Landscape in the Longue Durée

Pebbles are usually found only on the beach, in the liminal space between land and sea. But what happens when pebbles extend inland and create a ridge brushing against the sky? Landscape in the Longue Durée is a 4,000 year history of pebbles. It is based on the results of a four-year archaeological research project of the east Devon Pebblebed heathlands, a fascinating and geologically unique landscape in the UK whose bedrock is composed entirely of water-rounded pebbles. Christopher Tilley uses this landscape to argue that pebbles are like no other kind of stone – they occupy an especial place both in the prehistoric past and in our contemporary culture. It is for this reason that we must re-think continuity and change in a radically new way by considering embodied relations between people and things over the long term. Dividing the book into two parts, Tilley first explores the prehistoric landscape from the Mesolithic to the end of the Iron Age, and follows with an analysis of the same landscape from the eighteenth into the twenty-first century. The major findings of the four-year study are revealed through this chronological journey: from archaeological discoveries, such as the excavation of three early Bronze Age cairns, to the documentation of all 829 surviving pebble structures, and beyond, to the impact of the landscape on local economies and its importance today as a military training camp. The results of the study will inform many disciplines including archaeology, cultural and art history, anthropology, conservation, and landscape studies

An Anthropology of Landscape

An Anthropology of Landscape tells the fascinating story of a heathland landscape in south-west England and the way different individuals and groups engage with it. Based on a long-term anthropological study, the book emphasises four individual themes: embodied identities, the landscape as a sensuous material form that is acted upon and in turn acts on people, the landscape as contested, and its relation to emotion. The landscape is discussed in relation to these themes as both ‘taskscape’ and ‘leisurescape’, and from the perspective of different user groups. First, those who manage the landscape and use it for work: conservationists, environmentalists, archaeologists, the Royal Marines, and quarrying interests. Second, those who use it in their leisure time: cyclists and horse riders, model aircraft flyers, walkers, people who fish there, and artists who are inspired by it. The book makes an innovative contribution to landscape studies and will appeal to all those interested in nature conservation, historic preservation, the politics of nature, the politics of identity, and an anthropology of Britain

Experiencing sense of place in virtual and physical Avebury.

This paper discusses the findings from a project to construct a simulation of Avebury henge, a Late Neolithic/ Early Bronze Age monument in SW Britain, in a 3D, virtual world environment. The aims of the study were to explore the archaeological research and interpretation necessary to plan and construct such a simulation in an interactive, online environment, to identify which aspects of visualisation and soundscape design appear to have the greatest impact upon users’ sense of place in the virtual simulation and to explore the experiences of a small group of users in the virtual simulation and the effects of those experiences upon their sense of place at the physical site. The findings from this project demonstrated that in undertaking a simulation of an ancient site, a core set of sources need to be selected to create the main parts of the simulation. There is often much debate in archaeological literature regarding the way in which archaeological findings are interpreted, and a different virtual Avebury would be constructed if different interpretations had been chosen. Any simulation of an ancient site should therefore clearly recognise and state the basis upon which it has been designed. The evaluation showed that responses to virtual environments, and the resulting effect upon responses to physical environments, are complex and personal, resulting in a range of experiences and perceptions, suggesting that the range of users’ experiences might be a more significant issue than attempting to find any general consensus on user reactions to simulated ancient sites

A randomized trial of sodium fluoride as a treatment for postmenopausal osteoporosis

The anti-fracture efficacy of sodium fluoride (NaF) was evaluated in 84 postmenopausal white women with spinal osteoporosis. The dose of NaF used was 75 mg/day and all patients in this prospective, randomized, double-blind, placebo-controlled clinical trial received calcium supplements (carbonate salt) 1500 mg/day in addition to participating in a structured physical therapy program. For each of the outcome measures (change in stature, change in cortical bone mass in the forearm and development of new vertebral fractures determined by change in vertebral morphometry and by scintigraphy) there was no significant difference between the fluoride or placebo treated groups. Side effects, predominantly gastrointestinal symptoms and the development of the painful lower extremity syndrome, occurred significantly more frequently in the fluoride group ( P <0.05). Peripheral fractures were not more frequent in the fluoride group. We conclude that, in the dose and manner used in this study, NaF is no more effective than placebo in retarding the progression of spinal osteoporosis. There is no role for NaF in the treatment of osteoporosis outside the confines of clinical research.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45905/1/198_2005_Article_BF01625446.pd

ELOVL5 is a critical and targetable fatty acid elongase in prostate cancer

The androgen receptor (AR) is the key oncogenic driver of prostate cancer, and despite implementation of novel AR targeting therapies, outcomes for metastatic disease remain dismal. There is an urgent need to better understand androgen-regulated cellular processes to more effectively target the AR-dependence of prostate cancer cells through new therapeutic vulnerabilities. Transcriptomic studies have consistently identified lipid metabolism as a hallmark of enhanced AR signaling in prostate cancer, yet the relationship between AR and the lipidome remain undefined. Using mass spectrometry-based lipidomics, this study reveals increased fatty acyl chain length in phospholipids from prostate cancer cells and patient-derived explants as one of the most striking androgen-regulated changes to lipid metabolism. Potent and direct AR-mediated induction of ELOVL fatty acid elongase 5 (ELOVL5), an enzyme that catalyzes fatty acid elongation, was demonstrated in prostate cancer cells, xenografts, and clinical tumors. Assessment of mRNA and protein in large-scale datasets revealed ELOVL5 as the predominant ELOVL expressed and upregulated in prostate cancer compared to non-malignant prostate. ELOVL5 depletion markedly altered mitochondrial morphology and function, leading to excess generation of reactive oxygen species and resulting in suppression of prostate cancer cell proliferation, 3D growth, and in vivo tumor growth and metastasis. Supplementation with the monounsaturated fatty acid cis-vaccenic acid, a direct product of ELOVL5 elongation, reversed the oxidative stress and associated cell proliferation and migration effects of ELOVL5 knockdown. Collectively, these results identify lipid elongation as a pro-tumorigenic metabolic pathway in prostate cancer that is androgen-regulated, critical for metastasis, and targetable via ELOVL5