10 research outputs found
Patterns of antibody responses to nonviral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status
- Author
- BoscoloâRizzo Paolo
- Broglie Martina A.
- Brunner Cornelia
- Butt Julia
- Dietz Andreas
- Doescher Johannes
- Dyckhoff Gerhard
- EichmĂŒller Stefan B.
- Ezic Jasmin
- Gangkofner Dominik S.
- HeroldâMende Christel
- Hoffmann Thomas K.
- Holzinger Dana
- JĂ€ger Dirk
- Kestler Hans A.
- Kraus Johann M.
- Laban Simon
- Marienfeld Ralf B.
- Möller Peter
- Pawlita Michael
- Schroeder Lea
- Schuler Patrick J.
- Theodoraki Marie N.
- Völkel Gunnar
- Waterboer Tim
- Wichmann Gunnar
- Wigand Marlene
- Zörnig Inka
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
There have been hints that nonviral cancer antigens are differentially expressed in human papillomavirus (HPV)-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC). Antibody responses (AR) to cancer antigens may be used to indirectly determine cancer antigen expression in the tumor using a noninvasive and tissue-saving liquid biopsy. Here, we set out to characterize AR to a panel of nonviral cancer antigens in HPV-positive and HPV-negative HNSCC patients. A fluorescent microbead multiplex serology to 29 cancer antigens (16 cancer-testis antigens, 5 cancer-retina antigens and 8 oncogenes) and 29 HPV-antigens was performed in 382 HNSCC patients from five independent cohorts (153 HPV-positive and 209 HPV-negative). AR to any of the cancer antigens were found in 272/382 patients (72%). The ten most frequent AR were CT47, cTAGE5a, c-myc, LAGE-1, MAGE-A1, -A3, -A4, NY-ESO-1, SpanX-a1 and p53. AR to MAGE-A3, MAGE-A9 and p53 were found at significantly different prevalences by HPV status. An analysis of AR mean fluorescent intensity values uncovered remarkably different AR clusters by HPV status. To identify optimal antigen selections covering a maximum of patients with â€10 AR, multiobjective optimization revealed distinct antigen selections by HPV status. We identified that AR to nonviral antigens differ by HPV status indicating differential antigen expression. Multiplex serology may be used to characterize antigen expression using serum or plasma as a tissue-sparing liquid biopsy. Cancer antigen panels should address the distinct antigen repertoire of HPV-positive and HPV-negative HNSCC
Sex difference and intra-operative tidal volume: Insights from the LAS VEGAS study
- Author
- Adeline Gerard
- Adem Bytyqi
- Aggeliki Pandazi
- Ahmed Abdel-Razek
- Ahmed Chishti
- Ahmed Mostafa El-Shaarawy
- Alar Sormus
- Alastair Rose
- Albert Prades
- Alberto Lisi
- Alberto Zangrillo
- Aleksandra Lazukic
- Alena Breidablik
- Alenka Spindler-Vesel
- Alessandro Bacuzzi
- Alexander Kulikov
- Alexander Lugovoy
- Alexandre Molin
- Alexandru Bogdan Prodan
- Alexey Gritsan
- Alexey Ovezov
- Ali Saltali
- Alice Werger
- Alida Moise
- Alistair Cain
- Alyson Andrew
- Amanda Datson
- Ambra Licia Di Parma
- Amir Rafi
- Amir Shafi-Kabir
- Ana de Abajo Larriba
- Ana Fernandez- Bustamante
- Ana Maria Petcu
- Ana Pekle-Golez
- Ana Ricardo
- Andre Gottschalk
- Andrea Bell
- Andrea Brunelli
- Andrea Cortegiani
- Andreas Gueldner
- Andreas Reske
- Andrew Donovan
- Andrey Babayants
- Andrey Lubnin
- Andriy Grynyuk
- Andriy Mazur
- Anette Bundy
- Angela Almagro
- Angela Monteirosa
- Angelo Gratarola
- Ann De Bruyne
- Anna Fouracres
- Anna Marija Pavicic
- Annamaria Campanile
- Anne Duvekot
- Annika Aun
- Antoine Petit
- Antonella Marrella
- Antonino Giarratano
- Antonio MartĂnez Simon
- Antonio Zilic
- Antonis Andreou
- Arieh Eden
- Ashok Das
- Ashok Raj
- Audrey Pospiech
- Aurika Karbonskiene
- Bahar Kuvaki
- Barbka Novak-Supe
- Bas in âŻât Veld
- Baturay Kansu Kazbek
- Bea Bastin
- Ben Creagh-Brown
- Ben Schwerdtfeger
- Ben Shelley
- Benedikt Pannen
- Benoit Plichon
- Bernhard Urbanek
- Binnekade Jan M
- Bjorn Heyse
- Branka Maldini
- Branka Mazul-Sunko
- Branka Strazisar
- Branwen Ellison
- Brigitte Leva
- Cait Goodall
- Carlo Alberto Volta
- Carlos Ferrando
- Carlos Puigbo
- Catalin-Traian Guran
- Caterina Valeria Pesce
- Ceren Sanlikarip
- Cesar Aldecoa Alvares-Santullano
- Charley Higham
- Charlotte Severijns
- Christa Boer
- Christian Nestler
- Christopher Uhlig
- Christos Nouris
- Chryssa Pourzitaki
- Claire West
- Clare Jackson
- Colin Barrett
- Concezione Tommasino
- Corrado Liperi
- Cristina Saiz Ruiz
- Dalip Muhardri
- Dan Corneci
- Dan Costea
- Dana Tomescu
- Daniel Ferreira
- Daniela Filipescu
- Daniela La Bella
- Daniele Sances
- Danielle Franklin
- Darija Azenic-Venzera
- Daryl Kor
- David Kahn
- David Portch
- David Rogerson
- Davide D'antini
- Debbie Fuller
- Deborah Clements
- Dejana DjonoviÄ- OmanoviÄ
- Demet Sulemanji
- Denny Tran Thiem
- Diana Westerheide
- Dimitri Dylst
- Dimitrios Valsamidis
- Dimitris Karapanos
- Diogo Martins
- Dmitri Bystritski
- Dubravka Ivic
- Dunja Mihajlovic
- Egle Kontrimaviciute
- Eiko Herodes
- Elaine Rogers
- Elena Sardo
- Elisa Brugnoni
- Elisabeth Andersson
- Elizabeth Homan
- Elizabeth Luzier
- Emily Calton
- Emmanuel Futier
- Emmanuel Marret
- Emre Camci
- Enrique Moret
- Erick Morais
- Erika Salciute
- Ernesto Pastor
- Eyup Aydogan
- Fatma Mine Karaman
- Fatma Nur Akgun
- Fatos Sada
- Federica Scavonetto
- Felicity Mackenzie
- Ferim Gunenc
- Fernande Lois
- Fevzi Toraman
- Filippo Bressan
- Foteini Zafeiropoulou
- Francesca Montalto
- Francesca Rapido
- Francesco Bona
- Francis Joseph Borg
- Francisco Hidalgo Martinez
- Frederic Rodenas
- Frode Fjellanger
- Gabija Tomkute
- Gabriela Droc
- Gabriele Sales
- Galina Gritsan
- Gama de Abreu Marcelo
- Gary Mills
- Gary Minto
- Gecaj-Gashi Agreta
- Georgia Tsaousi
- Georgios Antholopoulos
- Georgios Gkiokas
- Gerd Struber
- Gianluca Castellani
- Gianluca Spano
- Gianmarco Giacoletto
- Gilda Cinnella
- Giorgia Cerati
- Giovanni Landoni
- Gisela Perez
- Giulia Pellerano
- Giuseppe Musella
- Giuseppe Servillo
- GlĂłria Tareco
- Goncalves Castro
- Gorjana Erceg
- Guy Rousseau
- Hana Harazim
- Hans Gombotz
- Hany Yassin
- Hedenstierna Goran
- Helen Roberts
- Helen Scholes
- Helfried Metzler
- Hemmes Sabrine N T
- Hermann Wrigge
- Hiesmayr Michael
- Hisham Hosny Abdelwahab
- Hol Liselotte
- Hollmann Markus W
- Hrvoje Vinkovic
- Ib Jammer
- Ines Arpino
- Inga Mladic-Batinica
- Ioana Cristina Grintescu
- Ioana Marina Grintescu
- Ioana Popescu Garotescu
- Iole Brunetti
- Iorel Gherghina
- Irene Wiersma
- Irina Grosu
- Irina Komissarova
- Iulia Cindea
- Ivan Kostadinov
- Ivan Mirkovic
- Ivana Oputric
- Ivana Volfova
- Jaber Samir
- Jadranka Pavicic Saric
- Jale Maral
- James Limb
- Jan Brujevic
- Jan Poelaert
- Jane Montgomery
- Janet Palmer
- Jannicke Mellin-Olsen
- Jasmina Markovic-Bozi
- Jasmina Pejakovic
- Jasminka Kopic
- Jasper De Jong
- Jaume Canet
- Jayne Foot
- Jaysimha Susarla
- Jens Hering
