Characterization of a missle flyout simulation

This thesis develops a systematic approach to exploring the response of a missile flyout software simulation to input noise. The research is intended to augment the current characterization tests employed by the Electronic Warfare Testing community. This thesis explores the direct relationship between specific input noise signals and individual simulation responses. The design defines an approach for characterizing the behavior of a deterministic simulation of tremendous complexity by controlling test conditions. Techniques for generating realistic random noise are derived. A statistical model of the relationship between input noise missile miss distance at the point of closest approach is presented. The statistical model coefficients are tested for validity. The techniques used are of general applicability to future missile simulation studies

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead