Linear, diatomic crystal: single-electron states and large-radius excitons

The large-radius exciton spectrum in a linear crystal with two atoms in the unit cell was obtained using the single-electron eigenfunctions and the band structure, which were found by the zero-range potential (ZRP) method. The ground-state exciton binding energies for the crystal in vacuum appeared to be larger than the corresponding energy gaps for any set of the crystal parameters.Comment: 9 pages, 1 figure, 1 tabl

The balance of pressor and depressor substances in the neurons of arcuate nucleus of hypothalamus in etiologically different arterial hypertension

Tishchenko S. V. The balance of pressor and depressor substances in the neurons of arcuate nucleus of hypothalamus in etiologically different arterial hypertension. Journal of Education, Health and Sport. 2019;9(4):492-502. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.2620542 http://ojs.ukw.edu.pl/index.php/johs/article/view/6858 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part B item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Authors 2019; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license Share alike. (http://creativecommons.org/licenses/by-nc-sa/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 05.04.2019. Revised: 15.04.2019. Accepted: 24.04.2019. The balance of pressor and depressor substances in the neurons of arcuate nucleus of hypothalamus in etiologically different arterial hypertension S. V. Tishchenko Zaporizhzhia State Medical University Department of Pathological Physiology Abstract It has been proved that arterial hypertension is not associated exclusively with an increase in vascular tone but also with a complex of pathological processes that results in cardiovascular pathology and lesions of the target organs. The central and peripheral contours of blood pressure regulation are well studied. Nevertheless, despite the presence of two regulatory contours the key structure that integrates and controls their function is the hypothalamus, in particular its arcuate nucleus. It is proved that the effectiveness of blood pressure regulation depends on those neuromodulators and neurohormones that are synthesized in the hypothalamus or transported to it. The most important neurohormones in the regulation of arterial blood presssure are brain natriuretic peptide, β-endorphin, neurotensin and angiotensin II. Equally important factor is the functional state of arcuate nucleus neurons, which depends on adequate blood supply, innervation and inter-neuronal relationships. The link between the above described processes is nitrogen monoxide system (NOS) and its universal messenger – nitric oxide NO. The purpose of the work was to determine the nature of the balance of pressor (angiotensin II and neurotensin) and depressor (brain natriuretic peptide and β-endorphin) neurohormones in the neurons of the arcuate nucleus of the hypothalamus and the ratio of NOS isoforms with hypertension of different etiology. Materials and methods. The studies were conducted on 32 mature male Wistar rats and 16 male spontaneously hypertensive rats. To study the content of neuropeptides and NOS enzyme isoforms, an immunohistochemical method was used, followed by digital image processing by Image J. The results that were obtained were calculated using the "Statistica 11.0" program. Conclusions 1. The same changes of neuropeptides’ content in hypothalamic arcuate nucleus are observed in the rats with arterial hypertension which are characterized by a decrease in the brain natriuretic peptide, β-endorphin and angiotensin II content with a significant increase in neurotensin content regardless of arterial hypertension etiology and pathogenesis. The peculiarities of the balance between depressor and pressor substances depend on the etiopathogenetic mechanisms – with the endocrine-salt model of arterial hypertension there is a significant predominance of depressor neuropeptides (in 4.3 times) whereas in essential hypertension this balance is similar to the control. 2. The changes of the NOS isoform ratio in the arcuate nucleus of hypothalamus are unidirectional, both with endocrine-salt model of arterial hypertension and essential hypertension – the content of eNOS decreases while nNOS and iNOS content increases. Key words: hypothalamus, arcuate nucleus, neuropeptides, nitric oxide, rats, arterial hypertensio

Diffraction radiation from a screen of finite conductivity

An exact solution has been found for the problem of diffraction radiation appearing when a charged particle moves perpendicularly to a thin finite screen having arbitrary conductivity and frequency dispersion. Expressions describing the Diffraction and Cherenkov emission mechanisms have been obtained for the spectral-angular forward and backward radiation densities.Comment: 6 pages, 4 figure

Biodistribution Studies of a New Antitumor Compound Based on Nanoporous Nanodiamond Composite Labeled with Rhenium-188