- Jens Krassler
- Jeroen van Melkebeek
- Jesus Rico
- Jill Deane
- Joana Amaral
- Johann Geib
- John Williams
- John Xuereb
- Jonathan Paddle
- Jose Antonio de Andrés Ibañez
- Jose Tatay Vivo
- Josep Fava
- Josip Zunic
- Julie Colley
- Juraj Sprung
- Jurgen Van Limmen
- Juri Karjagin
- Juri Oganjan
- Kaili Sarapuu
- Kamil Hudacek
- Karen Simeson
- Karginova Zalina
- Kassiani Theodoraki
- Katarina Bruncakova
- Katarina Liskova
- Katerina Jirmanova
- Katerina Vitkova
- Katharina Skirstad Hodt
- Kazimir Juricic
- Konstantinos Stroumpoulis
- Krishnan Kodaganallur
- Lars Gillberg
- Laura Pasin
- Laura Pistidda
- Leanne Welch
- Lenka Polakovicova
- Liliana Mirea
- Lisa Wayman
- Luc De Baerdemaeker
- Luca Brazzi
- Luca Montagnani
- Lucia Mirabella
- Lucia Stancombe
- Lucia Zamidei
- Lucian Horhota
- Lucy Brown
- Luigi Beretta
- Luigi Delunas
- Luigi Giancarlo
- Luiz Fernando
- Lynn Everett
- Madalina Dutu
- Magda Riciu
- Mahdy Abdelhady
- Maka Zuleika
- Manuel Granell
- Manuel Vico Avalos
- Mar Sendra
- Marc Solier
- Marcel Gama de Abreu
- Marco Baciarello
- Marco Venturino
- Marco Verri
- Marcos Vidal Melo
- Marcus J
- Marcus Schultz
- Margaret Szewczyk
- Mari Carmen Unzueta
- Maria de Lurdes
- Maria Jose Yepes Temino
- Maria Nadolski
- Maria Vargas
- Maria Zelinkova
- Marian Irinel Tudoroiu
- Mariana Correia
- Marie-Claire van Malderen
- Marina Juros-Zovko
- Marina Soro
- Mario Defez
- Marios-Konstantinos Tasoulis
- Mark Pulletz
- Markus Hollmann
- Marta Eugenia Sassone
- Martin Scharffenberg
- Martin Weiss
- Martina Kosinova
- Matea Bogdanovic Dvorscak
- Matthew Rucklidge
- Maud Beran
- Maudrian Burton
- Maureen Bezzina
- Maurizio Solca
- Maximilian Schaefer
- Merilin Mall
- Michael Hiesmayr
- Michael Lundberg
- Michal Drab
- Michela Generali
- Michele De Michele
- Mihai Popescu
- Mihaly Veres
- Mills Gary H
- Minca Voje
- Mine Yildiz
- Mirja Konrad
- Mirna Sehovic
- Miroljub Jovanov
- Mladen Carev
- Mohamed Magdy
- Mohamed Mahran
- Mona Momeni
- Monir Jawad
- Moses Chikungwa
- Mrutyunjaya Rambhatla
- Murat Yilmaz
- MĂłnica Rodriguez Nunez
- Natalia Anipchenko
- Natasa Dropulic
- Nathalie Roels
- Necmiye Hadimioglu
- Nenad Karanovic
- Nesil Coskunfirat
- Neval Boztug
- Nicholas Boyd
- Nijbroek Sunny G
- Nukhet Sivrikoz
- Nuzhet Mert Senturk
- Oguzhan Arun
- Oleg Korolkov
- Olga Smekalova
- Onur Selvi
- Otto Mohr
- Ozgur Senturk
- Pablo Monedero
- Panagiota Florou
- Paola Morelli
- Paolo Pelosi
- Paolo Severgnini
- Parizade Raymode
- Pasquale Raimondo
- Patrice Forget
- Paul Dennesen
- Paula Dzurnakova
- Pauline Mercer
- Pavel Prokoshev
- Peeter Kivik
- Pelosi Paolo
- Petar Miskovic
- Peter Carvalho
- Peter Kienbaum
- Peter Spieth
- Petr Stourac
- Philip Watt
- Philipp Simon
- Piet Wyffels
- Povilas Miliauskas
- Putensen Christian
- Rachel Walker
- Radek Filipsky
- Radovan Dudas
- Raquel Martinez
- Renatas Tikuisis
- Reuven Pizov
- Riccardo Ragazzi
- Rienk van Beek
- Roberto Dossi
- Roberto Zoppellari
- Rocio Perez
- Rosanna Sileo
- Ruby Molina
- Rupert Pearse
- Ruta Aukstakalniene
- Ruxandra Copotoiu
- Ruxandra Fota
- Sabrine Hemmes
- Salvatore Grasso
- Samir el Kafraw
- Samir Jaber
- Sanda-Maria Copotoiu
- Sandeep Kusre
- Sandeep Varma
- Sandrine Damster
- Santi Maurizio Raineri
- Sara Rodrigues
- Sara Sher
- Sarah Gibb
- Sarah Moreton
- Savino Spadaro
- Schmid Werner
- Schultz
- Selma Pernar
- Semih Kucukguclu
- Semra Kucukgoncu
- Septimiu Gheorghe Moldovan
- Sergei Fedorov
- Sergiy Vorotyntsev
- Serpa Neto Ary
- Serpil Ustalar Ozgen
- Severgnini Paolo
- Seyda Canli
- Shivarajan Algarsamy
- Silvius Negoita
- Simon Davies
- Simone Merzky
- Sipylaite Jurate
- Slavica Kvolik
- Sofia Appleton
- Sonja Skiljic
- Sopio Peradze
- Stanley Wutai
- Stefan de Hert
- Stefan Ivars
- Stefano Pezzatto
- Stefano Tredici
- Stephanie Jones
- Stephen Mowat
- Stijn van de Velde
- Suat Sanli
- Sudhakar Marri
- Suresh Venkatesh
- Susan Yates
- Susana Cadilha
- Suzana Parente
- Swart Pien
- Tanja Goranovic
- Tanja Treschan
- Tarek Metwally
- Tatiana Sidiropoulou
- Tatyana Kapkan
- Thais Creary
- Thea Koch
- Thomas Bluth
- Thomas Kiss
- Thomas Smith
- Thomas Wegscheider
- Toby Weingarten
- Tom Jacobs
- Tomas Kolacek
- Tomislav Radocaj
- Valentina Tarzia
- Valery Likhvantsev
- Vedran Frkovic
- Veerle van Mossevelde
- Vesna Novak-Jankovic
- Vicari Sottosanti
- Victoria Barsan
- Victoria Moral
- Vidal Melo Marcos F
- Villiam Sobona
- Vincenzo Russotto
- Vittoria Bartolini
- Werner Schmid
- Wolfgang Kroell
- Wrigge Hermann
- Yeo Tze
- Yigal Leykin
- Yousif Saeed
- Zeljka Gavranovic
- Zerrin Sungur
- Zivile Teberaite
- Zsolt Tolcser
- Zuleyha Kazak Bengisun
- Zuzana Kusnierikova
- Ćule Ozbilgin
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 01/01/2021
- Field of study
BACKGROUND: One key element of lung-protective ventilation is the use of a low tidal volume (VT). A sex difference in use of low tidal volume ventilation (LTVV) has been described in critically ill ICU patients.OBJECTIVES: The aim of this study was to determine whether a sex difference in use of LTVV also exists in operating room patients, and if present what factors drive this difference.DESIGN, PATIENTS AND SETTING: This is a posthoc analysis of LAS VEGAS, a 1-week worldwide observational study in adults requiring intra-operative ventilation during general anaesthesia for surgery in 146 hospitals in 29 countries.MAIN OUTCOME MEASURES: Women and men were compared with respect to use of LTVV, defined as VT of 8âmlâkg-1 or less predicted bodyweight (PBW). A VT was deemed 'default' if the set VT was a round number. A mediation analysis assessed which factors may explain the sex difference in use of LTVV during intra-operative ventilation.RESULTS: This analysis includes 9864 patients, of whom 5425 (55%) were women. A default VT was often set, both in women and men; mode VT was 500âml. Median [IQR] VT was higher in women than in men (8.6 [7.7 to 9.6] vs. 7.6 [6.8 to 8.4] mlâkg-1 PBW, Pâ<â0.001). Compared with men, women were twice as likely not to receive LTVV [68.8 vs. 36.0%; relative risk ratio 2.1 (95% CI 1.9 to 2.1), Pâ<â0.001]. In the mediation analysis, patients' height and actual body weight (ABW) explained 81 and 18% of the sex difference in use of LTVV, respectively; it was not explained by the use of a default VT.CONCLUSION: In this worldwide cohort of patients receiving intra-operative ventilation during general anaesthesia for surgery, women received a higher VT than men during intra-operative ventilation. The risk for a female not to receive LTVV during surgery was double that of males. Height and ABW were the two mediators of the sex difference in use of LTVV.TRIAL REGISTRATION: The study was registered at Clinicaltrials.gov, NCT01601223
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016) : part two
