Can the Inca site of Choqek'iraw be considered an agro-pastoral calendar?

International audience"Situated in the heart of the Vilcabamba cordillera in Peru, some 150 km northwest of Cuzco, the ancient Inca state capital, Choqek'iraw or Choquequirao (“the golden cradle” in Quechua), is one of the most beautiful achievements of Inca architecture, and one of the very few pre-Hispanic sites displaying large wall mosaics, the only one known from Inca times. This article will attempt to demonstrate that the figures represented on the walls convey cosmological significance and are laid out following textile principles. After describing the site and its geo-cultural setting, the mosaics' main characteristics will be examined in detail, in an attempt to grasp their meaning. Finally, the author suggests that some of the scenes depicted could have been inspired by pre-Columbian myths and could be linked to astronomical concepts." (source éditeur)"Ubicado en el corazón de la cordillera de Vilcabamba, a unos 150 kilómetros de Cuzco, la antigua capital del estado inca, Choqek'iraw o Choquequirao (la cuna del oro en quechua), es uno de los logros más hermosos de la arquitectura Inca y el único sitio de época inca, con un gran mosaico mural. En este trabajo se intentará demostrar que las figuras representadas en las paredes podrían transmitir significado cosmológico y se distribuyen siguiendo principios textiles. Asimismo, después de hacer una breve descripción del sitio, ubicándolo en sus contextos geográfico y cultural, se analizarán las principales decoraciones que allí se encuentran para tratar de entenderlas. Los temas representados podrían referirse a antiguos mitos andinos y concepciones de orden astronómicos." (source éditeur

Rare predicted loss-of-function variants of type I IFN immunity genes are associated with life-threatening COVID-19

BackgroundWe previously reported that impaired type I IFN activity, due to inborn errors of TLR3- and TLR7-dependent type I interferon (IFN) immunity or to autoantibodies against type I IFN, account for 15-20% of cases of life-threatening COVID-19 in unvaccinated patients. Therefore, the determinants of life-threatening COVID-19 remain to be identified in similar to 80% of cases.MethodsWe report here a genome-wide rare variant burden association analysis in 3269 unvaccinated patients with life-threatening COVID-19, and 1373 unvaccinated SARS-CoV-2-infected individuals without pneumonia. Among the 928 patients tested for autoantibodies against type I IFN, a quarter (234) were positive and were excluded.ResultsNo gene reached genome-wide significance. Under a recessive model, the most significant gene with at-risk variants was TLR7, with an OR of 27.68 (95%CI 1.5-528.7, P=1.1x10(-4)) for biochemically loss-of-function (bLOF) variants. We replicated the enrichment in rare predicted LOF (pLOF) variants at 13 influenza susceptibility loci involved in TLR3-dependent type I IFN immunity (OR=3.70[95%CI 1.3-8.2], P=2.1x10(-4)). This enrichment was further strengthened by (1) adding the recently reported TYK2 and TLR7 COVID-19 loci, particularly under a recessive model (OR=19.65[95%CI 2.1-2635.4], P=3.4x10(-3)), and (2) considering as pLOF branchpoint variants with potentially strong impacts on splicing among the 15 loci (OR=4.40[9%CI 2.3-8.4], P=7.7x10(-8)). Finally, the patients with pLOF/bLOF variants at these 15 loci were significantly younger (mean age [SD]=43.3 [20.3] years) than the other patients (56.0 [17.3] years; P=1.68x10(-5)).ConclusionsRare variants of TLR3- and TLR7-dependent type I IFN immunity genes can underlie life-threatening COVID-19, particularly with recessive inheritance, in patients under 60 years old