Remote sensing as an aid to route evaluation for relocated Louisiana Highway 1

NASA aerial photography in the form of color infrared and color positive transparencies is used as an aid for evaluation of the route proposed for relocated Louisiana Highway 1, between LaRose and Golden Meadow, in South Louisiana

Research and Publishing during COVID-19

This discussion will explore the impact of the COVID-19 pandemic on scholarly research and publishing. Travel restrictions, retracted funding, delayed or halted projects, and an increase in caretaker and other personal responsibilities at home compound to create unprecedented challenges for producing and publishing research. Early indicators show women, those with significant unpaid care responsibilities, and members of minoritized groups have been disproportionately impacted. For graduate students and early career faculty who depend on research and publication for promotion and tenure, the stakes are especially high. Join our panelists for a conversation about the how the COVID-19 pandemic is impacting the research landscape. Watch the video to see the discussion. Click on the download button for a list of readings and resources.https://digitalcommons.usu.edu/inter_inclusion/1001/thumbnail.jp

Large-Order Behavior of Two-coupling Constant ϕ4\phi^4-Theory with Cubic Anisotropy

For the anisotropic [u (\sum_{i=1^N {\phi}_i^2)^2+v \sum_{i=1^N \phi_i^4]-theory with {$N=2,3$} we calculate the imaginary parts of the renormalization-group functions in the form of a series expansion in $v$, i.e., around the isotropic case. Dimensional regularization is used to evaluate the fluctuation determinants for the isotropic instanton near the space dimension 4. The vertex functions in the presence of instantons are renormalized with the help of a nonperturbative procedure introduced for the simple g{\phi^4-theory by McKane et al.Comment: LaTeX file with eps files in src. See also http://www.physik.fu-berlin.de/~kleinert/institution.htm

Avaliação do perfil hematológico e bioquímico do sangue de cão com Ehrlichia platys realizada no laboratório de análises clínicas da Unidade Hospitalar para Animais de Companhia (UHAC) da PUC-PR. Relato de caso

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UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly

Early eukaryotic ribosome biogenesis involves large multi-protein complexes, which co-transcriptionally associate with pre-ribosomal RNA to form the small subunit processome. The precise mechanisms by which two of the largest multi-protein complexes—UtpA and UtpB—interact with nascent pre-ribosomal RNA are poorly understood. Here, we combined biochemical and structural biology approaches with ensembles of RNA–protein cross-linking data to elucidate the essential functions of both complexes. We show that UtpA contains a large composite RNA-binding site and captures the 5′ end of pre-ribosomal RNA. UtpB forms an extended structure that binds early pre-ribosomal intermediates in close proximity to architectural sites such as an RNA duplex formed by the 5′ ETS and U3 snoRNA as well as the 3′ boundary of the 18S rRNA. Both complexes therefore act as vital RNA chaperones to initiate eukaryotic ribosome assembly

The significance of peroxisomes in secondary metabolite biosynthesis in filamentous fungi

Peroxisomes are ubiquitous organelles characterized by a protein-rich matrix surrounded by a single membrane. In filamentous fungi, peroxisomes are crucial for the primary metabolism of several unusual carbon sources used for growth (e.g. fatty acids), but increasing evidence is presented that emphasize the crucial role of these organelles in the formation of a variety of secondary metabolites. In filamentous fungi, peroxisomes also play a role in development and differentiation whereas specialized peroxisomes, the Woronin bodies, play a structural role in plugging septal pores. The biogenesis of peroxisomes in filamentous fungi involves the function of conserved PEX genes, as well as genes that are unique for these organisms. Peroxisomes are also subject to autophagic degradation, a process that involves ATG genes. The interplay between organelle biogenesis and degradation may serve a quality control function, thereby allowing a continuous rejuvenation of the organelle population in the cells

Decoding the regulatory network of early blood development from single-cell gene expression measurements.

Reconstruction of the molecular pathways controlling organ development has been hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a strategy to address this problem that combines gene expression profiling of large numbers of single cells with data analysis based on diffusion maps for dimensionality reduction and network synthesis from state transition graphs. Applying the approach to hematopoietic development in the mouse embryo, we map the progression of mesoderm toward blood using single-cell gene expression analysis of 3,934 cells with blood-forming potential captured at four time points between E7.0 and E8.5. Transitions between individual cellular states are then used as input to develop a single-cell network synthesis toolkit to generate a computationally executable transcriptional regulatory network model of blood development. Several model predictions concerning the roles of Sox and Hox factors are validated experimentally. Our results demonstrate that single-cell analysis of a developing organ coupled with computational approaches can reveal the transcriptional programs that underpin organogenesis.We thank J. Downing (St. Jude Children's Research Hospital, Memphis, TN, USA) for the Runx1-ires-GFP mouse. Research in the authors' laboratory is supported by the Medical Research Council, Biotechnology and Biological Sciences Research Council, Leukaemia and Lymphoma Research, the Leukemia and Lymphoma Society, Microsoft Research and core support grants by the Wellcome Trust to the Cambridge Institute for Medical Research and Wellcome Trust - MRC Cambridge Stem Cell Institute. V.M. is supported by a Medical Research Council Studentship and Centenary Award and S.W. by a Microsoft Research PhD Scholarship.This is the accepted manuscript for a paper published in Nature Biotechnology 33, 269–276 (2015) doi:10.1038/nbt.315

Using clickers in a large business class: examining use behavior and satisfaction

YesAs more and more institutions are integrating new technologies (e.g., audience response systems such as clickers) into their teaching and learning systems, it is becoming increasingly necessary to have a detailed understanding of the underlying mechanisms of these advanced technologies and their outcomes on student learning perceptions. We proposed a conceptual model based on the technology acceptance model to understand students’ use behavior and satisfaction with clickers. The valid response from 138 second-year business students of Digital Marketing module taught in a British university, where clickers are extensively used in the teaching and learning process, made the basis for data analysis. The results provided a strong support for the proposed model with a reasonably adequate variance (i.e., adjusted R2) of 67% on behavioral intentions and sufficiently high variance on use behavior (i.e., 86%) and user satisfaction (i.e., 89%)

Expression of the Salmonella Spp. Virulence Factor SifA in Yeast Alters Rho1 Activity on Peroxisomes

SifA is a virulence protein required for assembly and tubulation of a modified phagosome that promotes Salmonella replication. We show that SifA expressed in yeast induces membrane invagination during peroxisome proliferation and requires functional Rho1p. This is consistent with SifA ability to interact with RhoA and the fact that it is a GEF structural homologue