A rapid graphical technique for obtaining radar data time history for close earth orbits

Radar tracking parameters and contact time errors from graphic estimation of radar tracking coverage of near earth orbit

Landscape of somatic single nucleotide variants and indels in colorectal cancer and impact on survival

Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge of CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional genes significantly mutated in CRC. We find that among hypermutated tumors, an increased mutation burden is associated with improved CRC-specific survival (HR=0.42, 95% CI: 0.21-0.82). Mutations in TP53 are associated with poorer CRC-specific survival, which is most pronounced in cases carrying TP53 mutations with predicted 0% transcriptional activity (HR=1.53, 95% CI: 1.21-1.94). Furthermore, we observe differences in mutational frequency of several genes and pathways by tumor location, stage, and sex. Overall, this large study provides deep insights into somatic mutations in CRC, and their potential relationships with survival and tumor features. Large scale sequencing study is of paramount importance to unravel the heterogeneity of colorectal cancer. Here, the authors sequenced 205 cancer genes in more than 2000 tumours and identified additional mutated driver genes, determined that mutational burden and specific mutations in TP53 are associated with survival odds

Ancestral Pueblo Archaeology: The Value of Synthesis

Archaeologists working in the Ancestral Pueblo region of the American Southwest have documented variability in sociopolitical and economic complexity, landscape use, community organization, mobility, and violence at a wide range of temporal and spatial scales from AD 500-1700. Recent studies have a strong synthetic orientation, employ methods that track material culture, mobility, and social networks at macroregional scales, and benefit from a renewed engagement with indigenous peoples. Much of this research relies on integrating vast amounts of data from numerous academic and cultural resource management projects and demonstrates the promise of an archaeology that relies on the cumulative acquisition and sharing of data. Given the scale and depth of this research, Ancestral Pueblo archaeology is an exceptional comparative case for archaeologists considering similar processes, especially at fine temporal and wide geographical scales, in ancient farming societies across the globe