- Author
- Abassi Yama
- Abelin Jennifer G
- Abolhalaj Milad
- Abraham Tara S
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F
- Adamus Tomasz
- Addepalli Murali
- Addepalli Murali
- Adjei Alex A
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C
- Albershardt Tina C
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T
- Alley Evan W
- Allison James
- Allison James
- Allison James
- Alston Tesha
- Alt JĂŒrgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anand Snjezana
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H I
- Andtbacka Robert H I
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S
- Antonia Scott J
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B
- Atkinson Victoria
- Au Katrina
- Autio Karen A
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Bartlett David
- Bartlett David
- Bartlett David
- Barton Sunjay M
- Barve Minal
- Bauer Todd
- Bauer Todd W
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A
- Bedognetti Davide
- Bedognetti Davide
- Bedognetti Davide
- Bell Bryan
- Bell Charles J M
- Bell Peter
- Beltran Pedro
- Bender Lewis H
- Bender Steven
- Bennett Mark K
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S
- Berzofsky Jay A
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M
- Bischoff Helge
- Blake Zoe
- Blake Zoe
- Blakely Collin
- Blazar Bruce R
- Blogowski Wojciech
- Bloom Anja C
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Bommareddy Praveen K
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
- Brech Dorothee
- Brenin David
- Broaddus V. C
- Brockstedt Dirk G
- Brockstedt Dirk G
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L
- Brown Sheila
- Bruce Jeffrey N
- Brunet Laura R
- Bruno Tullia C
- Bryan Jennifer
- Bryant Richard
- Buchbinder Elizabeth
- Bucsek Mark
- Budhu Sadna
- Budhu Sadna
- Budkowska Marta
- Bueno Raphael
- Buettner Florian
- Buettner Nico
- Bullock Kim
- Bullock Kim
- Burova Elena
- Burrill Joel
- Bussler Holm
- Butterfield Lisa H
- Butterfield Lisa H
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K
- Campesato Luis F
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M
- Carlino Matteo S
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A
- Carrero Rosa M S
- Carson Dennis A
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
- Cauwenberghs Sandra
- Caux Christophe
- Cebon Jonathan S
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cerullo Vincenzo
- Cervera-CarrascĂłn VĂctor
- Cesareni Gianni
- Cha John
- Cha John
- Cha John
- Champion Brian
- Chan Anissa S H
- Chan Chanty
- Chan Chanty
- Chan Ivan
- Chan Leo
- Chan Timothy A
- Chang Alfred E
- Chang Alfred E
- Chang Joe
- Chang Nancy N
- Chang Thomas
- Chanuc Fabien
- Chapelin Fanny
- Chaplin Jenny
- Chappel Scott C
- Charych Deborah H
- Charych Deborah H
- Chaudhuri Amitabha
- Chaussabel Damien
- Chen Ada
- Chen Ada
- Chen Gang
- Chen Jason
- Chen Jason
- Chen Xiaomu
- Chen Xin
- Chen Xiufen
- Chen Yu
- Chen Yu
- Chenchik Alex
- Chheda Zinal
- Chiang Eugene
- Chikina Maria
- Chittenden Thomas
- Chiu Hsiling
- Cho Charles
- Chongyung Fang
- Chou Margaret
- Choueiri Toni K
- Choy Carmen
- Clark Joseph I
- Clavijo Paul E
- Clifton Guy T
- Clynes Raphael
- Cobbold Mark
- Cobbold Mark
- Cobbold Mark
- Coder Brandon
- Coffman Robert L
- Cohen Cyrille
- Cohen Ezra E W
- Cohen Roger
- Colen Rivka
- Colevas A. D
- Collins Natalie
- Colrain Jillian
- Coltharp Carla
- Concha-Benavente Fernando
- Connolly Eileen P
- Conwell Darwin
- Conwell Darwin
- Corrales Leticia P
- Corrales Leticia P
- Coukos George
- Coukos George
- Coussens Lisa M
- Coussens Lisa M
- Craggs Graham
- Craig Andrew
- Crittenden Marka
- Cron Kyle R
- Cronstein Bruce N
- Crooks James
- Crosby Andrea
- Crosignani Stefano
- Crowder Robert
- Cruickshank Scott
- Csuka Orsolya
- Curbishley Stuart
- Curiel Tyler
- Curran Emily
- Curran Michael
- Curti Brendan
- Curti Brendan
- Da Costa Andre
- Dai Fu
- Dai Jie
- Dai Peihong
- Dalgleish Angus
- Dalvie Deepak
- Daniels Gregory A
- Daud Adil
- David Justin M
- Davies Bronwyn
- de Boisferon Marc H
- de Groot Patricia
- de Gruijl Tanja
- De Henau Olivier
- de Leon Laura
- De Maeseneire Coraline
- De Sanctis Francesco
- de Silva Suresh
- Deacon Donna
- Deacon Donna H
- DeBenedette Mark
- DeBenedette Mark
- Declerck Paul
- Decock Julie
- Decock Julie
- DeFalco Jeff
- Dela Cruz Filemon
- Delgoffe Greg
- Delgoffe Greg M
- Delgoffe Greg M
- Delgoffe Greg M
- Delogu Lucia
- Delorenzi Mauro
- Demaria Sandra
- Demaria Sandra
- Deng Liang
- Deng Weiwen
- Deng Wentao
- Denies Sofie
- Denis Caroline
- Desbien Anthony L
- deVries Michele
- Dhupkar Pooja
- Diab Adi
- Diab Adi
- Diab Adi
- Diaz Luis
- DiCostanzo AriCeli
- Diede Scott J
- Dietz Allan B
- Dillhoff Mary
- Dillon Patrick
- Dilworth Ryan
- Dimberg Anna
- Ding Yueyun
- Doberstein Stephen K
- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
- Doleschall Zoltan
- Doman Thompson
- Dominguez George
- Donahue Renee
- Donahue Renee
- Dorsey Frank C
- Dovedi Simon
- Downs-Canner Stephanie
- Drake Charles
- Drake Charles G
- Drake Charles G
- Driessens Gregory
- Driscoll Kyla
- Druker Brian J
- Dubensky Thomas W
- Dubensky Thomas W
- Dudimah Duafalia
- Duff Susan
- Dumontet Charles
- Dunai Cordelia
- Dunai Cordelia
- Dutcher Janice P
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- DâApuzzo Massimo
- Ebner Peggy
- Edwards Robert
- Edwards Robert P
- Edwards Robert P
- Eickhoff Jens
- Eisenhower Mary
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- Su Yu-Lin
- Sudarshan Naremaddepalli
- Sugarbaker David
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- Sultan Hussein
- Sun Shaoli
- Sundararaman Srividya
- Sung Leonard
- Suresh Rahul
- Surguladze David
- Suryawanshi Satyendra
- Suryawanshi Satyendra
- Suzuki Akiko
- Suzuki Ryuji
- Sweis Randy F
- Taback Bret
- Tagliaferri Mary
- Talbert Erin
- Tallarico John
- Tan Joanne B
- Tan Joanne B L
- Tan Wei
- Tan Yann C
- Tanaka Maki
- Tang Chad
- Tannir Nizar M
- Tannir Nizar M
- Taylor Allison
- Taylor Matthew
- Tcherepanova Irina
- ter Meulen Jan
- ter Meulen Jan
- Terabe Masaki
- Terabe Masaki
- Termini James
- Tetzlaff Michael
- Tewary Poonam
- Thakurta Anjan
- Thayer Matt
- Theodoraki Marie-Nicole
- Thimme Robert
- Thomas Portia
- Thomas Remy
- Thomas Vincent
- Thompson John A
- Thounaojam Menaka
- Thounaojam Menaka
- Thurston Gavin
- Tighe Rober
- Tilahun Ashenafi
- Tillé Laure
- Timmerman John
- Tipton Kimberly A
- Tipton Kimberly A
- Tognon Christina E
- Tomai Mark A
- Toms Anne
- Torno Sebold
- Torrey Heather
- Torti Vince
- Toth Laszlo
- Trager James B
- Trappey Alfred F
- Trivedi Sumita
- Truesdell Peter
- Tsang Kwong
- Tsang Kwong
- Tsang Kwong Y
- Tsaparikos Konstantinos
- Tsouko Efrosini
- Tsujikawa Takahiro
- Tsujikawa Takahiro
- Tsujikawa Takahiro
