Ageing as a price of cooperation and complexity: Self-organization of complex systems causes the ageing of constituent networks

The analysis of network topology and dynamics is increasingly used for the description of the structure, function and evolution of complex systems. Here we summarize key aspects of the evolvability and robustness of the hierarchical network-set of macromolecules, cells, organisms, and ecosystems. Listing the costs and benefits of cooperation as a necessary behaviour to build this network hierarchy, we outline the major hypothesis of the paper: the emergence of hierarchical complexity needs cooperation leading to the ageing of the constituent networks. Local cooperation in a stable environment may lead to over-optimization developing an ‘always-old’ network, which ages slowly, and dies in an apoptosis-like process. Global cooperation by exploring a rapidly changing environment may cause an occasional over-perturbation exhausting system-resources, causing rapid degradation, ageing and death of an otherwise ‘forever-young’ network in a necrosis-like process. Giving a number of examples we explain how local and global cooperation can both evoke and help successful ageing. Finally, we show how various forms of cooperation and consequent ageing emerge as key elements in all major steps of evolution from the formation of protocells to the establishment of the globalized, modern human society. Thus, ageing emerges as a price of complexity, which is going hand-in-hand with cooperation enhancing each other in a successful community

Dampak Polusi Udara terhadap Kesehatan dan Kesiapan Pertahanan Negara di Provinsi DKI Jakarta

Air pollution in DKI Jakarta Province has reached alarming levels, threatening the health and quality of life of millions of residents and damaging the integrity of national defense preparedness. As the capital and center of Indonesian government, Jakarta plays an important role in the country's defense and security structure. This research was conducted to understand and evaluate the complex impacts of air pollution, which relate not only to public health but also to defense readiness. Through empirical data analysis, interviews with stakeholders, and the application of geospatial intelligence from satellite imagery, this research found various variables that correlate between air pollution, public health, and defense readiness. One of the main findings is that high levels of air pollution have a significant impact on public health conditions, which in turn can disrupt the country's defense readiness. Therefore, these results demonstrate the need for comprehensive and coordinated mitigation actions between various parties, including the provincial government, central government, and the military. These policies and actions should focus on protecting public health, preserving critical military infrastructure, and preparing the country to face additional challenges that may arise, such as climate change. In an increasingly interconnected and complex global context, this research highlights the urgency for a more holistic approach to addressing the problem of air pollution and its multifaceted impact

EXPULSION OF HUNGARIANS FROM THE BJELOVAR REGION IN 1944

Pozitivističko pisanje povijesti antifašističke borbe u Hrvatskoj ostavilo je niz neistraženih tema. Među takove teme treba ubrojiti i odnos partizana prema Mađarima nastanjenima u okolici Bjelovara. Od nekoć vrlo brojne narodnosne manjine danas je Mađara na tom prostoru ostalo vrlo malo, a ovaj rad govori što se je dogodilo 1944., t.j. kako su komunisti-partizani »oslobađali« Mađare njihovih imanja i kako su ih prisilno mobilizirali.Once a strong group, the Hungarians are now relatively small minority in Croatia. Their absence is particularly noticeable in the Bjelovar region, where they once lived mixed with Croatian, Serbian, and German communities. The partisans conditioned their remaining in that region with their joining of the partisan movement. Since the Hungarians did not feel that the partisan cause was theirs, they were expelled from the Bjelovar region. This was another tabu theme of historiography; hence, this article represents the first attempt at its exploration

Bocepreviralapú hármas kezelés hatékonyságának és biztonságosságának retrospektív elemzése előrehaladott fibrosisstádiumú, hepatitis C-vírus 1-es genotípussal fertőzött, korábban sikertelenül kezelt magyar betegeknél

