42 research outputs found

    ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Ρ‚Π΅Π»Π»Π΅ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… систСм Π½Π° транспортС

    Get PDF
    The article discusses the application of intelligent transport systems for railway transport. The purpose of developing intelligent transport systems on railway transport is to strictly comply with the requirements for ensuring transport safety, reducing the level of environmental impact, significantly improving the efficiency of production activities. The software makes automatic accounting, control and analysis of fuel and energy resources consumption on the basis of the obtained data. At the same time, the dynamics of changes in fuel consumption indicators, actual and estimated costs of diesel fuel are visually reflected in real time on the monitor screen. If necessary, the system will help to identify the reasons for non-matching of these parameters and quickly contact the locomotive team to provide qualified assistance in their elimination. It is important that the hardware structure and the structure of the system software expand functionality, providing continuous operation and repair work, increasing the number of measured parameters, creating a closed fuel consumption control system in a locomotive economy. The use of these systems makes it possible to obtain an integrated assessment of the heat engineering condition of a locomotive with further scientifically substantiated correction of overhaul runs, to control its location and solve many other problems, which contributes to an increase in overhaul runs and the operational life of the locomotive.Π’ ΡΡ‚Π°Ρ‚ΡŒΠ΅ рассматриваСтся ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΈΠ½Ρ‚Π΅Π»Π»Π΅ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… транспортных систСм Π½Π° транспортС. ЦСлями Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ ΠΈΠ½Ρ‚Π΅Π»Π»Π΅ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹Ρ… транспортных систСм Π½Π° ΠΆΠ΅Π»Π΅Π·Π½ΠΎΠ΄ΠΎΡ€ΠΎΠΆΠ½ΠΎΠΌ транспортС ΡΠ²Π»ΡΡŽΡ‚ΡΡ Π½Π΅ΡƒΠΊΠΎΡΠ½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠ΅ Π²Ρ‹ΠΏΠΎΠ»Π½Π΅Π½ΠΈΠ΅ Ρ‚Ρ€Π΅Π±ΠΎΠ²Π°Π½ΠΈΠΉ ΠΏΠΎ ΠΎΠ±Π΅ΡΠΏΠ΅Ρ‡Π΅Π½ΠΈΡŽ бСзопасности ΠΏΠ΅Ρ€Π΅Π²ΠΎΠ·ΠΎΠΊ, сокращСниС уровня влияния Π½Π° ΠΎΠΊΡ€ΡƒΠΆΠ°ΡŽΡ‰ΡƒΡŽ срСду, сущСствСнноС ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΠ΅ эффСктивности производствСнной Π΄Π΅ΡΡ‚Π΅Π»ΡŒΠ½ΠΎΡΡ‚ΠΈ. На основС ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… Π΄Π°Π½Π½Ρ‹Ρ… ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ½ΠΎΠ΅ обСспСчСниС ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΡ‚ автоматичСский ΡƒΡ‡Π΅Ρ‚, ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒ ΠΈ Π°Π½Π°Π»ΠΈΠ· расхода Ρ‚ΠΎΠΏΠ»ΠΈΠ²Π½ΠΎ-энСргСтичСских рСсурсов. ΠŸΡ€ΠΈ этом Π½Π° экранС ΠΌΠΎΠ½ΠΈΡ‚ΠΎΡ€Π° наглядно Π² Ρ€Π΅ΠΆΠΈΠΌΠ΅ Ρ€Π΅Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ Π²Ρ€Π΅ΠΌΠ΅Π½ΠΈ отраТаСтся Π΄ΠΈΠ½Π°ΠΌΠΈΠΊΠ° измСнСния ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ Ρ‚ΠΎΠΏΠ»ΠΈΠ²ΠΎΠΈΡΠΏΠΎΠ»ΡŒΠ·ΠΎΠ²Π°Π½ΠΈΡ, фактичСскиС ΠΈ расчСтныС Π·Π°Ρ‚Ρ€Π°Ρ‚Ρ‹ Π΄ΠΈΠ·Ρ‚ΠΎΠΏΠ»ΠΈΠ²Π°. Π’ случаС нСобходимости систСма ΠΏΠΎΠΌΠΎΠΆΠ΅Ρ‚ Π²Ρ‹ΡΠ²ΠΈΡ‚ΡŒ ΠΏΡ€ΠΈΡ‡ΠΈΠ½Ρ‹ нСсостыковки этих ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ² ΠΈ ΠΎΠΏΠ΅Ρ€Π°Ρ‚ΠΈΠ²Π½ΠΎ ΡΠ²ΡΠ·Π°Ρ‚ΡŒΡΡ с Π»ΠΎΠΊΠΎΠΌΠΎΡ‚ΠΈΠ²Π½ΠΎΠΉ Π±Ρ€ΠΈΠ³Π°Π΄ΠΎΠΉ для оказания ΠΊΠ²Π°Π»ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠΉ ΠΏΠΎΠΌΠΎΡ‰ΠΈ ΠΏΠΎ ΠΈΡ… ΡƒΡΡ‚Ρ€Π°Π½Π΅Π½ΠΈΡŽ. Π’Π°ΠΆΠ½ΠΎ, Ρ‡Ρ‚ΠΎ конструкция Π°ΠΏΠΏΠ°Ρ€Π°Ρ‚Π½ΠΎΠΉ части ΠΈ структура ΠΏΡ€ΠΎΠ³Ρ€Π°ΠΌΠΌΠ½ΠΎΠ³ΠΎ обСспСчСния прСдусматриваСт Ρ€Π°ΡΡˆΠΈΡ€Π΅Π½ΠΈΠ΅ Π΅Π΅ Ρ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… возмоТностСй, Π² Ρ‚ΠΎΠΌ числС Π·Π° счСт ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΈ Π½Π΅ΠΏΡ€Π΅Ρ€Ρ‹Π²Π½ΠΎΠ³ΠΎ видСонаблюдСния Π·Π° дСйствиями Π»ΠΎΠΊΠΎΠΌΠΎΡ‚ΠΈΠ²Π½Ρ‹Ρ… ΠΈ Ρ€Π΅ΠΌΠΎΠ½Ρ‚Π½Ρ‹Ρ… Π±Ρ€ΠΈΠ³Π°Π΄, увСличСния количСства измСряСмых ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ², создания Π·Π°ΠΌΠΊΠ½ΡƒΡ‚ΠΎΠΉ систСмы контроля расхода Ρ‚ΠΎΠΏΠ»ΠΈΠ²Π° Π² Π»ΠΎΠΊΠΎΠΌΠΎΡ‚ΠΈΠ²Π½ΠΎΠΌ хозяйствС. ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π΄Π°Π½Π½Ρ‹Ρ… систСм позволяСт ΠΏΠΎΠ»ΡƒΡ‡ΠΈΡ‚ΡŒ ΠΈΠ½Ρ‚Π΅Π³Ρ€Π°Π»ΡŒΠ½ΡƒΡŽ ΠΎΡ†Π΅Π½ΠΊΡƒ тСплотСхничСского состояния Π»ΠΎΠΊΠΎΠΌΠΎΡ‚ΠΈΠ²Π° с дальнСйшСй Π½Π°ΡƒΡ‡Π½ΠΎ-обоснованной ΠΊΠΎΡ€Ρ€Π΅ΠΊΡ†ΠΈΠ΅ΠΉ ΠΌΠ΅ΠΆΡ€Π΅ΠΌΠΎΠ½Ρ‚Π½Ρ‹Ρ… ΠΏΡ€ΠΎΠ±Π΅Π³ΠΎΠ², ΠΏΡ€ΠΎΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π΅Π³ΠΎ мСстонахоТдСния ΠΈ Ρ€Π΅ΡˆΠΈΡ‚ΡŒ мноТСство Π΄Ρ€ΡƒΠ³ΠΈΡ… Π·Π°Π΄Π°Ρ‡, Ρ‡Ρ‚ΠΎ способствуСт ΡƒΠ²Π΅Π»ΠΈΡ‡Π΅Π½ΠΈΡŽ ΠΌΠ΅ΠΆΡ€Π΅ΠΌΠΎΠ½Ρ‚Π½Ρ‹Ρ… ΠΏΡ€ΠΎΠ±Π΅Π³ΠΎΠ² ΠΈ сроков эксплуатационной Ρ€Π°Π±ΠΎΡ‚Ρ‹ Π»ΠΎΠΊΠΎΠΌΠΎΡ‚ΠΈΠ²Π°

