548 research outputs found
Hybrid Volitional Control of a Robotic Transtibial Prosthesis using a Phase Variable Impedance Controller
For robotic transtibial prosthesis control, the global kinematics of the
tibia can be used to monitor the progression of the gait cycle and command
smooth and continuous actuation. In this work, these global tibia kinematics
are used to define a phase variable impedance controller (PVIC), which is then
implemented as the nonvolitional base controller within a hybrid volitional
control framework (PVI-HVC). The gait progression estimation and biomechanic
performance of one able-bodied individual walking on a robotic ankle prosthesis
via a bypass adapter are compared for three control schemes: a passive
benchmark controller, PVIC, and PVI-HVC. The different actuation of each
controller had a direct effect on the global tibia kinematics, but the average
deviation between the estimated and ground truth gait percentage were 1.6%,
1.8%, and 2.1%, respectively, for each controller. Both PVIC and PVI-HVC
produced good agreement with able-bodied kinematic and kinetic references. As
designed, PVI-HVC results were similar to those of PVIC when the user used low
volitional intent, but yielded higher peak plantarflexion, peak torque, and
peak power when the user commanded high volitional input in late stance. This
additional torque and power also allowed the user to volitionally and
continuously achieve activities beyond level walking, such as ascending ramps,
avoiding obstacles, standing on tip-toes, and tapping the foot. In this way,
PVI-HVC offers the kinetic and kinematic performance of the PVIC during level
ground walking, along with the freedom to volitionally pursue alternative
activities.Comment: 7 pages, 7 figures, submitted to ICRA 202
Generating and probing a two-photon Fock state with a single atom in a cavity
A two-photon Fock state is prepared in a cavity sustaining a "source mode "
and a "target mode", with a single circular Rydberg atom. In a third-order
Raman process, the atom emits a photon in the target while scattering one
photon from the source into the target. The final two-photon state is probed by
measuring by Ramsey interferometry the cavity light shifts induced by the
target field on the same atom. Extensions to other multi-photon processes and
to a new type of micromaser are briefly discussed
The impact of liver disease: a leading cause of hospital admissions in people living vith HIV
Background: This study reviews recent trends of HIV inpatient admissions over 5 Infectious diseases Units in Liguria, in 2012.
Patients and Methods: Five infectious diseases Units in Liguria, Italy, collected data on inpatient HIV admissions from January to December 2012, including patient demographic, discharge diagnosis, CD4 Tcell count, viral load (VL) and combined anti-retroviral treatment (cART).
Results: Rate of patient admissions per 100 years was 6.12 (number=257), in 62.6% (n=161) of admissions a VL under 50 copies/ml was observed. Furthermore, 86.4% (n=222) of admissions were on active cART. Median age was 49 years. Mortality rate was 10.2%. Hepatitis C coinfection occurred in 64.6% of patients (n=166). The most common diagnosis was infectious diseases (29.1%), respiratory diseases (16.6%) and neoplasms (15.%). Chronic HCV infection and its complications (cirrhosis and hepatocellular carcinoma) accounted for 31% of all discharging diagnosis.
Conclusions: The majority of inpatients admitted during 2012 in our Units were on cART and virologically suppressed. The complications of hepatitis C coinfection have a major impact on mortality rates and hospitalization rates in Italy. According to these observations, the availability of new drugs for chronic hepatitis C imposes a further effort to improve the quality of life of our patients
Women and Illegal Activities: Gender Differences and Women's Willingness to Comply Over Time
In recent years the topics of illegal activities such as corruption or tax evasion have attracted a great deal of attention. However, there is still a lack of substantial empirical evidence about the determinants of compliance. The aim of this paper is to investigate empirically whether women are more willing to be compliant than men and whether we observe (among women and in general) differences in attitudes among similar age groups in different time periods (cohort effect) or changing attitudes of the same cohorts over time (age effect) using data from eight Western European countries from the World Values Survey and the European Values Survey that span the period from 1981 to 1999. The results reveal higher willingness to comply among women and an age rather than a cohort effect. Working Paper 06-5
Cell-Specific DNA Methylation Patterns of Retina-Specific Genes
Many studies have demonstrated that epigenetic mechanisms are important in the regulation of gene expression during embryogenesis, gametogenesis, and other forms of tissue-specific gene regulation. We sought to explore the possible role of epigenetics, specifically DNA methylation, in the establishment and maintenance of cell type-restricted gene expression in the retina. To assess the relationship between DNA methylation status and expression level of retinal genes, bisulfite sequence analysis of the 1000 bp region around the transcription start sites (TSS) of representative rod and cone photoreceptor-specific genes and gene expression analysis were performed in the WERI and Y79 human retinoblastoma cell lines. Next, the homologous genes in mouse were bisulfite sequenced in the retina and in non-expressing tissues. Finally, bisulfite sequencing was performed on isolated photoreceptor and non-photoreceptor retinal cells isolated by laser capture microdissection. Differential methylation of rhodopsin (RHO), retinal binding protein 3 (RBP3, IRBP) cone opsin, short-wave-sensitive (OPN1SW), cone opsin, middle-wave-sensitive (OPN1MW), and cone opsin, long-wave-sensitive (OPN1LW) was found in the retinoblastoma cell lines that inversely correlated with gene expression levels. Similarly, we found tissue-specific hypomethylation of the promoter region of Rho and Rbp3 in mouse retina as compared to non-expressing tissues, and also observed hypomethylation of retinal-expressed microRNAs. The Rho and Rbp3 promoter regions were unmethylated in expressing photoreceptor cells and methylated in non-expressing, non-photoreceptor cells from the inner nuclear layer. A third regional hypomethylation pattern of photoreceptor-specific genes was seen in a subpopulation of non-expressing photoreceptors (Rho in cones from the Nrl −/− mouse and Opn1sw in rods). These results demonstrate that a number of photoreceptor-specific genes have cell-specific differential DNA methylation that correlates inversely with their expression level. Furthermore, these cell-specific patterns suggest that DNA methylation may play an important role in modulating photoreceptor gene expression in the developing mammalian retina
