5 research outputs found

    Profil Evolutif et Comorbidités des Troubles Fonctionnels Intestinaux (TFI) Persistants au CHU de Conakry

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    Introduction : Les troubles fonctionnels digestifs (TFI) ou syndrome de l’intestin irritable reprĂ©sentent un vĂ©ritable problème de santĂ© publique. Si cette affection n’engage pas le pronostic vital, elle altère significativement et de façon chronique la qualitĂ© de vie des malades. L’étiologie est mal connue et de nombreux facteurs sont impliquĂ©s. MĂ©thodes : Il s’agissait d’une Ă©tude transversale descriptive Ă  recueil prospectif de donnĂ©es rĂ©alisĂ©e en consultation externe du service d’hĂ©pato-gastroentĂ©rologie de l’hĂ´pital national Donka du CHU de Conakry allant du 1er Janvier 2019 au 31 DĂ©cembre 2020 chez les patients souffrants de TFI et rĂ©pondant aux critères de Rome IV. RĂ©sultats : Trois cent quatre-vingt-dix-huit cas de SII sur 1309 patients soit une prĂ©valence de 30,40%. On notait une prĂ©dominance fĂ©minine avec un sex ratio de 0,92. L’âge moyen de nos patients Ă©tait de 49 ans avec des extrĂŞmes de 10 et 88 ans. Les tranches d’âge de 25-34 ans et 35-44 ans Ă©taient les plus reprĂ©sentĂ©es avec des frĂ©quences respectives de 24,52% et 22,07%. Les principaux signes cliniques Ă©taient des douleurs abdominales (92,28%), de la constipation dans 84,41%, ballonnement abdominal 28,39% et diverses manifestations extradigestives : insomnie dans 32,08%, de cĂ©phalĂ©es dans 30,55% des cas, de la fibromyalgie 22,91%. Les principaux facteurs dĂ©clenchants Ă©taient : les facteurs psychologiques 32,08% et alimentaires (tubercules 14,13%, haricot 6,11%, le diner tardif et ou copieux 4,2% et les boissons gazeuses 3,44%). Le retentissement socioprofessionnel des TFI Ă©tait dominĂ© par l’absentĂ©isme dans 82,78% des cas, le retard au travail dans 20%. Les comorbiditĂ©s digestives les plus frĂ©quentes Ă©taient : le RGO, la dyspepsie, le dolichocĂ´lon ainsi que leur association. Conclusion  Le SII est un problème de santĂ© publique qui altère la qualitĂ© de vie des personnes atteintes. Les douleurs abdominales, la constipation et le ballonnement abdominal en constituent la triade symptomatique. Le stress est un facteur dĂ©clenchant de la symptomatologie. L’association du SII avec des comorbiditĂ©s digestives et extra-digestives est frĂ©quente. Introduction : Functional digestive disorders (TFI) or irritable bowel syndrome represent a real public health problem. Although this condition is not life-threatening, it significantly and chronically alters the quality of life of patients. The etiology is poorly understood and many factors are involved. Methods : This was a descriptive cross-sectional study with prospective data collection carried out in outpatient consultation of the hepato-gastroenterology department of the Donka national hospital of the Conakry University Hospital from January 1, 2019 to December 31, 2020 in patients suffering from TFI and meeting the Rome IV criteria. Results: Three hundred and ninety-eight cases of IBS out of 1309 patients, representing a prevalence of 30.40%. There was a female predominance with a sex ratio of 0.92. The average age of our patients was 49 years with extremes of 10 and 88 years. The age groups of 25-34 and 35-44 were the most represented with respective frequencies of 24.52% and 22.07%. The main clinical signs were abdominal pain (92.28%), constipation in 84.41%, abdominal bloating in 28.39% and various extradigestive manifestations: insomnia in 32.08%, headache in 30.55% of cases. cases, fibromyalgia 22.91%. The main triggering factors were: psychological factors 32.08% and dietary factors (tubers 14.13%, beans 6.11%, late or heavy dinner 4.2% and soft drinks 3.44%). The socio-professional impact of TFIs was dominated by absenteeism in 82.78% of cases, lateness for work in 20%. The most common digestive comorbidities were: GERD, dyspepsia, dolichocolon and their combination. Conclusion IBS is a public health problem that impairs the quality of life of those affected. Abdominal pain, constipation and abdominal bloating constitute the symptomatic triad. Stress is a triggering factor for the symptoms. The association of IBS with digestive and extra-digestive comorbidities is common

