13 research outputs found
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
- Author
- A Abbate
- A Abhyankar
- A Adams
- A Agafina
- A Akyea-Djamson
- A Alan
- A Alfieri
- A Alfrey
- A Alvarisqueta
- A Amos
- A Anadiotis
- A Anneveldt
- A Antolick
- A Arthur
- A Aslam
- Abaci F
- Abdullakutty J
- Abhaichand R
- Abib E Jr
- Aboufakher R
- Abrantes J
- Abreu M
- Abulencia K
- Acampora D
- Acampora M
- Accini Mendoza Jl
- Aceto L
- Acevedo B
- Acevedo L
- Acheatel R
- Actis Mv
- Adams M
- Adjic Nc
- Affaki Gs
- Agarwal Dk
- Aggarwal Rk
- Agosta Gf
- Aguilar M
- Aguilar M
- Ahire N
- Ahmad I
- Ahmed Sh
- Ahn Y
- Aish B
- Aiub F
- Aiub J
- Ajax K
- Ajioka M
- Akai Y
- Akatova E
- Akrap B
- Al Joundi T
- Al-Khalili F
- Albisu J
- Alcalde Jm
- Alcide P
- Alfonso T
- Allen J
- Alllison Dc
- Almaliky T
- Amerena J
- Andersen K
- Andor M
- Angelova I
- Angiolillo D
- Anita S
- Anker Sd
- Antalik L
- Antonicelli R
- Aparicio Cv
- Apel T
- Apostolovic S
- Ara M
- Aragorn L
- Arango Jl
- Araujo Fonseca M
- Ardissino D
- Arenas Leon Jl
- Arevalo S
- Argiolas G
- Arif I
- Armas E
- Aron G
- Arora S
- Asafu-Adjaye N
- Ashcom T
- Ashford M
- Ashino K
- Asim Oktay Ao
- Assarsson E
- Ata B
- Ather N
- Atieh M
- Aull L
- Avalos V
- Avdonina N
- Awasthi Ak
- Axthelm C
- Ayala M
- Ayasse D
- Ayasse M
- Azizad M
- Azize Gm
- B Becker
- Baar M
- Babu R
- Backer T
- Badea C
- Baden M
- Baehl S
- Baek C
- Baeumer A
- Bagi Es
- Bai A
- Bailey K
- Bailey S
- Bair S
- Baker A
- Baker C
- Bakhai A
- Bakker H
- Baksi A
- Baldin Mg
- Bali Hk
- Ballantyne C
- Ballmajo M
- Balode A
- Balukova E
- Bang Sa
- Banker D
- Banker K
- Baquero A
- Barbarash Ol
- Barbato E
- Barbosa E
- Barnett S
- Baron S
- Barreto M
- Barroso A
- Barroso W
- Bartkowiak A
- Bartosh L
- Bartuseviciene S
- Bashir K
- Baszak J
- Bata Ir
- Bayram E
- Beall K
- Beaudry M
- Beauregard La
- Beckett L
- Belejchak P
- Belle Isle J
- Belohlavek J
- Bendelow T
- Bender D
- Benedetti G
- Benjamin S
- Benton J
- Berdoff R
- Berger V
- Bergeron P
- Bergholtz T
- Bergler-Klein J
- Berk M
- Berli Ma
- Bernstein M
- Berra Fc
- Berti S
- Berulfsen A
- Bevilacqua Mt
- Bhadade S
- Bilazarian S
- Bilodeau N
- Binder A
- Binns Y
- Birdane A
- Bisne V
- Bitzer V
- Blagdon M
- Blahey M
- Blankenberg S
- Blazsek Z
- Bloch S
- Blom Kb
- Bluemel J
- Blumberg C
- Blumenthal R
- Bocanera M
- Bodanese L
- Boffetti P
- Bohra P
- Bohula E
- Boivin Mc
- Bolduc H
- Boley K
- Bolognesi Mg
- Bolsmann C
- Boman K
- Bonner J
- Borrayo Na
- Boström På
- Botelho R
- Botta C
- Boudreaux R
- Boulanger K
- Bourgeois S
- Bouvy C
- Bowen L
- Boyarkin M
- Bradley A
- Brady L
- Bramlet D
- Brath H
- Braun P
- Bredlau C
- Brickman T
- Briggs S
- Briké C
- Brodmann M
- Brons S
- Brousalis L
- Brouwer M
- Brown C
- Brown N
- Brown S
- Buchannan C
- Budaj A
- Budassi N
- Budkova J
- Bugan V
- Buhlman S
- Bulashova O
- Bunschoten P
- Burke W
- Burley T
- Burova N
- Burris H
- Burton C
- Burton J
- Burton M
- Burtt D
- Busak L
- Busic N
- Byars W
- Bøen Rh
- C Clavier-Firmin
- C Conradie
- C Contzen
- C Cotes
- C Covert
- C Cuneo
- Caballero-Valiente B
- Cabau Jr
- Calabrese A
- Campanale Eg
- Candusso R
- Cantor W
- CANTOS Trial Group. Krum H
- Capova L
- Carabajal T
- Carr K
- Carrillo J
- Caruso G
- Casala J
- Caso P
- Casoinic F
- Castillo J
- Castillo T
- Cech V
- Cei L
- Cendali G
- Cepinskiene L
- Cerda L
- Cermak O
- Chachalis G
- Chaggar S
- Chambers J
- Chamblee T
- Chang K
- Chang Kc
- Chang Wh
- Charlier F
- Charmarthi B
- Chattin W
- Chauhan D
- Chauhan H
- Chaussé I
- Chavada J
- Chaverra I
- Chaware G
- Chee L
- Chella S
- Chen Cp
- Chen J
- Chen Mh
- Chen Y
- Chen Yc
- Chen Zc
- Cheng Jj
- Cheng S
- Cheng Sm
- Cherlin R
- Cheung D
- Chhabra A
- Chintala P
- Chiodi L
- Choi Aj
- Chou S
- Chouinard G
- Christensen L
- Christenson S
- Chung A
- Churina S
- Cifkova R
- Ciglenecki N
- Cioffi A
- Cislowski D
- Cleveland T
- Clocotan M
- Cmrecnjak J
- Colfer H
- Colhoun H
- Collier D
- Collins R
- Coloma G
- Colquhoun D
- Colvin T
- Coman S
- Commerford P
- Commerford P
- Conrado Y
- Cools F
- Cornel Jh
- Corona V
- Coronel J
- Cosgrove N
- Cosgrove S
- Cosmi F
- Costa Amorim R
- Coufalova Z
- Covell W
- Cox B
- Cox R
- Craig W
- Crandall L
- Crawford G
- Crea F
- Crepps K
- Crocamo A
- Cromer M
- Cruz H
- Cruz H
- Cruz M
- Csala L
- Cucher F
- Cuentas I
- Cuervo A
- Curiac D
- Cymerman K
- Cyprian R
- Czerski T
- D'Amours Dg
- D Dash
- D Dattani
- D Denham
- D Desai
- D Desalle
- D Digangi
- D Dunn
- Da Costa F
- Da Silva A
- Da Silva D Jr
- Da Silva O Jr
- Dahlen G
- Dalseg Am
- Damron M
- Danik J
- Davalos C
- Dave B
- Dave K
- Davidsson K
