Mapping Terrestrial Impact Craters with the TanDEM-X Digital Elevation Model

The TanDEM-X mission generates a global digital elevation model (DEM) with unprecedented properties. We use it for mapping confirmed terrestrial impact craters as listed in the Earth Impact Database. Both for simple and complex craters detailed investigations of the morphology of the particular structure and of the surrounding terrain can be performed

Serotonin receptor HTR4 as a counter actor of lipid-induced increases of serum glucagon-like peptide-1 levels

Energy demand of neurons in brain that is covered by glucose supply from the blood is ensured by glucose transporters in capillaries and brain cells. In brain, the facilitative diffusion glucose transporters GLUT1-6 and GLUT8, and the N

The Economic Impact of FHSU on the Local Economy: FY 2022

We evaluate the economic impact Fort Hays State University has on the local economy during fiscal year 2022 by utilizing two estimation methods. These methods focus on the total spending from the institution, the faculty and staff, the students, and the visitors. The results of the analysis estimate the economic impact of the university ranges between $167,862,253 and$239,200,242

Exchange factors directly activated by cAMP mediate melanocortin 4 receptor-induced gene expression

G(s) protein-coupled receptors regulate many vital body functions by activation of cAMP response elements (CRE) via cAMP-dependent kinase A (PKA)-mediated phosphorylation of the CRE binding protein (CREB). Melanocortin 4 receptors (MC4R) are prototypical G(s)-coupled receptors that orchestrate the hypothalamic control of food-intake and metabolism. Remarkably, the significance of PKA for MC4R-induced CRE-dependent transcription in hypothalamic cells has not been rigorously interrogated yet. In two hypothalamic cell lines, we observed that blocking PKA activity had only weak or no effects on reporter gene expression. In contrast, inhibitors of exchange factors directly activated by cAMP-1/2 (EPAC-1/2) mitigated MC4R-induced CRE reporter activation and mRNA induction of the CREB-dependent genes c-fos and thyrotropin-releasing hormone. Furthermore, we provide first evidence that extracellular-regulated kinases-1/2 (ERK-1/2) activated by EPACs and not PKA are the elusive CREB kinases responsible for MC4R-induced CREB/CRE activation in hypothalamic cells. Overall, these data emphasize the pivotal role of EPACs rather than PKA in hypothalamic gene expression elicited by a prototypical Gs-coupled receptor

Prenatal alcohol and tetrahydrocannabinol exposure: Effects on spatial and working memory

IntroductionAlcohol and cannabis are widely used recreational drugs that can negatively impact fetal development, leading to cognitive impairments. However, these drugs may be used simultaneously and the effects of combined exposure during the prenatal period are not well understood. Thus, this study used an animal model to investigate the effects of prenatal exposure to ethanol (EtOH), Δ-9-tetrahydrocannabinol (THC), or the combination on spatial and working memory.MethodsPregnant Sprague–Dawley rats were exposed to vaporized ethanol (EtOH; 68 ml/h), THC (100 mg/ml), the combination, or vehicle control during gestational days 5–20. Adolescent male and female offspring were evaluated using the Morris water maze task to assess spatial and working memory.ResultsPrenatal THC exposure impaired spatial learning and memory in female offspring, whereas prenatal EtOH exposure impaired working memory. The combination of THC and EtOH did not exacerbate the effects of either EtOH or THC, although subjects exposed to the combination were less thigmotaxic, which might represent an increase in risk-taking behavior.DiscussionOur results highlight the differential effects of prenatal exposure to THC and EtOH on cognitive and emotional development, with substance- and sex-specific patterns. These findings highlight the potential harm of THC and EtOH on fetal development and support public health policies aimed at reducing cannabis and alcohol use during pregnancy

The TanDEM-X Digital Elevation Model and Terrestrial Impact Structures

We utilized the TanDEM-X digital elevation model (DEM) for investigating the complete record of confirmed terrestrial impact structures with respect to its suitability to support geological analysis. The consistently high resolution and high accuracy of this model is a prerequisite for detailed morphological studies. This DEM represents an interesting repository to aid in preparing and executing fieldwork for the exploration of new impact crater candidates. For a selection of small, mid-sized, and large impact structures, we here compare the TanDEM-X results with those from other DEMs that were derived either with synthetic aperture radar interferometry or from optical stereo pairs. Our analysis includes high-resolution mapping and the generation of detailed elevation cross sections. Only for very small impact craters, when the diameter is in the order of the pixel posting of TanDEM-X of 12 m or when the texture of the local environment does not support radar remote sensing, accurate analysis is hampered. Our results demonstrate that the high horizontal and vertical accuracies of the TanDEM-X DEM, coupled with its dense pixel grid, provide a considerable improvement in space-borne remote sensing of the complete record of simple and complex terrestrial impact structures over a wide range of diameters

AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival

Biomechanical strain imposed by age-related thickening of the basal lamina and augmented tissue stiffness in the prostate gland coincides with increased cancer risk. Here we hypothesized that the structural alterations in the basal lamina associated with age can induce mechanotransduction pathways in prostate epithelial cells (PECs) to promote invasiveness and cancer progression. To demonstrate this, we developed a 3D model of PEC acini in which thickening and stiffening of basal lamina matrix was induced by advanced glycation end-product (AGE)-dependent non-enzymatic crosslinking of its major components, collagen IV and laminin. We used this model to demonstrate that antibody targeted blockade of CTLD2, the second of eight C-type lectin-like domains in Endo180 (CD280, CLEC13E, KIAA0709, MRC2, TEM9, uPARAP) that can recognize glycosylated collagens, reversed actinomyosin-based contractility [myosin-light chain-2 (MLC2) phosphorylation], loss of cell polarity, loss of cell–cell junctions, luminal infiltration and basal invasion induced by AGE-modified basal lamina matrix in PEC acini. Our in vitro results were concordant with luminal occlusion of acini in the prostate glands of adult Endo180ΔEx2–6/ΔEx2–6 mice, with constitutively exposed CTLD2 and decreased survival of men with early (non-invasive) prostate cancer with high epithelial Endo180 expression and levels of AGE. These findings indicate that AGE-dependent modification of the basal lamina induces invasive behaviour in non-transformed PECs via a molecular mechanism linked to cancer progression. This study provides a rationale for targeting CTLD2 in Endo180 in prostate cancer and other pathologies in which increased basal lamina thickness and tissue stiffness are driving factors

On the evaluation of some three-body variational integrals

Stable recursive relations are presented for the numerical computation of the integrals $$\int d{\bf r}_1 d{\bf r}_2 r_1^{l-1} r_2^{m-1} r_{12}^{n-1} \exp{\{-\alpha r_1 -\beta r_2 -\gamma r_{12}\}}$$ ($l$, $m$ and $n$ integer, $\alpha$, $\beta$ and $\gamma$ real) when the indices $l$, $m$ or $n$ are negative. Useful formulas are given for particular values of the parameters $\alpha$, $\beta$ and $\gamma$.Comment: 12 pages, 1 figure (PS) and 3 tables. Old figures 2 and 3 replaced by Tables I and III. A further table added. Paper enlarged giving some tips on the convergence of quadrature

TerraSAR-X SAR Data Processing

The TerraSAR-X Mission started operational provision of SAR image products to the scientific and commercial user community in January 2008. An essential prerequisite for the excellent quality of the SAR products was the successful execution of a comprehensive commissioning phase (CP) in 2007. Here, the complete SAR system which comprises instrument commanding, instrument SAR data acquisition as well as SAR processing has been characterized, calibrated and verified. Finally SAR image product verification ensured that the product performance parameters are within the specification. Besides the versatile high-resolution X-Band SAR instrument in space, featuring Stripmap, ScanSAR and Spotlight imaging modes in different polarizations, the TerraSAR Multi-Mode SAR Processor (TMSP) is the central part of the ground segment. Most instrument and SAR calibration parameters have been derived on basis of SAR image products generated by the TMSP. Therefore, already in the beginning of the CP the products had to be relatively radiometric calibrated and geometrical undistorted. An indispensable prerequisite for this was the imaging mode independent normalization of the processor gain as well as the incorporation of external information, i.e. a digital elevation model for the projection of the elevation gain antenna pattern onto the terrain surface and a model of the atmosphere accounting for additional propagation delays. During the CP the TMSP has been adjusted to the in-orbit characteristics of the SAR data and instrument internal calibration. This includes adaptations of calibration pulse processing to a modified internal calibration strategy, accounting for duty cycle dependent pulse energy and temperature dependent gain levels as well as a fine tuning of the signal and geometry based Doppler centroid estimation algorithm. Furthermore, the determination of the reference function for range focusing has been optimized. Finally, the spectral weighting of the SAR data has been adjusted in order to obtain well balanced impulse response function properties in terms of resolution, side lobe ratios and azimuth ambiguities. The presentation reviews the essential features of the TMSP, summarizes the TMSP adjustments and presents results of the SAR product verification

Continuum Coupling and Single-Nucleon Overlap Integrals

The presence of a particle continuum, both of a resonant and non-resonant character, can significantly impact spectroscopic properties of weakly bound nuclei and excited nuclear states close to, and above, the particle emission threshold. In the framework of the continuum shell model in the complex momentum-plane, the so-called Gamow Shell Model, we discuss salient effects of the continuum coupling on the one-neutron overlap integrals and the associated spectroscopic factors in neutron-rich helium and oxygen nuclei. In particular, we demonstrate a characteristic near-threshold energy dependence of the spectroscopic factors for different l-waves. We show also that the realistic radial overlap functions, which are needed for the description of transfer reactions, can be generated by single-particle wave functions of the appropriately chosen complex potential.Comment: 9 figures; 23 pages; corrected version; accepted in Nuclear Physics