CO and HI observations of an enigmatic cloud

An isolated HI cloud with peculiar properties has recently been discovered by Dedes, Dedes, & Kalberla (2008, A&A, 491, L45) with the 300-m Arecibo telescope, and subsequently imaged with the VLA. It has an angular size of ~6', and the HI emission has a narrow line profile of width ~ 3 km/s. We explore the possibility that this cloud could be associated with a circumstellar envelope ejected by an evolved star. Observations were made in the rotational lines of CO with the IRAM-30m telescope, on three positions in the cloud, and a total-power mapping in the HI line was obtained with the Nancay Radio Telescope. CO was not detected and seems too underabundant in this cloud to be a classical late-type star circumstellar envelope. On the other hand, the HI emission is compatible with the detached-shell model that we developed for representing the external environments of AGB stars. We propose that this cloud could be a fossil circumstellar shell left over from a system that is now in a post-planetary-nebula phase. Nevertheless, we cannot rule out that it is a Galactic cloud or a member of the Local Group, although the narrow line profile would be atypical in both cases.Comment: Accepted for publication in Astronomy and Astrophysic

Circumstellar HI and CO around the carbon stars V1942 Sgr and V CrB

Context. The majority of stars that leave the main sequence are undergoing extensive mass loss, in particular during the asymptotic giant branch (AGB) phase of evolution. Observations show that the rate at which this phenomenon develops differs highly from source to source, so that the time-integrated mass loss as a function of the initial conditions (mass, metallicity, etc.) and of the stage of evolution is presently not well understood. Aims. We are investigating the mass loss history of AGB stars by observing the molecular and atomic emissions of their circumstellar envelopes. Methods. In this work we have selected two stars that are on the thermally pulsing phase of the AGB (TP-AGB) and for which high quality data in the CO rotation lines and in the atomic hydrogen line at 21 cm could be obained. Results. V1942 Sgr, a carbon star of the Irregular variability type, shows a complex CO line profile that may originate from a long-lived wind at a rate of ~ 10^-7 Msol/yr, and from a young (< 10^4 years) fast outflow at a rate of ~ 5 10^-7 Msol/yr. Intense HI emission indicates a detached shell with 0.044 Msol of hydrogen. This shell probably results from the slowing-down, by surrounding matter, of the same long-lived wind observed in CO that has been active during ~ 6 10^5 years. On the other hand, the carbon Mira V CrB is presently undergoing mass loss at a rate of 2 10^-7 Msol/yr, but was not detected in HI. The wind is mostly molecular, and was active for at most 3 10^4 years, with an integrated mass loss of at most 6.5 10^-3 Msol. Conclusions. Although both sources are carbon stars on the TP-AGB, they appear to develop mass loss under very different conditions, and a high rate of mass loss may not imply a high integrated mass loss.Comment: Accepted for publication in Astron. Astrophy

Evaluating two soil carbon models within the global land surface model JSBACH using surface and spaceborne observations of atmospheric CO₂

The trajectories of soil carbon (C) in the changing climate are of utmost importance, as soil carbon is a substantial carbon storage with a large potential to impact the atmospheric carbon dioxide (CO2) burden. Atmospheric CO2 observations integrate all processes affecting C exchange between the surface and the atmosphere. Therefore they provide a benchmark for carbon cycle models. We evaluated two distinct soil carbon models (CBALANCE and YASSO) that were implemented to a global land surface model (JSBACH) against atmospheric CO2 observations. We transported the biospheric carbon fluxes obtained by JSBACH using the atmospheric transport model TM5 to obtain atmospheric CO2. We then compared these results with surface observations from Global Atmosphere Watch (GAW) stations as well as with column XCO2 retrievals from the GOSAT satellite. The seasonal cycles of atmospheric CO2 estimated by the two different soil models differed. The estimates from the CBALANCE soil model were more in line with the surface observations at low latitudes (0 N–45 N) with only 1 % bias in the seasonal cycle amplitude (SCA), whereas YASSO was underestimating the SCA in this region by 32 %. YASSO gave more realistic seasonal cycle amplitudes of CO2 at northern boreal sites (north of 45 N) with underestimation of 15 % compared to 30 % overestimation by CBALANCE. Generally, the estimates from CBALANCE were more successful in capturing the seasonal patterns and seasonal cycle amplitudes of atmospheric CO2 even though it overestimated soil carbon stocks by 225 % (compared to underestimation of 36 % by YASSO) and its predictions of the global distribution of soil carbon stocks was unrealistic. The reasons for these differences in the results are related to the different environmental drivers and their functional dependencies of these two soil carbon models. In the tropical region the YASSO model showed earlier increase in season of the heterotophic respiration since it is driven by precipitation instead of soil moisture as CBALANCE. In the temperate and boreal region the role of temperature is more dominant. There the heterotophic respiration from the YASSO model had larger annual variability, driven by air temperature, compared to the CBALANCE which is driven by soil temperature. The results underline the importance of using sub-yearly data in the development of soil carbon models when they are used in shorter than annual time scales