This study evaluated a new drug delivery system for local radiotherapy on the base of nanoporous nanodiamond composites (NDC) labeled with β-emitting radionuclide rhenium-188. The biodistribution of labeled compound was assessed after intratumoral (i.t.) and intramuscular (i.m.) injection. 24 mice-bearing solid Ehrlich carcinoma xenografts received i.t. injections of 0.370 ± 0.074 MBq 188Re-nanoporous diamond composites. Another 24 intact mice were injected with the same preparation intramuscularly. The samples of different organs and tissues were collected for gamma count. After i.t. and i.m. administration of 188Re-nanoporous NDC a considerable amount of radioactivity retained at the site of injection. In tumor tissue the total amount of activity decreased from 92.68 % to 9.63 % of injected dose (ID) throughout the study. The removal of injected activity from muscular tissue was faster as compared with tumor tissue, and declined from 81.06 % to 8.40 % ID for up to 72 h. Therefore, after i.m. injection the accumulation of radioactivity in healthy organs and tissues was slightly higher than after i.t. injection. In conclusion, it was demonstrated that 188Renanoporous diamond composites had the potential radiotherapeutic significance. Keywords: composite materials, nanodiamond, rhenium-188, cancer radiotherapy, local radiotherapy

The balance of pressor and depressor substances in the neurons of arcuate nucleus of hypothalamus in etiologically different arterial hypertension

It has been proved that arterial hypertension is not associated exclusively with an increase in vascular tone but also with a complex of pathological processes that results in cardiovascular pathology and lesions of the target organs. The central and peripheral contours of blood pressure regulation are well studied. Nevertheless, despite the presence of two regulatory contours the key structure that integrates and controls their function is the hypothalamus, in particular its arcuate nucleus. It is proved that the effectiveness of blood pressure regulation depends on those neuromodulators and neurohormones that are synthesized in the hypothalamus or transported to it. The most important neurohormones in the regulation of arterial blood presssure are brain natriuretic peptide, β-endorphin, neurotensin and angiotensin II. Equally important factor is the functional state of arcuate nucleus neurons, which depends on adequate blood supply, innervation and inter-neuronal relationships. The link between the above described processes is nitrogen monoxide system (NOS) and its universal messenger – nitric oxide NO. The purpose of the work was to determine the nature of the balance of pressor (angiotensin II and neurotensin) and depressor (brain natriuretic peptide and β-endorphin) neurohormones in the neurons of the arcuate nucleus of the hypothalamus and the ratio of NOS isoforms with hypertension of different etiology. Materials and methods. The studies were conducted on 32 mature male Wistar rats and 16 male spontaneously hypertensive rats. To study the content of neuropeptides and NOS enzyme isoforms, an immunohistochemical method was used, followed by digital image processing by Image J. The results that were obtained were calculated using the "Statistica 11.0" program. Conclusions 1. The same changes of neuropeptides’ content in hypothalamic arcuate nucleus are observed in the rats with arterial hypertension which are characterized by a decrease in the brain natriuretic peptide, β-endorphin and angiotensin II content with a significant increase in neurotensin content regardless of arterial hypertension etiology and pathogenesis. The peculiarities of the balance between depressor and pressor substances depend on the etiopathogenetic mechanisms – with the endocrine-salt model of arterial hypertension there is a significant predominance of depressor neuropeptides (in 4.3 times) whereas in essential hypertension this balance is similar to the control. 2. The changes of the NOS isoform ratio in the arcuate nucleus of hypothalamus are unidirectional, both with endocrine-salt model of arterial hypertension and essential hypertension – the content of eNOS decreases while nNOS and iNOS content increases