- Tuck David
- Tumang Joseph
- Tumang Joseph
- Turbitt William J
- Turk Andrew T
- Tyner Jeffery W
- TĂ€htinen Siri
- TĂ€htinen Siri
- Uecker Darrin
- Uecker Darrin
- Uecker Darrin
- Ugel Stefano
- Ugel Stefano
- Uhlik Mark
- Ujhelyi Mihaly
- Ullenhag Gustav
- Unfricht Darryn
- Ungerleider Richard
- Urban Julie
- Urban Julie
- Valsesia-Wittmann Sandrine
- Valsesia-Wittmann Sandrine
- Van der Meijs Pien
- van Vugt Marianne
- van Zutphen Mariëlle
- Vanamee Eva
- Vanderslice Peter
- VanderVeen Laurie
- Vanpouille-Box Claire I
- VanVlasselaer Peter
- Varhegyi Nikole
- Vasilakos John P
- Vaske Charles
- Vassilev Lotta
- Velcheti Vamsidhar
- Velculescu Victor
- Verma Amita
- Verma Amita
- Vetto John
- Vianden Christina
- Vietsch Eveline E
- Vignali Dario
- Vignali Dario
- Vogel Katharina
- Volkmuth Wayne
- Volz Barbara
- vonEbyen Rie
- Vreeland Timothy J
- Vu Tuyen
- Wada Hiroshi
- Wagtmann Nicolai
- Waldman Michelle
- Waldman Scott A
- Waller John
- Wallraven Gladice
- Walsh Richard
- Walters Ian B
- Wang Ena
- Wang Ena
- Wang Hongjie
- Wang Ping
- Wang Shangzi
- Wang Weiyi
- Wang Ximi K
- Wang Yi
- Wang Ziming
- Ward Stephen T
- Waugh Katherine
- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R
- Weiner David
- Weiner Louis M
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
- Wenthe Jessica
- Wenthe Jessica
- Werner Lauryn R
- West Brian
- West James
- West James
- Wheatley Courtney
- Whetstone Ryan
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C
- Whiting Chan C
- Wicha Max S
- Wicha Max S
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W
- Wilkinson Robert W
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolchok Jedd D
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Chihunt
- Wong Deborah J
- Wong Gabriel
- Wong Kenneth R
- Wong Kenneth R
- Wong Michael K
- Wood Laura
- Woodside Darren G
- Workman Creg
- Wu Bill X
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- YlösmÀki Erkko
- YlösmÀki Erkko
- Young Gregory
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W
- Young Steve W
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zalevsky Jonathan
- Zappasodi Roberta
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Background
The immunological escape of tumors represents one of the main ob- stacles to the treatment of malignancies. The blockade of PD-1 or CTLA-4 receptors represented a milestone in the history of immunotherapy. However, immune checkpoint inhibitors seem to be effective in specific cohorts of patients. It has been proposed that their efficacy relies on the presence of an immunological response. Thus, we hypothesized that disruption of the PD-L1/PD-1 axis would synergize with our oncolytic vaccine platform PeptiCRAd.
Methods
We used murine B16OVA in vivo tumor models and flow cytometry analysis to investigate the immunological background.
Results
First, we found that high-burden B16OVA tumors were refractory to combination immunotherapy. However, with a more aggressive schedule, tumors with a lower burden were more susceptible to the combination of PeptiCRAd and PD-L1 blockade. The therapy signifi- cantly increased the median survival of mice (Fig. 7). Interestingly, the reduced growth of contralaterally injected B16F10 cells sug- gested the presence of a long lasting immunological memory also against non-targeted antigens. Concerning the functional state of tumor infiltrating lymphocytes (TILs), we found that all the immune therapies would enhance the percentage of activated (PD-1pos TIM- 3neg) T lymphocytes and reduce the amount of exhausted (PD-1pos TIM-3pos) cells compared to placebo. As expected, we found that PeptiCRAd monotherapy could increase the number of antigen spe- cific CD8+ T cells compared to other treatments. However, only the combination with PD-L1 blockade could significantly increase the ra- tio between activated and exhausted pentamer positive cells (p= 0.0058), suggesting that by disrupting the PD-1/PD-L1 axis we could decrease the amount of dysfunctional antigen specific T cells. We ob- served that the anatomical location deeply influenced the state of CD4+ and CD8+ T lymphocytes. In fact, TIM-3 expression was in- creased by 2 fold on TILs compared to splenic and lymphoid T cells. In the CD8+ compartment, the expression of PD-1 on the surface seemed to be restricted to the tumor micro-environment, while CD4 + T cells had a high expression of PD-1 also in lymphoid organs. Interestingly, we found that the levels of PD-1 were significantly higher on CD8+ T cells than on CD4+ T cells into the tumor micro- environment (p < 0.0001).
Conclusions
In conclusion, we demonstrated that the efficacy of immune check- point inhibitors might be strongly enhanced by their combination with cancer vaccines. PeptiCRAd was able to increase the number of antigen-specific T cells and PD-L1 blockade prevented their exhaus- tion, resulting in long-lasting immunological memory and increased median survival
Regional outcome disparities in German head and neck cancer patients: Shorter survival in Eastern Germany
- Author
- Publication venue
- Wiley
- Publication date
- 01/12/2023
- Field of study
Abstract Introduction Demographics are important prognostic factors in malignant diseases. A nationwide analysis concerning the prognostic impact of demographics in head and neck cancer (HNC) patients (HNCP) has not been performed previously. Methods A retrospective analysis of data from the Center for Cancer Registry Data (ZfKD) and the Federal Statistical Office (Destatis) between 2002 and 2017 was performed. A total of 212âČ920 HNCP were included. Incidence, tumor stage, age development, sex distribution, ageâ, residenceâ, and diagnosisâtimeâspecific survival were examined. Results Mean age of HNCP increased more rapidly than in the general population (slope coefficient: 0.29 vs. 0.20; pâ70âyears was found. Furthermore, an OS disadvantage was observed for East Germany compared to West Germany (median 47 vs. 60âmonths; pâ<â0.0001). This disparity was associated with a disproportionately high ratio of men in East Germany (men/women: 4.4 vs. 3.1; pâ<â0.0001) and a lower mean age (61 vs. 63âyears; pâ<â0.0001). In addition to stage, age and sex, residence in East Germany were confirmed as an independent factor for OS in a multivariate analysis. Conclusion Finally, three decades after the German reunion, a survival disadvantage for patients in East Germany still exists. This discrepancy may be a result of socioeconomic disparities
Patterns of antibody responses to nonviral cancer antigens in head and neck squamous cell carcinoma patients differ by human papillomavirus status
- Author
- BoscoloâRizzo Paolo
- Broglie Martina A
- Brunner Cornelia
- Butt Julia
- Dietz Andreas
- Doescher Johannes
- Dyckhoff Gerhard
