaFil: Yazev, S.. Applied Physics Institute, Irkutsk State University; RusiaFil: Sergienko, Y.. Blagoveschensk State Pedagogical University; RusiaFil: Gabovich, A.. Blagoveschensk State Pedagogical University; RusiaFil: Yurkov, V.. Blagoveschensk State Pedagogical University; RusiaFil: Levato, Orlando Hugo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Saffe, Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio. Universidad Nacional de San Juan. Instituto de Ciencias Astronómicas, de la Tierra y del Espacio; ArgentinaFil: Podesta, R.. Observatorio "Felix Aguiklar". Universidad Nacional de San Juan; ArgentinaFil: Lopez, C.. Observatorio "Felix Aguilar". Universidad nacional de San juan; Argentin

A multiwavelength study of the flat-spectrum radio quasar NVSS J141922-083830 covering four flaring episodes

We present multiwavelength observations and a model for flat-spectrum radio quasar (FSRQ) NVSS J141922-083830, originally classified as a blazar candidate of unknown type (BCU II object) in the Third Fermi-LAT AGN Catalog. Relatively bright flares (>3 magnitudes) were observed on 2015 February 21 (MJD 57074) and 2018 September 8 (MJD 58369) in the optical band with the MASTER Global Robotic Nettelescopes. Optical spectra obtained with the Southern African Large Telescopeon 2015 March 1 (MJD 57082), during outburst, and on 2017 May 30 (MJD 57903), during quiescence, showed emission lines at 5325 Å and at ≈3630 Å that we identified as the Mg ii 2798 Å and C iii] 1909 Å lines, respectively, and hence derived a redshift z = 0.903. Analysis of Fermi-Large Area Telescope (LAT) data was performed in the quiescent regime (5 yr of data) and during four prominent flaring states in 2014 February-April, 2014 October-November, 2015 February-March, and 2018 September. We present spectral and timing analysis with Fermi-LAT. We report a hardening of the gamma-ray spectrum during the last three flaring periods, with a power-law spectral index Γ = 2.0-2.1. The maximum gamma-ray flux level was observed on 2014 October 24 (MJD 56954) at (7.57 ± 1.83) × 10-7 ph cm-2 s-1. The multiwavelength spectral energy distribution (SED) during the 2015 February-March flare supports the earlier evidence of this blazar to belong to the FSRQ class. The SED can be well represented with a single-zone leptonic model with parameters typical of FSRQs, but also a hadronic origin of the high-energy emission cannot be ruled out. © 2022 The Author(s).Centre National d' Études Spatiales in France, (2014-2- DDT-002, 2016-2-LSP-001)Department of Science and Innovation, (64789)National Research Foundation, NRFMinistry of Education and Science of the Russian Federation, Minobrnauka, (FEUZ-2020- 0038)Istituto Nazionale di Astrofisica, INAFAdditional support for science analysis during the operations phase is gratefully acknowledged from the Istituto Nazionale di Astrofisica in Italy and the Centre National d' Études Spatiales in France. The SALT spectra were obtained under the programmes 2014-2- DDT-002 (PI: AK) and 2016-2-LSP-001 (PI: DB). DB, RJB, MB, SR, and AK acknowledge support from the National Research Foundation, South Africa and the South African Gamma-ray Astronomy Programme (SA-GAMMA). The work of MB is supported through the South African Research Chair Initiative of the National Research Foundation 13 and the Department of Science and Innovation, South Africa, under SARChI Chair grant No. 64789. The work of VK was supported by the Ministry of Science and Higher Education of the Russian Federation, topic No. FEUZ-2020- 0038

MASTER OT J004207.99+405501.1/M31LRN 2015 luminous red nova in M31: Discovery, light curve, hydrodynamics and evolution

We report the discovery and multicolour (VRIW) photometry of the rare explosive star MASTEROT J004207.99+405501.1 - a luminous red nova - in theAndromeda galaxy M31N2015-01a. We use our original light curve acquired with identical MASTER Global Robotic Net telescopes in one photometric system: VRI during the first 30 d and W (unfiltered) during 70 d. Also, we added published multicolour photometry data to estimate the mass and energy of the ejected shell and we discuss the likely formation scenarios of outbursts of this type. We propose an interpretation of the explosion that is consistent with an evolutionary scenario where the merging of stellar components or the disruption of the common envelope of a close binary can explain some luminous red novae. Radiative hydrodynamic simulations of a luminous red nova were carried out in extended parameter space to fit its light curves. We find that the multicolour passband light curves of the luminous red nova are consistent with an initial common envelope radius of 10 R⊙, a merger mass of 3M⊙ and an explosion energy of 3 × 1048 erg. As a result, the phenomenon of novae consists of two classes: classical nuclear novae and more rare events (red novae) connected with the loss of compact common envelopes. © 2017 The Authors. Published by Oxford University Press on behalf of the Royal Astronomical Society

Investigating adverse effects of chronic dietary exposure to herbicide glyphosate on zootechnical characteristics and clinical, biochemical and immunological blood parameters in broiler chickens

Although the herbicide glyphosate is widely used globally and considered safe, more evidence of its adverse effects on animals and humans is accumulating. The present investigation was aimed at evaluating the impact of different glyphosate concentrations on zootechnical characteristics and clinical, biochemical and immunological blood parameters in Ross 308 broiler chickens. Four groups were employed, including untreated control and three experimental groups fed diets enriched with glyphosate at doses of 10, 20 and 100 ppm that conformed to 0.5, 1 and 5 maximum residue limits, respectively. The results showed that glyphosate is a stress factor triggering a multifaceted effect on important blood parameters (e.g., white blood cell and phagocytic counts), which was shown for the first time in the experiments involving productive meat-type poultry. It was first revealed that glyphosate-induced changes in blood parameters may be related to a negative impact on the zootechnical characteristics including the digestive tract organ development and body weight gain. The study findings suggested that exposure to glyphosate in the feedstuffs can adversely affect the physiological condition and productivity of broilers

FEATURES OF IMMUNE DISTURBANCES IN COMMUNITY-ACQUIRED PNEUMONIAS

Abstract. Clinical and immunological examination was performed in a group of 120 patients with community-acquired pneumonia. The study included determination of humoral and cellular immunity factors, T-lymphocytes, T cell subpopulations and B cells in peripheral blood, measurements of circulating immune complexes, phagocytic activities of peripheral neutrophils, studies of cytokines (IL-2, IL-4, IL-6, IL-8, TNFalpha) in the course of disease. Abnormalities of immune response were found that determined the severity of pneumonia and extent of inflammatory lung affection. Insufficiency of phagocytic protection and abnormality of immune complex elimination, reduced activity of effector T cells, with underlying increased reaction of NK cells, deficiency of humoral immunity factors, as reduced B-lymphocyte levels, as well as a trend to decrease in in IgM and IgG levels, may, in sum, determine a severe clinical course, along with lobular affection of lungs in community-acquired pneumonia. Imbalance of cytokines, with predominant proinflammatory activity and reduced regulatory functions may represent a significant reason of these immune disturbances, thus justifying a need for development of immunomodulatory therapy