Правовий міф і правова міфотворчість як атрибути сучасного суспільства

Тіщенко Ю. В. Правовий міф і правова міфотворчість як атрибути сучасного суспільства : автореф. дис. ... канд. юрид. наук : 12.00.12 / Ю. В. Тіщенко; кер. роботи Ю. М. Оборотов; Нац. ун.-т "Одеська юридична академія". – Одеса, 2014. – 18 с.Дисертація на здобуття наукового ступеня кандидата юридичних наук за спеціальністю 12.00.12 - філософія права. - Національний університет «Одеська юридична академія». - Одеса, 2014. У дисертації розглядається природа, структура, функції правових міфів, їх місце у структурі правової реальності, а також процеси правової міфотворчості, характерні для сучасного суспільства. Доведено, що правовий міф не слід вважати негативним явищем дійсності, що деформує сприйняття реальності. Зроблено висновок, що правовий міф постає як особливий феномен, який існує на раціональному й чутгєвому рівнях правосвідомості, а також, у відображеній формі, в правових текстах, виражає ціннісні й антиціннісні правові установки і націлений на легітимацію правових явищ, інститутів і процесів. Виявлені властивості правового міфу: догматичність, соціальність, позатемпоральність, закономірність, функціональність, нераціональність, енергетнчність. багатозначність. Розкрито місце правового міфу у правовій реальності, зокрема, показано специфіку існування міфів у правосвідомості, системі джерел права та позитивному праві. Доведено, що правові міфи не с науковим знанням, а тому юридична наука має позбавлятися від них шляхом раціоналізації. Виявлено міфотворчу функцію юридичної думки.Диссертация на соискание ученой степени кандидата юридических наук по специальности 12.00.12 - философия права. - Национальный университет «Одесская юридическая академия». - Одесса, 2014. В диссертационном исследовании рассмотрена природа правового мифа, его место в правовой реальности, а также процессы правового мифотворчества в современном обществе. Современная философия права и общетеоретическая юриспруденция зачастую оставляют проблематику мифа в праве на обочине философско- правового дискурса, поскольку само признание существования в нраве мифов противоречит вековой традиции рассмотрения права как сугубо рациональной логической конструкции. Правовой миф представляет собой особый феномен, существующий на рациональном и чувственном уровнях правосознания, а также, в отраженной форме, в правовых текстах, выражающий ценностные или антиценностные правовые установки и нацеленный на легитимацию правовых явлений, институтов и процессов. Свойства правового мифа - наиболее существенные характеристики, отличающие его от других правовых явлений и присущие мифу как явлению правовой культуры. Правовой миф обладает догматичностью, социальностью, внетемпоральностью, закономерностью, функциональностью, иррациональностью, энергетичностью, многозначностью Мифы позитивного права, как правило, выражаются в нормативной форме, обеспечивают связь между правом и общественным мнением о нем. Гак, мифологические корни имеют нормативные положения о запрете вмешательства в частную жизнь и неприкосновенность жилища. Мифологическими корнями обладают также положения о клевете, закрепленные во многих законодательных актах различных правовых систем. В контексте правовой мифологии следует рассматривать положения уголовного законодательства об установлении ответственности за осквернение могил. Мифологические элементы можно найти в правовых нормах, предусматривающих ответственность за мародерство. Мифологема юриспруденции предстает как особая форма юридического знания, претендующая на научность, которая содержит в себе некритичную интерпретацию правового мифа, и базирующуюся на ней теоретическую юридическую конструкцию. Одной из распространенных мифологем современной юридической науки является миф о правах человека, который, по сути, вытесняет идею самого права. Еще одна распространенная мифологема правовое государство, включающая несколько мифологем низшего порядка: мифологемы безальтернативности бытия гражданского общества в правовом государстве, верховенства права, возможности действия права без государственного принуждения, сочетания профессионализма и демократизма в государственном управлении и т.д. Мифы юридической науки по сути негативные элементы правового мышления, поскольку наука должна стремиться избавляться от нерациональности, которые неизбежно несут с собой правовые мифы. Мифологизация правосознания становящейся нации является неизбежным спутником происходящих сегодня в Украине перемен.The thesis for a Candidate of Law Degree in the Specialty 12.00.12 - Philosophy of Law. - National University "Odessa Academy of Law". - Odessa, 2014. The thesis is devoted to the nature, structure, functions of the legal myths, to their place in the legal reality, as well as to the myth-making process, which are inherent for the contemporary society. Author proves that comprehending of the legal myth should not be based on its evaluation as negative phenomenon, which deforms reality. The thesis includes the understanding of the legal myth as special phenomenon, which exists at the rational and irrational levels of legal consciousness; in reflected form it also exists in legal texts, expressing legal values and legal anti-values and legitimating legal phenomena, institutions and processes. Authors shows the features of legal myth, such as dogmatisme, sociality, intemporality. functionality, irrationality, energeticness. plurality. The place of legal myth in legal reality is also shown. In particular, authors highlights the specifics of the myths of legal consciousness and of positive law. It is proved that jurisprudence should avoid the usage of myth, as they are not the scientific knowledge. The myth-making function of legal thought is highlighted