6 research outputs found
In vitro effect of relaxin in the rat corpus cavernosum under hyperglycemic and normoglycemic conditions.
Antitumoral effects of <i>Salvia absconditiflora</i> Greuter & Burdet <span style="font-size:8.0pt;mso-bidi-font-size:11.0pt" lang="EN-US">syn. <i>Salvia cryptantha</i> Montbret & Aucher ex Benth. on Breast cancer </span>
390-397This work aims to investigate the
antiproliferative properties of Salvia cryptantha on breast cancer. Salvia
cryptantha (SC)
extracts were studied for cytotoxicity against the breast cancer cell lines. In-vitro apoptosis studies of breast
cancer cells were performed by nnexin V staining in flow cytometry analyses.
Immunohistochemistry studies for Ki-67 and p16 in the tumoral tissue
sections of Dimethyl Benzanthracene (DMBA) induced
mammary tumor in rats were performed. In-vivo
anticancer activity testing was carried out by inhibiting the growth of mammary
tumor in rats. SC showed cytotoxicity to three cancer cell lines.
Annexin-positive cells level in SC treated cell lines were higher than the
untreated control cells. The expression of the Ki-67 decreased in treatment
groups compared with the control group. The expression of p16 protein was much
higher for the rats treated by SC, compared with the untreated control group.
In vivo studies showed that mean tumor volume inhibition ratio in SC treated
group was 38 % compared with the untreated rats. These results indicate that Salvia
cryptantha has
antitumoral potential against breast cancer.
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