    Аn experimental study of heat and mass transfer in a falling liquid film evaporation into a cross flow of a neutral gas

    Get PDF
    The work is devoted to the study of heat and mass transfer in a liquid film flowing down on a heated surface under conditions of evaporation into a crossflow of a gas neutral with respect to the liquid. The work aimed to experimentally determine the average heat transfer coefficients from a heated surface to the film, heat transfer and mass transfer from the film to the gas flow and to establish their dependence on the input parameters of the heat and mass transfer process. To achieve this goal, an experimental setup was created, and a research technique was developed based on the proposed mathematical model of the heat and mass transfer process. The results of the study showed that the dependences of the average heat and mass transfer coefficients on the initial liquid flow rate are extreme with the minimum values of these coefficients at the liquid flow rate, which corresponds to the critical value of the Reynolds criterion Re l cr β‰ˆ 500, which indicates a transition from the laminar falling films to turbulent mode under the considered conditions. The dependences of the heat and mass transfer coefficients on other process parameters for both modes of film falling are established. A generalization of the experimental data made it possible to obtain empirical equations for calculating these coefficients

    Les facteurs de la formation de la conduite destructive des infectΓ©s par le VIH

    Get PDF
    On sait que le VIH est une maladie infectieuse, qui provoque mΓ©diatement le dΓ©veloppement des maladies mentales, en consΓ©quence de la rΓ©action Γ  la maladie, des nΓ©cessitΓ©s de se tenir au traitement de longue durΓ©e, du dΓ©veloppement des dΓ©faites organiques de l'encΓ©phale. Ces derniΓ¨res armΓ©es l'intΓ©rΓͺt pour le style particulier de la conduite des infectΓ©s de l’VIH, qui est le sΓ©rieux problΓ¨me mΓ©dico-social (il complique le traitement, contribue Γ  la diffusion du VIH), a augmentΓ©

    Raman scattering from confined phonons in GaAs/AlGaAs quantum wires

    Get PDF
    We report on photoluminescence and Raman scattering performed at low temperature (T = 10 K) on GaAs/Al 0.3Ga 0.7As quantum-well wires with effective wire widths of L = 100.0 and 10.9 nm prepared by molecular beam epitaxial growth followed by holographic patterning, reactive ion etching, and anodic thinning. We find evidence for the existence of longitudinal optical phonon modes confined to the GaAs quantum wire. The observed frequency at Ο‰ L10 = 285.6 cm -1 for L = 11.0 nm is in good agreement with that calculated on the basis of the dispersive dielectric continuum theory of Enderlein† as applied to the GaAs/Al 0.3Ga 0.7As system. Our results indicate the high crystalline quality of the quantum-well wires fabricated using these techniques. Β© 1998 Academic Press

    World Health Organization: story of creation and development

    No full text
    Over its 70-year history, the World Health Organization (WHO) has become the leading global organization in the medical field. The publication analyses the history of the creation of the WHO. The authors also consider international health organizations, that have become the basis for the further creation of a global health organization

    ΠžΡΠΎΠ±Π΅Π½Π½ΠΎΡΡ‚ΡŒ тСчСния спаСчного процСсса Π±Ρ€ΡŽΡˆΠ½ΠΎΠΉ полости Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ с Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠΉ ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒΡŽ выраТСнности дисплазии ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Ρ‚ΠΊΠ°Π½ΠΈ

