Specific inhibition of GPI-anchored protein function by homing and self-association of specific GPI anchors

The functional specificity conferred by glycophosphatidylinositol (GPI) anchors on certain membrane proteins may arise from their occupancy of specific membrane microdomains. We show that membrane proteins with noninteractive external domains attached to the same carcinoembryonic antigen (CEA) GPI anchor, but not to unrelated neural cell adhesion molecule GPI anchors, colocalize on the cell surface, confirming that the GPI anchor mediates association with specific membrane domains and providing a mechanism for specific signaling. This directed targeting was exploited by coexpressing an external domain-defective protein with a functional protein, both with the CEA GPI anchor. The result was a complete loss of signaling capabilities (through integrin–ECM interaction) and cellular effect (differentiation blockage) of the active protein, which involved an alteration of the size of the microdomains occupied by the active protein. This work clarifies how the GPI anchor can determine protein function, while offering a novel method for its modulation

Duality Invariant Magnetohydrodynamics And Dyons

The theory of magnetohydrodynamics is extended to the cases of a plasma of separate magnetic and electric charges, as well as to a plasma of dyons respectively. In both these cases the system possesses electric-magnetic duality symmetry. In the former case we find that because of the existence of two independent generalized Ohm's law equations, the limit of infinite electric and magnetic conductivity results in the vanishing of both electric and magnetic fields, as well as the corresponding currents. In the dyonic case, we find that the resulting duality-invariant system of equations are equivalent to those of ordinary MHD, after suitable field redefinitions.Comment: 11 pages, late

A Boron–Boron Double Transborylation Strategy for the Synthesis of gem-Diborylalkanes

Olefin hydroboration reactions provide efficient access to synthetically versatile and easily handled organoboronic esters. In this study, we demonstrate that the commercially available organoborane reagent 9-borabicyclo[3.3.1]nonane (H-B-9-BBN) can serve as a catalyst for the sequential double hydroboration of alkynes using pinacolborane (HBpin). This strategy, which is effective for a wide range of terminal alkynes, is predicated upon a key C(sp3)-B/B-H transborylation reaction. Transition-state thermodynamic parameters and 10-boron-isotopic labeling experiments are indicative of a σ-bond metathesis exchange pathway

Proximity-induced magnetism in Pt layered with rare-earth–transition-metal ferrimagnetic alloys

The proximity-induced moment (PIM) in heavy metal layers may play a significant role in heterostructured spintronic systems. In particular, the PIM of a heavy metal adjacent to a magnetic layer has been linked to interfacial spin transport behavior. Element-resolved x-ray magnetic measurements were used to investigate PIM in Pt layered with two different rare-earth (RE):3d transition-metal (TM) ferrimagnetic alloys in which the net moment was dominated by either the RE or the TM at room temperature. We observed significant PIM in Pt confined to a 2-nm interfacial region for Pt/Co77Gd23 and Pt/(Fe50Co50)77Gd23 and, in both cases, the PIM was parallel to the TM sublattice rather than the RE or the net moment. Our results highlight the prominence of the d−d mediated interactions between the Pt and the constituents of the ferrimagnetic RE:TM alloys over the net macroscopic moment