The Golden Retriever Rule: Alaska’s Identity Privilege for Animal Adoption Agencies and for Adoptive Animal Owners

Sedan 1900-talets mitt har användandet av tegelkonstruktioner i bostadsbyggandet minskat kraftigt; materialet har under modernismen upplevts otidsenligt och byggnadssättet har ansetts ineffektivt. Trots att kanalmurstekniken, som är en byggteknik med bärande tegelkonstruktion och högt isoleringsvärde, togs fram på 1930-talet för att följa hårdare energihushållningskrav, har ändå lätta träregelkonstruktioner dominerat det svenska småhusbyggandet. Kraven på energihushållning har under åren ökat successivt och livscykelanalysen (LCA) har utvecklats. LCA är en metodik som analyserar produkters eller tjänsters klimatbelastning ur livscykelperspektiv. Svårigheter har dock funnits i att omsätta metodiken på större komponenter än enskilda material. Därför har europastandarder tagits fram som enkom tjänar till att systematisera livscykelanalyser av hela byggnader och de kommer att följas i denna studie. Syftet med examensarbetet är att jämföra hur ett typhus med tegel som stommaterial belastar miljön under produktion och drift i en livscykel satt till 100 år, jämfört med ett motsvarande trätyphus. Till tegelhusets nackdel talar den höga energiåtgången vid materialframställningen. Trä å sin sida löper stor risk för förkortad livscykel i och med riskerna för fuktskador. För att undersöka skillnaderna i trä- och tegelkonstruktioner har en typhusritning i kanalmurskonstruktion analyserats mot en motsvarande träkonstruktion, där byggnadstyperna har samma boarea och väggkonstruktionerna samma värmemotstånd. För att få fram husens skillnad energiåtgång under driftskedet har energibehovsberäkningar utförts för byggnaderna. Livscykelanalysen har utförts i programvaran Anavitor utifrån 3D-modeller med byggnadsinformation som matchas mot en materialdatabas med livscykeldata. Ur jämförelsen har resultat kunnat hämtas på vilken av konstruktionerna som belastar miljön minst över livscykeln, med avseende på klimatbelastning räknat i koldioxidekvivalenter. Resultat visar att ett tegelhus belastar miljön dubbelt så mycket som ett trähus i produktionsfasen medan tegelhuset är miljövänligare avseende underhåll och drift. Efter 100 år är skillnaden 7,3 ton koldioxidekvivalenter, till trähusets fördel. Enligt livscykelanalysen har byggnaderna, enligt de antaganden som gjorts, belastat miljön lika efter 168 år. Till tegelhusets fördel talar dess säkerhet gällande livslängd, beständighet, fuktsäkerhet och goda möjlighet till återbruk av stommaterialet.Since the mid-1900s has brick building marginalized; the material has in the modernist era been experienced as dated and the construction method considered inefficient. In the 1930s the canal wall technique were developed to meet the coming stringent energy requirements. Despite opportunities to meet modern building norms have yet lightweight timber structures dominated the Swedish construction sector concerning single-family houses since then. The requirements for energy conservation have increased over the years to an even greater degree, and Life Cycle Assessment (LCA) has been developed; a methodology that analyzes products from a life cycle perspective. There have been difficulties to put the methodology on larger components than individual materials. Therefore, European Standards have been developed that specifically serve to systematize Life Cycle Assessments of entire buildings, which will be followed in this study. The purpose of this study is to compare which impact a standard house with brick structure has a on the environment in a lifecycle set to 100 years, compared with a corresponding timber structure. To the disadvantage for a brick house speaks the high energy consumption in material production. Timber structures at their part are at high risk for shortened life cycle due to risk of moisture damage. To examine the differences in wood and brick structures has a standard house drawing in canal wall technique been analyzed against a corresponding wooden construction. The building types have the same floor area and the wall constructions have the same heat resistance. To receive the differences in energy use during the operational phase between the buildings has energy calculations been made. The life cycle analysis has been performed in the software Anavitor based on 3D models with building information that is matched against a database of materials life cycle data. The results from the comparison are measured in terms of carbon dioxide equivalents, and will show which construction type will make least impact on the environment. Results show that a brick house has doubled environmental impact compared to a wooden house in the production phase. The brick house is a better alternative concerning environmental impact during operational phase and maintenance. After 100 years, the difference is 7,3 tons of carbon dioxide equivalents to the advantage of the wooden house. According to the LCA and the assumptions made, the buildings have charged the environment equally after 168 years. To the advantage of the brick house speaks its longevity, durability, moisture resistance and good opportunity for reuse of the bricks

