Ethical issues associated with BST

The discussion about the importance of BST is increased because of food safety questions and the climate of uncertainty that they generated. It is the uncertainty issue that truly threatens to keep BST off the market at this point

Arc Phenomena in low-voltage current limiting circuit breakers

Circuit breakers are an important safety feature in most electrical circuits, and they act to prevent excessive currents caused by short circuits, for example. Low-voltage current limiting circuit breakers are activated by a trip solenoid when a critical current is exceeded. The solenoid moves two contacts apart to break the circuit. However, as soon as the contacts are separated an electric arc forms between them, ionising the air in the gap, increasing the electrical conductivity of air to that of the hot plasma that forms, and current continues to flow. The currents involved may be as large as 80,000 amperes. Critical to the success of the circuit breaker is that it is designed to cause the arc to move away from the contacts, into a widening wedge-shaped region. This lengthens the arc, and then moves it onto a series of separator plates called an arc divider or splitter. The arc divider raises the voltage required to sustain the arcs across it, above the voltage that is provided across the breaker, so that the circuit is broken and the arcing dies away. This entire process occurs in milliseconds, and is usually associated with a sound like an explosion and a bright ash from the arc. Parts of the contacts and the arc divider may melt and/or vapourise. The question to be addressed by the Study Group was to mathematically model the arc motion and extinction, with the overall aim of an improved understanding that would help the design of a better circuit breaker. Further discussion indicated that two key mechanisms are believed to contribute to the movement of the arc away from the contacts, one being self-magnetism (where the magnetic field associated with the arc and surrounding circuitry acts to push it towards the arc divider), and the other being air flow (where expansion of air combined with the design of the chamber enclosing the arc causes gas flow towards the arc divider). Further discussion also indicated that a key aspect of circuit breaker design was that it is desirable to have as fast a quenching of the arc as possible, that is, the faster the circuit breaker can act to stop current flow, the better. The relative importance of magnetic and air pressure effects on quenching speed is of central interest to circuit design

Identification of a novel prostate cancer biomarker, caveolin-1: Implications and potential clinical benefit

While prostate cancer is a common disease in men, it is uncommonly life-threatening. To better understand this phenomenon, tumor biologists have sought to elucidate the mechanisms that contribute to the development of virulent prostate cancer. The recent discovery that caveolin-1 (Cav-1) functions as an important oncogene involved in prostate cancer progression reflects the success of this effort. Cav-1 is a major structural coat protein of caveolae, specialized plasma membrane invaginations involved in multiple cellular functions, including molecular transport, cell adhesion, and signal transduction. Cav-1 is aberrantly overexpressed in human prostate cancer, with higher levels evident in metastatic versus primary sites. Intracellular Cav-1 promotes cell survival through activation of Akt and enhancement of additional growth factor pro-survival pathways. Cav-1 is also secreted as a biologically active molecule that promotes cell survival and angiogenesis within the tumor microenvironment. Secreted Cav-1 can be reproducibly detected in peripheral blood using a sensitive and specific immunoassay. Cav-1 levels distinguish men with prostate cancer from normal controls, and preoperative Cav-1 levels predict which patients are at highest risk for relapse following radical prostatectomy for localized disease. Thus, secreted Cav-1 is a promising biomarker in identifying clinically significant prostate cancer

Metastatic Papillary Thyroid Carcinoma Causing Hand Weakness

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63112/1/105072502760043530.pd

Endocrine tumours of the pancreas: Review and recent advances

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/75105/1/j.1440-1622.2001.02191.x.pd

Forest Products Research at U.S. Universities in 1982

This is a survey of professional staffing, research emphasis, and funding levels of the 37 universities in the United States that conduct forest products research. The survey was conducted by the Subcommittee on Forest Products Research, National Planning Group for Forestry (NPG-2)

The Glaciochemistry of Snowpits from Quelccaya Ice Cap, Peru, 1982

We present glaciochemical data from a pilot study of two snow-pits from Quelccaya ice cap, Peruvian Andes. These are the first samples to be analyzed from Quelccaya for nitrate and sulfate by ion chromatography (IC), for nitrate-plus-nitrite, reactive silicate and reactive iron by colorimetry, and for sodium by atomic absorption spectrophotometry. The 3 m pits used in this study represent a one year record of mass accumulation and the 29 samples collected provide the first glaciochemical data from this area which can be compared with glaciochemical studies from other locations. Reactive iron, reactive silicate and sodium, and the profiles of \u3e0.63µm microparticles from Thompson and others (1984) are coincident, suggesting that transport and deposition into this area of each species are controlled by similar processes. The common source is probably local, resulting from crustaI weathering. In general, the reactive silicate values are lower than those observed in other alpine glacier ice. The highest sulfate and nitrate values were observed in the upper few centimeters of the snow-pit. Most of the sulfate concentrations were less than 3 µM and are similar to values obtained for fresh surface snows from Bolivia (Stallard and Edmond 1981). Since biological gaseous emissions are thought to be the major source of sulfur and nitrogen to the atmosphere over the Amazon basin, the sulfate and nitrate fluctuations may be due to seasonal biological input and/or seasonal shifts in wind direction bringing material to Quelccaya. With only one exception, the colorimetric nitrate-plus-nitrite data were higher than the IC nitrate data. Unfortunately, the IC analyses were conducted 81 d after the colorimetric analyses. The difference between the two data sets could be attributable to the following; (I) the colorimetric technique may yield erroneously high results as suggested for polar ice by Herron (1982), (2) the IC technique yields erroneously low results due, in part, to the possible exclusion of nitrite concentrations, and/or (3) nitrite was lost via biological removal during the 81 d period before the IC analyses. If the IC data are correct, the mean nitrate value is O.4 µM (n = 29). This value is similar to those reported from pre-industrial aged polar ice (Herron 1982). If the colorimetric mean value (1.1 µM) is correct, it is similar to colorimetrically determined values from other high-elevation alpine ice (Lyons and Mayewski 1983)