- Davies M
- Davies N
- Davis B
- Davis M
- Dawkins-Hughes S
- Dawood Sy
- Dayer M
- De Boer P
- De Caterina R
- De Jong C
- De Knijf K
- De Krumbach L
- De Los Milagros Had M
- De Los Rios M
- De Rosa S
- De Vos A
- De Wolf L
- Dean J
- Debnam S
- Decsi K
- Decsi Kl
- Dedek V
- Dedkova S
- Defosse C
- Degennaro N
- Dehning M
- Dela Llana A
- Delfonso F
- Delforge M
- Delgadillo T
- Dellasa M
- Dellborg M
- Dellorso M
- Demidova M
- Den Hartog F
- Denecke C
- Dengler T
- Dermitzakis A
- Deslongchamps F
- Dessalvi Cc
- Destro M
- Dettmer M
- Devasia T
- Deweerdt N
- Dhanak R
- Dhawan M
- Di Biase M
- Diago M
- Diaz M
- Dicken T
- Dickstein K
- Diederich C
- Diederich M
- Diehl R
- Diller P
- Dimattia M
- Dimitrov G
- Diodati J
- Dobariya H
- Dobilas V
- Dodds G
- Doesborg L
- Doggett J
- Dognini Gp
- Doi M
- Dokupilova A
- Dommerholt R
- Donahue K
- Donath M
- Donaubauer T
- Dong X
- Dormidontova G
- Dorogova I
- Dos Santos A
- Dos Santos F
- Dos Santos P
- Doughty A
- Doughty L
- Dovgalevskiy Y
- Dovgolis S
- Dragutksy B
- Dreese M
- Drost I
- Drouin K
- Duchesne L
- Duckert A
- Duda N
- Dudarev M
- Dudhatra N
- Duff J
- Duhan S
- Dunhurst F
- Dussan Ma
- Dutka C
- Dwenger E
- Dzupina A
- Dékány Jn
- E Eleuteri
- E Englmann
- Earl J
- East C
- Eaton C
- Eaves W
- Ebeling K
- Ebrahim I
- Eccleston D
- Echeverria L
- Eder F
- Edgerton L
- Edillo C
- Edwards J
- Edwards T
- Eichinger G
- Einhorn D
- Eki Y
- El Hachem M
- El Hafi S
- Ellenbroek D
- Ellis M
- Emil B
- Endo T
- Engelen W
- Erhard M
- Erickson B
- Ervin W
- Eskridge L
- Espinosa V
- Everett Bm
- F Fedele
- F Fonseca
- F Fucci
- Facello A
- Facello M
- Faghih M
- Fail P
- Falcon D
- Fang C
- Fang Cy
- Farias E
- Fattal P
- Fawson A
- Feitosa G
- Felario Junior Ga
- Felix L
- Feng Y
- Feng Z
- Ferdinand K
- Ferkl R
- Fernandez Aa
- Ferrari V
- Ferrario M
- Ferraz R
- Ferreira Dos Santos T
- Ferreira-Jardim A
- Fien E
- Filardi Pp
- Filho P
- Fintel D
- Firek C
- Fischer Sm
- Fisher J
- Fitilev S
- Fitz-Patrick D
- Fitzpatrick L
- Flaksa I
- Flather M
- Flezar M
- Fliesser-Goerzer E
- Flores E
- Flores E
- Flores Gs
- Flores H
- Floro T
- Foerster A
- Folkeringa Rj
- Fonseca A
- Fontaine S
- Forgon T
- Forgosh L
- Forker A
- Forster T
- Foster M
- Foucauld J
- Fowler V
- Fox B
- Franco M
- Francoeur L
- Frandsen B
- Frandsen B
- Frankenstein L
- Fratczak M
- Freitas E
- French J
- Frivold G
- Fruchter G
- Fu G
- Fucak E
- Fuchs R
- Fucili A
- Fukuike C
- Fullerton D
- Fulop P
- Fulop T
- Fulwani M
- Furch G
- Furuseth B
- G Gacioch
- G Gosselin
- Gabito A
- Gabor M
- Gabriel J
- Gabrielli D
- Gaeb-Strasas B
- Gamba C
- Ganau A
- Gapon L
- Garas S
- Garcia Duran R
- Garcia Pinna J
- Garcia Rinaldi R
- Garcia F
- Garcia N
- Garcia-Fragoso V
- Garcia-Portela M
- Garner K
- Gazizianova V
- Gelb R
- Genest J
- Genova D
- George F
- Germann H
- Gersh B
- Gervais B
- Ghali J
- Ghondale N
- Ghosh N
- Ghosh S
- Giese C
- Gilbert J
- Gilley J
- Gits F
- Glancy R
- Glenny J
- Glover J
- Glynn Rj
- Godoy Sanchez M
- Goette A
- Goff R
- Goffinet C
- Gohel P
- Goldberg N
- Gomez Sanchez J
- Gonsorcik J
- Gonzales D
- Gonzales V
- Gonzalez E
- Gordeev I
- Gorges R
- Gospodinov K
- Gotcheva N
- Goudev A
- Gould R
- Govindaraj D
- Goyal B
- Goyal S
- Grabeau R
- Grable M
- Graham J
- Graham Ja
- Graif J
- Gralow J
- Gravellone M
- Gravenhorst-Muenter U
- Green E
- Greener R
- Greenway F
- Grieshaber V
- Griffin S
- Grigaraviciene I
- Grigorova V
- Gros C
- Grosse A
- Grover A
- Grundtvig M
- Gudipati Rvc
- Guerrero A
- Guillinta P
- Gundala Ak
- Gupta A
- Gupta A
- Gupta M
- Gupta V
- Gutmann J
- Guzman I
- Guzman P
- Gwyn M
- Gyorgyova E
- H Haldane
- H Hansen
- H Haught
- H Hill
- Haase F
- Haege R
- Haenel T
- Hage F
- Hageman T
- Hagemann D
- Hagenow A
- Hagiwara Y
- Haidar A
- Haider K
- Hakas J
- Haldis T
- Hall C
- Hall L
- Hall S
- Halliwell Tc
- Halpern S
- Hamer Bjb
- Hamud-Socoro A
- Han B
- Han S
- Hanak P
- Hanefeld M
- Hangyal T
- Hansson A
- Hanustiakova A
- Hao Y
- Hardas S
- Hardee L
- Harrell W
- Harrington A
- Harris B
- Hartleib M
- Hartwell J
- Hasan F
- Hasbani E
- Hasegawa K
- Hattler B
- Haughton G
- Haynes E
- Haywood A
- He Y
- He Z
- Heaney L
- Hecht J
- Heeren G
- Hegedus V
- Heider J
- Heisters J
- Henley L
- Hennig D
- Henriksson A
- Hermans K
- Hernandez E
- Hernandez I
- Hernandez M
- Hernández N
- Herrman Jp
- Herzog W
- Hess E
- Hettwer Magedanz E
- Hickey L
- Hiden C
- Hielscher S
- Higuchi T
- Higuchi Y
- Hilkert R
- Hilton T
- Himpel-Boenninghoff A
- Hinderaker P
- Hioki M
- Hirayama A
- Hiroma J
- Ho Cj
- Hodnett P
- Hoffman M
- Hofsoey K
- Hogan C
- Hollanders G
