991 research outputs found
NASA/DOD Aerospace Knowledge Diffusion Research Project. Paper 33: Technical communications practices and the use of information technologies as reported by Dutch and US aerospace engineers
As part of Phase 4 of the NASA/DOD Aerospace Knowledge Diffusion Research Project, two studies were conducted that investigated the technical communications practices of Dutch and U.S. aerospace engineers and scientists. A self-administered questionnaire was distributed to aerospace engineers and scientists at the National Aerospace Laboratory (The Netherlands), and NASA ARC (U.S.), and NASA LaRC (U.S.). This paper presents responses of the Dutch and U.S. participants to selected questions concerning four of the seven project objectives: determining the importance of technical communications to aerospace engineering professionals, investigating the production of technical communications, examining the use and importance of computer and information technology, and exploring the use of electronic networks
Kepler Presearch Data Conditioning II - A Bayesian Approach to Systematic Error Correction
With the unprecedented photometric precision of the Kepler Spacecraft,
significant systematic and stochastic errors on transit signal levels are
observable in the Kepler photometric data. These errors, which include
discontinuities, outliers, systematic trends and other instrumental signatures,
obscure astrophysical signals. The Presearch Data Conditioning (PDC) module of
the Kepler data analysis pipeline tries to remove these errors while preserving
planet transits and other astrophysically interesting signals. The completely
new noise and stellar variability regime observed in Kepler data poses a
significant problem to standard cotrending methods such as SYSREM and TFA.
Variable stars are often of particular astrophysical interest so the
preservation of their signals is of significant importance to the astrophysical
community. We present a Bayesian Maximum A Posteriori (MAP) approach where a
subset of highly correlated and quiet stars is used to generate a cotrending
basis vector set which is in turn used to establish a range of "reasonable"
robust fit parameters. These robust fit parameters are then used to generate a
Bayesian Prior and a Bayesian Posterior Probability Distribution Function (PDF)
which when maximized finds the best fit that simultaneously removes systematic
effects while reducing the signal distortion and noise injection which commonly
afflicts simple least-squares (LS) fitting. A numerical and empirical approach
is taken where the Bayesian Prior PDFs are generated from fits to the light
curve distributions themselves.Comment: 43 pages, 21 figures, Submitted for publication in PASP. Also see
companion paper "Kepler Presearch Data Conditioning I - Architecture and
Algorithms for Error Correction in Kepler Light Curves" by Martin C. Stumpe,
et a
Zircon as a tracer of plumbing processes in an active magmatic system: insights from mingled magmas of the 2010 dome collapse, Montserrat, Lesser Antilles Arc, Caribbean
This project has received funding from the European Union's Hori-zon 2020 research and innovation programme under the Marie Skodowska-Curie grant agreement No. 749611 (JHS) . We also ac-knowledge funding from the Natural Environment Research Council Isotope Geoscience Facilities Steering Committee, grant IP-1746-1117 (JB) . The work has been financially supported by the Spanish grant CGL 2017-84469-P (JHS) . Funding for open access charge: Universidad de Granada/CBUA. Alexander Varychev at the University of Heidelberg, Germany, and Jeremy Rushton at the British Geological Survey, U.K., are thanked for help with analytical work. Jose Luis Macias is thanked for editorial handling. We are obliged to two anonymous reviewers for the time and effort they took to help us improve the clarity and rigour of our interpretations. 19Soufriere Hills Volcano, Montserrat, erupted from 1995 to 2010, with activity including dome growth, destructive pyroclastic density currents and Vulcanian explosions. Monitoring data, such as gas emissions, show the system is still in a state of unrest. The recent eruptions provide an opportunity to study, in real time, a complex subduction-related subvolcanic transaustal melt-mush reservoir, its magma fluxes, and the timing of crystal and melt storage prior to eruptive paroxysms. How and when mush destabilisation occurs prior to volcanic eruptions continues to be a question of intense debate. Evidence of mafic magma intrusion, a potential eruptive trigger, is preserved in enclaves with quenched and diffuse margins that are mingled with crystal-rich andesite. Here, in this first study of Soufriere Hills Volcano zircon, we report zircon ages and compositions for mafic-intermediate enclaves and host andesites from the most recent dome collapse in 2010 to place temporal constraints on magma reservoir processes. Zircon U-238-Th-230 ages disequilibrium crystallisation ages ranging between c. 2-250 ka constrain the longevity of the magmatic plumbing system. Uniform Hf isotopes, epsilon Hf 11.3 +/- 12 to 14.6 +/- 1.5, indicate invariant compositions that are typical for island arc magma sources. Zircon trace element concentrations and Ti-in-zircon crystallisation temperatures indicate crystallisation in isolated, small-volume, lenses with variable fractions of melt of heterogeneous compositions. We suggest amalgamation of assorted crystal cargoes from these lenses occurred prior to eruption during mush