- EichmĂŒller Stefan B
- Ezic Jasmin
- Gangkofner Dominik S
- HeroldâMende Christel
- Hoffmann Thomas K
- Holzinger Dana
- JĂ€ger Dirk
- Kestler Hans A
- Kraus Johann M
- Laban Simon
- Marienfeld Ralf B
- Möller Peter
- Pawlita Michael
- Schroeder Lea
- Schuler Patrick J
- Theodoraki Marie N
- Völkel Gunnar
- Waterboer Tim
- Wichmann Gunnar
- Wigand Marlene
- Zörnig Inka
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
There have been hints that nonviral cancer antigens are differentially expressed in human papillomavirus (HPV)âpositive and HPVânegative head and neck squamous cell carcinoma (HNSCC). Antibody responses (AR) to cancer antigens may be used to indirectly determine cancer antigen expression in the tumor using a noninvasive and tissueâsaving liquid biopsy. Here, we set out to characterize AR to a panel of nonviral cancer antigens in HPVâpositive and HPVânegative HNSCC patients. A fluorescent microbead multiplex serology to 29 cancer antigens (16 cancerâtestis antigens, 5 cancerâretina antigens and 8 oncogenes) and 29 HPVâantigens was performed in 382 HNSCC patients from five independent cohorts (153 HPVâpositive and 209 HPVânegative). AR to any of the cancer antigens were found in 272/382 patients (72%). The ten most frequent AR were CT47, cTAGE5a, câmyc, LAGEâ1, MAGEâA1, âA3, âA4, NYâESOâ1, SpanXâa1 and p53. AR to MAGEâA3, MAGEâA9 and p53 were found at significantly different prevalences by HPV status. An analysis of AR mean fluorescent intensity values uncovered remarkably different AR clusters by HPV status. To identify optimal antigen selections covering a maximum of patients with â€10 AR, multiobjective optimization revealed distinct antigen selections by HPV status. We identified that AR to nonviral antigens differ by HPV status indicating differential antigen expression. Multiplex serology may be used to characterize antigen expression using serum or plasma as a tissueâsparing liquid biopsy. Cancer antigen panels should address the distinct antigen repertoire of HPVâpositive and HPVânegative HNSCC
Meta-Analysis Investigating Associations Between Healthy Diet and Fasting Glucose and Insulin Levels and Modification by Loci Associated With Glucose Homeostasis in Data From 15 Cohorts
- Author
- Adela Hruby
- Albert Hofman
- Andrea Ganna
- André G. Uitterlinden
- Ani Manichaikul
- Berglund
- Bild
- Burke
- Choi
- Christopher J. Groves
- Constantina Papoutsakis
- Dariush Mozaffarian
- David R. Jacobs
- David S. Siscovick
- Denise K. Houston
- Dupuis
- Emily Sonestedt
- Erik Ingelsson
- Erika Ax
- Esposito
- Feinleib
- Ferrucci
- Frank B. Hu
- Frank J. A. van Rooij
- Franks
- Franks
- Frayling
- Frida Renström
- Fried
- Genovefa Kolovou
- George Dedoussis
- Grant
- Gulcher
- Halton
- Hedstrand
- Higgins
- Higgins
- Hofman
- Houston
- Hu
- Hunter
- Ilkka SeppÀlÀ
- Inga Prokopenko
- Ingegerd Johansson
- Ingrid B. Borecki
- Ioanna Ntalla
- Jack L. Follis
- Jacobs
- Jacobs
- Jacqueline C. M. Witteman
- James B. Meigs
- James S. Pankow
- Jennifer A. Nettleton
- Jessica C. Kiefte-de Jong
- Jorma Viikari
- Josée Dupuis
- Julius S. Ngwa
- Kanoni
- Kari North
- Kathleen Stirrups
- Kenneth Mukamal
- Kurt K. Lohman
- L. Adrienne Cupples
- Lawrence de Koning
- Liese
- Liu
- Lockheart
- Luc Djoussé
- Luigi Ferrucci
- Lyssenko
- M. Carola Zillikens
- Maria Dimitriou
- Marie-France Hivert
- Marju Orho-Melander
- Mark I. McCarthy
- Mary K. Wojczynski
- Mika KÀhönen
- Mozaffarian
- Mozaffarian
- Nanri
- Neelam Hassanali
- Nettleton
- Nettleton
- Nettleton
- Nicola M. McKeown
- Olli Raitakari
- Olov Rolandsson
- Pan
- Panos Deloukas
- Papoutsakis
- Paré
- Paul F. Jacques
- Paul W. Franks
- Pearson
- Per Sjogren
- Pereira
- Positively disruptive [editorial]
- Raitakari
- Renström
- Rozenn N. Lemaitre
- Splansky
- Stavroula Kanoni
- Stefania Bandinelli
- Stephen B. Kritchevsky
- Terho LehtimÀki
- The ARIC investigators
- Theodoraki
- Toshiko Tanaka
- Ulrika Ericson
- Venkat Narayan
- Vera MikkilÀ
- Villegas
- Yongmei Liu
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- Field of study
Evidence for three genetic loci involved in both anorexia nervosa risk and variation of body mass index
- Author
- Abecasis G. R.
- Absher D.
- Adair L. S.
- Adan R.
- Adan Roger A. H.
- Alavere H.
- Albrecht E.
- Albrecht E.
- Alexander Graeme
- Alfredsson Lars
- Alizadeh B.
- Amin N.
- Amin N.
- Amouyel P.
- Anderson Carl A.
- Ando Tetsuya
- Andreassen Ole A.
- Ang W.
- Antel J.
- Aschauer Harald
- Aspelund T.
- Asselbergs F. W.
- Assimes T. L.
- Atalay M.
- Atalay M.
- Attwood A. P.
- Baker Jessica H.
- Balmforth A. J.
- Bandinelli S.
- Barrett Jeff C.
- Barrett Jeffrey C.
- Barroso I.
- Barroso I.
- Basart H.
- Beilby J.
- Bencko Vladimir
- Benke K.
- Berenson G. S.
- Berg J.
- Bergen A. W.
- Bergen Andrew W.
- Bergen N.
- Bergmann S.
- Berndt S. I.
- Berrettini W.
- Berrettini Wade
- Berrettini Wade H.
- Berry D. J.
- Bierut L. J.
- Blackburn H.
- Blackburn Hannah
- Blackwood D.
- Boehm B. O.
- Boehnke M.
- Boerwinkle E.
- Boerwinkle E.
- Boezen H. M.
- Boni Claudette
- Bonnycastle L. L.
- Boomsma D. I.
- Boomsma D. I.
- Boraska Perica V.
- Borecki I. B.
- Boyd H. A.
- Bradfield J. P.
- Bragg-Gresham J. L.
- Brambilla P.
- Brandt Harry
- Brandys M.
- Brandys Marek K.
- Breen Gerome
- Bruinenberg M.
- Bruinenberg M.
- Bruson Alice
- Bulik C. M.
- Bulik Cynthia M.
- Bulik Cynthia M.
- Bulik Cynthia M.
- Burghardt Roland
- Buring J. E.
- Busonero F.
- Byrne E. M.
- BĂŒhren Katharina
- BĂŒltmann U.
- Cadby G.
- Campbell H.
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- Campbell H.
- Carlberg Laura
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- Cavanagh J.
- Chanock S. J.
- Chanock S. J.
- Charoen P.
- Chasman D. I.
- Chasman D. I.
- Chen W.
- Chen Wei-Min
- Children's Hospital of Philadelphia/Price Foundation
- Chines P. S.
- Cichon Sven
- Clair D. S.
- Clementi Maurizio
- Cohen-Woods Sarah
- Coin L.
- Collier D.
- Collier David A.
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- Couper D.
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- Croteau-Chonka D. C.
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- Farmer Anne
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- Finan Chris
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- Gejman P. V.
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- Gieger C.
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- Hendriks Judith
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- Workalemahu T.
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- WTCCC3
- Yaghootkar H.
- Yang J.
- Yilmaz Zeynep
- Young L.
- Zeggini E.
- Zeggini E.
- Zeggini Eleftheria
- Zeggini Eleftheria
- Zerwas Stephanie
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- Zillikens M.
- Zipfel S.