- Holmes Z
- Holoubek D
- Holscher A
- Hominal M
- Homza M
- Hong T
- Hong T
- Hoogslag Pam
- Horackova K
- Horak A
- Hornig M
- Horvat P
- Hosokawa S
- Hotchkiss D
- Houra M
- Hristova K
- Hsieh Ic
- Huang A
- Huang P
- Huang Ph
- Humbert J
- Hurtig U
- Hutchens E
- Huynh T
- Hwang Jj
- Hwang Jj
- Hyun K
- Härstedt N
- Høivik Ho
- I Ilic
- I Ivanov
- Iachini K
- Iannopollo G
- Ibarra J
- Ibarra M
- Ibañez J
- Iby M
- Ichisawa M
- Igbokidi O
- Iijima T
- Ilahi T
- Ilic S
- Ilsley M
- Imbrognio M
- Imre Bs
- Inada T
- Inagaki M
- Indolfi C
- Infusino F
- Invitti C
- Ipp E
- Isaza D
- Istratoaie O
- Istvan Kp
- Iteld B
- Ito K
- Ivan P
- Iveta H
- Izmozherova N
- J Jiang
- J Johnson
- J Johnston
- J Jose
- Jacques G
- Jafri A
- Jafry B
- Jagtap P
- Jaguszewska G
- Jain A
- Jansen M
- Jardula M
- Jayasinghe R
- Jefferson D
- Jenkins R
- Jensen Ed
- Jeric M
- Jerzewski A
- Jeserich M
- Jia Z
- Jiang T
- Jiang X
- Jimenez D
- Jirvankar P
- Johansen Bb
- Johansen E
- Johansson K
- Johnson E
- Jones S
- Jonsson Je
- Joosten C
- Joshi U
- Julien Ve
- JuliĂŁo K
- Jure D
- Jure H
- Jutrisa N
- K Kaigawa
- K Katahira
- K Kiroglu
- K Kordic
- K Kostov
- Kabakchieva Vm
- Kaczmarek N
- Kafarakis P
- Kaiserova L
- Kajihara S
- Kala P
- Kaldara E
- Kalina A
- Kalkman C
- Kam J
- Kamensky G
- Kamiya H
- Kamiya J
- Kan G
- Kaneno Y
- Kanitz S
- Kapp I
- Kara Yd
- Karakai H
- Karel I
- Karpuram M
- Karsai Xz
- Kastelein Jjp
- Kataoka M
- Katona A
- Katova T
- Kaur H
- Kawahara M
- Kawai M
- Kawasaki T
- Kawka-Urbanek T
- Kazanskay E
- Ke Y
- Keba E
- Keenan S
- Kelehan S
- Kellnerova I
- Kelly R
- Kelt T
- Kendall T
- Kereiakes D
- Khan A
- Khan M
- Khan R
- Khan S
- Khariouzov A
- Khirmanov V
- Khromtsova O
- Kick J
- Kiefer R
- Kietselaer B
- Kim B
- Kim Ks
- Kim M
- Kimmel M
- King A
- King T
- Kirkland S
- Kiss Rg
- Kissel S
- Kitchens D
- Klamm M
- Klein C
- Klein P
- Klemsdal To
- Kleve R
- Klugherz B
- Knight J
- Knutsson A
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- Kobalava Z
- Kodem Dr
- Koeitti P
- Koenig W
- Kojima E
- Kok M
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- Koleckar P
- Kolikova V
- Kolleroy C
- Kolokathis F
- Komati S
- Komura Y
- Kondagunta V
- Konradi A
- Kooiman E
- Kopaczewski J
- Kopczyńska M
- Korban E
- Koren M
- Kormann A
- Korte M
- Korth-Wiemann B
- Kose V
- Kosmacheva E
- Kostakou P
- Kostis J
- Kotek L
- Kouz Sm
- Kovacic D
- Kovacs A
- Kozak M
- Kozlova S
- Krapivsky A
- Kreckova M
- Kreutter F
- Krupciakova B
- Krupicka J
- Kuenzler J
- Kulibaba E
- Kulkarni L
- Kullal P
- Kultursay H
- Kumar Ks
- Kumbla M
- Kuntzsch A
- Kuo Jy
- Kuramochi T
- Kuruma T
- Kusnick B
- Kuzin A
- Kyo E
- L Levinson
- L Lim
- L Link
- L Liu
- Laane E
- Labovitz R
- Lachance P
- Lai Wt
- Lail J
- Lainscak M
- Lake J
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- Landzberg J
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- Ledger G
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- Leggewie S
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- Lembo G
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- Liberato Nl
- Libov I
- Lierse T
- Ligueros M
- Lillo J
- Lima F
- Limaye Ap
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- Lindner C
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- Lipchenko A
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- Lok Dja
- Long C
- Longaker R
- Lopes R
- Lopez P
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- Lorenzatti A
- Lousberg A
- Lozhkina N
- Lu Z
- Luciardi H
- Lucksinger G
- Luecke-Uzar M
- Luedemann J
- Lukac J
- Lundqvist M
- Lupkovics G
- Luquez H
- Luz Serrano H
- Lv Y
- Lynd S
- Lysek R
- Lönnberg I
- M Malek
- M Mallagray
- M Mandati
- M Mandviwala
- M Marsters
- M Mays
- M Mcdonald
- M Medvegy
- M Meinrich
- M Mikus
- M Milanova
- M Moustafa
- Ma C
- Ma G
- Maboyi S
- Macdonald J
- Macfadyen Jg
- Machova V
- Madder R
- Maehara G
- Maffei L
- Magness K
- Maheshwari A
- Maheux K
- Maia L
- Majercak I
- Majul C
- Makedonska Jj
- Makhe B
- Makotoko E
- Malchikova S
- Maletz L
- Malhotra S
- Malhotra V
- Malik J
- Mancikova I
- Mandic L
- Manenti E
- Manfreda S
- Manga P
- Mani Ck
- Mani H
- Manne S
- Manning B
- Mannucci E
- Manolis A
- Manolis Aj
- Manov E
- Mantas I
- Manuel J
- Manukov D
- Manukov I
- Manyari D
- Manzur F
- Marcela Wenetz Lm
- Marchelletta N
- Marchi Al
- Marcinkeviciene J
- Marcun R
- Marengo Garcia De Carvalho L
- Marinaro S
- Marino P
- Mariottoni B
- Maron B
- Marschke T
- Marshall L
- Martin E
- Martin L
- Martinez E
- Martinez J
- Maruzzo S
- Marziali A
- Masarikova L
- Massaccesi R
- Mathew A
- Matyasek I