    No full text
    Aim. To assess adhesions of the abdominal cavity in children with varying degrees of connective tissue dysplasia (CTD) severity. Methods. A total of 91 children with average age of 10.6 1.4 years were observed from 2005 to 2019. Composed of 53 boys (58.2%) and 38 girls (41.8%). Patients were divided into two groups: group 1 (69 children without CTD) and group 2 (22 children with CTD). Clinical data and screening cards were used to diagnose DST. All patients underwent an assessment for the clinical course, a macroscopic visual assessment adhesive process severity in the abdominal cavity according to three different scales (Nair, F. Coccolini, N.I. Ayushinova). Immunohistochemistry was performed against collagen I, III, IV type, Laminin 1, angiogenesis factors, transforming growth factor beta (TGF-), and Fibroblast Growth Factor Receptor 1 (FGFR1). A semi-quantitative counting method was used to record the relative number of immunopositive structures. Statistical analysis was carried out by methods of variation statistics using the Chi-square test and MannWhitney U-tests, as well as the Spearman rank correlation method for the reliability of differences between groups. Results. In the adhesive process visualization, the N.I. Ayushinov scale was revealed to be the most informative, showing the average score of 7 0.8 points in group 2 and 14 1.2 in group 1 (rs 0.35; p 0.05). In group 2, the adhesive material showed no (56%) or chaotic fragments (44%) of type I collagen, and the ratio of type I to type III collagen is 2.7: 5.1. In group 1, the ratio of type I to type III collagen is 5.9:1.8. The ratio of collagen IV to type I is 6.5: 2.9. Both groups have a moderate (++) amount of TGF-. TGF- is positive with macrophages. FGFR1 was found in the control group (++++). A positive response was seen in fibroblasts and macrophages (U = 79.00; p = 0.006). Statistically significant analyzes of vascular endothelial growth factor in compared groups (rs = 0.632, p 0.001) had a positive correlation.. Conclusion. Thus, the study showed features of clinical course and morphological changes during the development of adhesions in the abdominal cavity in children with varying degrees of severity of CTD. Data obtained dictate the need for an individual approach in predicting adhesive disease, as well as targeted preventive care.ЦСль. ΠžΡ†Π΅Π½ΠΊΠ° спаСчного процСсса Π±Ρ€ΡŽΡˆΠ½ΠΎΠΉ полости Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ с Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠΉ ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒΡŽ выраТСнности дисплазии ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Ρ‚ΠΊΠ°Π½ΠΈ (Π”Π‘Π’). ΠœΠ΅Ρ‚ΠΎΠ΄Ρ‹. Π’ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄ c 2005 ΠΏΠΎ 2019 Π³. наблюдался 91 Ρ€Π΅Π±Π΅Π½ΠΎΠΊ со спаСчной болСзнью Π±Ρ€ΡŽΡˆΠ½ΠΎΠΉ полости Π² возрастС 10,6 1,4 Π³ΠΎΠ΄Π°. ΠœΠ°Π»ΡŒΡ‡ΠΈΠΊΠΎΠ² Π±Ρ‹Π»ΠΎ 53 (58,2 %), Π΄Π΅Π²ΠΎΡ‡Π΅ΠΊ 38 (41,8 %). ΠŸΠ°Ρ†ΠΈΠ΅Π½Ρ‚Ρ‹ Π±Ρ‹Π»ΠΈ Ρ€Π°Π·Π΄Π΅Π»Π΅Π½Ρ‹ Π½Π° 2 Π³Ρ€ΡƒΠΏΠΏΡ‹: Π³Ρ€ΡƒΠΏΠΏΠ° 1 (69 Π΄Π΅Ρ‚Π΅ΠΉ Π±Π΅Π· Π”Π‘Π’) ΠΈ Π³Ρ€ΡƒΠΏΠΏΠ° 2 (22 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π° с Π”Π‘Π’). Диагностику Π”Π‘Π’ осущСствляли Π½Π° основании ΠΊΠ»ΠΈΠ½ΠΈΠΊΠΎ-Π»Π°Π±ΠΎΡ€Π°Ρ‚ΠΎΡ€Π½Ρ‹Ρ… Π΄Π°Π½Π½Ρ‹Ρ… ΠΈ скрининговых ΠΊΠ°Ρ€Ρ‚. Π£ всСх ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π° ΠΎΡ†Π΅Π½ΠΊΠ° клиничСского тСчСния, макроскопичСская Π²ΠΈΠ·ΡƒΠ°Π»ΡŒΠ½Π°Ρ ΠΎΡ†Π΅Π½ΠΊΠ° выраТСнности спаСчного процСсса Π² Π±Ρ€ΡŽΡˆΠ½ΠΎΠΉ полости ΠΏΠΎ Ρ‚Ρ€Π΅ΠΌ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹ΠΌ шкалам (Nair, F. Coccolini, Н.