Spatial coherence effects on second- and fourth-order temporal interference

We report the results of two experiments performed with two-photon light, produced via collinear degenerate optical spontaneous parametric downconversion (SPDC), in which both second-order (one-photon) and fourth-order (two-photon) interferograms are recorded in a Mach-Zehnder interferometer (MZI). In the first experiment, high-visibility fringes are obtained for both the second- and fourth-order interferograms. In the second experiment, the MZI is modified by the removal of a mirror from one of its arms; this leaves the fourth-order interferogram unchanged, but extinguishes the second-order interferogram. A theoretical model that takes into consideration both the temporal and spatial degrees-of-freedom of the two-photon state successfully explains the results. While the temporal interference in the MZI is independent of the spatial coherence of the source, that of the modified MZI is not

ILLUMA-T (Integrated LCRD LEO User Modem and Amplifier Terminal) Payload

Presentation on ILLUMA-T (Integrated LCRD LEO User Modem and Amplifier Terminal) Payload at the Japanese Experiment Module (JEM) External Payload Interface Coordination Meeting on May 9, 2018 at the Japan Aerospace Exploration Agency (JAXA) in Tsukuba, Japan. Meeting to discuss details of installing payload on JEM

Phase-unlocked Hong-Ou-Mandel interferometry

There is a fundamental dimensional mismatch between the Hong-Ou-Mandel (HOM) interferometer and two-photon (2P) states: while the latter are represented using two temporal (or spectral) dimensions, the HOM interferometer allows access to only one temporal dimension. We introduce a linear 2P interferometer containing two independent delays spanning the 2P state. By unlocking the fixed phase relationship between the interfering 2P probability amplitudes in a HOM interferometer, one of these probability amplitudes now serves as a delay-free 2P reference against which the other beats, thereby resolving ambiguities in 2P state identification typical of HOM interferometry and extending its utility to a large family of 2P states

Experimental demonstration of photon efficient coherent temporal combining for data rate scaling

The next generation free-space optical (FSO) communications infrastructure will need to support a wide range of links from space-based terminals at LEO, GEO, and deep space to the ground. Efficiently enabling such a diverse mission set requires a common ground station architecture capable of providing excellent sensitivity (i.e., few photons-per-bit) while supporting a wide range of data rates. One method for achieving excellent sensitivity performance is to use integrated digital coherent receivers. Additionally, coherent receivers provide full-field information, which enables efficient temporal coherent combining of block repeated signals. This method allows system designers to trade excess link margin for increased data rate without requiring hardware modifications. We present experimental results that show a 45-dB scaling in data rate over a 41-dB range of input powers by block-repeating and combining a PRBS sequence up to 36,017 times. Keywords: digital signal processing, optical receivers, phase shift keying, coherent combiningUnited States. Dept. of Defense. Assistant Secretary of Defense for Research & Engineering (Contract FA8721-05-C-0002

Eligibility for interventions, co-occurrence and risk factors for unhealthy behaviours in patients consulting for routine primary care: results from the Pre-Empt study

Smoking, excessive drinking, lack of exercise and a poor diet remain key causes of premature morbidity and mortality globally, yet it is not clear what proportion of patients attending for routine primary care are eligible for interventions about these behaviours, the extent to which they co-occur within individuals, and which individuals are at greatest risk for multiple unhealthy behaviours. The aim of the trial was to examine 'intervention eligibility' and co-occurrence of the 'big four' risky health behaviours - lack of exercise, smoking, an unhealthy diet and excessive drinking - in a primary care population. Data were collected from adult patients consulting routinely in general practice across South Wales as part of the Pre-Empt study; a cluster randomised controlled trial. After giving consent, participants completed screening instruments, which included the following to assess eligibility for an intervention based on set thresholds: AUDIT-C (for alcohol), HSI (for smoking), IPAQ (for exercise) and a subset of DINE (for diet). The intervention following screening was based on which combination of risky behaviours the patient had. Descriptive statistics, χ2 tests for association and ordinal regressions were undertaken. Two thousand sixty seven patients were screened: mean age of 48.6 years, 61.9 % female and 42.8 % in a managerial or professional occupation. In terms of numbers of risky behaviours screened eligible for, two was the most common (43.6 %), with diet and exercise (27.2 %) being the most common combination. Insufficient exercise was the most common single risky behaviour (12.0 %). 21.8 % of patients would have been eligible for an intervention for three behaviours and 5.9 % for all four behaviours. Just 4.5 % of patients did not identify any risky behaviours. Women, older age groups and those in managerial or professional occupations were more likely to exhibit all four risky behaviours. Very few patients consulting for routine primary care screen ineligible for interventions about common unhealthy behaviours, and most engage in more than one of the major common unhealthy behaviours. Clinicians should be particularly alert to opportunities to engaging younger, non professional men and those with multi-morbidity about risky health behaviour. ISRCTN22495456. BACKGROUND METHODS RESULTS CONCLUSION TRIAL REGISTRATIO

Atomoxetine Enhances Connectivity of Prefrontal Networks in Parkinson's Disease.

Cognitive impairment is common in Parkinson's disease (PD), but often not improved by dopaminergic treatment. New treatment strategies targeting other neurotransmitter deficits are therefore of growing interest. Imaging the brain at rest ('task-free') provides the opportunity to examine the impact of a candidate drug on many of the brain networks that underpin cognition, while minimizing task-related performance confounds. We test this approach using atomoxetine, a selective noradrenaline reuptake inhibitor that modulates the prefrontal cortical activity and can facilitate some executive functions and response inhibition. Thirty-three patients with idiopathic PD underwent task-free fMRI. Patients were scanned twice in a double-blind, placebo-controlled crossover design, following either placebo or 40-mg oral atomoxetine. Seventy-six controls were scanned once without medication to provide normative data. Seed-based correlation analyses were used to measure changes in functional connectivity, with the right inferior frontal gyrus (IFG) a critical region for executive function. Patients on placebo had reduced connectivity relative to controls from right IFG to dorsal anterior cingulate cortex and to left IFG and dorsolateral prefrontal cortex. Atomoxetine increased connectivity from the right IFG to the dorsal anterior cingulate. In addition, the atomoxetine-induced change in connectivity from right IFG to dorsolateral prefrontal cortex was proportional to the change in verbal fluency, a simple index of executive function. The results support the hypothesis that atomoxetine may restore prefrontal networks related to executive functions. We suggest that task-free imaging can support translational pharmacological studies of new drug therapies and provide evidence for engagement of the relevant neurocognitive systems.This work was funded by the Wellcome trust (103838), Parkinson’s UK, National Institute for Health Research’s Cambridge Biomedical Research Centre and the Medical Research Council (MC_US_A060_0016 and RG62761) and the James F McDonnell Foundation (21st century science initiative on Understanding Human Cognition). The BCNI is supported by a joint award from the Wellcome Trust and Medical Research Council.This is the final version of the article. It first appeared from Nature Publishing Group via http://dx.doi.org/10.1038/npp.2016.1