- Mauersberger K
- Maus O
- Mavromatis K
- Maximov D
- Mayer T
- Maynard R
- Mays B
- Mazutavicius R
- Mbulaiteye A
- Mcalister R
- Mccoy C
- Mccrary D Jr
- Mccullough-O'Brien H
- Mcgill J
- Mcgrew F
- Mcintosh C
- Mckenzie A
- Mckenzie C
- Mckibbin A
- Mclaurin B
- Mclellan Ba
- Mcmahon G
- Mcneil D
- Mcneill R
- Mcpherson C
- Medina F
- Megalou A
- Mehrle A
- Mehta A
- Mehta S
- Meijlis P
- Meissner A
- Mejia I
- Melbie K
- Mellberg L
- Melliza T
- Mendoza N
- Mendoza Y
- Mercuro G
- Merkely B
- Messina T
- Mestdagh I
- Meyer R
- Michalaros Y
- Michalska A
- Michaud N
- Michel K
- Mickel C
- Micko K
- Mihaly N
- Mikdadi G
- Mikusova T
- Milicic D
- Militaru C
- Miliuniene R
- Milkas A
- Miller A
- Miller C
- Miller G
- Miller R
- Miller W
- Minescu B
- Minocha G
- Mitchell J
- Mittal A
- Miyamoto T
- Moats Djr
- Modi R
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- Yong H
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- Yoshimoto E
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- Youssef G
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- Zieve F
- Zineldine A.
- Zirlik A
- Zucchetti C
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, nonfatal stroke, or cardiovascular death. RESULTS: At 48 months, the median reduction from baseline in the high-sensitivity C-reactive protein level was 26 percentage points greater in the group that received the 50-mg dose of canakinumab, 37 percentage points greater in the 150-mg group, and 41 percentage points greater in the 300-mg group than in the placebo group. Canakinumab did not reduce lipid levels from baseline. At a median follow-up of 3.7 years, the incidence rate for the primary end point was 4.50 events per 100 person-years in the placebo group, 4.11 events per 100 person-years in the 50-mg group, 3.86 events per 100 person-years in the 150-mg group, and 3.90 events per 100 person-years in the 300-mg group. The hazard ratios as compared with placebo were as follows: in the 50-mg group, 0.93 (95% confidence interval [CI], 0.80 to 1.07; P = 0.30); in the 150-mg group, 0.85 (95% CI, 0.74 to 0.98; P = 0.021); and in the 300-mg group, 0.86 (95% CI, 0.75 to 0.99; P = 0.031). The 150-mg dose, but not the other doses, met the prespecified multiplicity-adjusted threshold for statistical significance for the primary end point and the secondary end point that additionally included hospitalization for unstable angina that led to urgent revascularization (hazard ratio vs. placebo, 0.83; 95% CI, 0.73 to 0.95; P = 0.005). Canakinumab was associated with a higher incidence of fatal infection than was placebo. There was no significant difference in all-cause mortality (hazard ratio for all canakinumab doses vs. placebo, 0.94; 95% CI, 0.83 to 1.06; P = 0.31). Conclusions: Antiinflammatory therapy targeting the interleukin-1β innate immunity pathway with canakinumab at a dose of 150 mg every 3 months led to a significantly lower rate of recurrent cardiovascular events than placebo, independent of lipid-level lowering. (Funded by Novartis; CANTOS ClinicalTrials.gov number, NCT01327846.
BUILD EXITO: a multi-level intervention to support diversity in health-focused research
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- A Feldman
- A Griffith
- A Nora
- AB Hunter
- Adrienne Zell
- AJ Kezar
- AR Minerick
- B Junge
- C Hill
- C Pfund
- Carlos J. Crespo
- CL Outcalt
- Cynthia Morris
- D Lopatto
- D Lopatto
- Dawn M. Richardson
- De’ Sha S. Wolf
- DM Merolla
- E Anderson
- E Seymour
- EJ Shaw
- F Stage
- G Bangera
- G Light
- HA Valantine
- HB Carlone
- Investing in the Future: Strategic Plan for Biomedical and Behavioral Research Training
- J Bean
- J Engle
- J Ishiyama
- JM Osborn
- JO Shanahan
- K Intemann
- K Shaw
- KR McLeroy
- KW Bauer
- LC Auchincloss
- M Fechheimer
- M Harrison
- M Syed
- MJ Graham
- MK Egan
- N Denson
- NA Bowman
- P Gurin
- PB Thayer
- RS Hathaway
- S Hurtado
- S Manson
- S Wuchty
- SE Straus
- TA Campbell
- TE Keller
- Thomas E. Keller
- V Tinto
- V Tinto
- V Tinto
- V Tinto
- WS Swail
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Clinical Reliability of Different Facial Measurements in Determining Vertical Dimension of Occlusion in Dentulous and Edentulous Subjects
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- Aboul-Ela LM Mahmoud KAR.
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- Atwood DA.
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- Harris HL.
- Harvey W.
- Hellsing G Ekstrand K.
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- Ismail J George A.
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- Jarabak JR.