И. Аюшинова). Π˜ΠΌΠΌΡƒΠ½ΠΎΠ³ΠΈΡΡ‚ΠΎΡ…ΠΈΠΌΠΈΡ‡Π΅ΡΠΊΠΈΠ΅ исслСдования ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΊ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Ρƒ I, III, IV Ρ‚ΠΈΠΏΠΎΠ², ΠΊ Laminin 1, Ρ„Π°ΠΊΡ‚ΠΎΡ€Π°ΠΌ Π°Π½Π³ΠΈΠΎΠ³Π΅Π½Π΅Π·Π°, TGF- ΠΈ FGFR1. БтатистичСский Π°Π½Π°Π»ΠΈΠ· осущСствляли ΠΌΠ΅Ρ‚ΠΎΠ΄Π°ΠΌΠΈ Π²Π°Ρ€ΠΈΠ°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΉ статистики с использованиСм Ρ…ΠΈ-ΠΊΠ²Π°Π΄Ρ€Π°Ρ‚-тСста, U-тСстов ΠœΠ°Π½Π½Π°Π£ΠΈΡ‚Π½ΠΈ, для достовСрности Ρ€Π°Π·Π»ΠΈΡ‡ΠΈΠΉ ΠΌΠ΅ΠΆΠ΄Ρƒ Π³Ρ€ΡƒΠΏΠΏΠ°ΠΌΠΈ, Ρ‚Π°ΠΊΠΆΠ΅ ΠΌΠ΅Ρ‚ΠΎΠ΄ Ρ€Π°Π½Π³ΠΎΠ²ΠΎΠΉ коррСляции Π‘ΠΏΠΈΡ€ΠΌΠ΅Π½Π°. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. Для ΠΎΡ†Π΅Π½ΠΊΠΈ спаСчного процСсса Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½ΠΎΠΉ оказалась шкала Н.И. Аюшинова. ΠŸΡ€ΠΈ этом Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ 2 срСдний Π±Π°Π»Π» составил 7 0,8 Π±Π°Π»Π»Π°, Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ 1 14 1,2 Π±Π°Π»Π»Π° (rs 0,35; Ρ€ 0,05). Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ 2 Π² ΠΈΠ½Ρ‚Ρ€Π°Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… спайках отсутствовали (56 %) ΠΈΠ»ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΡΠ»ΠΈΡΡŒ Ρ…Π°ΠΎΡ‚ΠΈΡ‡Π½Ρ‹Π΅ Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚Ρ‹ (44 %) ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° I Ρ‚ΠΈΠΏΠ°. Π‘ΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° I Ρ‚ΠΈΠΏΠ° ΠΊ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Ρƒ III Ρ‚ΠΈΠΏΠ° составляло 2,7:5,1. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ 1 ΡΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° I Ρ‚ΠΈΠΏΠ° ΠΊ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Ρƒ III Ρ‚ΠΈΠΏΠ° 5,9:1,8. Π‘ΠΎΠΎΡ‚Π½ΠΎΡˆΠ΅Π½ΠΈΠ΅ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Π° IV ΠΊ ΠΊΠΎΠ»Π»Π°Π³Π΅Π½Ρƒ I Ρ‚ΠΈΠΏΠ° 6,5:2,9. Π’ ΠΎΠ±ΠΎΠΈΡ… Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… Π±Ρ‹Π»ΠΎ ΡƒΠΌΠ΅Ρ€Π΅Π½Π½ΠΎΠ΅ (++) количСство TGF-. FGFR1 ΠΈΠΌΠ΅Π» мСсто Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ 1 (++++). ΠŸΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½Π°Ρ рСакция Π±Ρ‹Π»Π° Π² фибробластах ΠΈ ΠΌΠ°ΠΊΡ€ΠΎΡ„Π°Π³Π°Ρ… (U = 79,00; Ρ€ = 0,006). БтатистичСски Π·Π½Π°Ρ‡ΠΈΠΌΡ‹Π΅ значСния ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΈΡΡŒ для VEGF Π² сравниваСмых Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… (rs = 0,632; Ρ€ 0,001) с ΠΏΠΎΠ»ΠΎΠΆΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ коррСляционной связью. Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±Ρ€Π°Π·ΠΎΠΌ, ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½ΠΎΠ΅ исслСдованиС ΠΏΠΎΠΊΠ°Π·Π°Π»ΠΎ особСнности клиничСского тСчСния ΠΈ морфологичСских ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ ΠΏΡ€ΠΈ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠΈ спаСчного процСсса Π±Ρ€ΡŽΡˆΠ½ΠΎΠΉ полости Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ с Ρ€Π°Π·Π»ΠΈΡ‡Π½ΠΎΠΉ ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒΡŽ выраТСнности дисплазии ΡΠΎΠ΅Π΄ΠΈΠ½ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎΠΉ Ρ‚ΠΊΠ°Π½ΠΈ. ΠŸΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Π΅ Π΄Π°Π½Π½Ρ‹Π΅ Π΄ΠΈΠΊΡ‚ΡƒΡŽΡ‚ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄Π° Π² ΠΏΡ€ΠΎΠ³Π½ΠΎΠ·ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ спаСчной Π±ΠΎΠ»Π΅Π·Π½ΠΈ, Π° Ρ‚Π°ΠΊΠΆΠ΅ Ρ†Π΅Π»Π΅Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½ΠΎΠΉ Π»Π΅Ρ‡Π΅Π±Π½ΠΎ-профилактичСской ΠΏΠΎΠΌΠΎΡ‰ΠΈ