destabilisation triggered by mafic magma recharge. Zircon textures, on the other hand, shed light on recent centimetre-scale magma mingling immediately prior to eruption. Euhedral-subhedral zircon is preferentially preserved in or near quenched contacts of the least-evolved enclave and host andesite. By contrast, reheating of the andesite by the mafic magma recharge in the presence of zircon-undersaturated melts promoted zircon resorption. This led to the formation of subhedral-anhedral corroded zircon that is typical in the host andesite mush. Zircon thus reveals processes ranging from 100,000s of years of andesite storage to short-term partial destruction in response to transient heating and magma mixing events.European Commission 749611Natural Environment Research Council Isotope Geoscience Facilities Steering Committee IP-1746-1117Spanish Government CGL 2017-84469-PUniversidad de Granada/CBU
Impact of previous hepatitis B infection on the clinical outcomes from chronic hepatitis C? A population-level analysis
Chronic coinfection with hepatitis C virus (HCV) and hepatitis B virus (HBV) is associated with adverse liver outcomes. The clinical impact of previous HBV infection on liver disease in HCV infection is unknown. We aimed at determining any association of previous HBV infection with liver outcomes using antibodies to the hepatitis B core antigen (HBcAb) positivity as a marker of exposure. The Scottish Hepatitis C Clinical Database containing data for all patients attending HCV clinics in participating health boards was linked to the HBV diagnostic registry and mortality data from Information Services Division, Scotland. Survival analyses with competing risks were constructed for time from the first appointment to decompensated cirrhosis, hepatocellular carcinoma (HCC) and liver‐related mortality. Records of 8513 chronic HCV patients were included in the analyses (87 HBcAb positive and HBV surface antigen [HBsAg] positive, 1577 HBcAb positive and HBsAg negative, and 6849 HBcAb negative). Multivariate cause‐specific proportional hazards models showed previous HBV infection (HBcAb positive and HBsAg negative) significantly increased the risks of decompensated cirrhosis (hazard ratio [HR]: 1.29, 95% CI: 1.01‐1.65) and HCC (HR: 1.64, 95% CI: 1.09‐2.49), but not liver‐related death (HR: 1.02, 95% CI: 0.80‐1.30). This is the largest study to date showing an association between previous HBV infection and certain adverse liver outcomes in HCV infection. Our analyses add significantly to evidence which suggests that HBV infection adversely affects liver health despite apparent clearance. This has important implications for HBV vaccination policy and indications for prioritization of HCV therapy
Precision asteroseismology of the pulsating white dwarf GD 1212 using a two-wheel-controlled Kepler spacecraft
We present a preliminary analysis of the cool pulsating white dwarf GD 1212,
enabled by more than 11.5 days of space-based photometry obtained during an
engineering test of the two-reaction-wheel-controlled Kepler spacecraft. We
detect at least 19 independent pulsation modes, ranging from 828.2-1220.8 s,
and at least 17 nonlinear combination frequencies of those independent
pulsations. Our longest uninterrupted light curve, 9.0 days in length,
evidences coherent difference frequencies at periods inaccessible from the
ground, up to 14.5 hr, the longest-period signals ever detected in a pulsating
white dwarf. These results mark some of the first science to come from a
two-wheel-controlled Kepler spacecraft, proving the capability for
unprecedented discoveries afforded by extending Kepler observations to the
ecliptic.Comment: 8 pages, 4 figures, accepted for publication in The Astrophysical
Journa
Planet Hunters. V. A Confirmed Jupiter-Size Planet in the Habitable Zone and 42 Planet Candidates from the Kepler Archive Data
We report the latest Planet Hunter results, including PH2 b, a Jupiter-size
(R_PL = 10.12 \pm 0.56 R_E) planet orbiting in the habitable zone of a
solar-type star. PH2 b was elevated from candidate status when a series of
false positive tests yielded a 99.9% confidence level that transit events
detected around the star KIC 12735740 had a planetary origin. Planet Hunter
volunteers have also discovered 42 new planet candidates in the Kepler public
archive data, of which 33 have at least three transits recorded. Most of these
transit candidates have orbital periods longer than 100 days and 20 are
potentially located in the habitable zones of their host stars. Nine candidates
were detected with only two transit events and the prospective periods are
longer than 400 days. The photometric models suggest that these objects have
radii that range between Neptune to Jupiter. These detections nearly double the
number of gas giant planet candidates orbiting at habitable zone distances. We
conducted spectroscopic observations for nine of the brighter targets to
improve the stellar parameters and we obtained adaptive optics imaging for four
of the stars to search for blended background or foreground stars that could
confuse our photometric modeling. We present an iterative analysis method to
derive the stellar and planet properties and uncertainties by combining the
available spectroscopic parameters, stellar evolution models, and transiting
light curve parameters, weighted by the measurement errors. Planet Hunters is a
citizen science project that crowd-sources the assessment of NASA Kepler light
curves. The discovery of these 43 planet candidates demonstrates the success of