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- Publication venue
- 'Jaypee Brothers Medical Publishing'
- Publication date
- Field of study
Governance and Virtue: The Case of Public Order Policing
- Author
- A Bertland
- A Gowri
- A MacIntyre
- A MacIntyre
- A Maclntyre
- A Nicholls
- A Rorty
- AA Alves
- AC Michalos
- AC Michalos
- AJ Fives
- AJG Sison
- AJG Sison
- AJG Sison
- AJS Sison
- B Czarniawska
- B Jennings
- B Parkan
- B Robinson
- C Crockett
- C Dierksmeier
- CD Batson
- CL Hartman
- D Chismar
- D Dobbs
- D Koehn
- D Koehn
- D Melé
- D Sims
- DH Bayley
- DS Bright
- E Chell
- EC Limbs
- EJ Romar
- EM Hartman
- G Moore
- G Ryle
- G Thomas
- GF Cavanagh
- J Fontrodona
- J Maanen Van
- J McCracken
- J Rawls
- JA Collinson
- JA Swanson
- JT Whetstone
- K Morrell
- K Morrell
- K Morrell
- K Morrell
- Kevin Morrell
- KJ Shanahan
- LF Goldstein
- M Crossan
- M Lipsky
- MC Marchese
- MC Nussbaum
- Metropolitan Police Service
- MG Bal
- Ministry of Justice
- Ministry of Justice
- MJ Drake
- MJ Kurzynski
- MK Brown
- MP Nichols
- N Fielding
- P Dick
- P Foot
- P Hadreas
- PE Murphy
- PG Lewis
- R Atkinson
- R Beadle
- R Beadle
- R Beadle
- R Beadle
- R Chun
- R Nozick
- R Sorabji
- RB Louden
- RC Solomon
- RC Solomon
- RN Harris
- RP Nielsen
- S Arjoon
- SM Mintz
- SP Sethi
- Stephen Brammer
- T McAdams
- TA Wright
- VP Lau
- Y Cai
- Y Gabriel
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Pathogen-Host Associations and Predicted Range Shifts of Human Monkeypox in Response to Climate Change in Central Africa
- Author
- Anne W. Rimoin
- AT Peterson
- AT Peterson
- AT Peterson
- AW Rimoin
- AW Rimoin
- AW Rimoin
- BA Walther
- C Gonzalez
- C Kummerow
- C Schmaljohn
- CH Graham
- CK Ellis
- CL Hutson
- DB Di Giulio
- DG Long
- DJ Rogers
- DL Warren
- E Nakouné
- EA Gould
- ED Root
- EJ Wittmann
- Emile Okitolonda
- F Keesing
- Henri A. Thomassen
- Hermann Meyer
- HV Pham
- IK Damon
- J Elith
- J Elith
- J Fair
- J Melski
- JA Patz
- James O. Lloyd-Smith
- Jean-Jacques Muyembe
- JG Canadell
- JJ Sejvar
- JM Lobo
- JO Lloyd-Smith
- Joseph N. Fair
- JS Mackenzie
- Julia A. G. Shiplacoff
- K Brugger
- KD Lafferty
- KD Reed
- KM Pepin
- L Aragao
- L Gilbert
- L Khodakevich
- L Khodakevich
- L Khodakevich
- Linda L. Wright
- Lisa E. Hensley
- LR Beck
- M Kulldorff
- M Kulldorff
- M Kulldorff
- Matthew LeBreton
- MC Hansen
- MG Reynolds
- MR Raupach
- MS Wisz
- Nathan D. Wolfe
- Neville K. Kisalu
- P Chylek
- P Formenty
- PA Hernandez
- PG Baines
- Prime M. Mulembakani
- RB Myneni
- RJ Eisen
- RJ Hijmans
- Robert L. Shongo
- RP Anderson
- RS Levine
- S Asefi-Najafabady
- S Brooker
- SA Madhi
- Salvi Asefi-Najafabady
- Sara C. Johnston
- Seth Blumberg
- SJ Phillips
- T Fuller
- T Newbold
- TD Mitchell
- TG Farr
- Thomas B. Smith
- Timothée L. Kinkela
- TM Shanahan
- Trevon Fuller
- W Buermann
- Wolfgang Buermann
- YJF Hutin
- Yury E. Khudyakov
- Z Wan
- ZM Wan
- ZY Jiang
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Pharmacotherapy of inflammatory bowel disease: Novel therapeutic approaches
- Author
- A Guglietta
- A Kornbluth
- A Papa
- A Sachmechian
- A Sinha
- AA Vrij
- AE Slonim
- AP Kirk
- B Davidsen
- B Feagan
- B Sands
- B Sands
- BE Sands
- BE Sands
- BG Feagan
- BG Feagan
- BG Feagan
- BI Korelitz
- BI Korelitz
- BS Qiu
- C Bariol
- C Dejaco
- C Fiocchi
- C Folwaczny
- C Gasche
- C Montfrans Van
- C Wagner
- CA Sninsky
- Centocor Inc
- CG Su
- CG Su
- CN Bernstein
- D Present
- D Vaughan
- DB Sachar
- DG Binion
- DH Present
- DH Present
- DJ Tyrrell
- DK Bonen
- DS Hans
- E Ehrenpreis
- E Langholz
- E Louis
- E Vasiliauskas
- EB Odeka
- EJ Breese
- EV Loftus Jr
- F Fata
- F Hadziselimovic
- F Shanahan
- FH Gordon
- FH Gordon
- G Assche Van
- G Assche Van
- G D’Haens
- G Trallori
- GA Thomas
- GD D’Haens
- GR D’Haens
- GR Lichtenstein
- GR Lichtenstein
- GR Lichtenstein
- GR Lichtenstein
- H Debinski
- H Masuda
- HC Reinecker
- HF Cui
- HM Dullemen van
- I Dotan
- I Dotan
- J Bauditz
- J George
- J Hampe
- J Keane
- J Meenan
- J Panes
- JF Colombel
- JH Warw
- JK Marshall
- JM Reimund
- JM Sabate
- JP Hugot
- JR Korzenik
- JR Korzenik
- JR Korzenik
- JV Hawkins
- K Williams
- KA Lang
- KA Papadakis
- L Ramdin
- L Torkvist
- L Torkvist
- LS Brown
- LW Moreland
- M Jeffers
- M Olivia-Hemker
- MK Pugsley
- N Sumer
- NP Michell
- P Heath
- P Munkholm
- P Munkholm
- P Rutgeerts
- P Rutgeerts
- P Rutgeerts
- P Rutgeerts
- P Rutgeerts
- PA Jiminez
- PE Hesterberg
- PG Andreas
- PJ Rutgeerts
- PL Beck
- PM Ginsburg
- PR Gaffney
- PR Gaffney
- R Boismenu
- R Day
- R Evans
- R Miceli
- R Petroniene
- RB Sartor
- RC Evans