INTRODUCTION: During 2011 and 2013, 155 Hungarian hepatitis C genotype 1 infected patients, mostly with advanced liver fibrosis, who did not respond to prior peginterferon + ribavirin dual therapy, started boceprevir based triple therapy in an early access program. AIM AND METHOD: Efficacy and safety of the therapy was retrospectively assessed based on sustained virologic responses, as well as on frequency and type of serious adverse events and of those leading to therapy discontinuation. RESULTS: In an intent-to-treat analysis 39.4% patients (61/155) reached sustained virologic response. Amongst pervious relapsers, partial responders and null-responders 59.5%, 41.4 % and 22.9% (p<0.05 compared to the other two categories) reached sustained virologic response, respectively, while amongst non-cirrhotics and cirrhotics 52.5% and 31.3% (p<0.05 compared to the non-cirrhotics) achieved sutained virologic response, respectively. Six out of the 33 most difficult to cure patients (previous null responder and cirrhotic) have reached sustained virologic response (18.2%). Frequency of early discontinuations due to insufficient virologic response was 31.1%, while due to adverse event 10.3%. Reported frequency of serious adverse event was 9.8%. These events represented anemia, diarrhoea, depression, agranulocytosis, elevated aminotransferases, generalized dermatitis and severe gingivitis with loss of teeth, prolonged QT interval on ECG, generalized oedema and severe dyspnoea, uroinfection, exacerbation of Crohn's disease, Campylobacter pylori infection and unacceptable weakness and fatigue. Eight patients received transfusion, 4 patients erythropoietin and 1 granulocyte colony stimulating factor during therapy. No death has been reported. CONCLUSIONS: With boceprevir based triple therapy, one of the bests available in 2011-2013 in Hungary, a relevant proportion of hepatitis C infected patients with advanced liver fibrosis achieved sustained viral response. In this cohort, side-effects resembled those reported in registration studies, and resulted in therapy discontinuation with consequent treatment failure in a relevant number of patients. Efficacy and tolerability of boceprevir-based triple therapy are suboptimal, particularly in the most difficult to cure patient population. Orv. Hetil., 2016, 157(34), 1366-1374

Research Progress of α-Glucuronidase, an Enzyme for Degrading Hemicellulose Side-Chain

半纤维素是自然界中最丰富的可再生资源之一,将半纤维素降解为单糖并转化为燃料或化学品一直是科学界研究的热点。半纤维素是由木糖基主链以及α-葡萄糖醛酸等侧链共同组成的异质多聚体。α-葡萄糖醛酸酶是半纤维素完全降解过程中的关键酶之一,能够水解4-O-甲基葡萄糖醛酸与木糖之间的α-1,2-糖苷键。本文综述了α-葡萄糖醛酸酶的分类、催化机制及晶体结构、酶学性质和基因克隆表达等方面的研究进展,同时对该研究进行了展望。Hemicellulose is one of the most abundant renewable resources in nature.The bioconversion of hemicellulose into biofuels or chemicals is a research hotspot in the world.Hemicellulose consists of a backbone of xylan residues and some branches like glucuronic acid.α-Glucuronidase, which is capable to hydrolysis the α-1,2-glycosidic bond between xylan and glucuronic acid, is one of the key enzyme to degrade hemicellulose completely.The recent research progresses on catalysis mechanism, structure, charaterization, and gene cloning of α-glucuronidase are summarized in this paper.国家自然科学基金(31170067;21303142); 国家重点基础研究发展计划(973计划;2010CB732201); 福建省自然科学基金(2012J05029); 农业部“引进国际先进农业科学技术”项目(2013-Z70

Antemurale Christianitatis? Propaganda antyturecka a wyprawa Jana Olbrachta z 1497 r. w świetle źródeł

This paper refers to the problem of Johannes Olbracht’s crusade of the year 1497, and above all the anti-Turkish propaganda present in many sources concerning this issue. The aim of this paper is to consider the concept of Antemurale Christianitatis which became popular at the end of the 15th century and to analyze some of the sources in order to answer the question to what extent this anti-Turkish ideology voiced in these sources was indeed the true reason of Johannes Olbracht’s crusade, or whether it was but a propagandist pretext for executing his political goals