An Efficient Information Extraction Mechanism with Page Ranking and a Classification Strategy based on Similarity Learning of Web Text Documents

Users have recently had more access to information thanks to the growth of the www information system. In these situations, search engines have developed into an essential tool for consumers to find information in a big space. The difficulty of handling this wealth of knowledge grows more difficult every day. Although search engines are crucial for information gathering, many of the results they offer are not required by the user because they are ranked according on user string matches. As a result, there were semantic disparities between the terms used in the user inquiry and the importance of catch phrases in the results. The problem of grouping relevant information into categories of related topics hasn't been solved. A Ranking Based Similarity Learning Approach and SVM based classification frame work of web text to estimate the semantic comparison between words to improve extraction of information is proposed in the work. The results of the experiment suggest improvisation in order to obtain better results by retrieving more relevant results

Aβ1─42 C-terminus fragment derived peptides prevent the self-assembly of the parent peptide

A series of peptides derived from the C-terminus fragment (Aβ38–42) of Aβ showed significant to complete reduction in Aβ-induced toxicity

C‑Terminal Fragment, Aβ_32–37, Analogues Protect Against Aβ Aggregation-Induced Toxicity

Amyloid-β aggregation is a major etiological phenomenon in Alzheimer’s disease. Herein, we report peptide-based inhibitors that diminish the amyloid load by obviating Aβ aggregation. Taking the hexapeptide fragment, Aβ_32–37, as lead, more than 40 new peptides were synthesized. Upon evaluation of the newly synthesized hexapeptides as inhibitors of Aβ toxicity by the MTT-based cell viability assay, a number of peptides exhibited significant Aβ aggregation inhibitory activity at sub-micromolar concentration range. A hexapeptide (<b>1</b>) showed complete mitigation of Aβ toxicity in the cell culture assay at 2 μM. In the ThT fluorescence assay, upon incubation of Aβ with this peptide, we observed no increase in the ThT fluorescence relative to control. The secondary structure estimation by circular dichroism spectroscopy and morphological examination by transmission electron microscopy further confirmed the results