- RD Cohen
- RD Cohen
- RD Cohen
- RD Cohen
- RJ Farrel
- RJ Farrell
- RJ Farrell
- RJ Farrell
- RN Fedorak
- RN Fedorak
- RY Chong
- S Deventer van
- S Ganesan
- S Ghosh
- S Ghosh
- S Hanauer
- S Iyer
- S Kane
- S Lichtiger
- S Murthy
- S Nikolaus
- S Schreiber
- S Schreiber
- S Shivananda
- S Stephens
- S Targan
- Sands B Winston BD, Salzberg B, Sufdi M, Barish C, Wruble L, Wilkins R, Shapiro M, Schwertschlag US, RHIL-11 Crohn’s Study Group
- SB Hanauer
- SB Hanauer
- SH Murch
- SJ Bickston
- SJ Bickston
- SJ Deventer van
- SJ Probert
- SJH Deventer van
- SJH Deventer van
- SM Madsen
- T Yoshida
- TA Judge
- TF Roe
- U Ruther
- W Sandborn
- WA Stack
- Wettstein Ar
- WJ Murphy
- WJ Sandborn
- WJ Sandborn
- WJ Sandborn
- WJ Sandborn
- WJ Sandborn
- WY Chey
- WY Chey
- X Du
- Y Bouhnik
- Y Ogura
- YS Ang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2004
- Field of study
Rethinking Bile Acid Metabolism and Signaling for Type 2 Diabetes Treatment
- Author
- A Carino
- A Gottardi De
- A Mencarelli
- A Myronovych
- A Parseus
- A Perino
- AA Mahmoud
- AB Reiss
- AC Donepudi
- AK McGavigan
- B Cariou
- B Cariou
- B Goodwin
- B Kong
- Bethany P. Cummings
- BM Forman
- C Jiang
- C Jiang
- C Murphy
- C Thomas
- C Thomas
- CA Brighton
- CM Shanahan
- CR Flynn
- CR Pullinger
- D He
- D Stroup
- D. P. Poole
- DA Briere
- DJ Pournaras
- DM Baker
- DM Heuman
- DW Russell
- E Bertaggia
- EJ Tarling
- F Alemi
- F Kern Jr
- F Li
- G Salen
- G Vassileva
- GS Gerhard
- H Wang
- H Zhai
- HE Raybould
- HI Swanson
- HL Janssen
- HY Bhutta
- I Preuss
- J Li-Hawkins
- J Wang
- JA Holt
- JI Yang
- JM Ridlon
- JY Chiang
- JY Chiang
- K Slatis
- Karolina E. Zaborska
- KE Zaborska
- KH Song
- KH Song
- KK Ryan
- KM Habegger
- KR Shima
- L Ding
- L Galarneau
- L Wang
- LA Velazquez-Villegas
- LR Hagey
- M Becker-Andre
- M Dufer
- M Makishima
- M Mueller
- M Nitta
- M Norlin
- M Noshiro
- M Schwarz
- M Simonen
- M Watanabe
- M Zhang
- ME Patti
- MF Schmidt
- MJ Potthoff
- MS Trabelsi
- N Pean
- O Shaham
- P Lefebvre
- P Pathak
- PR Schauer
- R Kohli
- R Kohli
- R Kohli
- RA Haeusler
- RE Kuhre
- RE Steinert
- S Andersson
- S Cipriani
- S Ferdinandusse
- S Fiorucci
- S Fiorucci
- S Fiorucci
- S Fiorucci
- S Fiorucci
- S Fiorucci
- S Fiorucci
- S Fiorucci
- S Khurana
- SI Sayin
- SJ Chung
- SK Erickson
- T Fedorowski
- T Inagaki
- T Li
- T Li
- T Lieu
- T Maruyama
- T Maruyama
- TA Kerr
- TD Adams
- TQ Aguiar Vallim de
- TQ Aguiar Vallim de
- TT Lu
- TW Pols
- U Ozcan
- V Keitel
- V Keitel
- V Keitel
- V Keitel
- V Sepe
- WH Bachrach
- WM Pandak
- Y Kawamata
- Y Li
- Y Xu
- Y Yang
- Y Zhang
- Y Zhang
- YK Lee
- Z Wu
- Zheng Hao
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Holocene Supra-Regional Environmental Changes as Trigger for Major Socio-Cultural Processes in Northeastern Africa and the Sahara
- Author
- A Almogi-Labin
- A Berger
- A Gautier
- A Girod
- A Perego
- A Zerboni
- A Zerboni
- A Zerboni
- A-E Lebatard
- A-M Lezine
- AB Smith
- AH Osborne
- AL Lamb
- AM Mercuri
- Andrea Zerboni
- AR Warfe
- B Bell
- B Gabriel
- B Kimura
- BJ Johnson
- C Swezey
- C Wolff
- CO Hunt
- CV Haynes Jr
- CV Haynes Jr
- D Ariztegui
- D Geraads
- D Gronenborn
- D Huyge
- D Verschuren
- D Wengrow
- DG Anderson
- DV Flores
- DW Phillipson
- E Cancellieri
- E Cancellieri
- EJ Rohling
- EJ Rohling
- ER Thomas
- F Briois
- F Debono
- F Dramis
- F Gasse
- F Gasse
- F Gasse
- F Gasse
- F Gasse
- F Marshall
- F Welc
- F Wendorf
- FA Hassan
- FA Hassan
- FA Street
- G Camps
- GM Zuppi
- H Baioumy
- H Cheng
- H Flohn
- H-J Pachur
- H-J Pachur
- H-TAA Ibrahim
- HF Lamb
- HJ Pachur
- I Shaw
- J Moeyersons
- J Reinold
- J-D Stanley
- J-P Roset
- J-P Roset
- JC Ritchie
- JD Clark
- JD Clark
- JR Smith
- JSL Casford
- K Neumann
- K Neumann
- K Nicoll
- KW Butzer
- L SchĂĽler
- LG Thompson
- M Cremaschi
- M Cremaschi
- M Cremaschi
- M Cremaschi
- M Cremaschi
- M Curtis
- M Honegger
- M Honegger
- M Honegger
- M Honegger
- M Jackes
- M Kobusiewicz
- M Madella
- M Rossignol-Strick
- M Servant
- M Servant
- M Williams
- MA Tafuri
- MAJ Williams
- MAJ Williams
- MAJ Williams
- MAJ Williams
- MAJ Williams
- MAJ Williams
- Maria Carmela Gatto
- MC Gatto
- MC Gatto
- MC Gatto
- MD Krom
- MG Macklin
- MH Marshall
- N Brooks
- N Brooks
- N Brooks
- N Marriner
- N Petit-Maire
- N Roberts
- N Roberts
- N Shirai
- NA Drake
- North Greenland Ice Core Project members
- O Bubenzer
- P Bobrowski
- P Braconnot
- P Breunig
- P deMenocal
- P Hoelzmann
- P Hoelzmann
- P Hoelzmann
- P Rognon
- P Rognon
- P Storemyr
- PA Barker
- PA Mayewski
- PI Abell
- PM Vermeersch
- R Fattovich
- R Haaland
- R Hennekam
- R Kuper
- R Mawson
- R Phillipps
- R Schild
- R Vernet
- RE Becker
- S Hendrickx
- S Kröpelin
- S Kröpelin
- S Kröpelin
- S Kröpelin
- S Lernia di
- S Lernia di
- S Lernia di
- S Lernia di
- S Lernia di
- S Lernia di
- S Lernia di
- S Salvatori
- S Salvatori
- SA Brandt
- SA Brandt
- SE Nicholson
- SE Nicholson
- T Gebru
- T Kobashi
- TM Shanahan
- TT Barrows
- U Thorweihe
- V Linseele
- V Linseele
- VJ Terwilliger
- VJ Terwilliger
- W Anderson
- W Wendrich
- WM Edmunds
- Z Yan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Advancing a Biopsychosocial and Contextual Model of Sleep in Adolescence: A Review and Introduction to the Special Issue
- Author
- A Charuvastra
- A Hvolby
- A Košćec
- A Muro
- A Muzur
- A Sadeh
- A Sadeh
- A Storfer-Isser
- A Winsler
- AA Borbély
- AA Borbély
- AA Borbély
- AG Thomas
- AJ Fuligni
- AK Hildenbrand
- AK Pesonen
- AL Bryant
- AL Bryant
- AM Dotterer
- AM Gregory
- AM Gregory
- AM Gregory
- AM Gregory
- AM Meijer
- American Academy of Pediatrics
- American Psychiatric Association
- American Psychiatric Association
- AR Wolfson
- AR Wolfson
- AR Wolfson
- AR Wolfson
- AT Vazsonyi
- B Anderson
- B Laursen
- B Thorleifsdottir
- BF Pennington
- BG Bell
- BH Hansen
- BH Hansen
- BM Roane
- BS Molina
- C Cajochen
- C Gillen-O’Neel
- CAP Walther
- CD Catrett
- CF Yen
- CJ Calamaro
- CK Yang
- CL Sisk
- CM Leone
- CM Worthman
- CN Hart
- D Cicchetti
- D Cicchetti
- D Coghill
- D Dexter
- D Lufi
- D Vinha
- DA Fair
- DC Jarrin
- DE Logan
- DJ Maume
- DJ Safron
- DJ Taylor
- DK Eaton
- DL King
- DM Gardner
- DW Beebe
- DW Beebe
- DW Beebe
- E Moore
- E Scharfe
- EA Storch
- EB Klerman
- EG Willcutt
- EH Telzer
- EJ Costello
- EJ Paavonen
- EJ Sonuga-Barke
- EJ Susman
- EK Adam
- EL McGlinchey
- EM O’Brien
- EO Johnson
- EO Johnson
- EO Johnson
- ET Aronen
- F Danner
- F Edwards
- FM Fischer
- FP Cappuccio
- FV O’Callaghan
- FX Castellanos
- FX Castellanos
- G Curcio
- G Fallone
- G Fallone
- GC Adams
- GJ DuPaul
- GJ Elder
- GS Noble
- GW Ladd
- H Bajoghli
- H Lazaratou
- H Noland
- H Peach
- H Shinkoda
- HD Peach
- HQ Zhou
- I Brković
- I Feinberg
- I Feinberg
- IG Campbell
- IM Colrain
- J Bulck Van den
- J Maslowsky
- J Owens
- J Owens
- J Tynjala
- JA Accardo
- JA Havas De
- JA Owens
- JC Barnes
- JD Burke
- JE Gangwisch
- JE James
- JF Dewald
- JF Diaz-Morales
- JG Bachman
- JG Johnson
- JL Ireland
- JM Armstrong
- JM Langberg
- JM Langberg
- JM Langberg
- JM Langberg
- JN Giedd
- Joshua M. Langberg
- JS Eccles
- K Bartel
- K Fredriksen
- K Fukuda
- K Kirmil-Gray
- K Larson
- K Lycett
- K Lycett
- K McRae
- K Miller
- KE Pasch
- KE Pasch
- Kelly C. Byars
- KL Wahlstrom
- KL Wahlstrom
- KN Ochsner
- KR Merikangas
- KT Baum
- L Hale
- L Shanahan
- L Steinberg
- L Tamm
- LC Deault
- LD Doane
- LD Doane
- LG Lundh
- LJ Meltzer
- LM Terman
- LP Spear
- LR McKnight-Eily
- LR Teixeira
- LR Teixeira
- LR Teixeira
- LS Talbot
- M Claes
- M Cohen-Zion
- M Cooley-Quille
- M Gradisar
- M Guidolin
- M Hansen
- M Helsen
- M Hoeve
- M Kirby
- M Kopasz
- M Lasgaard
- M Moore
- M Sarchiapone
- MA Carskadon
- MA Carskadon
- MA Carskadon
- MA Short
- MA Short
- MA Short
- MA Stein
- MG Umlauf
- MG Umlauf
- MH Sibley
- MJ Prinstein
- MM Ohayon
- MM Wong
- MM Wong
- MP Marshal
- MT Banich
- N Cain
- N Gujar
- N Lemos
- N Lovato
- N Michels
- National Sleep Foundation
- NE Mahon
- NL Galambos
- NM Kouzma
- NS Danielsson
- OG Jenni
- P McNamara
- P Wilkinson
- PJ Fite
- PK Kerig
- PK Kerig
- PM Lewinsohn
- PM Russo
- R Gruber
- R Gruber
- R Gruber
- R Gruber
- R Gruber
- R Kirov
- R Manni
- R Tavernier
- R Tavernier
- RA Barkley
- RA Harris
- RC Meldrum
- RE Dahl
- RE Dahl
- RE Dahl
- RE Roberts
- RE Roberts
- RE Roberts
- RG Astill
- RG Fontaine
- RJ Kelly
- RJ Kelly
- RM Pressman
- RR Bootzin
- RW Larson
- S Brand
- S Brand
- S Cortese
- S Eggermont
- S Lemola
- S Lemola
- S Mrug
- S Negriff
- S Petegem Van
- S Pieters
- S Pieters
- S Sondheim
- S Whitfield-Gabrieli
- SE Carrell
- SI Kuo
- SJ Broyd
- SJ Lepore
- SL Rubens
- SL Smalley
- SP Becker
- SP Becker
- SP Becker
- SP Hinshaw
- SS Clinkinbeard
- SS Lee
- Stephen P. Becker
- SY Yoon
- T Arora
- T Munezawa
- T Olds
- T Roehrs
- T Roenneberg
- T Shochat
- T Shochat
- T Yip
- TF Dorofaeff
- TJ Dishion
- TJ Dishion
- TJ Power
- TJ Power
- TJ Whitford
- TL Sletten
- TR Goldstein
- U Bronfenbrenner
- U Bronfenbrenner
- V Kubiszewski
- V Moreau
- V Moreau
- V Sung
- VM Schroeder
- W Kliewer
- WA Collins
- WH Lin
- WM Bukowski
- WM Reinke
- WQ Sun
- X Liu
- Y Kaneita
- YK Do
- Z Xu
