Recreational fishing in California’s Central Valley: results of a 2015 study

In 2015, baseline expenditure and trip behavior information about angler activity across a 14-county region of California’s Central Valley was collected. The motivation for this study was twofold: to learn about existing recreational fishing levels in the Sacramento River system, and to understand how these levels might change if fishing opportunities in areas above dams also changed. That is, under what conditions might anglers be interested in new fishing opportunities for species such as salmon, if fish passage improvements over dams were to occur? This talk will discuss current highlights from this study including results from a preliminary model developed to estimate the probability of fishing at a particular location as a function of site conditions and angler characteristics

Levodopa inhibits the development of lens-induced myopia in chicks

Animal models have demonstrated a link between dysregulation of the retinal dopamine system and the development of myopia (short‑sightedness). We have previously demonstrated that topical application of levodopa in chicks can inhibit the development of form‑deprivation myopia (fDM) in a dose‑dependent manner. Here, we examine whether this same protection is observed in lens‑induced myopia (LiM), and whether levodopa’s protection against fDM and LiM occurs through a dopamine D1- or D2-like receptor mechanism. To do this, levodopa was first administered daily as an intravitreal injection or topical eye drop, at one of four ascending doses, to chicks developing LiM. Levodopa’s mechanism of action was then examined by co-administration of levodopa injections with D1-like (SCH-23390) or D2-like (spiperone) dopamine antagonists in chicks developing FDM or LIM. For both experiments, levodopa’s effectiveness was examined by measuring axial length and refraction after 4 days of treatment. Levodopa inhibited the development of LIM in a dose-dependent manner similar to its inhibition of fDM when administered via intravitreal injections or topical eye drops. in both fDM and LiM, levodopa injections remained protective against myopia when co‑administered with ScH‑ 23390, but not spiperone, indicating that levodopa elicits its protection through a dopamine D2-like receptor mechanism in both paradigms.This work was partially funded by ANU Connect Ventures through a Discovery Translation Fund Grant (Project ID: DTF216

Author correction : Levodopa inhibits the development of lens-induced myopia in chicks

Animal models have demonstrated a link between dysregulation of the retinal dopamine system and the development of myopia (short‑sightedness). We have previously demonstrated that topical application of levodopa in chicks can inhibit the development of form‑deprivation myopia (FDM) in a dose‑dependent manner. Here, we examine whether this same protection is observed in lens‑induced myopia (LIM), and whether levodopa’s protection against FDM and LIM occurs through a dopamine D1‑ or D2‑like receptor mechanism. To do this, levodopa was first administered daily as an intravitreal injection or topical eye drop, at one of four ascending doses, to chicks developing LIM. Levodopa’s mechanism of action was then examined by co‑administration of levodopa injections with D1‑like (SCH‑23390) or D2‑like (spiperone) dopamine antagonists in chicks developing FDM or LIM. For both experiments, levodopa’s effectiveness was examined by measuring axial length and refraction after 4 days of treatment. Levodopa inhibited the development of LIM in a dose‑dependent manner similar to its inhibition of FDM when administered via intravitreal injections or topical eye drops. In both FDM and LIM, levodopa injections remained protective against myopia when co‑administered with SCH‑23390, but not spiperone, indicating that levodopa elicits its protection through a dopamine D2‑like receptor mechanism in both paradigms

LMDA Review, volume 8, issue 1

Contents include: From the President, Jayme Koszyn, Blaulapalooza in Imilwaukee, Notes from Avignon: Diary of a Francophile Theatre Junkie, 1997 Conference News, Canadian Regional News, A Letter to My Colleagues from Lynn M. Thomson, ATHR Group Meets, Proposes Panel for New \u27Turgs, Regional News: The Chicago Gang Meets Again, Member News, and Regional VP\u27s.https://soundideas.pugetsound.edu/lmdareview/1015/thumbnail.jp

LMDA Review, volume 9, issue 1

Contents include: Mid-Year Meetings, Words of Thanks from Jayme Koszyn Outgoing President of LMDA, Anne Cattaneo of Lincoln Center Theater Receives Dramaturgy Award, May I have the Envelope, Please?, Rent Settlement, On Advocacy, A VP is a VIP is a VP, LMDA Canada, Next Annual LMDA Conference, Early Career Dramaturg Program, Script Exchange, ATHE \u2799 Toronto Border to Board, ATHE \u2799 Toronto Debut Panel, ATHE \u27 99 Toronto Call for Directors, Actors, Dramaturgs for the New Play Development Workshop, Report on Last June\u27s Conference, Report on Last June\u27s Conference LMDA University Caucus Pre-Conference and Source Books, Minutes June 1998, LMDA Job Line, Job Listings, and the Membership Directory, LMDA Online, Supplement to the LMDA Bibliography, and Call for Papers Theatre Topics: Dramaturgy, Pedagogy, Performance.https://soundideas.pugetsound.edu/lmdareview/1018/thumbnail.jp

A Novel BMPR2 Mutation Associated with Pulmonary Arterial Hypertension in an Octogenarian

We describe the case of an 83-year-old man with a family history of pulmonary hypertension (PH) who presented with severe pulmonary arterial hypertension (PAH) and later tested positive for a novel bone morphogenetic protein receptor 2 (BMPR2) gene mutation. To our knowledge, this may be the oldest reported patient with PAH in whom a BMPR2 mutation was initially identified

De schadelijke werking van het zaad van de Ricinus communis op de gezondheid : een bedrijfsgeneeskundig onderzoek bij havenwerkers te Rotterdam

Large predators often play important roles in structuring marine communities. To understand the role that these predators play in ecosystems, it is crucial to have knowledge of their interactions and the degree to which their trophic roles are complementary or redundant among species. We used stable isotope analysis to examine the isotopic niche overlap of dolphins Tursiops cf. aduncus, large sharks (\u3e1.5 m total length), and smaller elasmobranchs (sharks and batoids) in the relatively pristine seagrass community of Shark Bay, Australia. Dolphins and large sharks differed in their mean isotopic values for δ13C and δ15N, and each group occupied a relatively unique area in isotopic niche space. The standard ellipse areas (SEAc; based on bivariate standard deviations) of dolphins, large sharks, small sharks, and rays did not overlap. Tiger sharks Galeocerdo cuvier had the highest δ15N values, although the mean δ13C and δ15N values of pigeye sharks Carcharhinus amboinensis were similar. Other large sharks (e.g. sicklefin lemon sharksNegaprion acutidens and sandbar sharks Carcharhinus plumbeus) and dolphins appeared to feed at slightly lower trophic levels than tiger sharks. In this seagrass-dominated ecosystem, seagrass-derived carbon appears to be more important for elasmobranchs than it is for dolphins. Habitat use patterns did not correlate well with the sources of productivity supporting diets, suggesting that habitat use patterns may not necessarily be reflective of the resource pools supporting a population and highlights the importance of detailed datasets on trophic interactions for elucidating the ecological roles of predators

Epidemiology of Concomitant Infection Due to Loa loa and Mansonella perstans in Gabon

Loa loa and Mansonella perstans are blood filarial parasites, endemic in the central and western African forest block, and transmitted by chrysops and culicoides flies, respectively. Loa loa is pathogenic and represents a major obstacle to the control of co-endemic filariae. Treatment of individuals with >8000 Loa loa microfilariae/ml can result in severe adverse reactions. M. perstans is prevalent in the tropics, with undefined clinical symptoms. We screened 4392 individuals for these infections in 212 Gabonese villages. The overall prevalence rates were 22.4% for Loa loa microfilariae, 10.2% for M. perstans, and 3.2% for mixed infection. These rates varied across the different ecosystems: forest, savannah, Lakeland, river (Ogouée), and equator. A correlation was found between the prevalence and intensity of microfilariae, while a negative relationship was found between clinical symptoms (pruritis, Calabar swelling) and the prevalence of Loa loa microfilaremia. This study confirms the spatial uniformity of the relationship between parasitological indices, and provides a map and baseline data for implementation of mass chemotherapy for these infections

Diversity analysis of cotton (Gossypium hirsutum L.) germplasm using the CottonSNP63K Array

Cotton germplasm resources contain beneficial alleles that can be exploited to develop germplasm adapted to emerging environmental and climate conditions. Accessions and lines have traditionally been characterized based on phenotypes, but phenotypic profiles are limited by the cost, time, and space required to make visual observations and measurements. With advances in molecular genetic methods, genotypic profiles are increasingly able to identify differences among accessions due to the larger number of genetic markers that can be measured. A combination of both methods would greatly enhance our ability to characterize germplasm resources. Recent efforts have culminated in the identification of sufficient SNP markers to establish high-throughput genotyping systems, such as the CottonSNP63K array, which enables a researcher to efficiently analyze large numbers of SNP markers and obtain highly repeatable results. In the current investigation, we have utilized the SNP array for analyzing genetic diversity primarily among cotton cultivars, making comparisons to SSR-based phylogenetic analyses, and identifying loci associated with seed nutritional traits. (Résumé d'auteur

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure