93 research outputs found
Do Social Bonds Matter for Emerging Adults?
The extent to which social bonds and turning points influence criminal activity has been the focus of much empirical research. However, there have been few empirical studies exploring social bonds and turning points and offending for those who have experienced emerging adulthood, a recently identified stage of the life course. Using data from the National Longitudinal Study of Adolescent Health we examined if indicators of social bonds and turning points were predictors of criminal offending. Several of the turning points and social bonds included in these analyses were found to influence decreases in criminal offending for a cohort of emerging adults. We extend previous research by examining the influence of social bonds and turning points on patterns of criminal offending during emerging adulthood
Clinical outcomes and response to treatment of patients receiving topical treatments for pyoderma gangrenosum: a prospective cohort study
Background: pyoderma gangrenosum (PG) is an uncommon dermatosis with a limited evidence base for treatment.
Objective: to estimate the effectiveness of topical therapies in the treatment of PG.
Methods: prospective cohort study of UK secondary care patients with a clinical diagnosis of PG suitable for topical treatment (recruited July 2009 to June 2012). Participants received topical therapy following normal clinical practice (mainly Class I-III topical corticosteroids, tacrolimus 0.03% or 0.1%). Primary outcome: speed of healing at 6 weeks. Secondary outcomes: proportion healed by 6 months; time to healing; global assessment; inflammation; pain; quality-of-life; treatment failure and recurrence.
Results: Sixty-six patients (22 to 85 years) were enrolled. Clobetasol propionate 0.05% was the most commonly prescribed therapy. Overall, 28/66 (43.8%) of ulcers healed by 6 months. Median time-to-healing was 145 days (95% CI: 96 days, ∞). Initial ulcer size was a significant predictor of time-to-healing (hazard ratio 0.94 (0.88;80 1.00); p = 0.043). Four patients (15%) had a recurrence.
Limitations: No randomised comparator
Conclusion: Topical therapy is potentially an effective first-line treatment for PG that avoids possible side effects associated with systemic therapy. It remains unclear whether more severe disease will respond adequately to topical therapy alone
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Policy Entrepreneurship by International Bureaucracies: The Evolution of Public Information in UN Peacekeeping
The UN Secretariat’s role in the expansion of peacekeeping after the cold war is debated. Different theoretical accounts offer competing interpretations: principal–agent models and sociological institutionalism tend to emphasize the Secretariat’s risk-averse behaviour; organizational learning scholarship and international political sociology find evidence of the Secretariat’s activism; constructivism analyses instances of both. I argue that the UN Secretariat can be both enthusiastic and cautious about new tasks depending on the circumstances and the issue area. For example, UN officials have been the driving force behind the development of public information campaigns by peacekeeping missions aimed at the local population. During the cold war, it was not regarded as necessary for UN missions to communicate with the public in the area of operation: their interlocutors were parties to the conflict and the diplomatic community. With the deployment of the first multidimensional missions in the late 1980s and the early 1990s, UN staff realized the need to explain the organization’s role to the local population and provide information about UN-supported elections. In promoting this innovation, they played the role of policy entrepreneurs. The institutionalization of this innovation, however, was not an automatic process and required continuous advocacy by UN information staff
When Open-Ended Questions Don't Work: The Role of Palliative Paternalism in Difficult Medical Decisions
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