2,397 research outputs found

    Quality of Life in a Mixed Ethnic Population after Myocardial Infarction

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    Background: Although South Asian people are a significant ethnic group at increased risk of coronary heart disease and high mortality rates and experience greater delays with respect to diagnosis, referral and treatment, comparatively little is known about their quality of life during recovery from a myocardial infarction.Objectives: We sought to determine and compare the impact of ethnicity on quality of life after myocardial infarction (MI) in a mixed ethnic population (South Asian and white people) in the UK.Methods: A 2x2 mixed-group design with repeated measures on the second factor. The independent variables were ethnic group (white/South Asian) and time since MI (2 weeks/3 months). The dependent variables were the subscale scores on the Short-Form 36-item health survey (SF-36) and the Hospital Anxiety and Depression Scale (HADS).Results: At 2 weeks, significant differences were observed between groups on 5 of the 8 SF-36 subscale domain scores, with the white group reporting higher quality of life. Significant improvement in reported quality of life occurred in both groups over time on all domains of the SF-36, except bodily pain. There was a significantly greater improvement in favour of the white group for the role-physical domain. There was no significant difference between groups in terms of anxiety or depression at 2 weeks. Both groups showed a significant reduction in anxiety and depression by 3 months, but the degree of reduction was not significantly different between them. At 3 months, there was no significant difference between groups in terms of anxiety scores, but the South Asian group scored significantly higher on the depression scale.Conclusions: South Asian people have significantly poorer quality of life than white people after MI. While both groups showed improvement over time, South Asian people reported significantly less improvement in physical role function and were more depressed at 3 months. Identifying the factors accounting for such differences is important to develop models of care for delivering the most effective and culturally-sensitive interventions to this group

    Micro-scale flow on naturally occurring and engineered functional surfaces

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    The deposition and controlled flow of continuous thin liquid film droplets on surfaces containing complex microscale surface patterning (either man-made or naturally occurring) plays a key part in numerous engineering and biologically related fields. For example, in an engineering context, complex surface patterning is present in processes involving printing/photolithography [1] and the application of precision protective coatings [2]; in biological systems they occur in such diverse areas as plant disease control [3], in redistribution of lung linings in respiratory systems [4], and in sustaining life itself, as in the unusual case of the Namibian desert beetle which drinks by harvesting morning mists [5] -- the mist condenses on hydrophilic bumps on its upper surface to form larger droplets which then roll down waxy hydrophobic channels between the bumps to reach the beetle's mouth

    Properties of the Bose glass phase in irradiated superconductors near the matching field

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    Structural and transport properties of interacting localized flux lines in the Bose glass phase of irradiated superconductors are studied by means of Monte Carlo simulations near the matching field B_Phi, where the densities of vortices and columnar defects are equal. For a completely random columnar pin distribution in the xy-plane transverse to the magnetic field, our results show that the repulsive vortex interactions destroy the Mott insulator phase which was predicted to occur at B = B_Phi. On the other hand, for ratios of the penetration depth to average defect distance lambda/d <= 1, characteristic remnants of the Mott insulator singularities remain visible in experimentally accessible quantities as the magnetization, the bulk modulus, and the magnetization relaxation, when B is varied near B_Phi. For spatially more regular disorder, e.g., a nearly triangular defect distribution, we find that the Mott insulator phase can survive up to considerably large interaction range \lambda/d, and may thus be observable in experiments.Comment: RevTex, 17 pages, eps files for 12 figures include

    Thin Air, Thick Vessels: Historical and Current Perspectives on Hypoxic Pulmonary Hypertension

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    The association between pulmonary hypertension (PH) and hypoxia is well-established, with two key mechanistic processes, hypoxic pulmonary vasoconstriction and hypoxia-induced vascular remodeling, driving changes in pulmonary arterial pressure. In contrast to other forms of pulmonary hypertension, the vascular changes induced by hypoxia are reversible, both in humans returning to sea-level from high altitude and in animal models. This raises the intriguing possibility that the molecular drivers of these hypoxic processes could be targeted to modify pulmonary vascular remodeling in other contexts. In this review, we outline the history of research into PH and hypoxia, before discussing recent advances in our understanding of this relationship at the molecular level, focussing on the role of the oxygen-sensing transcription factors, hypoxia inducible factors (HIFs). Emerging links between HIF and vascular remodeling highlight the potential utility in inhibiting this pathway in pulmonary hypertension and raise possible risks of activating this pathway using HIF-stabilizing medications

    Information Presentation

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    The goal of the Information Presentation Directed Research Project (DRP) is to address design questions related to the presentation of information to the crew. The major areas of work, or subtasks, within this DRP are: 1) Displays, 2) Controls, 3) Electronic Procedures and Fault Management, and 4) Human Performance Modeling. This DRP is a collaborative effort between researchers at Johnson Space Center and Ames Research Center

    Stochastic Variational Search for ΛΛ4^{4}_{\Lambda\Lambda}H

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    A four-body calculation of the pnΛΛpn\Lambda\Lambda bound state, $^{\ 4}_{\Lambda\Lambda}H,isperformedusingthestochasticvariationalmethodandphenomenologicalpotentials.TheH, is performed using the stochastic variational method and phenomenological potentials. The NN,, \Lambda N,and, and \Lambda\LambdapotentialsaretakenfromarecentLetterbyFilikhinandGal,PRL89,172502(2002).AlthoughtheirFaddeev−Yakubovskycalculationfoundnobound−statesolutionoverawiderangeof potentials are taken from a recent Letter by Filikhin and Gal, PRL{\bf 89}, 172502 (2002). Although their Faddeev-Yakubovsky calculation found no bound-state solution over a wide range of \Lambda\Lambdainteractionstrengths,thepresentvariationalcalculationgivesabound−stateenergy,whichisclearlylowerthanthe interaction strengths, the present variational calculation gives a bound-state energy, which is clearly lower than the _\Lambda^3{H}+\Lambdathreshold,evenforaweak threshold, even for a weak \Lambda\Lambdainteractionstrengthdeducedfromarecentexperimental interaction strength deduced from a recent experimental B_{\Lambda\Lambda}(^{6}_{\Lambda\Lambda}{He})value.Thebindingenergiesobtainedarecloseto,andslightlylargerthan,thevaluesobtainedfromthethree−body value. The binding energies obtained are close to, and slightly larger than, the values obtained from the three-body d\Lambda\Lambda$ model in the Letter.Comment: Corrected typos, added addtional calculations regarding a truncated to l=0 interaction model, 4 pages, 3 figure
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