Existence and uniqueness of mild solutions of nonlinear difference-integrodifferential equation with nonlocal condition

In this paper we investigate the existence, uniqueness and continuous dependence of solutions of the difference-integrodifferential equations. The results are obtained by using the well known Banach fixed point theorem, the theory of semigroups and the inequality established by B. G. Pachpatte

Existence and uniqueness of solution of inhomogeneous semilinear evolution equation with nonlocal condition

In this paper, we study the existence and uniqueness of solution of inhomogeneous semilinear evolution equation with nonlocal condition in cone metric space. The result is obtained by using the some extensions of Banach's contraction principle in complete cone metric space

BIBLIOMETRIC ANALYSIS OF NAMED ENTITY RECOGNITION FOR CHEMOINFORMATICS AND BIOMEDICAL INFORMATION EXTRACTION OF OVARIAN CANCER

With the massive amount of data that has been generated in the form of unstructured text documents, Biomedical Named Entity Recognition (BioNER) is becoming increasingly important in the field of biomedical research. Since currently there does not exist any automatic archiving of the obtained results, a lot of this information remains hidden in the textual details and is not easily accessible for further analysis. Hence, text mining methods and natural language processing techniques are used for the extraction of information from such publications.Named entity recognition, is a subtask that comes under information extraction that focuses on finding and categorizing specific entities in text. In this paper, bibliometric analysis of named entity recognition of ovarian cancer is carried out using information about publications from Scopus. The most productive journals, countries and authors are determined. The most frequently cited article and its citation history has been described. Also bibliometric maps based on citation network among countries are constructed. This study can assist people in the medical field to get a comprehensive understanding of the study of BioNER. It can also be utilized for reference works, for the research and application of the BioNER visualization methods

Therapeutic approaches to drug targets in atherosclerosis

AbstractNon-communicable diseases such as cancer, atherosclerosis and diabetes are responsible for major social and health burden as millions of people are dying every year. Out of which, atherosclerosis is the leading cause of deaths worldwide. The lipid abnormality is one of the major modifiable risk factors for atherosclerosis. Both genetic and environmental components are associated with the development of atherosclerotic plaques. Immune and inflammatory mediators have a complex role in the initiation and progression of atherosclerosis. Understanding of all these processes will help to invent a range of new biomarkers and novel treatment modalities targeting various cellular events in acute and chronic inflammation that are accountable for atherosclerosis. Several biochemical pathways, receptors and enzymes are involved in the development of atherosclerosis that would be possible targets for improving strategies for disease diagnosis and management. Earlier anti-inflammatory or lipid-lowering treatments could be useful for alleviating morbidity and mortality of atherosclerotic cardiovascular diseases. However, novel drug targets like endoglin receptor, PPARα, squalene synthase, thyroid hormone analogues, scavenger receptor and thyroid hormone analogues are more powerful to control the process of atherosclerosis. Therefore, the review briefly focuses on different novel targets that act at the starting stage of the plaque form to the thrombus formation in the atherosclerosis

Influence of earthquake excitations on concrete gravity dams founded on homogeneous and layered foundation

The present paper investigates the response of dams with homogeneous and layered foundation systems under different earthquake excitations. For this purpose, the finite element analyses are conducted for three cases: Case 1—Effect of horizontal (H) component on a dam-homogenous foundation system, Case 2—Effect of combination of horizontal and vertical (H + V) component on a dam-homogenous foundation system and Case 3—Effect of combination of horizontal and vertical (H + V) component on the dam-layered foundation system. Tensile crack failure in the dam is captured by providing the nonlinear behavior using the concrete damaged plasticity model. Nonlinear material behavior is given to the underlying foundation using the Mohr–Coulomb failure model. The one-way plane strain infinite elements are used for the earthquake wave propagation through the vertical and bottom faces of the foundation domain. Eleven seismic ground motions that correspond with the Conditional Mean Spectrum are adopted for earthquake analyses. Results show that the (H + V) component when compared to the (H) component of seismic ground motions, has considerable influence on the dissipation energy and crest acceleration response; however, it has a marginal impact on the displacement and stress response of the dam. As compared to a homogeneous foundation, a layered foundation greatly affects the overall earthquake response of the dam since a substantial amplification of earthquake waves is seen through it. It is observed that the tensile crack failure in the dam is significantly increased due to the (H + V) component of seismic ground motions and is barely affected by the layered foundation

On the seismic performance evaluation of dam-foundation-reservoir system for the effect of frequency content and foundation flexibility

The present paper investigates the effect of earthquake frequency content and foundation flexibility on the performance of the Koyna dam-foundation-reservoir system. Ground motions that match the conditional mean spectrum (CMS) are adopted for the seismic analysis. The concrete damaged plasticity model is used to represent the dam's nonlinear behavior; however, the foundation is assumed to be linear elastic. To study the foundation flexibility effect on the seismic performance of the dam, three different cases which comprise different elastic modulus of the foundation are considered. The damage indices, based on the crack length and dissipation energy, are evaluated for the performance assessment of the dam-foundation-reservoir system. The ground motion parameters such as predominant period, mean period, and effective ground period are chosen in order to explore the earthquake frequency content effect on the performance of dam-foundation-reservoir system. Results indicate that foundation flexibility has a significant effect on the dam. Further, the frequency content has a substantial impact on the dam's seismic response compared to the intensity and duration of ground motion. It can be concluded that the mean period is a good indicator of the earthquake frequency content and has a strong correlation with the damage parameters

Radiation-induced oxidative stress regulates protein synthesis by modulating the expression of heme-regulated eIF2α kinase in human K562 cells

95-103Inhibition of protein synthesis executed at the initiation step is the overall response of cells during stress. Here, we evaluated the effect of gamma radiation induced oxidative stress on protein synthesis in human K562 cells. In erythroid cells such as K562, the heme-regulated eukaryotic initiation factor 2α (eIF2α) kinase, also called the heme-regulated inhibitor (HRI), is abundant and is instrumental in regulating protein synthesis. We, therefore, examined the modulation of expression and activity of HRI in K562 cells at various time points following their exposure to 6 Gy of gamma radiation. Radiation-induced oxidative stress was reflected by a dose-dependent increase in the intracellular reactive oxygen species with time up to 6 h. Further, cell membrane damage in terms of lipid peroxidation and lipid hydroperoxide formation was also observed. Interestingly, radiation induced oxidative stress led to a significant decrease in the rate of protein synthesis caused due to induced activation as well as expression of HRI within 1 h. Furthermore, radiation exposure also caused increased expression of heat shock protein 90 (Hsp90) in 1 h. These results have demonstrated shutdown of global protein synthesis in K562 cells during radiation induced oxidative stress, mediated by overexpression and activation of HRI possibly caused by Hsp90