3,596 research outputs found

    Oregon Wine Board Meeting Minutes September 11, 2012

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    These meeting minutes list individuals in attendance and missing at the September 11, 2012 Oregon Wine Board (OWB) meeting, held via conference call. Dewey Weddington provided a marketing update focused on planning for Oregon Wine Month and the Oregon Wine Industry Symposium. The meeting also included discussion of the 2011-2012 year-end financial review and a presentation of the budget for the following year. The meeting lasted 2 hours 6 minutes, and the Board went into Executive Session after the meeting was adjourned

    Probing terahertz surface plasmon waves in graphene structures

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    Epitaxial graphene mesas and ribbons are investigated using terahertz (THz) nearfield microscopy to probe surface plasmon excitation and THz transmission properties on the sub-wavelength scale. The THz near-field images show variation of graphene properties on a scale smaller than the wavelength, and excitation of THz surface waves occurring at graphene edges, similar to that observed at metallic edges. The Fresnel reflection at the substrate SiC/air interface is also found to be altered by the presence of graphene ribbon arrays, leading to either reduced or enhanced transmission of the THz wave depending on the wave polarization and the ribbon width.Comment: accepted for publication in Applied Physics Lette

    Factors associated with the presence of diabetic ketoacidosis at diagnosis of diabetes in children and young adults: a systematic review

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    Objective To identify the factors associated with diabetic ketoacidosis at diagnosis of type 1 diabetes in children and young adults

    Stringent neutron-star limits on large extra dimensions

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    Supernovae (SNe) are copious sources for Kaluza-Klein gravitons which are generic for theories with large extra dimensions. These massive particles are produced with average velocities ~0.5 c so that many of them are gravitationally retained by the SN core. Every neutron star thus has a halo of KK gravitons which decay into nu bar-nu, e^+e^- and gamma gamma on time scales \~10^9 years. The EGRET gamma-flux limits (E_gamma ~ 100 MeV) for nearby neutron stars constrain the fundamental scale for n=2 extra dimensions to M >500 TeV, and M>30 TeV for n=3. The upcoming GLAST satellite is a factor ~30 more sensitive and thus may detect KK decays, for example at the nearby neutron star RX J185635--3754. The requirement that neutron stars are not excessively heated by KK decays implies M>1700 TeV for n=2, and M>60 TeV for n=3.Comment: Minor changes, matches version to appear in PR

    The pathway to diagnosis of type 1 diabetes in children: a questionnaire study.

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    OBJECTIVE: To explore the pathway to diagnosis of type 1 diabetes (T1D) in children. DESIGN: Questionnaire completed by parents. PARTICIPANTS: Parents of children aged 1 month to 16 years diagnosed with T1D within the previous 3 months. SETTING: Children and parents from 11 hospitals within the East of England. RESULTS: 88/164 (54%) invited families returned the questionnaire. Children had mean±SD age of 9.41±4.5 years. 35 (39.8%) presented with diabetic ketoacidosis at diagnosis. The most common symptoms were polydipsia (97.7%), polyuria (83.9%), tiredness (75.9%), nocturia (73.6%) and weight loss (64.4%) and all children presented with at least one of those symptoms. The time from symptom onset to diagnosis ranged from 2 to 315 days (median 25 days). Most of this was the appraisal interval from symptom onset until perceiving the need to seek medical advice. Access to healthcare was good but one in five children presenting to primary care were not diagnosed at first encounter, most commonly due to waiting for fasting blood tests or alternative diagnoses. Children diagnosed at first consultation had a shorter duration of symptoms (p=0.022) and children whose parents suspected the diagnosis were 1.3 times more likely (relative risk (RR) 1.3, 95% CI 1.02 to 1.67) to be diagnosed at first consultation. CONCLUSIONS: Children present with the known symptoms of T1D but there is considerable scope to improve the diagnostic pathway. Future interventions targeted at parents need to address the tendency of parents to find alternative explanations for symptoms and the perceived barriers to access, in addition to symptom awareness.The study was funded by the Royal College of General Practitioners Scientific Foundation Board (SFB-2011-15). JUS was supported by a National Institute of Health Research (NIHR) Academic Clinical Fellowship and subsequently Clinical Lectureship, and FMW by an NIHR Clinician Scientist award. SJS was supported by the Medical Research Council www.mrc.ac.uk [Unit Programme number MC_UU_12015/1]. The views expressed in this publication are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health.This is the final version of the article. It was first published by BMJ Group at http://bmjopen.bmj.com/content/5/3/e006470.ful

    Patient-Centered Outcomes From Multiparametric MRI and MRI-Guided Biopsy for Prostate Cancer: A Systematic Review.

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    OBJECTIVE: To identify and characterize patient-centered outcomes (PCOs) relating to multiparametric MRI (mpMRI) and MRI-guided biopsy as diagnostic tests for possible prostate cancer. METHODS: Medline via OVID, EMBASE, PsycInfo, and the Cochrane Central register of Controlled Trials (CENTRAL) were searched for relevant articles. Hand searching of reference lists and snowballing techniques were performed. Studies of mpMRI and MRI-guided biopsy that measured any PCO were included. There were no restrictions placed on year of publication, language, or country for study inclusion. All database search hits were screened independently by two reviewers, and data were extracted using a standardized form. RESULTS: Overall, 2,762 database search hits were screened based on title and abstract. Of these, 222 full-text articles were assessed, and 10 studies met the inclusion criteria. There were 2,192 participants featured in the included studies, all of which were conducted in high-income countries. Nineteen different PCOs were measured, with a median of four PCOs per study (range 1-11). Urethral bleeding, pain, and urinary tract infection were the most common outcomes measured. In the four studies that compared mpMRI or MRI-guided biopsy to transrectal ultrasound biopsy, most adverse outcomes occurred less frequently in MRI-related tests. These four studies were assessed as having a low risk of bias. DISCUSSION: PCOs measured in studies of mpMRI or MRI-guided biopsy thus far have mostly been physical outcomes, with some evidence that MRI tests are associated with less frequent adverse outcomes compared with transrectal ultrasound biopsy. There was very little evidence for the effect of mpMRI and MRI-guided biopsy on emotional, cognitive, social, or behavioral outcomes

    The Orbit of the Eclipsing X-ray Pulsar EXO 1722-363

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    With recent and archival Rossi X-Ray Timing Explorer (RXTE) X-ray measurements of the heavily obscured X-ray pulsar EXO 1722-363 (IGR J17252-3616), we carried out a pulse timing analysis to determine the orbital solution for the first time. The binary system is characterized by a_x sin(i) = 101 +/- 3 lt-s and P_orb = 9.7403 +/- 0.0004 days (90% confidence), with the precision of the orbital period being obtained by connecting datasets separated by more than 7 years (272 orbital cycles). The orbit is consistent with circular, and e < 0.19 at the 90% confidence level. The mass function is 11.7 +/- 1.2 M_sun and confirms that this source is a High Mass X-ray Binary (HMXB) system. The orbital period, along with the previously known ~414 s pulse period, places this system in the part of the Corbet diagram populated by supergiant wind accretors. Using previous eclipse time measurements by Corbet et al. and our orbital solution, combined with the assumption that the primary underfills its Roche lobe, we find i > 61 degrees at the 99% confidence level, the radius of the primary is between 21 R_sun and 37 R_sun, and its mass is less than about 22 M_sun. The acceptable range of radius and mass shows that the primary is probably a supergiant of spectral type B0I-B5I. Photometric measurements of its likely counterpart are consistent with the spectral type and luminosity if the distance to the system is between 5.3 kpc and 8.7 kpc. Spectral analysis of the pulsar as a function of orbital phase reveals an evolution of the hydrogen column density suggestive of dense filaments of gas in the downstream wake of the pulsar, with higher levels of absorption seen at orbital phases 0.5-1.0, as well as a variable Fe K_alpha line.Comment: Submitted to ApJ, 11 pages, 11 figure

    A 33 GHz Survey of Local Major Mergers: Estimating the Sizes of the Energetically Dominant Regions from High Resolution Measurements of the Radio Continuum

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    We present Very Large Array observations of the 33 GHz radio continuum emission from 22 local ultraluminous and luminous infrared (IR) galaxies (U/LIRGs). These observations have spatial (angular) resolutions of 30--720 pc (0.07"-0.67") in a part of the spectrum that is likely to be optically thin. This allows us to estimate the size of the energetically dominant regions. We find half-light radii from 30 pc to 1.7 kpc. The 33 GHz flux density correlates well with the IR emission, and we take these sizes as indicative of the size of the region that produces most of the energy. Combining our 33 GHz sizes with unresolved measurements, we estimate the IR luminosity and star formation rate per area, and the molecular gas surface and volume densities. These quantities span a wide range (4 dex) and include some of the highest values measured for any galaxy (e.g., ΣSFR33GHz≤104.1M⊙yr−1kpc−2\mathrm{\Sigma_{SFR}^{33GHz} \leq 10^{4.1} M_{\odot} yr^{-1} kpc^{-2}}). At least 1313 sources appear Compton thick (NH33GHz≥1024cm−2\mathrm{N_{H}^{33GHz} \geq 10^{24} cm^{-2}}). Consistent with previous work, contrasting these data with observations of normal disk galaxies suggests a nonlinear and likely multi-valued relation between SFR and molecular gas surface density, though this result depends on the adopted CO-to-H2_{2} conversion factor and the assumption that our 33 GHz sizes apply to the gas. 11 sources appear to exceed the luminosity surface density predicted for starbursts supported by radiation pressure and supernovae feedback, however we note the need for more detailed observations of the inner disk structure. U/LIRGs with higher surface brightness exhibit stronger [{\sc Cii}] 158μ\mum deficits, consistent with the suggestion that high energy densities drive this phenomenon.Comment: 32 pages, 11 figures, 7 tables. Accepted for publication in Ap
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