- Zipfel Stephan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 17/05/2016
- Field of study
The maintenance of normal body weight is disrupted in patients with anorexia nervosa (AN) for prolonged periods of time. Prior to the onset of AN, premorbid body mass index (BMI) spans the entire range from underweight to obese. After recovery, patients have reduced rates of overweight and obesity. As such, loci involved in body weight regulation may also be relevant for AN and vice versa. Our primary analysis comprised a cross-trait analysis of the 1000 single-nucleotide polymorphisms (SNPs) with the lowest P-values in a genome-wide association meta-analysis (GWAMA) of AN (GCAN) for evidence of association in the largest published GWAMA for BMI (GIANT). Subsequently we performed sex-stratified analyses for these 1000 SNPs. Functional ex vivo studies on four genes ensued. Lastly, a look-up of GWAMA-derived BMI-related loci was performed in the AN GWAMA. We detected significant associations (P-values <5 Ă 10â5, Bonferroni-corrected P<0.05) for nine SNP alleles at three independent loci. Interestingly, all AN susceptibility alleles were consistently associated with increased BMI. None of the genes (chr. 10: CTBP2, chr. 19: CCNE1, chr. 2: CARF and NBEAL1; the latter is a region with high linkage disequilibrium) nearest to these SNPs has previously been associated with AN or obesity. Sex-stratified analyses revealed that the strongest BMI signal originated predominantly from females (chr. 10 rs1561589; Poverall: 2.47 Ă 10â06/Pfemales: 3.45 Ă 10â07/Pmales: 0.043). Functional ex vivo studies in mice revealed reduced hypothalamic expression of Ctbp2 and Nbeal1 after fasting. Hypothalamic expression of Ctbp2 was increased in diet-induced obese (DIO) mice as compared with age-matched lean controls. We observed no evidence for associations for the look-up of BMI-related loci in the AN GWAMA. A cross-trait analysis of AN and BMI loci revealed variants at three chromosomal loci with potential joint impact. The chromosome 10 locus is particularly promising given that the association with obesity was primarily driven by females. In addition, the detected altered hypothalamic expression patterns of Ctbp2 and Nbeal1 as a result of fasting and DIO implicate these genes in weight regulation
Intraoperative ventilator settings and their association with postoperative pulmonary complications in neurosurgical patients: Post-hoc analysis of LAS VEGAS study
- Author
- Abdel-Razek Ahmed
- Abdelhady Mahdy
- Abdelwahab Hisham Hosny
- Ahmed Ahmed Gouda
- Akgun Fatma Nur
- Algarsamy Shivarajan
- Almagro Angela
- Alvares-Santullano Cesar Aldecoa
- Amaral Joana
- Andersson Elisabeth
- Andreou Antonis
- Andrew Alyson
- Anipchenko Natalia
- Antholopoulos Georgios
- Appleton Sofia
- Arpino Ines
- Arun Oguzhan
- Aukstakalniene Ruta
- Aun Annika
- Avalos Manuel Vico
- Aydogan Eyup
- Azenic-Venzera Darija
- Babayants Andrey
- Baciarello Marco
- Bacuzzi Alessandro
- Ball Lorenzo
- Barrett Colin
- Barsan Victoria
- Bartolini Vittoria
- Bastin Bea
- Battaglini Denise
- Bell Andrea
- Bengisun Zuleyha Kazak
- Beran Maud
- Beretta Luigi
- Bezzina Maureen
- Binnekade Jan
- Bluth Thomas
- Bluth Thomas
- Boer Christa
- Bona Francesco
- Borg Francis Joseph
- Bos Lieuwe
- Boyd Nicholas
- Boztug Neval
- Brazzi Luca
- Breidablik Alena
- Bressan Filippo
- Brown Lucy
- Brugnoni Elisa
- Brujevic Jan
- Bruncakova Katarina
- Brunelli Andrea
- Brunetti Iole
- Bundy Anette
- Burton Maudrian
- Bystritski Dmitri
- Bytyqi Adem
- Cadilha Susana
- Cain Alistair
- Calton Emily
- Camci Emre
- Campanile Annamaria
- Canet Jaume
- Canet Jaume
- Canli Seyda
- Carev Mladen
- Carvalho Peter
- Castellani Gianluca
- Cerati Giorgia
- Chikungwa Moses
- Chishti Ahmed
- Cindea Iulia
- Cinnella Gilda
- Clements Deborah
- Colley Julie
- Copotoiu Ruxandra
- Copotoiu Sanda-Maria
- Corneci Dan
- Correia Mariana
- Cortegiani Andrea
- Coskunfirat Nesil
- Costea Dan
- Creagh-Brown Ben
- Creary Thais
- D'Antini Davide
- Damster Sandrine
- Das Ashok
- Datson Amanda
- Davies Simon
- de Abajo Larriba Ana
- de Abreu Marcel Gama
- de Andrés Ibañez Jose Antonio
- de Baerdemaeker Luc
- de Bruyne Ann
- de Hert Stefan
- de Jong Jasper
- de Lurdes Goncalves Castro Maria
- de Michele Michele
- Deane Jill
- Defez Mario
- Delunas Luigi
- Dennesen Paul
- di Parma Ambra Licia
- DjonoviÄ-OmanoviÄ Dejana
- Donovan Andrew
- Dossi Roberto
- Drab Michal
- Droc Gabriela
- Dropulic Natasa
- Dudas Radovan
- Dutu Madalina
- Duvekot Anne
- Dvorscak Matea Bogdanovic
- Dylst Dimitri
- Dzurnakova Paula
- Eden Arieh
- el Kafrawy Samir
- el-Shaarawy Ahmed Mostafa
- Ellison Branwen
- Erceg Gorjana
- Everett Lynn
- Fava Josep
- Fedorov Sergei
- Fernandez-Bustamante Ana
- Fernando Luiz
- Ferrando Carlos
- Ferreira Daniel
- Filipescu Daniela
- Filipsky Radek
- Fjellanger Frode
- Florou Panagiota
- Foot Jayne
- Forget Patrice
- Fota Ruxandra
- Fouracres Anna
- Franklin Danielle
- Frkovic Vedran
- Fuller Debbie
- Futier Emmanuel
- Gama de Abreu Marcelo
- Garotescu Ioana Popescu
- Gavranovic Zeljka
- Gecaj-Gashi Agreta
- Geib Johann
- Generali Michela
- Gerard Adeline
- Gherghina Iorel
- Giacoletto Gianmarco
- Giancarlo Luigi
- Giarratano Antonino
- Gibb Sarah
- Gillberg Lars
- Gkiokas Georgios
- Gombotz Hans
- Goodall Cait
- Goranovic Tanja
- Gottschalk Andre
- Granell Manuel
- Grasso Salvatore
- Gratarola Angelo
- Grintescu Ioana Cristina
- Grintescu Ioana Marina
- Gritsan Alexey
- Gritsan Galina
- Grosu Irina
- Grynyuk Andriy
- Gueldner Andreas
- Gunenc Ferim
- Guran Catalin-Traian
- Hadimioglu Necmiye
- Harazim Hana
- Hasan Wael Fathy
- Hemmes Sabrine
- Hemmes Sabrine N. T.
- Hering Jens
- Herodes Eiko
- Heyse Bjorn
- Hiesmayr Michael
- Hiesmayr Michael
- Higham Charley
- Hodt Katharina Skirstad
- Hollmann M. Wiersma
- Hollmann Markus
- Homan Elizabeth
- Horhota Lucian
- Hudacek Kamil
- in 't Veld Bas
- Ivars Stefan
- Ivic Dubravka
- Jaber Samir
- Jaber Samir
- Jackson Clare
- Jacobs Tom
- Jammer Ib
- Jawad Monir
- Jirmanova Katerina
- Jones Stephanie
- Jovanov Miroljub
- Jurate Sipylaite
- Juricic Kazimir
- Juros-Zovko Marina
- Kahn David
- Kapkan Tatyana
- Karaman Fatma Mine
- Karanovic Nenad
- Karapanos Dimitris
- Karbonskiene Aurika
- Karjagin Juri
- Kazbek Baturay Kansu
- Kienbaum Peter
- Kiss Thomas
- Kivik Peeter
- Koch Thea
- Kodaganallur Krishnan
- Kolacek Tomas
- Komissarova Irina
- Konrad Mirja
- Kontrimaviciute Egle
- Kopic Jasminka
- Kor Daryl
- Korolkov Oleg
- Kosinova Martina
- Kostadinov Ivan
- Krassler Jens
- Kroell Wolfgang
- Kucukgoncu Semra
- Kucukguclu Semih
- Kulikov Alexander
- Kusnierikova Zuzana
- Kusre Sandeep
- Kuvaki Bahar
- Kvolik Slavica
- la Bella Daniela
- Landoni Giovanni
- Lazukic Aleksandra
- Leva Brigitte
- Leykin Yigal
- Likhvantsev Valery
- Limb James
- Liperi Corrado
- Lisi Alberto
- Liskova Katarina
- Lois Fernande
- Lubnin Andrey
- Lugovoy Alexander
- Lundberg Michael
- Luzier Elizabeth
- Mackenzie Felicity
- Magdy Mohamed
- Mahran Mohamed
- Maldini Branka
- Mall Merilin
- Maral Jale
- Markovic-Bozic Jasmina
- Marrella Antonella
- Marret Emmanuel
- Marri Sudhakar
- Martinez Francisco Hidalgo
- Martinez Raquel
- Martins Diogo
- Mazul-Sunko Branka
- Mazur Andriy
- Mellin-Olsen Jannicke
- Melo Marcos Vidal
- Mercer Pauline
- Merzky Simone
- Metwally Tarek
- Metzler Helfried
- Mihajlovic Dunja
- Miliauskas Povilas
- Mills Gary
- Mills Gary H.
- Minto Gary
- Mirabella Lucia
- Mirea Liliana
- Mirkovic Ivan
- Miskovic Petar
- Mladic-Batinica Inga
- Mohr Otto
- Moise Alida
- Moldovan Septimiu Gheorghe
- Molin Alexandre
- Molina Ruby
- Momeni Mona
- Monedero Pablo
- Montagnani Luca
- Montalto Francesca
- Monteirosa Angela
- Montgomery Jane
- Morais Erick
- Moral Victoria
- Morelli Paola
- Moret Enrique
- Moreton Sarah
- Mowat Stephen
- Muhardri Dalip
- Musella Giuseppe
- Nadolski Maria
- Negoita Silvius
- Nestler Christian
- Nouris Christos
- Novak-Jankovic Vesna
- Novak-Supe Barbka
- Nunez M. nica Rodriguez
- Nutt Helen
- Oganjan Juri
- Oputric Ivana
- Ovezov Alexey
- Ozbilgin Ćule
- Ozgen Serpil Ustalar
- Paddle Jonathan
- Palmer Janet
- Pandazi Aggeliki
- Pannen Benedikt
- Parente Suzana
- Pasin Laura
- Pastor Ernesto
- Pavicic Anna Marija
- Pearse Rupert
- Pejakovic Jasmina
- Pekle-Golez Ana
- Pellerano Giulia
- Pelosi Paolo
- Pelosi Paolo
- Peradze Sopio
- Perez Gisela
- Perez Rocio
- Pernar Selma
- Pesce Caterina Valeria
- Petcu Ana Maria
- Petit Antoine
- Pezzatto Stefano
- Pistidda Laura
- Pizov Reuven
- Plichon Benoit
- Poelaert Jan
- Polakovicova Lenka
- Popescu Mihai
- Portch David
- Pospiech Audrey
- Pourzitaki Chryssa
- Prades Albert
- Prodan Alexandru Bogdan
- Prokoshev Pavel
- Puigbo Carlos
- Pulletz Mark
- Putensen Christian
- Radocaj Tomislav
- Rafi Amir
- Ragazzi Riccardo
- Raimondo Pasquale
- Raineri Santi Maurizio
- Raj Ashok
- Rambhatla Mrutyunjaya
- Rapido Francesca
- Raymode Parizade
- Reske Andreas
- Ricardo Ana
- Riciu Magda
- Rico Jesus
- Robba Chiara
- Roberts Helen
- Rodenas Frederic
- Rodrigues Sara
- Roels Nathalie
- Rogers Elaine
- Rogerson David
- Rose Alastair
- Rousseau Guy
- Rucklidge Matthew
- Ruiz Cristina Saiz
- Russotto Vincenzo
- Sada Fatos
- Saeed Yousif
- Salciute Erika
- Sales Gabriele
- Saltali Ali
- Sances Daniele
- Sanli Suat
- Sanlikarip Ceren
- Sarapuu Kaili
- Sardo Elena
- Saric Jadranka Pavicic
- Sassone Marta Eugenia
- Scavonetto Federica
- Schaefer Maximilian
- Scharffenberg Martin
- Schmid Werner
- Schmid Werner
- Scholes Helen
- Schultz Marcus
- Schultz Marcus J.
- Schwerdtfeger Ben
- Sehovic Mirna
- Selvi Onur
- Sendra Mar
- Senturk Nuzhet Mert
- Senturk Ozgur
- Serpa Neto Ary
- Servillo Giuseppe
- Severgnini Paolo
- Severgnini Paolo
- Severijns Charlotte
- Shafi-Kabiri Amir
- Shelley Ben
- Sher Sara
- Sidiropoulou Tatiana
- Sileo Rosanna
- Simeson Karen
- Simon Antonio MartĂnez
- Simon Philipp
- Sivrikoz Nukhet
- Skiljic Sonja
- Smekalova Olga
- Smith Thomas
- Sobona Villiam
- Solca Maurizio
- Solier Marc
- Sormus Alar
- Soro Marina
- Sottosanti Vicari
- Spadaro Savino
- Spano Gianluca
- Spieth Peter
- Spindler-Vesel Alenka
- Sprung Juraj
- Stancombe Lucia
- Stourac Petr
- Strazisar Branka
- Stroumpoulis Konstantinos
- Struber Gerd
- Sulemanji Demet
- Sungur Zerrin
- Susarla Jaysimha
- Szewczyk Margaret
- Tareco GlĂłria
- Tarzia Valentina
- Tasoulis Marios-Konstantinos
- Teberaite Zivile
- Temino Maria Jose Yepes
- Theodoraki Kassiani
- Thiem Denny Tran
- Tikuisis Renatas
- Tolcser Zsolt
- Tomescu Dana
- Tomkute Gabija
- Tommasino Concezione
- Toraman Fevzi
- Tredici Stefano
- Treschan Tanja
- Tsaousi Georgia
- Tudoroiu Marian Irinel
- Tze Yeo
- Uhlig Christopher
- Unzueta Mari Carmen
- Urbanek Bernhard
- Valsamidis Dimitrios
- van Beek Rienk
- van de Velde Stijn
- van Limmen Jurgen
- van Malderen Marie-Claire
- van Melkebeek Jeroen
- van Mossevelde Veerle
- Vargas Maria
- Varma Sandeep
- Venkatesh Suresh
- Venturino Marco
- Veres Mihaly
- Verri Marco
- Vidal Melo Marcos F.
- Vinkovic Hrvoje
- Vitkova Katerina
- Vivo Jose Tatay
- Voje Minca
- Volfova Ivana
- Volta Carlo Alberto
- Vorotyntsev Sergiy
- Walker Rachel
- Watt Philip
- Wayman Lisa
- Wegscheider Thomas
- Weingarten Toby
- Weiss Martin
- Welch Leanne
- Werger Alice
- West Claire
- Westerheide Diana
- Wiersma Irene
- Williams John
- Wrigge Hermann
- Wrigge Hermann
- Wutai Stanley
- Wyffels Piet
- Xuereb John
- Yassin Hany
- Yates Susan
- Yildiz Mine
- Yilmaz Murat
- Zafeiropoulou Foteini
- Zalina Karginova
- Zamidei Lucia
- Zangrillo Alberto
- Zelinkova Maria
- Zilic Antonio
- Zoppellari Roberto
- Zuleika Maka
- Zunic Josip
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 02/04/2020
- Field of study
Background: Limited information is available regarding intraoperative ventilator settings and the incidence of postoperative pulmonary complications (PPCs) in patients undergoing neurosurgical procedures. The aim of this post-hoc analysis of the 'Multicentre Local ASsessment of VEntilatory management during General Anaesthesia for Surgery' (LAS VEGAS) study was to examine the ventilator settings of patients undergoing neurosurgical procedures, and to explore the association between perioperative variables and the development of PPCs in neurosurgical patients. Methods: Post-hoc analysis of LAS VEGAS study, restricted to patients undergoing neurosurgery. Patients were stratified into groups based on the type of surgery (brain and spine), the occurrence of PPCs and the assess respiratory risk in surgical patients in Catalonia (ARISCAT) score risk for PPCs. Results: Seven hundred eighty-four patients were included in the analysis; 408 patients (52%) underwent spine surgery and 376 patients (48%) brain surgery. Median tidal volume (VT) was 8 ml [Interquartile Range, IQR = 7.3-9] per predicted body weight; median positive end-expiratory pressure (PEEP) was 5 [3 to 5] cmH20. Planned recruitment manoeuvres were used in the 6.9% of patients. No differences in ventilator settings were found among the sub-groups. PPCs occurred in 81 patients (10.3%). Duration of anaesthesia (odds ratio, 1.295 [95% confidence interval 1.067 to 1.572]; p = 0.009) and higher age for the brain group (odds ratio, 0.000 [0.000 to 0.189]; p = 0.031), but not intraoperative ventilator settings were independently associated with development of PPCs. Conclusions: Neurosurgical patients are ventilated with low VT and low PEEP, while recruitment manoeuvres are seldom applied. Intraoperative ventilator settings are not associated with PPCs
Recommended from our members
31st Annual Meeting and Associated Programs of the Society for Immunotherapy of Cancer (SITC 2016): part two: National Harbor, MD, USA. 9-13 November 2016
- Author
- Abassi Yama
- Abelin Jennifer G.
