Farmstead and Household Archaeology at the Barrett Farm, Concord, Massachusetts

Changes in the landscape across the Barrett farmstead in Concord, Massachusetts, are examined and related to changes in the household during the 1850s and 1860s. Although the Barrett family had a long and prosperous tradition of farming in Concord, this changed at the end of the 19th-century, as the farm was reduced in size and the operation reduced in scale. The majority of artifacts and data recovered from an excavation in 2007 by UMass Boston dealt with the 19th-century occupation of the farmstead. Changes in the household and across the farmstead in the 19th-century can be seen archaeologically through the formation of features, including a ceramic midden behind the collapsed east ell. Changes in the landscape are linked to specific households. The economic factors affecting the 19th-century households are examined. The archaeological evidence, supported by documents, help show how external pressures shaped the landscape of a New England farmstead

Evaluating Disparities in Proton Radiation Therapy Use in AHOD1331, a Contemporary Children\u27s Oncology Group Trial for Advanced-Stage Hodgkin Lymphoma

The indications for proton radiation therapy carry the strongest evidence in pediatric cancers. In a recently published letter, Bitterman et al reviewed factors associated with receipt of proton radiation therapy in patients enrolled in Children\u27s Oncology Group (COG) solid tumor and CNS tumor trials. They demonstrated that Black children were less likely to receive this treatment than non-Hispanic white patients, a disparity that persisted when controlling for other demographic and clinical variables. We strongly commend them for their work, as addressing racism and infrastructural barriers to care requires its identification

Effects of enamel matrix derivative and transforming growth factor-β1 on human osteoblastic cells

<p>Abstract</p> <p>Background</p> <p>Extracellular matrix proteins are key factors that influence the regenerative capacity of tissues. The objective of the present study was to evaluate the effects of enamel matrix derivative (EMD), TGF-β1, and the combination of both factors (EMD+TGF-β1) on human osteoblastic cell cultures.</p> <p>Methods</p> <p>Cells were obtained from alveolar bone of three adult patients using enzymatic digestion. Effects of EMD, TGF-β1, or a combination of both were analyzed on cell proliferation, bone sialoprotein (BSP), osteopontin (OPN) and alkaline phosphatase (ALP) immunodetection, total protein synthesis, ALP activity and bone-like nodule formation.</p> <p>Results</p> <p>All treatments significantly increased cell proliferation compared to the control group at 24 h and 4 days. At day 7, EMD group showed higher cell proliferation compared to TGF-β1, EMD + TGF-β1 and the control group. OPN was detected in the majority of the cells for all groups, whereas fluorescence intensities for ALP labeling were greater in the control than in treated groups; BSP was not detected in all groups. All treatments decreased ALP levels at 7 and 14 days and bone-like nodule formation at 21 days compared to the control group.</p> <p>Conclusions</p> <p>The exposure of human osteoblastic cells to EMD, TGF-β1 and the combination of factors <it>in vitro </it>supports the development of a less differentiated phenotype, with enhanced proliferative activity and total cell number, and reduced ALP activity levels and matrix mineralization.</p

Farmstead and household archaeology at the Barrett Farm, Concord, Massachusetts

Changes in the landscape across the Barrett farmstead in Concord, Massachusetts, are examined and related to changes in the household during the 1850s and 1860s. Although the Barrett family had a long and prosperous tradition of farming in Concord, this changed at the end of the 19th-century, as the farm was reduced in size and the operation reduced in scale. The majority of artifacts and data recovered from an excavation in 2007 by UMass Boston dealt with the 19th-century occupation of the farmstead. Changes in the household and across the farmstead in the 19th-century can be seen archaeologically through the formation of features, including a ceramic midden behind the collapsed east ell. Changes in the landscape are linked to specific households. The economic factors affecting the 19th-century households are examined. The archaeological evidence, supported by documents, help show how external pressures shaped the landscape of a New England farmstead

Diagnosis of Fournier's Gangrene on Bedside Ultrasound

[West J Emerg Med. 2014;15(2):122.

Ultrasound Diagnosis of Urethral Calculi

This images case demonstrates the utility of bedside focused ultrasound performed by the Emergency Physician in making the accurate diagnosis of an impacted urethral stone. [West J Emerg Med. 2012;13(6):515

Hepatic Portal Venous Gas: Findings on Ultrasound and CT

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Ultrasound Detection of a Renal Mass in a Patient with Flank Pain and Hematuria

Flank pain with hematuria is a common chief complaint in the emergency department (ED). Patients are often diagnosed with renal calculi or pyelonephritis and discharged with analgesics or antibiotics and follow-up. This case study describes a patient who presented to the ED with a 1 week history of flank pain and hematuria and was subsequently found to have a large renal mass on bedside ultrasound