An Investment and Equality-Led Sustainable Development Strategy for Europe

Austerity policies coupled with rising inequality in Europe have resulted in a prolonged stagnation and a vicious circle of chronically low demand, slow down in investment and productivity, and economic, social and political instability. In order to end this vicious cycle, Europe needs directed public investment policies accompanied by industrial policy, higher equality, stimulated demand, and regulation of finance and corporate governance. Our research presents strong empirical evidence that expansionary fiscal policy is sustainable when wage and public investment policies are combined with progressive tax policy; the impact is stronger when these policies are implemented in a coordinated fashion across Europe due to strong positive spill over effects on demand. A strong investment performance also requires a process of de-financialization of the economy and a new approach to corporate governance

Prospectus, September 19, 1979

PARKLAND--A KING\u27S PALACE; Student elections lacks voters, candidates, and issues; Parkland College Results of Student Government Election Sept. 12, 13, 1979; Bad Co.: not much fantasy; No record for PC; U.S. productivity down; Sigma Theta Phi: the rush is on; Pro Kennedy group holds first meeting: Notice; WPCD: African affairs needed; Inventory Lists; Parkland Art Program sponsors St. Louis trip; PC offers music; Goldrush has new life; \u27Forum\u27 talks stugo and drinking age; All-Comers pulls surprises; Classifeds; Otrabanda comes to PC; Last Chance to Sign Up for Student Health Insurance; Seven fare well in Freddy; Fast Freddy Contest; Crowd at presentation; U.S. table tennis getting popular; Spikers hopes are high; Elam strides toward victory; Parkland Women\u27s Volleyball Rosterhttps://spark.parkland.edu/prospectus_1979/1012/thumbnail.jp

Надзор органов прокуратуры за коррупционной сферой бизнеса в России и Беларуси в современных условиях

Материалы IX Междунар. науч. конф., 21–22 мая 2015 г

The Lantern Vol. 73, No. 1, Fall 2005

• Newspaper Clippings Found on the Wall of Giuseppe Luchenzo\u27s Home When it was Raided by Police • All the Time in the World • The Man Who Would Win • Souffle Suit • A Day in the Mind • Context • Felicity / Awareness • Frivolous • Thank You Note to J.S.B. • September 17, 2005 • Eight Ways of Looking at a Highway • Dusty Glass Spreads Air Like Light • Clockwork • Rubber Band • Outside Eye or I Am? • A Mundane Mysticism • Half Carat • Things I Learned on My Trip to the Mutter Museum of Medical Oddities • Peer Editing • The Attic Bones • Yeshttps://digitalcommons.ursinus.edu/lantern/1167/thumbnail.jp

Exploration of a Potential DOOR Endpoint for Hospital-acquired Bacterial Pneumonia and Ventilator-associated Bacterial Pneumonia Using Six Registrational Trials for Antibacterial Drugs

BACKGROUND: Desirability of outcome ranking (DOOR) is an innovative approach to clinical trial design and analysis that uses an ordinal ranking system to incorporate the overall risks and benefits of a therapeutic intervention into a single measurement. Here we derived and evaluated a disease-specific DOOR endpoint for registrational trials for hospital-acquired bacterial pneumonia and ventilator-associated bacterial pneumonia (HABP/VABP). METHODS: Through comprehensive examination of data from nearly 4000 participants enrolled in six registrational trials for HABP/VABP submitted to the Food and Drug Administration (FDA) between 2005 and 2022, we derived and applied a HABP/VABP specific endpoint. We estimated the probability that a participant assigned to the study treatment arm would have a more favorable overall DOOR or component outcome than a participant assigned to comparator. RESULTS: DOOR distributions between treatment arms were similar in all trials. DOOR probability estimates ranged from 48.3% to 52.9% and were not statistically different. There were no significant differences between treatment arms in the component analyses. Although infectious complications and serious adverse events occurred more frequently in ventilated participants compared to non-ventilated participants, the types of events were similar. CONCLUSIONS: Through a data-driven approach, we constructed and applied a potential DOOR endpoint for HABP/VABP trials. The inclusion of syndrome-specific events may help to better delineate and evaluate participant experiences and outcomes in future HABP/VABP trials and could help inform data collection and trial design

Exploration of a Potential Desirability of Outcome Ranking Endpoint for Complicated Intra-Abdominal Infections Using 9 Registrational Trials for Antibacterial Drugs