    Profil Evolutif et Comorbidités des Troubles Fonctionnels Intestinaux (TFI) Persistants au CHU de Conakry

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    Introduction : Les troubles fonctionnels digestifs (TFI) ou syndrome de l’intestin irritable reprĂ©sentent un vĂ©ritable problème de santĂ© publique. Si cette affection n’engage pas le pronostic vital, elle altère significativement et de façon chronique la qualitĂ© de vie des malades. L’étiologie est mal connue et de nombreux facteurs sont impliquĂ©s. MĂ©thodes : Il s’agissait d’une Ă©tude transversale descriptive Ă  recueil prospectif de donnĂ©es rĂ©alisĂ©e en consultation externe du service d’hĂ©pato-gastroentĂ©rologie de l’hĂ´pital national Donka du CHU de Conakry allant du 1er Janvier 2019 au 31 DĂ©cembre 2020 chez les patients souffrants de TFI et rĂ©pondant aux critères de Rome IV. RĂ©sultats : Trois cent quatre-vingt-dix-huit cas de SII sur 1309 patients soit une prĂ©valence de 30,40%. On notait une prĂ©dominance fĂ©minine avec un sex ratio de 0,92. L’âge moyen de nos patients Ă©tait de 49 ans avec des extrĂŞmes de 10 et 88 ans. Les tranches d’âge de 25-34 ans et 35-44 ans Ă©taient les plus reprĂ©sentĂ©es avec des frĂ©quences respectives de 24,52% et 22,07%. Les principaux signes cliniques Ă©taient des douleurs abdominales (92,28%), de la constipation dans 84,41%, ballonnement abdominal 28,39% et diverses manifestations extradigestives : insomnie dans 32,08%, de cĂ©phalĂ©es dans 30,55% des cas, de la fibromyalgie 22,91%. Les principaux facteurs dĂ©clenchants Ă©taient : les facteurs psychologiques 32,08% et alimentaires (tubercules 14,13%, haricot 6,11%, le diner tardif et ou copieux 4,2% et les boissons gazeuses 3,44%). Le retentissement socioprofessionnel des TFI Ă©tait dominĂ© par l’absentĂ©isme dans 82,78% des cas, le retard au travail dans 20%. Les comorbiditĂ©s digestives les plus frĂ©quentes Ă©taient : le RGO, la dyspepsie, le dolichocĂ´lon ainsi que leur association. Conclusion  Le SII est un problème de santĂ© publique qui altère la qualitĂ© de vie des personnes atteintes. Les douleurs abdominales, la constipation et le ballonnement abdominal en constituent la triade symptomatique. Le stress est un facteur dĂ©clenchant de la symptomatologie. L’association du SII avec des comorbiditĂ©s digestives et extra-digestives est frĂ©quente. Introduction : Functional digestive disorders (TFI) or irritable bowel syndrome represent a real public health problem. Although this condition is not life-threatening, it significantly and chronically alters the quality of life of patients. The etiology is poorly understood and many factors are involved. Methods : This was a descriptive cross-sectional study with prospective data collection carried out in outpatient consultation of the hepato-gastroenterology department of the Donka national hospital of the Conakry University Hospital from January 1, 2019 to December 31, 2020 in patients suffering from TFI and meeting the Rome IV criteria. Results: Three hundred and ninety-eight cases of IBS out of 1309 patients, representing a prevalence of 30.40%. There was a female predominance with a sex ratio of 0.92. The average age of our patients was 49 years with extremes of 10 and 88 years. The age groups of 25-34 and 35-44 were the most represented with respective frequencies of 24.52% and 22.07%. The main clinical signs were abdominal pain (92.28%), constipation in 84.41%, abdominal bloating in 28.39% and various extradigestive manifestations: insomnia in 32.08%, headache in 30.55% of cases. cases, fibromyalgia 22.91%. The main triggering factors were: psychological factors 32.08% and dietary factors (tubers 14.13%, beans 6.11%, late or heavy dinner 4.2% and soft drinks 3.44%). The socio-professional impact of TFIs was dominated by absenteeism in 82.78% of cases, lateness for work in 20%. The most common digestive comorbidities were: GERD, dyspepsia, dolichocolon and their combination. Conclusion IBS is a public health problem that impairs the quality of life of those affected. Abdominal pain, constipation and abdominal bloating constitute the symptomatic triad. Stress is a triggering factor for the symptoms. The association of IBS with digestive and extra-digestive comorbidities is common

