DTB 071 Alexis Thornton-Crump 4-21-2023

In this interview, Alexis Thornton-Crump is interviewed by Ryan Morini over Zoom about her memories and reflections regarding the Down the Bay community. Ms. Thornton-Crump begins with some of her earliest memories from Down the Bay, and some of her family history that led to her growing up there. She recalls some of the businesses that were in the neighborhood at that time, and her experiences attending W.H. Council Elementary and Most Pure Heart of Mary High School. Ms. Thornton-Crump also relates memories of urban renewal, and some of the changes she observed Down the Bay and in Mobile since that time

The Use and Explanation of the Phase Angle in Forced Vibration Testing

Forced vibration testing is a tool used to characterize a structure’s dynamic properties. When subjecting a structure to a forced harmonic load, the results help define the structure’s fundamental frequencies and dominant mode shapes. However, when conducting testing, it is difficult to determine the contributions of each mode to the response at a given location in the structure. The recorded response from a forced vibration test is a combination of unknown modal constituents. Excitation may not result in the pure, single mode response that the experimenter desires, but may instead result in a combination of modal responses that obscure the recorded data or even weaken the overall response. The phase angle is the lag in the response of the structure to the applied harmonic load. Often, engineers focus on the amplitude of the response but overlook the phase angle in their analysis. The investigation conducted herein used a configurable three-story MATLAB model capable of simulating forced vibration tests to determine the role of the phase angle in forced vibration testing. The results produced by the model were also used to analyze modal contributions to the structural response. A data-driven numerical approach and algebraic theoretical approach were both used to characterize the harmonic response. This study describes how the phase angle could indicate when modal contamination occurs, helping engineers filter forced vibration results and understand when a pure mode response is being achieved

Augustana Seniors Fall 1883: Gustaf Sven Swenson

Gustaf Swenson was a senior at Augustana College, Rock Island, Illinois, in the fall of 1883. His name appears in the college catalog of 1883 – 1884, along with his birthplace, the year of his birth, and a few other facts. From this start, we researched the genealogy and family history of Gustaf Swenson. This paper contains a short biography of Gustaf Swenson, a report on his ancestors, a report on his descendants, and some open questions for further research

Sharing Success: Expansion of a Tutor-Run Assessment Method to Multiple Courses and Colleges

Objectives: In 2014, data were presented on a successful pilot program using quizzes written by tutors in a single course at Wegmans School of Pharmacy. The objective of this study was to use the methods from the pilot to expand the program to other pharmacology courses at Wegmans School of Pharmacy as well as the University of Arkansas for Medical Sciences College of Pharmacy. Methods: Methods from the previous study were replicated, whereby tutors wrote weekly quizzes administered using ExamSoft®. The optional quizzes were openly accessible to students in preparation for course exams. Performance data were collected from students in one course at each institution and compared to the pilot study. Performance data collected included quiz and course exam scores. All students that utilized quizzes, as well as tutors, were surveyed to assess perceptions of the method. Results: The use and impact of quizzes was similar to the results in the pilot study. However, the magnitude of improvements was slightly lower than what was observed initially. Exam scores were significantly higher than quiz scores on 6/10 exams measured, compared to 5/5 exams in the pilot. Students who utilized the quizzes performed significantly better than those that did not on 3/10 exams (3/5 in the pilot), and earned significantly higher course averages. Student (n=155) and peer instructor (n=13) feedback remained positive after expansion of the program. Implications: This method is a tool that can be translated to different courses and different institutions with a valuable impact on student performance

Is retention of the acetabular component at revision surgery a long-term solution?

BACKGROUND: Acetabular retention in revision total hip arthroplasty (THA) may be advantageous, yet long-term survival data is limited. Thus, we investigated long-term survivorship of retained acetabular components in revision THA with analysis of rerevision rate, instability risk, and clinical outcomes. METHODS: We reviewed 98 hips with polyethylene wear and/or osteolysis that were revised with retained acetabular components. Acetabular inclination and anteversion were measured from prerevision radiographs. A retrospective chart review was performed, collecting outcomes of interest including Harris hip score, instability events, and rerevision surgery. Kaplan-Meier analysis was used to calculate the risk of revision over time. Predictors of survival including acetabular component position were analyzed by multiple logistic regression. RESULTS: Average follow-up was 13 years (range, 5-24). Survivorship rates at 5, 10, 15, and 20 years were 89.7%, 81.6%, 70.8%, and 63.8%, respectively. There was improvement in average Harris hip score (61 to 76, CONCLUSIONS: Retention of a well-fixed acetabular component in revision THA provides acceptable long-term outcomes with a 15-year survivorship of 71%. Instability and aseptic loosening were the most common reasons for rerevision. Surgeons may consider retaining the acetabular component at revision surgery if the implant is well-fixed and well-positioned

Effects of Feeding a Novel Alfalfa Leaf Pellet Product (ProLEAF MAX) and Alfalfa Stems (ProFiber Plus) on Performance in the Feedlot and Carcass Quality of Beef Steers