IMPROVING HEALTH LITERACY AS A METHOD OF INCREASING ADHERENCE IN INSTITUTIONALIZED GERIATRIC PHYSICAL THERAPY PATIENTS

The global population of long-term care facility (LTCF) residents \u3e 65 years of age has high rates of sedentary behavior, and is expected to increase in number in the coming years. LTCF residents benefit from physical therapy, which can increase patients’ activity levels while treating symptoms of the inevitable aging process. A novel method is needed to increase LTCF resident adherence to physical therapy programs (PTPs). Health literacy (HL), which is the ability to interpret and understand health related information, presents as one such method to increase patient adherence. The geriatric population has the lowest HL rates out of all adult age groups, but LTCF physical therapists are in a prime position to successfully educate their patients. Within this paper are recommendations to increase the health literacy and consequent PTP adherence of elderly LTCF patients. Recommendations were organized within the Social-Ecological Model to account for the unique influence of the LTCF environment. Four Intrapersonal, one Interpersonal, two Organization and three Community recommendations were produced to increase patients’ health literacy. The substantiating evidence for the Intrapersonal and Interpersonal recommendations were strong overall, while the Organization and Community recommendations had a wider range of evidence strength ratings. Health literacy offers a promising intervention to increase the program adherence of elderly physical therapy patients in LTCFs, though all levels of recommendations require further validation before being implemented in a clinical setting

Reducing costs of repairable spare parts supply systems via dynamic scheduling

We study a system consisting of one repair shop and one stockpoint, where spare parts of repairables are kept on stock to serve an installed base of systems. Part requests are met from stock if possible, and backordered otherwise. Our objective is to determine initial stock levels and a policy for scheduling repair jobs such that holding and backorder cost are minimized. We propose two dynamic scheduling rules, compare their performance with the static priority rule, and show that even when stock levels and static priorities have been optimized simultaneously, dynamic scheduling rules often reduce total cost by more than 10%

Cellular expression and crystal structure of the murine cytomegalovirus MHC-Iv glycoprotein, m153

Mouse cytomegalovirus (MCMV), a β-herpesvirus that establishes latent and persistent infections in mice, is a valuable model for studying complex virus-host interactions. MCMV encodes the m145 family of putative immunoevasins with predicted MHC-I structure. Functions attributed to some family members include downregulation of host MHC-I (m152) and NKG2D ligands (m145, m152, m155) and interaction with inhibitory or activating NK receptors (m157). We present the cellular, biochemical and structural characterization of m153, which is a heavily glycosylated homodimer, that does not require β2m or peptide, and is expressed at the surface of MCMV-infected cells. Its 2.4 Å crystal structure confirms that this compact molecule preserves an MHC-I-like fold and reveals a novel mode of dimerization, confirmed by site-directed mutagenesis, and a distinctive disulfide-stabilized extended amino terminus. The structure provides a useful framework for comparative analysis of the divergent members of the m145 family

Anti-Nucleocapsid Protein Immune Responses Counteract Pathogenic Effects of Rift Valley Fever Virus Infection in Mice

The known virulence factor of Rift Valley fever virus (RVFV), the NSs protein, counteracts the antiviral effects of the type I interferon response. In this study we evaluated the expression of several genes in the liver and spleen involved in innate and adaptive immunity of mice immunized with a RVFV recombinant nucleocapsid protein (recNP) combined with Alhydrogel adjuvant and control animals after challenge with wild type RVFV. Mice immunized with recNP elicited an earlier IFNβ response after challenge compared to non-immunized controls. In the acute phase of liver infection in non-immunized mice there was a massive upregulation of type I and II interferon, accompanied by high viral titers, and the up- and downregulation of several genes involved in the activation of B- and T-cells, indicating that both humoral and cellular immunity is modulated during RVFV infection. Various genes involved in pro-inflammatory responses and with pro-apoptotic effects were strongly upregulated and anti-apoptotic genes were downregulated in liver of non-immunized mice. Expression of many genes involved in B- and T-cell immunity were downregulated in spleen of non-immunized mice but normal in immunized mice. A strong bias towards apoptosis and inflammation in non-immunized mice at an acute stage of liver infection associated with suppression of several genes involved in activation of humoral and cellular immunity in spleen, suggests that RVFV evades the host immune response in more ways than only by inhibition of type I interferon, and that immunopathology of the liver plays a crucial role in RVF disease progression