    Π­Ρ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ Π—D-Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ с Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡŒΠ½Ρ‹ΠΌ эхинококкозом

    No full text
    BACKGROUND: Laparoscopy in the treatment of abdominal echinococcosis is accompanied by complications. Therefore, studies on optimizing surgical approaches that reduce intra- and postoperative complications in liver echinococcosis are extremely relevant. AIM: This study aimed to assess the possibility of using three-dimensional (3D) technologies in children with abdominal echinococcosis to determine whether it can increase the efficiency of laparoscopic treatment and reduce complications. MATERIALS AND METHODS: A prospective analysis was conducted from 2013 to 2019 among 43 children with isolated liver echinococcosis who underwent multiport laparoscopic echinococcectomy. In the preoperative period, 25 patients from the main group used a complex of modern 3D technology: creating a 3D reconstruction of a liver with a parasitic cyst and then printing a 3D model of an organ with vessels and bile ducts. RESULTS: The use of virtual computer visualization with the 3D reconstruction of the parasitic cyst and adjacent blood vessels with bile ducts made it possible to produce a 3D liver model. This approach provided the possibility of personalized laparoscopic access and precision in performing surgeries. Postoperatively, residual cavity (n = 1, 4.0%) was observed in the main group and biliary fistula and residual cavity (n = 2, 11.1%) in the comparison group CONCLUSIONS: Thus, the use of 3D technologies in children with abdominal echinococcosis can increase the efficiency of laparoscopic treatment and reduce the number of early and late complications.ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ. ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ лапароскопичСских Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Π² Π»Π΅Ρ‡Π΅Π½ΠΈΠΈ абдоминального эхинококкоза сопровоТдаСтся Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ΠΌ ослоТнСний. ΠŸΠΎΡΡ‚ΠΎΠΌΡƒ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ исслСдований, Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½Π½Ρ‹Ρ… Π½Π° ΠΎΠΏΡ‚ΠΈΠΌΠΈΠ·Π°Ρ†ΠΈΡŽ хирургичСских ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ΠΎΠ², ΠΎΠ±Π΅ΡΠΏΠ΅Ρ‡ΠΈΠ²Π°ΡŽΡ‰ΠΈΡ… сниТСниС ΠΈΠ½Ρ‚Ρ€Π°- ΠΈ послСопСрационных ослоТнСний ΠΏΡ€ΠΈ эхинококкозС ΠΏΠ΅Ρ‡Π΅Π½ΠΈ, ΡΠ²Π»ΡΡŽΡ‚ΡΡ ΠΊΡ€Π°ΠΉΠ½Π΅ Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΌΠΈ. ЦСль. ΠžΡ†Π΅Π½ΠΊΠ° возмоТности примСнСния 3D-Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ с Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡŒΠ½Ρ‹ΠΌ эхинококкозом, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ²ΡˆΠΈΡ… ΠΏΠΎΠ²Ρ‹ΡΠΈΡ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ лапароскопичСского лСчСния ΠΈ ΡΠ½ΠΈΠ·ΠΈΡ‚ΡŒ количСство ослоТнСний. ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ проспСктивный Π°Π½Π°Π»ΠΈΠ· историй Π±ΠΎΠ»Π΅Π·Π½ΠΈ с 2013 ΠΏΠΎ 2019 Π³. Ρƒ 43 Π΄Π΅Ρ‚Π΅ΠΉ с ΠΈΠ·ΠΎΠ»ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΌ эхинококкозом ΠΏΠ΅Ρ‡Π΅Π½ΠΈ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ Π²Ρ‹ΠΏΠΎΠ»Π½ΡΠ»Π°ΡΡŒ многопортовая лапароскопичСская эхинококкэктомия. Π’ ΠΏΡ€Π΅Π΄ΠΎΠΏΠ΅Ρ€Π°Ρ†ΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π΅ 25 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚Π°ΠΌ основной Π³Ρ€ΡƒΠΏΠΏΡ‹ примСнялся комплСкс соврСмСнных 3D-Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ (созданиС ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠΉ 3D-рСконструкции ΠΏΠ΅Ρ‡Π΅Π½ΠΈ с ΠΏΠ°Ρ€Π°Π·ΠΈΡ‚Π°Ρ€Π½ΠΎΠΉ кистой ΠΈ ΠΏΠ΅Ρ‡Π°Ρ‚ΡŒ 3D-ΠΌΠΎΠ΄Π΅Π»ΠΈ ΠΎΡ€Π³Π°Π½Π° с сосудами ΠΈ ТСлчСвыводящими ΠΏΡ€ΠΎΡ‚ΠΎΠΊΠ°ΠΌΠΈ). Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. ИспользованиС ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠΉ Π²ΠΈΡ€Ρ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΠΉ Π²ΠΈΠ·ΡƒΠ°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ с Ρ‚Ρ€Π΅Ρ…ΠΌΠ΅Ρ€Π½ΠΎΠΉ рСконструкциСй ΠΏΠ°Ρ€Π°Π·ΠΈΡ‚Π°Ρ€Π½ΠΎΠΉ кисты ΠΈ ΠΏΡ€ΠΈΠ»Π΅ΠΆΠ°Ρ‰ΠΈΡ… ΠΊ Π½Π΅ΠΉ кровСносных сосудов с ΠΆΠ΅Π»Ρ‡Π½Ρ‹ΠΌΠΈ ΠΏΡ€ΠΎΡ‚ΠΎΠΊΠ°ΠΌΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΠΈΠ·Π³ΠΎΡ‚ΠΎΠ²ΠΈΡ‚ΡŒ 3D-модСль ΠΏΠ΅Ρ‡Π΅Π½ΠΈ. Π”Π°Π½Π½Ρ‹ΠΉ ΠΏΠΎΠ΄Ρ…ΠΎΠ΄ обСспСчил Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ пСрсонализированного лапароскопичСского Π²ΠΌΠ΅ΡˆΠ°Ρ‚Π΅Π»ΡŒΡΡ‚Π²Π°. ΠŸΡ€ΠΈ этом Π² основной Π³Ρ€ΡƒΠΏΠΏΠ΅ ΠΎΡ‚ΠΌΠ΅Ρ‡Π°Π»ΠΎΡΡŒ Π² послСопСрационном ΠΏΠ΅Ρ€ΠΈΠΎΠ΄Π΅ Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ ΠΎΠ΄Π½ΠΎΠ³ΠΎ (4,0 %) ослоТнСния (остаточная ΠΏΠΎΠ»ΠΎΡΡ‚ΡŒ). Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ сравнСния ΠΈΠΌΠ΅Π»ΠΎ мСсто Π΄Π²Π° (11,1 %) ослоТнСния Π² Π²ΠΈΠ΄Π΅ ΠΆΠ΅Π»Ρ‡Π½ΠΎΠ³ΠΎ свища ΠΈ остаточной полости. Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±Ρ€Π°Π·ΠΎΠΌ, ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ 3D-Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΉ Ρƒ Π΄Π΅Ρ‚Π΅ΠΉ с Π°Π±Π΄ΠΎΠΌΠΈΠ½Π°Π»ΡŒΠ½Ρ‹ΠΌ эхинококкозом позволяСт ΠΏΠΎΠ²Ρ‹ΡΠΈΡ‚ΡŒ эффСктивност

