83 research outputs found
Lipoprotein Particle Size and Concentration by Nuclear Magnetic Resonance and Incident Type 2 Diabetes in Women
Get PDFUltraÀÀnen hyödyntÀminen lÀÀketieteellisessÀ diagnostiikassa: Perusteet ja laitetarkastelu
No full textA deletion mutation in apolipoprotein A-I gene ApoA-I (Lys 106-0). Quantitative and qualitative effects on lipoprotein classes and subclasses
No full textIn vivo metabolism of apoA-I and apoA-II in subjects with apoA-ILys 107->0 associated with reduced HDL cholesterol and LP(AI w AII) deficiency.
No full textEffects of dietary cholesterol on plasma lipoproteins and their subclasses in IDDM patients
No full textCorrelation of Pharmacological Properties of a Group of Hypolipaemic Drugs by Molecular Topology
No full text
Modulated serum activities and concentrations of paraoxonase in high density lipoprotein deficiency states
No full textParaoxonase is a high density lipoprotein (HDL) associated enzyme with a hypothesised role in the protection of low density lipoproteins (LDL) from oxidative stress. The present study examined paraoxonase in several genetically distinct HDL deficiency states. Despite reduction or even absence of detectable HDL, enzyme activity was present in sera from A-I-Pisa, A-I- Helsinki, A-I-Milano and Tangier patients. Both enzyme activities and peptide concentrations were modulated (reduced) but specific activities were broadly similar to controls, suggesting an impact on peptide concentration rather than an inhibition of enzyme activity. Despite the absence of HDL in A-I- Pisa and Tangier subjects, there was no association of paraoxonase with very low density lipoproteins or LDL. Paraoxonase function is maintained in HDL deficient states. It implies that certain HDL-associated anti-atherogenic processes may not be entirely compromised by HDL deficiency. This has important implications for the cardiovascular risk associated with modulated HDL concentrations
Modulated serum acitivities and concentrations of paraoxonase in high density lipoprotein deficiency states
No full textParaoxonase is a high density lipoprotein (HDL) associated enzyme with a hypothesised role in the protection of low density lipoproteins (LDL) from oxidative stress. The present study examined paraoxonase in several genetically distinct HDL deficiency states. Despite reduction or even absence of detectable HDL, enzyme activity was present in sera from A-I-Pisa, A-I-Helsinki, A-I-Milano and Tangier patients. Both enzyme activities and peptide concentrations were modulated (reduced) but specific activities were broadly similar to controls, suggesting an impact on peptide concentration rather than an inhibition of enzyme activity. Despite the absence of HDL in A-I-Pisa and Tangier subjects, there was no association of paraoxonase with very low density lipoproteins or LDL. Paraoxonase function is maintained in HDL deficient states. It implies that certain HDL-associated anti-atherogenic processes may not be entirely compromised by HDL deficiency. This has important implications for the cardiovascular risk associated with modulated HDL concentrations
A compound heterozygote for hepatic lipase gene mutations Leu332 -> Phe and Thr383->Met: correlation between in vitro HL activity and phenotypic expresion
No full text- âŠ
