The crowbar model of method and its implications

There is a rough, long-term tradeoff between rate of innovation and degree of strong realism in scientific practice, a point reflected in historically changing conceptions of method as they retreat from epistemological foundationism to a highly fallibilistic, modeling perspective. The successively more liberal, innovation-stimulating methods open up to investigation deep theoretical domains at the cost, in many cases, of moving away from strong realism as a likely outcome of research. The crowbar model of method highlights this tension, expressed as the crowbar compromise and the crowbar fallacy. The tools-to-theories heuristic, described and evaluated by Gigerenzer and colleagues, can be regarded as an attempt by some scientific realists to overcome this compromise. Instead, it is an instance of it. Nonetheless, in successful applications the crowbar model implies a modest, instrumental (nonrepresentational) realism

Guest editors’ introduction

Guest editors' introduction to "Innovation in/through science"

Models and Inferences in Science

The book answers long-standing questions on scientific modeling and inference across multiple perspectives and disciplines, including logic, mathematics, physics and medicine. The different chapters cover a variety of issues, such as the role models play in scientific practice; the way science shapes our concept of models; ways of modeling the pursuit of scientific knowledge; the relationship between our concept of models and our concept of science. The book also discusses models and scientific explanations; models in the semantic view of theories; the applicability of mathematical models to the real world and their effectiveness; the links between models and inferences; and models as a means for acquiring new knowledge. It analyzes different examples of models in physics, biology, mathematics and engineering. Written for researchers and graduate students, it provides a cross-disciplinary reference guide to the notion and the use of models and inferences in science

British signals intelligence and the 1916 Easter Rising in Ireland

Historians for decades have placed Room 40, the First World War British naval signals intelligence organization, at the centre of narratives about the British anticipation of and response to the Easter Rising in Ireland in 1916. A series of crucial decrypts of telegrams between the German embassy in Washington and Berlin, it has been believed, provided significant advance intelligence about the Rising before it took place. This article upends previous accounts by demonstrating that Room 40 possessed far less advance knowledge about the Rising than has been believed, with most of the supposedly key decrypts not being generated until months after the Rising had taken place

Nonuniform Cardiac Denervation Observed by 11C-meta-Hydroxyephedrine PET in 6-OHDA-Treated Monkeys

Parkinson's disease presents nonmotor complications such as autonomic dysfunction that do not respond to traditional anti-parkinsonian therapies. The lack of established preclinical monkey models of Parkinson's disease with cardiac dysfunction hampers development and testing of new treatments to alleviate or prevent this feature. This study aimed to assess the feasibility of developing a model of cardiac dysautonomia in nonhuman primates and preclinical evaluations tools. Five rhesus monkeys received intravenous injections of 6-hydroxydopamine (total dose: 50 mg/kg). The animals were evaluated before and after with a battery of tests, including positron emission tomography with the norepinephrine analog 11C-meta-hydroxyephedrine. Imaging 1 week after neurotoxin treatment revealed nearly complete loss of specific radioligand uptake. Partial progressive recovery of cardiac uptake found between 1 and 10 weeks remained stable between 10 and 14 weeks. In all five animals, examination of the pattern of uptake (using Logan plot analysis to create distribution volume maps) revealed a persistent region-specific significant loss in the inferior wall of the left ventricle at 10 (P<0.001) and 14 weeks (P<0.01) relative to the anterior wall. Blood levels of dopamine, norepinephrine (P<0.05), epinephrine, and 3,4-dihydroxyphenylacetic acid (P<0.01) were notably decreased after 6-hydroxydopamine at all time points. These results demonstrate that systemic injection of 6-hydroxydopamine in nonhuman primates creates a nonuniform but reproducible pattern of cardiac denervation as well as a persistent loss of circulating catecholamines, supporting the use of this method to further develop a monkey model of cardiac dysautonomia

Nickles, Thomas, What is a Problem that We Might Solve It? Synthese, 47(1,1981), 85-118.*

Discusses criteria for an adequate theory of problems (33 divided into 3 categories), critiques Laudan\u27s theory in light of these criteria, and offers his own account