Alfalfa is often included in the diets of beef animals; however, the nutrient content of alfalfa is variable depending on the region in which it is grown, climate, soil, and many other factors. The leaf portion of alfalfa has a less variable nutrient composition than the stem portion of the plant. The variability that is present in the alfalfa plant can make the development of total mixed rations of consistent nutrient content difficult. As such, the purpose of this study was to determine how the inclusion of fractionated alfalfa leaves and alfalfa stems impacts performance and carcass quality of finishing beef steers. Twenty-four steers were allocated to one of three treatments: a control group fed a typical finishing diet with alfalfa as the forage (CON; n = 8), a typical diet that replaced alfalfa with fractionated alfalfa leaf pellets and alfalfa stems (ProLEAF MAX™ + ProFiber Plus™; PLM+PFP; n = 8), or a typical diet that replaced alfalfa with alfalfa stems (PFP; n = 8) for 63 days. Steers were fed individually once daily, weighed every 14 days and ultrasound images were collected every 28 days. At the end of the feeding trial, steers were harvested at a commercial facility and carcass data was obtained. Analysis of dry matter intake demonstrated that steers receiving the PFP and CON diets consumed more feed (P \u3c 0.001) than steers consuming the PLM+PFP diet. Steers receiving the PLM+PFP diet gained less (P \u3c 0.001) weight than the steers receiving the other two dietary treatments. No differences (P \u3e 0.10) in feed efficiency or carcass characteristics were observed. Steers receiving the PFP diet had improved (P = 0.016) cost of gain ($0.93 per kg) when compared with steers receiving PLM+PFP ($1.08 per kg) diet. Overall, our findings demonstrate that the inclusion of PFP in place of alfalfa hay in a finishing diet has the potential to improve cost of gain, without negatively affecting growth, performance, or carcass characteristics of finishing feedlot steers

Hyperinsulinism Caused by Paternal-Specific Inheritance of a Recessive Mutation in the Sulfonylurea-Receptor Gene

Neonatal hyperinsulinism (HI) is a genetic disorder of pancreatic b-cells characterized by failure to suppress insulin secretion in the presence of hypoglycemia, resulting in brain damage or death if not adequately treated. Germline mutations in four genes have been associated with HI. Some patients have focal regions of b-cell proliferation (focal HI). Seventy HI probands in whom at least one S U R - 1 mutation was identified were studied. Clinical data from patients with two S U R - 1 mutant alleles were compared with those from patients with single paternally inherited mutations. Thirtyseven probands were homozygous or compound heterozygous for S U R - 1 mutations. In 33 probands, only a single mutation was identified, and in 31, the parental origin of the proband could be determined; in 29, the mutation was on the paternal allele (P \u3c 0.0002). For three of these, pancreatic tissue was available and showed focal b-cell hyperplasia. DNA extracted from the focal lesion and adjacent normal pancreas revealed loss of the maternal chromosome 11p15, resulting in reduction to homozygosity for the S U R - 1 mutation within the focal lesion only. Using the Tdt-mediated dUTP nick end labeling (TUNEL) reaction, apoptotic b-cells were identified exclusively within the focal region. At diagnosis, disease severity was similar in patients with paternally inherited mutations and those with two mutations. For patients who did not undergo surgery, those with only paternal mutations entered clinical remission within 16 ± 6.2 months, compared with 48 ± 23 months for those with two S U R - 1 mutations (P = 0.001). In conclusion, we identified a novel mechanism to explain the pathophysiology of focal HI and provide evidence to suggest that this entity may be self-limiting, since affected b-cells undergo apoptosis

Title

Persistent hypoglycaemia in infancy is most commonly caused by hyperinsulinism. A case is reported of the somatic loss of the maternal 11p in an insulin secreting focal adenoma in association with a germline SUR-1mutation on the paternal allele in a baby boy with hyperinsulinism diagnosed at 49 days old. A reduction to homozygosity of an SUR-1 mutation is proposed as a critical part of the cause of focal hyperinsulinism

Assessing simulation ecosystem processes for climate variability research at Glacier National Park

Glacier National Park served as a test site for ecosystem analyses that involved a suite of integrated models embedded within a geographic information system. The goal of the exercise was to provide managers with maps that could illustrate probable shifts in vegetation, net primary production (NPP), and hydrologic responses associated with two selected climatic scenarios. The climatic scenarios were (a) a recent 12-yr record of weather data, and (b) a reconstituted set that sequentially introduced in repeated 3-yr intervals wetter–cooler, drier–warmer, and typical conditions. To extrapolate the implications of changes in ecosystem processes and resulting growth and distribution of vegetation and snowpack, the model incorporated geographic data. With underlying digital elevation maps, soil depth and texture, extrapolated climate, and current information on vegetation types and satellite-derived estimates of leaf area indices, simulations were extended to envision how the park might look after 120 yr. The predictions of change included underlying processes affecting the availability of water and nitrogen. Considerable field data were acquired to compare with model predictions under current climatic conditions. In general, the integrated landscape models of ecosystem processes had good agreement with measured NPP, snowpack, and streamflow, but the exercise revealed the difficulty and necessity of averaging point measurements across landscapes to achieve comparable results with modeled values. Under the extremely variable climate scenario significant changes in vegetation composition and growth as well as hydrologic responses were predicted across the park. In particular, a general rise in both the upper and lower limits of treeline was predicted. These shifts would probably occur along with a variety of disturbances (fire, insect, and disease outbreaks) as predictions of physiological stress (water, nutrients, light) altered competitive relations and hydrologic responses. The use of integrated landscape models applied in this exercise should provide managers with insights into the underlying processes important in maintaining community structure, and at the same time, locate where changes on the landscape are most likely to occur

Biocatalytic self-assembly cascades

The properties of supramolecular materials are dictated by both kinetic and thermodynamic aspects, providing opportunities to dynamically regulate morphology and function. Herein, we demonstrate time-dependent regulation of supramolecular self-assembly by connected, kinetically competing enzymatic reactions. Starting from Fmoc-tyrosine phosphate and phenylalanine amide in the presence of an amidase and phosphatase, four distinct self-assembling molecules may be formed which each give rise to distinct morphologies (spheres, fibers, tubes/tapes and sheets). By varying the sequence or ratio in which the enzymes are added to mixtures of precursors, these structures can be (transiently) accessed and interconverted. The approach provides insights into dynamic self-assembly using competing pathways that may aid the design of soft nanostructures with tunable dynamic properties and life times