    Profil Epidémiologique des Troubles Fonctionnels Intestinaux (TFI) Persistants au CHU de Conakry

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    Introduction : Les troubles fonctionnels Intestinaux (TFI) ou syndrome de l’intestin irritable reprĂ©sentent un vĂ©ritable problème de santĂ© publique. Si cette affection n’engage pas le pronostic vital, elle altère significativement et de façon chronique la qualitĂ© de vie des malades. L’étiologie est mal connue et de nombreux facteurs sont impliquĂ©s. MĂ©thodes : Il s’agissait d’une Ă©tude transversale descriptive Ă  recueil prospectif de donnĂ©es rĂ©alisĂ©e en consultation externe du service d’hĂ©pato-gastroentĂ©rologie de l’hĂ´pital national Donka du CHU de Conakry pour une durĂ©e de 2 ans. RĂ©sultats : Trois cent quatre-vingt-dix-huit cas de TFI sur 1309 patients avaient Ă©tĂ© recensĂ© soit une prĂ©valence de 30,40%. On notait une prĂ©dominance fĂ©minine avec un sex ratio de 0,92. L’âge moyen de nos patients Ă©tait de 49 ans avec des extrĂŞmes de 10 et 88 ans. Les tranches d’âge de 25-34 ans et 35-44 ans Ă©taient les plus reprĂ©sentĂ©es avec des frĂ©quences respectives de 24,52% et 22,07%. Les principaux signes cliniques Ă©taient des douleurs abdominales (92,28%), de la constipation dans 84,41%, ballonnement abdominal 28,39% et diverses manifestations extradigestives : insomnie dans 32,08%, de cĂ©phalĂ©es dans 30,55% des cas, de la fibromyalgie 22,91%. Les principaux facteurs dĂ©clenchants Ă©taient : les facteurs psychologiques 32,08% et alimentaires (tubercules 14,13%, haricot 6,11%, le dĂ®ner tardif et ou copieux 4,2% et les boissons gazeuses 3,44%). Le retentissement socioprofessionnel des TFI Ă©tait dominĂ© par l’absentĂ©isme dans 82,78% des cas, le retard au travail dans 20%. Les comorbiditĂ©s digestives les plus frĂ©quentes Ă©taient : le reflux gastro Ĺ“sophagien (RGO), la dyspepsie, le dolichocĂ´lon ainsi que leur association. Les examens  complĂ©mentaires morphologiques Ă©taient reprĂ©sentĂ©s par (une Ă©chographie abdominale et pelvienne a Ă©tĂ© rĂ©alisĂ©e chez 50,11% de nos patients et elle objectivait une aĂ©rocolie dans 45% des cas ;un scanner abdominopelvien  fait dans 3,56% des cas, examen sans anomalie ; une ano-recto-sigmoĂŻdoscopie dans 17,80% des cas et une ; coloscopie dans 4,98% des cas, toutes normales ; une fibroscopie oeso-gastroduodĂ©nale chez  25% de nos patients et Ă©tait normale ;un lavement barytĂ© double contraste 11,20%. Conclusion : Le TFI est un problème de santĂ© publique qui altère la qualitĂ© de vie des personnes atteintes. Les douleurs abdominales, la constipation et le ballonnement abdominal en constituent la triade symptomatique. Le stress est un facteur dĂ©clenchant de la symptomatologie. L’association du SII avec des comorbiditĂ©s digestives et extra-digestives est frĂ©quente. Les examens complĂ©mentaires morphologique ont des consĂ©quences financières difficiles dans la majoritĂ© des cas chez nos patients.   Introduction : Functional digestive disorders (TFI) or irritable bowel syndrome represent a real public health problem. Although this condition is not life-threatening, it significantly and chronically alters the quality of life of patients. The etiology is poorly understood and many factors are involved. Methods : This was a descriptive cross-sectional study with prospective data collection carried out in the outpatient clinic of the hepato-gastroenterology department of the Donka National Hospital of the Conakry University Hospital for a period of 2 years. Results : Three hundred and ninety-eight cases of TFI out of 1309 patients were identified, representing a prevalence of 30.40%. There was a female predominance with a sex ratio of 0.92. The average age of our patients was 49 years with extremes of 10 and 88 years. The age groups of 25-34 and 35-44 were the most represented with respective frequencies of 24.52% and 22.07%. The main clinical signs were abdominal pain (92.28%), constipation in 84.41%, abdominal bloating in 28.39%, and various extra digestive manifestations: insomnia in 32.08%, headache in 30.55% of cases. cases, fibromyalgia 22.91%. The main triggering factors were: psychological factors 32.08% and dietary factors (tubers 14.13%, beans 6.11%, late or heavy dinner 4.2% and soft drinks 3.44%). The socio-professional impact of TFIs was dominated by absenteeism in 82.78% of cases, and lateness for work in 20%. The most frequent digestive comorbidities were: gastroesophageal reflux disease (GERD), dyspepsia, dolichocolon and their association. Additional morphological examinations were represented by (an abdominal and pelvic ultrasound was carried out in 50.11% of our patients and it revealed aerocolia in 45% of cases; an abdominopelvic scan was performed in 3.56% of cases, examination without abnormality; an anorecto-sigmoidoscopy in 17.80% of cases and the colonoscopy in 4.98% of cases, all normal; an esophagogastroduodenal fibroscopy in 25% of our patients and was normal; a double contrast barium enema 11 .20%. Conclusion: TFI is a public health problem that impairs the quality of life of those affected. Abdominal pain, constipation, and abdominal bloating constitute the symptomatic triad. Stress is a triggering factor for the symptoms. The association of IBS with digestive and extra-digestive comorbidities is common. Additional morphological examinations have difficult financial consequences in the majority of cases among our patients

