504 research outputs found

    Spatial fluctuations at vertices of epithelial layers: quantification of regulation by Rho pathway

    Full text link
    In living matter, shape fluctuations induced by acto-myosin are usually studied in vitro via reconstituted gels, whose properties are controlled by changing the concentrations of actin, myosin and cross-linkers. Such an approach deliberately avoids to consider the complexity of biochemical signaling inherent to living systems. Acto-myosin activity inside living cells is mainly regulated by the Rho signaling pathway which is composed of multiple layers of coupled activators and inhibitors. We investigate how such a pathway controls the dynamics of confluent epithelial tissues by tracking the displacements of the junction points between cells. Using a phenomenological model to analyze the vertex fluctuations, we rationalize the effects of different Rho signaling targets on the emergent tissue activity by quantifying the effective diffusion coefficient, the persistence time and persistence length of the fluctuations. Our results reveal an unanticipated correlation between layers of activation/inhibition and spatial fluctuations within tissues. Overall, this work connects the regulation via biochemical signaling with mesoscopic spatial fluctuations, with potential application to the study of structural rearrangements in epithelial tissues.Comment: 8 pages, 3 figure

    Familial chylomicronemia: A rare case report

    Get PDF
    We report a 5-day-old neonate born out of 3rd-degree consanguinity who presented with milky blood, hepatosplenomegaly, and lipemia retinalis (fundus examination). The baby was asymptomatic, euglycemic, and did not have xanthomas. Lipid profile was altered (total cholesterol - 2340 mg/dl, triglycerides (TG) - >10,000 mg/dl, high-density lipoprotein - <5 mg/dl, lipoprotein (a) - <10.1 mg/dl, and apolipoprotein A1 - 795 mg/dl). Lipid profile of mother, father, and elder sibling were normal. The baby was started on skimmed milk powder and medium-chain TGs powder. The baby is under follow-up and lipid profile is improving

    Biology and biometry of milkfish Chanos chanos (Forsskal)

    Get PDF
    Observations made on length-weight relationship for adult milkfish, ova-diameter frequency distribution, relationship between fecundity and total length, fecundity and standard length; and weight and fecundity are presented. The regression lines for 17 morphometric characters in relation to the standard length were worked out. Snout to anal origin grows faster than snout to ventral origin. Head length; shows faster rate of growth than head depth. The stomach content revealed the presence of diatoms predominantly. Fecundity varied between 1424 and 5321 thousands in the fish in the size range of 1,100 - 1,340 mm

    10-[2-(Dimethyl­amino)eth­yl]-9-(4-methoxy­phen­yl)-3,3,6,6-tetra­methyl-3,4,6,7,9,10-hexa­hydro­acridine-1,8(2H,5H)-dione

    Get PDF
    In the title compound, C28H38N2O3, the central ring of the acridinedione system adopts a boat conformation, while one of the outer rings adopts a half-chair conformation and the conformation of the other outer ring is between a sofa and a half-chair. The acridinedione system is buckled, with an angle of 22.01 (3)°. The crystal packing comprises layers of mol­ecules laid parallel to the ac plane, being reinforced by an intermolecular C—H⋯O interaction

    Movement of deep-sea coral populations on climatic timescales

    Get PDF
    During the past 40,000 years, global climate has moved into and out of a full glacial period, with the deglaciation marked by several millennial-scale rapid climate change events. Here we investigate the ecological response of deep-sea coral communities to both glaciation and these rapid climate change events. We find that the deep-sea coral populations of Desmophyllum dianthus in both the North Atlantic and the Tasmanian seamounts expand at times of rapid climate change. However, during the more stable Last Glacial Maximum, the coral population globally retreats to a more restricted depth range. Holocene populations show regional patterns that provide some insight into what causes these dramatic changes in population structure. The most important factors are likely responses to climatically driven changes in productivity, [O_2] and [CO_3^(2–)]

    Propositional Dynamic Logic for Message-Passing Systems

    Full text link
    We examine a bidirectional propositional dynamic logic (PDL) for finite and infinite message sequence charts (MSCs) extending LTL and TLC-. By this kind of multi-modal logic we can express properties both in the entire future and in the past of an event. Path expressions strengthen the classical until operator of temporal logic. For every formula defining an MSC language, we construct a communicating finite-state machine (CFM) accepting the same language. The CFM obtained has size exponential in the size of the formula. This synthesis problem is solved in full generality, i.e., also for MSCs with unbounded channels. The model checking problem for CFMs and HMSCs turns out to be in PSPACE for existentially bounded MSCs. Finally, we show that, for PDL with intersection, the semantics of a formula cannot be captured by a CFM anymore
    corecore