XPOL - the correlation polarimeter at the IRAM 30m telescope

XPOL, the first correlation polarimeter at a large millimeter telescope, uses a flexible digital correlator to measure all four Stokes parameters simultaneously, i.e. the total power I, the linear polarization components Q and U, and the circular polarization V. The versatility of the backend provides adequate bandwidth for efficient continuum observations as well as sufficient spectral resolution (40 kHz) for observations of narrow lines. We demonstrate that the polarimetry specific calibrations are handled with sufficient precision, in particular the relative phase between the Observatory's two orthogonally linearly polarized receivers. The many facets of instrumental polarization are studied at 3mm wavelength in all Stokes parameters: on-axis with point sources and off-axis with beam maps. Stokes Q which is measured as the power difference between the receivers is affected by instrumental polarization at the 1.5% level. Stokes U and V which are measured as cross correlations are very little affected (maximum sidelobes 0.6% (U) and 0.3% (V)). These levels critically depend on the precision of the receiver alignment. They reach these minimum levels set by small ellipticities of the feed horns when alignment is optimum (<~ 0.3"). A second critical prerequisite for low polarization sidelobes turned out to be the correct orientation of the polarization splitter grid. Its cross polarization properties are modeled in detail. XPOL observations are therefore limited only by receiver noise in Stokes U and V even for extended sources. Systematic effects set in at the 1.5% level in observations of Stokes Q. With proper precautions, this limitation can be overcome for point sources. Stokes Q observations of extended sources are the most difficult with XPOL.Comment: 31 pages, accepted for publication by Publications of the Astronomical Society of the Pacific on 2008/05/2

MicroRNA-24 regulates vascularity after myocardial infarction

BACKGROUND: Myocardial infarction leads to cardiac remodeling and development of heart failure. Insufficient myocardial capillary density after myocardial infarction has been identified as a critical event in this process, although the underlying mechanisms of cardiac angiogenesis are mechanistically not well understood. METHODS AND RESULTS: Here, we show that the small noncoding RNA microRNA-24 (miR-24) is enriched in cardiac endothelial cells and considerably upregulated after cardiac ischemia. MiR-24 induces endothelial cell apoptosis, abolishes endothelial capillary network formation on Matrigel, and inhibits cell sprouting from endothelial spheroids. These effects are mediated through targeting of the endothelium-enriched transcription factor GATA2 and the p21-activated kinase PAK4, which were identified by bioinformatic predictions and validated by luciferase gene reporter assays. Respective downstream signaling cascades involving phosphorylated BAD (Bcl-XL/Bcl-2-associated death promoter) and Sirtuin1 were identified by transcriptome, protein arrays, and chromatin immunoprecipitation analyses. Overexpression of miR-24 or silencing of its targets significantly impaired angiogenesis in zebrafish embryos. Blocking of endothelial miR-24 limited myocardial infarct size of mice via prevention of endothelial apoptosis and enhancement of vascularity, which led to preserved cardiac function and survival. CONCLUSIONS: Our findings indicate that miR-24 acts as a critical regulator of endothelial cell apoptosis and angiogenesis and is suitable for therapeutic intervention in the setting of ischemic heart disease. [KEYWORDS: Animals, Apoptosis/drug effects, Arterioles/pathology, Capillaries/pathology, Cell Hypoxia, Cells, Cultured/drug effects/metabolism, Collagen, Drug Combinations, Drug Evaluation, Preclinical, Endothelial Cells/ metabolism/pathology, GATA2 Transcription Factor/biosynthesis/genetics, Gene Expression Profiling, Heart Failure/etiology, Heme Oxygenase-1/biosynthesis/genetics, Laminin, Male, Mice, Mice, Inbred C57BL, MicroRNAs/antagonists & inhibitors/genetics/ physiology, Myocardial Infarc

Multispectral imaging of organ viability during uterine transplantation surgery in rabbits and sheep

Uterine transplantation surgery (UTx) has been proposed as a treatment for permanent absolute uterine factor infertility (AUFI) in the case of the congenital absence or surgical removal of the uterus. Successful surgical attachment of the organ and its associated vasculature is essential for the organ’s reperfusion and long-term viability. Spectral imaging techniques have demonstrated the potential for the measurement of hemodynamics in medical applications. These involve the measurement of reflectance spectra by acquiring images of the tissue in different wavebands. Measures of tissue constituents at each pixel can then be extracted from these spectra through modeling of the light–tissue interaction. A multispectral imaging (MSI) laparoscope was used in sheep and rabbit UTx models to study short- and long-term changes in oxygen saturation following surgery. The whole organ was imaged in the donor and recipient animals in parallel with point measurements from a pulse oximeter. Imaging results confirmed the re-establishment of adequate perfusion in the transplanted organ after surgery. Cornual oxygenation trends measured with MSI are consistent with pulse oximeter readings, showing decreased StO2 immediately after anastomosis of the blood vessels. Long-term results show recovery of StO2 to preoperative levels

Assessing seasonality of biochemical CO2 exchange model parameters from micrometeorological flux observations at boreal coniferous forest

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