A Culturally Nuanced Test of Gottfredson and Hirschi’s ‘‘General Theory’’: Dimensionality and Generalizability in Japan and the United States
The current research addresses two specific issues that direct attention to the relatively neglected topic of the cross-cultural applicability of Gottfredson and Hirschi’s ‘‘general theory’’ that has been developed in and tested primarily in the United States. With theoretical and empirical guidance from the literature on dimensionality of low self-control, we first predict that the six elements identified in the theory form a multidimensional latent construct in two diverse societies—Japan and the United States. Drawing on the literature concerning cultural variability in individualism, and inconsistent with self-control theory, the authors then expect that although low self-control leads to deviance in both societies, the causal relationship is stronger among Americans than among Japanese. Analysis of identical survey data collected simultaneously from college students in Japan and the United States provides somewhat mixed support for our expectations and the findings appear largely consistent with predictions by self-control theory.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
Onstage and off: The shifting relevance of gender in women’s prisons
uncorrected proofEven though international research on men’s prisons is no longer oblivious to gender, approaches to women’s prisons have tended to be more gender-bound as a whole. Besides having informed a specific reflexive agenda of representation, the angle of gender has presided to most research issues as an analytical overall parti pris: from the gendered nature of prison regimes to the gendered character of prison cultures, socialities and ‘pains of imprisonment’. This more ‘gendercentric’ agenda is however becoming more diversified for theoretical and empirical reasons alike. These involve a recognition of the diversity of women prisoners’ experiences and identities, and an attention to a wider variety of aspects of carceral life. Drawing on field approaches to the Portuguese carceral world spanning three decades, I propose to take this debate further by focusing on contextual shifts in the actual saliency of gender as a category of identity and social life in women’s prisons.(undefined)(undefined)info:eu-repo/semantics/publishedVersio
The methylation status of the embryonic limb skeletal progenitors determines their cell fate in chicken
Digits shape is sculpted by interdigital programmed cell death during limb development. Here, we show that DNA breakage in the periphery of 5-methylcytosine nuclei foci of interdigital precursors precedes cell death. These cells showed higher genome instability than the digit-forming precursors when exposed to X-ray irradiation or local bone morphogenetic protein (BMP) treatments. Regional but not global DNA methylation differences were found between both progenitors. DNA-Methyl-Transferases (DNMTs) including DNMT1, DNMT3B and, to a lesser extent, DNMT3A, exhibited well-defined expression patterns in regions destined to degenerate, as the interdigital tissue and the prospective joint regions. Dnmt3b functional experiments revealed an inverse regulation of cell death and cartilage differentiation, by transcriptional regulation of key genes including Sox9, Scleraxis, p21 and Bak1, via differential methylation of CpG islands across their promoters. Our findings point to a regulation of cell death versus chondrogenesis of limb skeletal precursors based on epigenetic mechanisms.We thank Prof. Miguel Lafarga for helpful comments and advice. We thank Dr Jose E Gomez-Arozamena for helping us with the irradiation experiments. We are grateful to Montse Fernandez Calderon, Susana Dawalibi, and Sonia Perez Mantecon, for excellent technical assistance. This work was supported by a Grant (BFU2017–84046-P) from the Spanish Science and Innovation Ministry to JAM. C.S.F is recipient of a FPI grant (BES-2015–074267)
Evaluating the drivers of and obstacles to the willingness to use cognitive enhancement drugs: the influence of drug characteristics, social environment, and personal characteristics
Sattler S, Mehlkop G, Graeff P, Sauer C. Evaluating the drivers of and obstacles to the willingness to use cognitive enhancement drugs: the influence of drug characteristics, social environment, and personal characteristics. Substance Abuse Treatment, Prevention, and Policy. 2014;9(1): 8.Background
The use of cognitive enhancement (CE) by means of pharmaceutical agents has been the subject of intense debate both among scientists and in the media. This study investigates several drivers of and obstacles to the willingness to use prescription drugs non-medically for augmenting brain capacity.
Methods
We conducted a web-based study among 2,877 students from randomly selected disciplines at German universities. Using a factorial survey, respondents expressed their willingness to take various hypothetical CE-drugs; the drugs were described by five experimentally varied characteristics and the social environment by three varied characteristics. Personal characteristics and demographic controls were also measured.
Results
We found that 65.3% of the respondents staunchly refused to use CE-drugs. The results of a multivariate negative binomial regression indicated that respondents’ willingness to use CE-drugs increased if the potential drugs promised a significant augmentation of mental capacity and a high probability of achieving this augmentation. Willingness decreased when there was a high probability of side effects and a high price. Prevalent CE-drug use among peers increased willingness, whereas a social environment that strongly disapproved of these drugs decreased it. Regarding the respondents’ characteristics, pronounced academic procrastination, high cognitive test anxiety, low intrinsic motivation, low internalization of social norms against CE-drug use, and past experiences with CE-drugs increased willingness. The potential severity of side effects, social recommendations about using CE-drugs, risk preferences, and competencies had no measured effects upon willingness.
Conclusions
These findings contribute to understanding factors that influence the willingness to use CE-drugs. They support the assumption of instrumental drug use and may contribute to the development of prevention, policy, and educational strategies
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