    Efficacy of praziquantel against urinary schistosomiasis and reinfection in Senegalese school children where there is a single well-defined transmission period

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    Background: Human schistosomiasis is a significant health problem in Sub-Saharan Africa. In Niakhar, West central Senegal, the transmission of S. haematobium occurs seasonally between July and November. No control measures have been implemented despite high prevalence reported in previous studies. This aim of this study was to i) determine the current prevalence of S. haematobium in children at Niakhar, ii) assess the efficacy of one dose of PZQ (40 mg/kg) against S. haematobium and iii) monitor reinfection. Methods: The current study was carried out in a cohort of 329 children aged five to 15 years enrolled from six villages in Niakhar to determine the efficacy of one dose of PZQ, as well as reinfection. Parasitological screening was performed in June 2011 to determine the baseline prevalence of S. haematobium, and then a single dose of PZQ was administered to all selected subjects in the transmission season in August 2011. The efficacy of PZQ treatment and reinfection were monitored respectively five weeks after in September 2011 and from February to March 2012. Results: At baseline, the overall prevalence and the heavy intensity of infection were 73.2 % and 356.1eggs/10 ml of urine. Significant differences in the prevalence and intensity of S. haematobium infection were noted between villages. A single dose of PZQ significantly reduced the prevalence of S. haematobium infection from 73.2 % to 4.6 % and the geometric mean intensity of infection from 356.1 to 43.3 eggs/10 ml of urine. The cure rates ranged from 89.4 % to 100 %. The egg reduction rates also ranged from 77.6 % to 100 %. Two to three months after the period of transmission, the overall rate of reinfection was 12.6 % and was significantly higher in male children than in female children. The overall prevalence at this period was 13.8 %, which was significantly lower than the prevalence at baseline (73.2 %). Conclusion: The Niakhar study area remains a hot spot of urinary schistosomiasis in Senegal with differences in transmission between villages. This study suggests that when transmission is strictly seasonal, Praziquantel shows the expected efficacy in reducing the prevalence and intensity of infection, but also a significant effect on the occurrence of reinfection
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