citizen scientists at identifying planet candidates, even in longer period
orbits with only two or three transit events.Comment: 35 pages, 11 figures, 6 tables, accepted and published on ApJ ApJ,
776, 1
Kepler Eclipsing Binary Stars. VI. Identification of Eclipsing Binaries in the K2 Campaign 0 Data-set
The original {\it Kepler} mission observed and characterized over 2400
eclipsing binaries in addition to its prolific exoplanet detections. Despite
the mechanical malfunction and subsequent non-recovery of two reaction wheels
used to stabilize the instrument, the {\it Kepler} satellite continues
collecting data in its repurposed {\it K2} mission surveying a series of fields
along the ecliptic plane. Here we present an analysis of the first full
baseline {\it K2} data release: the Campaign 0 data-set. In the 7761 light
curves, we have identified a total of 207 eclipsing binaries. Of these, 97 are
new discoveries that were not previously identified. Our pixel-level analysis
of these objects has also resulted in identification of several false positives
(observed targets contaminated by neighboring eclipsing binaries), as well as
the serendipitous discovery of two short period exoplanet candidates. We
provide catalog cross-matched source identifications, orbital periods,
morphologies and ephemerides for these eclipsing systems. We also describe the
incorporation of the K2 sample into the Kepler Eclipsing Binary
Catalog\footnote{\url{keplerebs.villanova.edu/k2}}, present spectroscopic
follow-up observations for a limited selection of nine systems, and discuss
prospects for upcoming {\it K2} campaigns.Comment: Accepted for publication in MNRAS. 51 pages [20 figures, 8 tables].
Results available online in the Kepler Eclipsing Binary Star Catalog
http://keplerebs.villanova.edu/k
Low dose influenza virus challenge in the ferret leads to increased virus shedding and greater sensitivity to oseltamivir
Ferrets are widely used to study human influenza virus infection. Their airway physiology and cell receptor distribution makes them ideal for the analysis of pathogenesis and virus transmission, and for testing the efficacy of anti-influenza interventions and vaccines. The 2009 pandemic influenza virus (H1N1pdm09) induces mild to moderate respiratory disease in infected ferrets, following inoculation with 106 plaque-forming units (pfu) of virus. We have demonstrated that reducing the challenge dose to 102 pfu delays the onset of clinical signs by 1 day, and results in a modest reduction in clinical signs, and a less rapid nasal cavity innate immune response. There was also a delay in virus production in the upper respiratory tract, this was up to 9-fold greater and virus shedding was prolonged. Progression of infection to the lower respiratory tract was not noticeably delayed by the reduction in virus challenge. A dose of 104 pfu gave an infection that was intermediate between those of the 106 pfu and 102 pfu doses. To address the hypothesis that using a more authentic low challenge dose would facilitate a more sensitive model for antiviral efficacy, we used the well-known neuraminidase inhibitor, oseltamivir. Oseltamivir-treated and untreated ferrets were challenged with high (106 pfu) and low (102 pfu) doses of influenza H1N1pdm09 virus. The low dose treated ferrets showed significant delays in innate immune response and virus shedding, delayed onset of pathological changes in the nasal cavity, and reduced pathological changes and viral RNA load in the lung, relative to untreated ferrets. Importantly, these observations were not seen in treated animals when the high dose challenge was used. In summary, low dose challenge gives a disease that more closely parallels the disease parameters of human influenza infection, and provides an improved pre-clinical model for the assessment of influenza therapeutics, and potentially, influenza vaccines
Kepler Presearch Data Conditioning I - Architecture and Algorithms for Error Correction in Kepler Light Curves
Kepler provides light curves of 156,000 stars with unprecedented precision.
However, the raw data as they come from the spacecraft contain significant
systematic and stochastic errors. These errors, which include discontinuities,
systematic trends, and outliers, obscure the astrophysical signals in the light
curves. To correct these errors is the task of the Presearch Data Conditioning
(PDC) module of the Kepler data analysis pipeline. The original version of PDC
in Kepler did not meet the extremely high performance requirements for the
detection of miniscule planet transits or highly accurate analysis of stellar
activity and rotation. One particular deficiency was that astrophysical
features were often removed as a side-effect to removal of errors. In this
paper we introduce the completely new and significantly improved version of PDC
which was implemented in Kepler SOC 8.0. This new PDC version, which utilizes a
Bayesian approach for removal of systematics, reliably corrects errors in the
light curves while at the same time preserving planet transits and other
astrophysically interesting signals. We describe the architecture and the
algorithms of this new PDC module, show typical errors encountered in Kepler
data, and illustrate the corrections using real light curve examples.Comment: Submitted to PASP. Also see companion paper "Kepler Presearch Data
Conditioning II - A Bayesian Approach to Systematic Error Correction" by Jeff
C. Smith et a
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