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Safety of Nonsteroidal Anti-inflammatory Drugs in Major Gastrointestinal Surgery: A Prospective, Multicenter Cohort Study
- Author
- Abbas Z
- Abburu S
- Abdelhadi M
- Abdikadir HR
- Abdulmajid A
- Abid A
- Abid H
- Abuhussein N
- Abul MH
- Acquaah F
- Acres M
- Adams R
- Adams RD
- Adebayo AA
- Adeleja I
- Adjei H
- Afzal Z
- Agarwal V
- Ahern N
- Ahmad K
- Ahmad S
- Ahmed F
- Ahmed H
- Ahmed M
- Ahmed N
- Ahmed S
- Ahmed S
- Ahn JS
- Aidoo-Micah GE
- Aildasani L
- Aithie JM
- Akhtar S
- Al-Mousawi A
- Al-Obaedi O
- Al-Obaedi O
- Al-Robeye A
- Ali A
- Ali B
- Ali H
- Ali M
- Ali S
- Alizadeh M
- Allan C
- Allen JLY
- Allot R
- Allot R
- Allot R
- Amajuoyi A
- Amin H
- Amin H
- Amin O
- Amphlett AH
- Anandarajah C
- Anderson L
- Anderson LB
- Anderson SM
- Ang A
- Angelov S
- Anilkumar A
- Anim-Addo N
- Ansari N
- Antoniou I
- Archer CH
- Arif T
- Arif T
- Asbjoernsen CA
- Ashfaq U
- Ashken L
- Ashraf S
- Ashraf SF
- Ashton AJ
- Ashwood J
- Aslanyan A
- Asmadi A
- Assadullah S
- Atayi A
- Atraszkiewicz BA
- Attalla M
- Austreng L
- Auyoung E
- Avery P
- Axelson T
- Aziz H
- Aziz N
- Baker AN
- Bakewell ZR
- Bakhsh A
- Bakhsh A
- Balaji S
- Balian V
- Balian V
- Balian V
- Bamgbose FA
- Barai I
- Barnes J
- Barrow TR
- Barthorpe AE
- Bartlett J
- Bartlett RD
- Barton EC
- Bassam N
- Bassett J
- Bassiony S
- Bath MF
- Batho A
- Batt E
- Bazeer HZ
- Beckett J
- Beecroft S
- Behar N
- Bell A
- Bell L
- Bell N
- Bemand TP
- Bergara T
- Bernstein I
- Bethell GS
- Bhanderi S
- Bhangu A
- Bhangu A
- Bhangu A
- Bhaskaran G
- Bhatt N
- Bhatti M
- Bhome R
- Bhudia R
- Bingham G
- Blege HK
- Blessed R
- Bloomer J
- Bloomfield T
- Blore CD
- Bolton L
- Bolton W
- Bonsu S
- Bookless LR
- Bose R
- Botchey S
- Boulton AJ
- Boxall N
- Boyle J
- Braganza L
- Brathwaite-Shirley C
- Bravo M
- Brecher J
- Bremner RH
- Brennan C
- Brennan E
- Brennan K
- Brent G
- Brewer CF
- Brewster O
- Bright M
- Brown D
- Brown E
- Brown E
- Brown EJ
- Brown FS
- Broyd A
- Brzyska K
- Buakuma P
- Buchan AM
- Buckle RT
- Bucko AM
- Bulley F
- Bullman LM
- Bullock NP
- Burgess A
- Burke D
- Burke D
- Burke E
- Burke J
- Burney LJ
- Callan R
- Campbell J
- Canning E
- Canning N
- Cao Y
- Cardwell AE
- Carr L
- Carr R
- Carroll AF
- Carter D
- Carthew L
- Chamberlain M
- Chan C
- Chan N
- Chandan N
- Chapman SJ
- Charalambos MA
- Charalambous G
- Charania A
- Charavanamuttu V
- Chaudhary M
- Chaudhry FI
- Chaudhry WW
- Cheema H
- Chen JH
- Chen M
- Chen X
- Cheng K
- Chervenkoff J
- Cheskes L
- Cheung F
- Chew L
- Chew LS
- Chhabra A
- Chhina C
- Chilima CP
- Chillarge G
- Chilvers NJ
- Chin H
- Chin R
- Chisholm EG
- Chitnis AR
- Chiu SM
- Chong BF
- Chong J
- Choo KP
- Chrastek D
- Chua EY
- Chung A
- Claireaux HA
- Claireaux HA
- Clark IJ
- Clarke AK
- Cleere J
- Clement KD
- Clesham K
- Coates A
- Coates A
- Coates A
- Cody A
- Cody N
- Coffey CJ
- Coffey D
- Coffin J
- Cole SJ
- Collaborative S
- Collier H
- Collins A
- Collins D
- Collinson S
- Cooper D
- Cooper GE
- Copley HC
- Copley PC
- Cornish E
- Cotton A
- Coulson R
- Cox SE
- Craig AR
- Craig E
- Craig-McQuaide A
- Crewdson JA
- Croall A
- Crozier L
- Cullen C
- Cullen S
- Culleton G
- Cumber E
- Cumber EM
- Cumming S
- Cundy OJ
- Cunha P
- Curran A
- Cuthbert G
- Cymes W
- Daoub A
- Darr S
- Das M
- Datta U
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2017
- Field of study
Background
Significant safety concerns remain surrounding the use of nonsteroidal anti-inflammatory drugs (NSAIDs) following gastrointestinal surgery, leading to wide variation in their use. This study aimed to determine the safety profile of NSAIDs after major gastrointestinal surgery.
Methods
Consecutive patients undergoing elective or emergency abdominal surgery with a minimum one-night stay during a 3-month study period were eligible for inclusion. The administration of any NSAID within 3 days following surgery was the main independent variable. The primary outcome measure was the 30-day postoperative major complication rate, as defined by the Clavien–Dindo classification (Clavien–Dindo III–V). Propensity matching with multivariable logistic regression was used to produce odds ratios (OR) and 95 % confidence intervals.
Results
From 9264 patients, 23.9 % (n = 2212) received postoperative NSAIDs. The overall major complication rate was 11.5 % (n = 1067). Following propensity matching and adjustment, use of NSAIDs were not significantly associated with any increase in major complications (OR 0.90, 0.60–1.34, p = 0.560).
Conclusions
Early use of postoperative NSAIDs was not associated with an increase in major complications following gastrointestinal surgery