- Abolhalaj Milad
- Abraham Tara S.
- Adam Ammar
- Adams David
- Adams Homer
- Adams Sarah F.
- Adamus Tomasz
- Addepalli Murali
- Adjei Alex A.
- Agapova Larissa
- Agarwala Sanjiv
- Ager Casey
- Aggarwal Charu
- Agnello Giulia
- Agudo Judith
- Aguilar Ethan G.
- Aguilera Todd
- Ahamadi Malidi
- Ahn Yong-Oon
- Ahrens Eric T.
- Aizer Ayal
- Ajina Reham
- Akerley Wallace
- Al-Muftah Mariam
- Albershardt Tina C.
- Albrekt Ann-Sofie
- Alekar Shilpa
- Alemany Ramon
- Alexander Brian
- Allbritton Omaira
- Allen Clint T.
- Alley Evan W.
- Allison James
- Alston Tesha
- Alt JĂŒrgen
- Alters Susan
- Amatulli Michael
- Anand Snjezana
- Anderson Clark
- Anderson Mark
- Andersson Bengt
- Andre Pascale
- Andtbacka Robert H. I.
- Angiuoli Sam
- Ansari Tameem
- Anthony Scott
- Antonarakis Emmanuel S.
- Antonia Scott J.
- Anwar Firoz
- Aquino-Michaels Keston
- Archer Jacob F.
- Arina Ainhoa
- Armand Philippe
- Armenta Paul
- Armet Caroline M.
- Arnoux Thomas
- Ascarateil Stephane
- Askmyr David
- Atkins Michael
- Atkins Michael B.
- Atkinson Victoria
- Au Katrina
- Autio Karen A.
- Awad Mark
- Bagarazzi Mark
- Bai Dina
- Baia Gilson
- Baird Jason
- Bajaj Anshika
- Balatoni Timea
- Balboni Tracy
- Balch Leslie
- Bang Andrew
- Bao Riyue
- Bao Yangyi
- Barakat David
- Barberi Theresa
- Barker Christopher A.
- Barnea Eytan
- Barras David
- Bartkowiak Todd
- Bartlett David
- Barton Sunjay M.
- Barve Minal
- Bauer Todd
- Bauer Todd W.
- Bauman Julie
- Baumgaertner Petra
- Bauml Joshua
- Beceren-Braun Figen
- Beck Kristen
- Becker Annette
- Beckers Johannes
- Beckett Michael A.
- Bedognetti Davide
- Bell Bryan
- Bell Charles J. M.
- Bell Peter
- Beltran Pedro
- Bender Lewis H.
- Bender Steven
- Bennett Mark K.
- Benz Steven
- Bera Tapan
- Berglund Peter
- Berkey Sara
- Bernatchez Chantale
- Berry John S.
- Berzofsky Jay A.
- Bhardwaj Nina
- Bian Zhen
- Bianco Alberto
- Biediger Ronald J.
- Bifulco Carlo
- Bigley Alison
- Bingham Patrick
- Biniszkiewicz Detlev M.
- Bischoff Helge
- Blake Zoe
- Blakely Collin
- Blazar Bruce R.
- Blogowski Wojciech
- Bloom Anja C.
- Boehm Jesse
- Bokovanov Vladimir
- Bommareddy Praveen K.
- Booth Jamie
- Bornschlegl Svetlana
- Bose Nandita
- Bossenmaier Birgit
- Boughorbel Sabri
- Boyer Jean
- Bramante Simona
- Branstetter Daniel
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- Brockstedt Dirk G.
- Brody Joshua
- Bronson Roderick
- Brooks Alan
- Brooks Alan D.
- Broucek Joseph
- Brown Alice
- Brown Brian
- Brown Brittany
- Brown Gail L.
- Brown Sheila
- Bruce Jeffrey N.
- Brunet Laura Rosa
- Bruno Tullia C.
- Bryan Jennifer
- Bryant Richard
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- Burrill Joel
- Bussler Holm
- Butterfield Lisa H.
- Byrne-Steele Miranda
- Cagney Daniel
- Calderon Hugo
- Callahan Margaret K.
- Campesato Luis Felipe
- Campogan Dwayne
- Cao Felicia
- Capasso Cristian
- Caplazi Patrick
- Cappuccini Federica
- Carcaboso Angel M.
- Carlino Matteo S.
- Carpi Sara
- Carrasco Ruben
- Carrera Diego A.
- Carrero Rosa M. Santana
- Carson Dennis A.
- Castellini Laura
- Cathomas Richard
- Cauvin Annick
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- Caux Christophe
- Cebon Jonathan S.
- Ceccarelli Michele
- Celis Esteban
- Cerignoli Fabio
- Cerullo Vincenzo
- Cervera-CarrascĂłn VĂctor
- Cesareni Gianni
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- Choy Carmen
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- Clynes Raphael
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- Coder Brandon
- Coffman Robert L.
- Cohen Cyrille
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- Coussens Lisa M.
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- Daud Adil
- David Justin M.
- Davies Bronwyn
- de Boisferon Marc Hillairet
- de Groot Patricia
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- de Silva Suresh
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- Delogu Lucia
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- Dhupkar Pooja
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- Diaz Luis
- DiCostanzo AriCeli
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- Dobkin Julie
- Doener Fatma
- Dolegowska Barbara
- Doleschall Zoltan
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- Dominguez George
- Donahue Renee
- Dorsey Frank Charles
- Dovedi Simon
- Downs-Canner Stephanie
- Drake Charles
- Drake Charles G.
- Driessens Gregory
- Driscoll Kyla
- Druker Brian J.
- Dubensky Thomas W.
- Dudimah Duafalia
- Duff Susan
- Dumontet Charles
- Dunai Cordelia
- Dutcher Janice P.
- Duttagupta Priyanka
- Duvvuri Uma
- Dyson Mike
- DâApuzzo Massimo
- Ebner Peggy
- Edwards Robert
- Edwards Robert P.
- Eickhoff Jens
- Eisenhower Mary
- El Alaoui Meddy
- El Alaoui Said
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- Engelhard Victor H.
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- Faâak Faisal
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- Ferris Robert L.
- Fesenkova Valentyna
- Field Jessica J.
- Fisher Kerry
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- Fitzharris Bernie
- Flano Emilio
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- Flies Dallas B.
- Flynn Patrick
- Fogler William
- Fong Lawrence
- Formenti Silvia C.
- Foster Cathie
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- Fox Bernard
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- Fridman Leticia
- Friedman Alan
- Friedman David
- Fromm George
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- Fu Yang-Xin
- Fu Yichun
- Fuertes Marraco Silvia A.
- Fugle Caroline W.
- Fuhrmann Steven
- Fukaya Satoshi
- Fulton Noreen
- Fuoco Claudia
- Fusciello Manlio
- Fuseri Nicolas
- Gabitzsch Elizabeth
- Gabrail Nashat
- Gabrilovich Dmitry
- Gajewski Thomas
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- Galeassi Nadejda
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- Gameiro Sofia
- Gameiro Sofia R.
- Gandhi Anita
- Gao Chan
- Gardai Shyra J.
- Gardner Kellie
- Gartrell Robyn
- Gasmi Billel
- Gastineau Dennis A.
- Gaughan Elizabeth
- Gauthier Audrey
- Gauthier Kelsey S.
- Geissler Michael
- Gergel Ivan
- Geukens Nick
- Gfeller David
- Ghadially Hormas
- Ghamsari Lila
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- Giaccia Amato
- Gibney Geoffrey
- Giffin Louise
- Gillies Stephen D.
- Giri Sanjeev
- Gladstone Douglas
- Glickman Laura Hix
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- Godwin John
- Gomes Bruno
- Gong Jian
- Gonzales Rodney JM Macedo
- Gooding William
- Goodman Reid
- Gopal Ajay
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- Gordon Nancy
- Gottschalk Stephen
- Gough Michael
- Gowda Nagaraj
- Goyal Sharad
- Graff Jeremy
- Graham Charles
- Graves Edward
- Gray Michael
- Greasley Samantha
- Greenberg Norman
- Greiff Lennart
- Greiner John W.
- Grenga Italia
- Gressett Monica M.
- Griesinger Frank
- Grigoryeva Olga
- Grigsby Iwen
- Grivas Petros
- Grogan Elizabeth W.
- Grogan Jane
- Grose Mark
- Grosh William
- Gross Matt
- Grossenbacher Steven K.
- Grossmann Kenneth
- