2,151 research outputs found
Synchronization of estrus and ovulation in dairy heifers using norgestomet, GnRH, and PGF2α
Two experiments were performed using the same treatments. All heifers received two injections of PGF2α 14 days apart. Controls then were inseminated after detected estrus. Heifers assigned to the two treatments also received 6 mg of norgestomet for 8 days beginning 7 days before the second of two PGF2α injections. The heifers in the last treatment also received GnRH 48 hr after the second PGF2α injection to induce ovulation in any heifer not observed in estrus before a fixed-time insemination at 72 hr after PGF2α. In Experiment 1, any control heifer or herifer in the two treatments not detected in estrus by 72 hr after PGF2α received a fixed-time insemination at 72 hr. Heifers receiving GnRH tended to have fewer standing events and a shorter duration of estrus. Fixed-time inseminations reduced conception compared to those after detected estrus. In Experiment 2, when inseminations were performed only after detected estrus, all measures of fertility were unaffected by treatments. These results indicated that addition of norgestomet and(or) GnRH did not improve measures of estrus synchronization or fertility of dairy heifers.; Dairy Day, 1997, Kansas State University, Manhattan, KS, 1997
Diverging volumetric trajectories following pediatric traumatic brain injury.
Traumatic brain injury (TBI) is a significant public health concern, and can be especially disruptive in children, derailing on-going neuronal maturation in periods critical for cognitive development. There is considerable heterogeneity in post-injury outcomes, only partially explained by injury severity. Understanding the time course of recovery, and what factors may delay or promote recovery, will aid clinicians in decision-making and provide avenues for future mechanism-based therapeutics. We examined regional changes in brain volume in a pediatric/adolescent moderate-severe TBI (msTBI) cohort, assessed at two time points. Children were first assessed 2-5 months post-injury, and again 12 months later. We used tensor-based morphometry (TBM) to localize longitudinal volume expansion and reduction. We studied 21 msTBI patients (5 F, 8-18 years old) and 26 well-matched healthy control children, also assessed twice over the same interval. In a prior paper, we identified a subgroup of msTBI patients, based on interhemispheric transfer time (IHTT), with significant structural disruption of the white matter (WM) at 2-5 months post injury. We investigated how this subgroup (TBI-slow, N = 11) differed in longitudinal regional volume changes from msTBI patients (TBI-normal, N = 10) with normal WM structure and function. The TBI-slow group had longitudinal decreases in brain volume in several WM clusters, including the corpus callosum and hypothalamus, while the TBI-normal group showed increased volume in WM areas. Our results show prolonged atrophy of the WM over the first 18 months post-injury in the TBI-slow group. The TBI-normal group shows a different pattern that could indicate a return to a healthy trajectory
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Functional Brain Hyperactivations Are Linked to an Electrophysiological Measure of Slow Interhemispheric Transfer Time after Pediatric Moderate/Severe Traumatic Brain Injury.
Increased task-related blood oxygen level dependent (BOLD) activation is commonly observed in functional magnetic resonance imaging (fMRI) studies of moderate/severe traumatic brain injury (msTBI), but the functional relevance of these hyperactivations and how they are linked to more direct measures of neuronal function remain largely unknown. Here, we investigated how working memory load (WML)-dependent BOLD activation was related to an electrophysiological measure of interhemispheric transfer time (IHTT) in a sample of 18 msTBI patients and 26 demographically matched controls from the UCLA RAPBI (Recovery after Pediatric Brain Injury) study. In the context of highly similar fMRI task performance, a subgroup of TBI patients with slow IHTT had greater BOLD activation with higher WML than both healthy control children and a subgroup of msTBI patients with normal IHTT. Slower IHTT treated as a continuous variable was also associated with BOLD hyperactivation in the full TBI sample and in controls. Higher WML-dependent BOLD activation was related to better performance on a clinical cognitive performance index, an association that was more pronounced within the patient group with slow IHTT. Our previous work has shown that a subgroup of children with slow IHTT after pediatric msTBI has increased risk for poor white matter organization, long-term neurodegeneration, and poor cognitive outcome. BOLD hyperactivations after msTBI may reflect neuronal compensatory processes supporting higher-order capacity demanding cognitive functions in the context of inefficient neuronal transfer of information. The link between BOLD hyperactivations and slow IHTT adds to the multi-modal validation of this electrophysiological measure as a promising biomarker
Magnetic Fields of Spherical Compact Stars in Braneworld
We study the dipolar magnetic field configuration in dependence on brane
tension and present solutions of Maxwell equations in the internal and external
background spacetime of a magnetized spherical star in a Randall-Sundrum II
type braneworld. The star is modelled as sphere consisting of perfect highly
magnetized fluid with infinite conductivity and frozen-in dipolar magnetic
field. With respect to solutions for magnetic fields found in the Schwarzschild
spacetime brane tension introduces enhancing corrections both to the interior
and the exterior magnetic field. These corrections could be relevant for the
magnetic fields of magnetized compact objects as pulsars and magnetars and may
provide the observational evidence for the brane tension through the
modification of formula for magneto-dipolar emission which gives amplification
of electromagnetic energy loss up to few orders depending on the value of the
brane tension.Comment: 11 pages, 5 figures, 1 tabl
Chloroplast DNA evolution among legumes: Loss of a large inverted repeat occurred prior to other sequence rearrangements
We have compared the sequence organization of four previously uncharacterized legume chloroplast DNAs - from alfalfa, lupine, wisteria and subclover — to that of legume chloroplast DNAs that either retain a large, ribosomal RNA-encoding inverted repeat (mung bean) or have deleted one half of this repeat (broad bean). The circular, 126 kilobase pair (kb) alfalfa chloroplast genome, like those of broad bean and pea, lacks any detectable repeated sequences and contains only a single set of ribosomal RNA genes. However, in contrast to broad bean and pea, alfalfa chloroplast DNA is unrearranged (except for the deletion of one segment of the inverted repeat) relative to chloroplast DNA from mung bean. Together with other findings reported here, these results allow us to determine which of the four possible inverted repeat configurations was deleted in the alfalfa-pea-broad bean lineage, and to show how the present-day broad bean genome may have been derived from an alfalfa-like ancestral genome by two major sequence inversions. The 147 kb lupine chloroplast genome contains a 22 kb inverted repeat and has essentially complete colinearity with the mung bean genome. In contrast, the 130 kb wisteria genome has deleted one half of the inverted repeat and appears colinear with the alfalfa genome. The 140 kb subclover genome has been extensively rearranged and contains a family of at least five dispersed repetitive sequence elements, each several hundred by in size; this is the first report of dispersed repeats of this size in a land plant chloroplast genome. We conclude that the inverted repeat has been lost only once among legumes and that this loss occurred prior to all the other rearrangements observed in subclover, broad bean and pea. Of those lineages that lack the inverted repeat, some are stable and unrearranged, other have undergone a moderate amount of rearrangement, while still others have sustained a complex series of rearrangement either with or without major sequence duplications and transpositions.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46960/1/294_2004_Article_BF00355401.pd
Exoplanet Catalogues
One of the most exciting developments in the field of exoplanets has been the
progression from 'stamp-collecting' to demography, from discovery to
characterisation, from exoplanets to comparative exoplanetology. There is an
exhilaration when a prediction is confirmed, a trend is observed, or a new
population appears. This transition has been driven by the rise in the sheer
number of known exoplanets, which has been rising exponentially for two decades
(Mamajek 2016). However, the careful collection, scrutiny and organisation of
these exoplanets is necessary for drawing robust, scientific conclusions that
are sensitive to the biases and caveats that have gone into their discovery.
The purpose of this chapter is to discuss and demonstrate important
considerations to keep in mind when examining or constructing a catalogue of
exoplanets. First, we introduce the value of exoplanetary catalogues. There are
a handful of large, online databases that aggregate the available exoplanet
literature and render it digestible and navigable - an ever more complex task
with the growing number and diversity of exoplanet discoveries. We compare and
contrast three of the most up-to-date general catalogues, including the data
and tools that are available. We then describe exoplanet catalogues that were
constructed to address specific science questions or exoplanet discovery space.
Although we do not attempt to list or summarise all the published lists of
exoplanets in the literature in this chapter, we explore the case study of the
NASA Kepler mission planet catalogues in some detail. Finally, we lay out some
of the best practices to adopt when constructing or utilising an exoplanet
catalogue.Comment: 14 pages, 6 figures. Invited review chapter, to appear in "Handbook
of Exoplanets", edited by H.J. Deeg and J.A. Belmonte, section editor N.
Batalh
Detection Of KOI-13.01 Using The Photometric Orbit
We use the KOI-13 transiting star-planet system as a test case for the
recently developed BEER algorithm (Faigler & Mazeh 2011), aimed at identifying
non-transiting low-mass companions by detecting the photometric variability
induced by the companion along its orbit. Such photometric variability is
generated by three mechanisms, including the beaming effect, tidal ellipsoidal
distortion, and reflection/heating. We use data from three Kepler quarters,
from the first year of the mission, while ignoring measurements within the
transit and occultation, and show that the planet's ephemeris is clearly
detected. We fit for the amplitude of each of the three effects and use the
beaming effect amplitude to estimate the planet's minimum mass, which results
in M_p sin i = 9.2 +/- 1.1 M_J (assuming the host star parameters derived by
Szabo et al. 2011). Our results show that non-transiting star-planet systems
similar to KOI-13.01 can be detected in Kepler data, including a measurement of
the orbital ephemeris and the planet's minimum mass. Moreover, we derive a
realistic estimate of the amplitudes uncertainties, and use it to show that
data obtained during the entire lifetime of the Kepler mission, of 3.5 years,
will allow detecting non-transiting close-in low-mass companions orbiting
bright stars, down to the few Jupiter mass level. Data from the Kepler Extended
Mission, if funded by NASA, will further improve the detection capabilities.Comment: Accepted to AJ on October 4, 2011. Kepler Q5 Long Cadence data will
become publicly available on MAST by October 23. Comments welcome (V2: minor
changes, to reflect proof corrections
Addressing student models of energy loss in quantum tunnelling
We report on a multi-year, multi-institution study to investigate student
reasoning about energy in the context of quantum tunnelling. We use ungraded
surveys, graded examination questions, individual clinical interviews, and
multiple-choice exams to build a picture of the types of responses that
students typically give. We find that two descriptions of tunnelling through a
square barrier are particularly common. Students often state that tunnelling
particles lose energy while tunnelling. When sketching wave functions, students
also show a shift in the axis of oscillation, as if the height of the axis of
oscillation indicated the energy of the particle. We find inconsistencies
between students' conceptual, mathematical, and graphical models of quantum
tunnelling. As part of a curriculum in quantum physics, we have developed
instructional materials to help students develop a more robust and less
inconsistent picture of tunnelling, and present data suggesting that we have
succeeded in doing so.Comment: Originally submitted to the European Journal of Physics on 2005 Feb
10. Pages: 14. References: 11. Figures: 9. Tables: 1. Resubmitted May 18 with
revisions that include an appendix with the curriculum materials discussed in
the paper (4 page small group UW-style tutorial
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