    ΠœΠΎΡ€Ρ„ΠΎΠΌΠ΅Ρ‚Ρ€ΠΈΡ‡Π΅ΡΠΊΠΈΠΉ Π°Π½Π°Π»ΠΈΠ· ΠΌΠ΅ΠΆΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ вСщСства гипСртрофичСских Ρ€ΡƒΠ±Ρ†ΠΎΠ² Π½Π° Ρ„ΠΎΠ½Π΅ ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΡ€ΡƒΠ±Ρ†ΠΎΠ²ΠΎΠ³ΠΎ лСчСния

    No full text
    AIM: This study aimed to assess the formation of scar tissue after burns under the influence of an anti-scar gel. Understanding of the processes involving scars and the morphofunctional features of the tissue at different stages of development allows targeted selection of therapy and prevention of scars. MATERIALS AND METHODS: We conducted a comparative prospective analysis from 2005 to 2020. Of which two groups were identified. In group 1 (n = 47), burns were treated according to the standard scheme without the use of modern wound coverings. In group 2 (n = 41), early primary prevention of pathological scarring was performed, where the Contractubex gel was applied to the area of burn injury from the moment of epithelialization. Histological examination included the analysis of skin biopsies in the area of damage before and after conservative treatment. RESULTS: Histological examination showed quantitative changes in the cellular composition of the scar tissue in all groups. The average quantitative index of the fibroblast activity was significantly reduced in group 2 using Contractubex gel. Thickness of collagen fibers, according to the morphometric analysis, is most reduced in all layers of the dermis in group 2 (p 0.05). In group 1, collagen fibers are represented as nodular clusters; in some areas of the reticular layer of the dermis, fibers have a more fragmented appearance. In group 2, the use of Contractubex leads to a significant decrease in the level of tumor growth factor- in the papillary and reticular layers of the dermis. CONCLUSION: The use of Contractubex gel in the early prevention of pathological scarring significantly reduces the need for subsequent reconstructive surgical interventionsЦСль. Π’ Π΄Π°Π½Π½ΠΎΠΉ ΡΡ‚Π°Ρ‚ΡŒΠ΅ Ρ†Π΅Π»ΡŒΡŽ исслСдования послуТила ΠΎΡ†Π΅Π½ΠΊΠ° формирования Ρ€ΡƒΠ±Ρ†ΠΎΠ²ΠΎΠΉ Ρ‚ΠΊΠ°Π½ΠΈ послС ΠΎΠΆΠΎΠ³ΠΎΠ² ΠΏΠΎΠ΄ воздСйствиСм ΠΏΡ€ΠΎΡ‚ΠΈΠ²ΠΎΡ€ΡƒΠ±Ρ†ΠΎΠ²ΠΎΠ³ΠΎ гСля. Π’Π°ΠΊ ΠΊΠ°ΠΊ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠ΅ процСссов, происходящих Π² Ρ€ΡƒΠ±Ρ†Π°Ρ…, ΠΈ ΠΌΠΎΡ€Ρ„ΠΎΡ„ΡƒΠ½ΠΊΡ†ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… особСнностСй Ρ‚ΠΊΠ°Π½ΠΈ Π½Π° Ρ€Π°Π·Π½Ρ‹Ρ… этапах развития позволяСт ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΡ‚ΡŒ Ρ‚Π°Ρ€Π³Π΅Ρ‚Π½Ρ‹ΠΉ ΠΏΠΎΠ΄Π±ΠΎΡ€ Ρ‚Π΅Ρ€Π°ΠΏΠΈΠΈ ΠΈ ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ Ρ€ΡƒΠ±Ρ†ΠΎΠ². ΠœΠ°Ρ‚Π΅Ρ€ΠΈΠ°Π»Ρ‹ ΠΈ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹. ΠŸΡ€ΠΎΠ²Π΅Π΄Π΅Π½ ΡΡ€Π°Π²Π½ΠΈΡ‚Π΅Π»ΡŒΠ½Ρ‹ΠΉ проспСктивный Π°Π½Π°Π»ΠΈΠ· с 2005 ΠΏΠΎ 2020 Π³. Π‘Ρ‹Π»ΠΈ Π²Ρ‹Π΄Π΅Π»Π΅Π½Ρ‹ 2 Π³Ρ€ΡƒΠΏΠΏΡ‹. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ 1 (47 Π±ΠΎΠ»ΡŒΠ½Ρ‹Ρ…) Π»Π΅Ρ‡Π΅Π½ΠΈΠ΅ ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚ΠΎΠ² с ΠΎΠΆΠΎΠ³Π°ΠΌΠΈ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΏΠΎ стандартной схСмС Π±Π΅Π· примСнСния соврСмСнных Ρ€Π°Π½Π΅Π²Ρ‹Ρ… ΠΏΠΎΠΊΡ€Ρ‹Ρ‚ΠΈΠΉ. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ 2 (41 ΠΏΠ°Ρ†ΠΈΠ΅Π½Ρ‚) ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ Ρ€Π°Π½Π½ΡŽΡŽ ΠΏΠ΅Ρ€Π²ΠΈΡ‡Π½ΡƒΡŽ ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΡƒ образования патологичСского Ρ€ΡƒΠ±Ρ†Π°, Π³Π΄Π΅ ΠΈΠΌ с ΠΌΠΎΠΌΠ΅Π½Ρ‚Π° наступлСния эпитСлизации Π½Π° ΠΎΠ±Π»Π°ΡΡ‚ΡŒ ΠΎΠΆΠΎΠ³ΠΎΠ²ΠΎΠΉ Ρ‚Ρ€Π°Π²ΠΌΡ‹ Π΅ΠΆΠ΅Π΄Π½Π΅Π²Π½ΠΎ наносили гСль ΠšΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚ΡƒΠ±Π΅ΠΊΡ. ГистологичСскоС исслСдованиС Π²ΠΊΠ»ΡŽΡ‡Π°Π»ΠΎ Π°Π½Π°Π»ΠΈΠ· Π±ΠΈΠΎΠΏΡ‚Π°Ρ‚ΠΎΠ² ΠΊΠΎΠΆΠΈ Π² Π·ΠΎΠ½Π΅ поврСТдСния Π΄ΠΎ ΠΈ послС консСрвативного лСчСния. Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹. По Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Π°ΠΌ гистологичСского исслСдования Ρƒ всСх исслСдуСмых Π² Π³Ρ€ΡƒΠΏΠΏΠ°Ρ… Π½Π°Π±Π»ΡŽΠ΄Π°ΡŽΡ‚ΡΡ количСствСнныС измСнСния ΠΊΠ»Π΅Ρ‚ΠΎΡ‡Π½ΠΎΠ³ΠΎ состава Ρ€ΡƒΠ±Ρ†ΠΎΠ²ΠΎΠΉ Ρ‚ΠΊΠ°Π½ΠΈ. УсрСднСнный количСствСнный ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΡŒ активности фибробластов достовСрно сниТСн Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ 2 ΠΏΡ€ΠΈ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠΈ гСля ΠšΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚ΡƒΠ±Π΅ΠΊΡ. Π’ΠΎΠ»Ρ‰ΠΈΠ½Π° ΠΊΠΎΠ»Π»Π°Π³Π΅Π½ΠΎΠ²Ρ‹Ρ… Π²ΠΎΠ»ΠΎΠΊΠΎΠ½, ΠΏΡ€ΠΈ морфомСтричСском Π°Π½Π°Π»ΠΈΠ·Π΅, Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ сниТСна Π²ΠΎ всСх слоях Π΄Π΅Ρ€ΠΌΡ‹ ΠΊΠΎΠΆΠΈ Π² Π³Ρ€ΡƒΠΏΠΏΠ΅ 2 (p 0,05). Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ 1 ΠΊΠΎΠ»Π»Π°Π³Π΅Π½ΠΎΠ²Ρ‹Π΅ Π²ΠΎΠ»ΠΎΠΊΠ½Π° прСдставлСны Π² Π²ΠΈΠ΄Π΅ ΡƒΠ·Π΅Π»ΠΊΠΎΠ²Ρ‹Ρ… скоплСний, Π² Π½Π΅ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Ρ… участках сСтчатого слоя Π΄Π΅Ρ€ΠΌΡ‹ Π²ΠΎΠ»ΠΎΠΊΠ½Π° ΠΈΠΌΠ΅ΡŽΡ‚ Π±ΠΎΠ»Π΅Π΅ Ρ„Ρ€Π°Π³ΠΌΠ΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΉ Π²ΠΈΠ΄. Π’ Π³Ρ€ΡƒΠΏΠΏΠ΅ 2, с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ ΠšΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚ΡƒΠ±Π΅ΠΊΡΠ°, Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ достовСрноС сниТСниС уровня TGF- Π² сосочковом ΠΈ сСтчатом слоях Π΄Π΅Ρ€ΠΌΡ‹. Π—Π°ΠΊΠ»ΡŽΡ‡Π΅Π½ΠΈΠ΅. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±Ρ€Π°Π·ΠΎΠΌ, ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ гСля ΠšΠΎΠ½Ρ‚Ρ€Π°ΠΊΡ‚ΡƒΠ±Π΅ΠΊΡ Π² схСмах Ρ€Π°Π½Π½Π΅ΠΉ ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ образования патологичСского Ρ€ΡƒΠ±Ρ†Π° Π·Π½Π°Ρ‡ΠΈΡ‚Π΅Π»ΡŒΠ½ΠΎ ΡƒΠΌΠ΅Π½ΡŒΡˆΠ°Π΅Ρ‚ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ ΠΏΠΎΡΠ»Π΅Π΄ΡƒΡŽΡ‰ΠΈΡ… рСконструктивных хирургичСских Π²ΠΌΠ΅ΡˆΠ°Ρ‚Π΅Π»ΡŒΡΡ‚Π²
    corecore