BACKGROUND: Desirability of outcome ranking (DOOR) is a novel approach to clinical trial design that incorporates safety and efficacy assessments into an ordinal ranking system to evaluate overall outcomes of clinical trial participants. Here, we derived and applied a disease-specific DOOR endpoint to registrational trials for complicated intra-abdominal infection (cIAI). METHODS: Initially, we applied an a priori DOOR prototype to electronic patient-level data from 9 phase 3 noninferiority trials for cIAI submitted to the US Food and Drug Administration between 2005 and 2019. We derived a cIAI-specific DOOR endpoint based on clinically meaningful events that trial participants experienced. Next, we applied the cIAI-specific DOOR endpoint to the same datasets and, for each trial, estimated the probability that a participant assigned to the study treatment would have a more desirable DOOR or component outcome than if assigned to the comparator. RESULTS: Three key findings informed the cIAI-specific DOOR endpoint: (1) a significant proportion of participants underwent additional surgical procedures related to their baseline infection; (2) infectious complications of cIAI were diverse; and (3) participants with worse outcomes experienced more infectious complications, more serious adverse events, and underwent more procedures. DOOR distributions between treatment arms were similar in all trials. DOOR probability estimates ranged from 47.4% to 50.3% and were not significantly different. Component analyses depicted risk-benefit assessments of study treatment versus comparator. CONCLUSIONS: We designed and evaluated a potential DOOR endpoint for cIAI trials to further characterize overall clinical experiences of participants. Similar data-driven approaches can be utilized to create other infectious disease-specific DOOR endpoints

The Lantern Vol. 74, No. 2, Spring 2007

• La Viuda • The Curb After Light Drizzling • Loose Cream • The Problem of Ants • Streetplay • Avignon, Anno Domini 1348 • Autophagia • Silverette-New Wave Fascist Date Routine • Mint Shavings • Dogtags • Millenials • Rain That Sleeps by Itself at Track Number 5 • Amorphous • I Found a Flashlight • Sippikkul Muthu: Pearl Within Shell • Of Lies • The Complications of a Fish-Only Diet • Ashes • Unto the Fourth Generation • Marooned on Piano Island • Sweethttps://digitalcommons.ursinus.edu/lantern/1170/thumbnail.jp

Salivary testosterone and cortisol levels in borderline personality disorder before and after a 12-week group dialectical behavior therapy intervention

BackgroundBorderline Personality Disorder (BPD) is a chronic, debilitating, and difficult to treat condition. BPD has recently been linked to steroid hormone dysregulation and medical conditions characterized by disturbed androgen metabolism. This study aimed to investigate cortisol and testosterone levels in BPD, and changes in hormones following psychological treatment.MethodsParticipants with BPD (n = 33) completed a 12-week Dialectical Behavior Therapy group program. Pre and post salivary testosterone and cortisol were analyzed. Baseline hormones in the BPD group were compared to age-and-sex matched controls (n = 33). Non-parametric tests were utilized to investigate group differences, pre-post treatment hormone and symptom changes, and associations between symptoms and hormone levels.ResultsParticipants with BPD had significantly higher testosterone levels than controls. Mean testosterone levels in females with BPD were double that of female controls. Testosterone and cortisol levels were related, and some BPD symptoms were associated with with hormone levels. BPD symptoms reduced significantly with treatment, however pre to post hormone levels did not change.ConclusionsThis study supports an association between BPD symptoms and neuroendocrine dysfunction at baseline, however we found no reduction in hormone dysfunction post treatment. Further research into relationships between stress signaling and neuroendocrine disturbances in BPD may inform aetiological and treatment models.Trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12618000477224. Registered on 3 April 2018

The Lantern Vol. 74, No. 1, Fall 2006

• Seven Haikus About Insomnia • Lunch Hour • Divorced Parents and Flower Guts • 24 • Lily • Growth • Narcissistically Admiring You • Mysterious Avocado • Aloha Roast • Summer • Lines • Internalizing • San Francisco • Numb Candle • Moments No. 1 • Tanka • Euphemism • We be Malllllll • Dragon Magic • Time for the Magic Show • Green • Job • The Shire • Venom • The Seasons of Love • The Position • Fragments of an Artist • Peace • Vagabond Nights • Rerum Concordia Discorshttps://digitalcommons.ursinus.edu/lantern/1169/thumbnail.jp