A chamber experiment for the feasibility study of an artificial plasma reflector for OTH radar applications

The feasibility of using two intersecting beams for plasma generation in the upper atmosphere as an over-the-horizon radar reflector was investigated. A cube was filled with dry air to a pressure corresponding to the simulated altitude, and two components of a split microwave beam were fed into the cube at right angles. Plasma layers were generated where the two beams intersected. Three critical issues were addressed: (1) reflectivity of the generated plasma layers; (2) propagation of high power microwave pulses; and (3) lifetime of the plasma

The feasibility of wind and solar energy application for oil and gas offshore platform

Renewable energy is an energy which is freely available in nature such as winds and solar energy. It plays a critical role in greening the energy sector as these sources of energy produce little or no pollution to environment. This paper will focus on capability of renewable energy (wind and solar) in generating power for offshore application. Data of wind speeds and solar irradiation that are available around SHELL Sabah Water Platform for every 10 minutes, 24 hours a day, for a period of one year are provided by SHELL Sarawak Sdn. Bhd. The suitable wind turbine and photovoltaic panel that are able to give a high output and higher reliability during operation period are selected by using the tabulated data. The highest power output generated using single wind energy application is equal to 492 kW while for solar energy application is equal to 20 kW. Using the calculated data, the feasibility of renewable energy is then determined based on the platform energy demand

Artificial Immune Algorithm Based Gravimetric Fluid Dispensing Machine

One of the most prominent methods used in handling the end process for materials-mixing is by having a dispensing system. An effective dispensing method using Pulse Width Modulation (PWM) at the end of the dispensing sequence with Artificial Immune System (AIS) automatic dispensing parameter fine tuning capability is proposed by optimizing the components of Dispensing Time and Stopping Time Delay to obtain constant and accurate reading from the precision balance scale. Based on the new dispensing sequence, experimental tests had been carried out using different materials with varying viscosities. The results denote that the combination of both PWM and AIS techniques would minimize the error rate for overshooting while exhibiting better accuracy. These are important in order to overcome the limitations of the conventional volumetric dispensing and manual parameter tuning presently applied in the dispensing system used in the coatings industry

Wind-induced evaporative cooling passive system for tropical hot and humid climate

Over the years, the desire to have better thermal comfort in terms of living has been extensively discussed and is in high demand, especially in metropolitan cities. Alongside the desired outcomes, air conditioning facilities have been implemented, but they also bring negative consequences, such as a high energy bill and multi-dimensional environmental impacts. To counter these problems, a hybrid technique combining the evaporative cooling technique with a venturi-shaped natural ventilation tower is proposed. Evaporative cooling takes advantage of cooling in response to the wind blowing through a layer of wetted surface that is built with permeable materials. Combining with the specially designed venturi-shaped natural ventilation tower to improve the volume intake of wind externally, this system is aimed to reduce temperature and achieve thermal comfort by cooling down the air with circulation in a continuous accumulative mode. To gauge the efficiency and effectiveness of this hybrid technique, an evaporative system known as the wind-induced evaporative cooling (WIEC) system is directly fed into a testing chamber (installed with sensors) fabricated with a scale of 1:6. The system was tested in a hot and humid climate with a temperature range of 27°C–34°C. The finding shows that our system is able to reduce temperatures up to 3.873°C with an output cooling capacity of 9 W–476.3 W, which shows the feasibility of this study

Chemoattractant Receptor Homologous to the T Helper 2 Cell (CRTH2) Is Not Expressed in Human Amniocytes and Myocytes

BACKGROUND: 15-deoxy-Δ 12,14- Prostaglandin J2 (15dPGJ2) inhibits Nuclear factor kappa B (NF-κB) in human myocytes and amniocytes and delays inflammation induced preterm labour in the mouse. 15dPGJ2 is a ligand for the Chemoattractant Receptor Homologous to the T helper 2 cell (CRTH2), a G protein-coupled receptor, present on a subset of T helper 2 (Th2) cells, eosinophils and basophils. It is the second receptor for Prostaglandin D2, whose activation leads to chemotaxis and the production of Th2-type interleukins. The cellular distribution of CRTH2 in non-immune cells has not been extensively researched, and its identification at the protein level has been limited by the lack of specific antibodies. In this study we explored the possibility that CRTH2 plays a role in 15dPGJ2-mediated inhibition of NF-κB and would therefore represent a novel small molecule therapeutic target for the prevention of inflammation induced preterm labour. METHODS: The effect of a small molecule CRTH2 agonist on NF-κB activity in human cultured amniocytes and myocytes was assessed by detection of p65 and phospho-p65 by immunoblot. Endogenous CRTH2 expression in amniocytes, myocytes and peripheral blood mononuclear cells (PBMCs) was examined by PCR, western analysis and flow cytometry, with amniocytes and myocytes transfected with CRTH2 acting as a positive control in flow cytometry studies. RESULTS: The CRTH2 agonist had no effect on NF-κB activity in amniocytes and myocytes. Although CRTH2 mRNA was detected in amniocytes and myocytes, CRTH2 was not detectable at the protein level, as demonstrated by western analysis and flow cytometry. 15dPGJ2 inhibited phospho-65 in PBMC'S, however the CRTH2 antagonist was not able to attenuate this effect. In conclusion, CRTH2 is not expressed on human amniocytes or myocytes and plays no role in the mechanism of 15dPGJ2-mediated inhibition of NF-κB

Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Background Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of this study was to examine the association between hospital infrastructure, resource availability, and processes on early outcomes after cancer surgery worldwide.Methods A multimethods analysis was performed as part of the GlobalSurg 3 study-a multicentre, international, prospective cohort study of patients who had surgery for breast, colorectal, or gastric cancer. The primary outcomes were 30-day mortality and 30-day major complication rates. Potentially beneficial hospital facilities were identified by variable selection to select those associated with 30-day mortality. Adjusted outcomes were determined using generalised estimating equations to account for patient characteristics and country-income group, with population stratification by hospital.Findings Between April 1, 2018, and April 23, 2019, facility-level data were collected for 9685 patients across 238 hospitals in 66 countries (91 hospitals in 20 high-income countries; 57 hospitals in 19 upper-middle-income countries; and 90 hospitals in 27 low-income to lower-middle-income countries). The availability of five hospital facilities was inversely associated with mortality: ultrasound, CT scanner, critical care unit, opioid analgesia, and oncologist. After adjustment for case-mix and country income group, hospitals with three or fewer of these facilities (62 hospitals, 1294 patients) had higher mortality compared with those with four or five (adjusted odds ratio [OR] 3.85 [95% CI 2.58-5.75]; p<0.0001), with excess mortality predominantly explained by a limited capacity to rescue following the development of major complications (63.0% vs 82.7%; OR 0.35 [0.23-0.53]; p<0.0001). Across LMICs, improvements in hospital facilities would prevent one to three deaths for every 100 patients undergoing surgery for cancer.Interpretation Hospitals with higher levels of infrastructure and resources have better outcomes after cancer surgery, independent of country income. Without urgent strengthening of hospital infrastructure and resources, the reductions in cancer-associated mortality associated with improved access will not be realised

Pre-Bilaterian Origins of the Hox Cluster and the Hox Code: Evidence from the Sea Anemone, Nematostella vectensis

BACKGROUND: Hox genes were critical to many morphological innovations of bilaterian animals. However, early Hox evolution remains obscure. Phylogenetic, developmental, and genomic analyses on the cnidarian sea anemone Nematostella vectensis challenge recent claims that the Hox code is a bilaterian invention and that no “true” Hox genes exist in the phylum Cnidaria. METHODOLOGY/PRINCIPAL FINDINGS: Phylogenetic analyses of 18 Hox-related genes from Nematostella identify putative Hox1, Hox2, and Hox9+ genes. Statistical comparisons among competing hypotheses bolster these findings, including an explicit consideration of the gene losses implied by alternate topologies. In situ hybridization studies of 20 Hox-related genes reveal that multiple Hox genes are expressed in distinct regions along the primary body axis, supporting the existence of a pre-bilaterian Hox code. Additionally, several Hox genes are expressed in nested domains along the secondary body axis, suggesting a role in “dorsoventral” patterning. CONCLUSIONS/SIGNIFICANCE: A cluster of anterior and posterior Hox genes, as well as ParaHox cluster of genes evolved prior to the cnidarian-bilaterian split. There is evidence to suggest that these clusters were formed from a series of tandem gene duplication events and played a role in patterning both the primary and secondary body axes in a bilaterally symmetrical common ancestor. Cnidarians and bilaterians shared a common ancestor some 570 to 700 million years ago, and as such, are derived from a common body plan. Our work reveals several conserved genetic components that are found in both of these diverse lineages. This finding is consistent with the hypothesis that a set of developmental rules established in the common ancestor of cnidarians and bilaterians is still at work today

Long-term antithrombotic management patterns in Asian patients with acute coronary syndrome: 2-year observations from the EPICOR Asia study.

BACKGROUND: Despite guideline recommendations, dual antiplatelet therapy (DAPT) is frequently used for longer than 1 year after an acute coronary syndrome (ACS) event. In Asia, information on antithrombotic management patterns (AMPs), including DAPT post discharge, is sparse. This analysis evaluated real-world AMPs up to 2 years post discharge for ACS. HYPOTHESIS: There is wide variability in AMP use for ACS management in Asia. METHODS: EPICOR Asia (NCT01361386) is a prospective observational study of patients discharged after hospitalization for an ACS in eight countries/regions in Asia, followed up for 2 years. Here, we describe AMPs used and present an exploratory analysis of characteristics and outcomes in patients who received DAPT for ≤12 months post discharge compared with >12 months. RESULTS: Data were available for 12 922 patients; of 11 639 patients discharged on DAPT, 2364 (20.3%) received DAPT for ≤12 months and 9275 (79.7%) for >12 months, with approximately 60% still on DAPT at 2 years. Patients who received DAPT for >12 months were more likely to be younger, obese, lower Killip class, resident in India (vs China), and to have received invasive reperfusion. Clinical event rates during year 2 of follow-up were lower in patients with DAPT >12 vs ≤12 months, but no causal association can be implied in this non-randomized study. CONCLUSIONS: Most ACS patients remained on DAPT up to 1 year, in accordance with current guidelines, and over half remained on DAPT at 2 years post discharge. Patients not on DAPT at 12 months are a higher risk group requiring careful monitoring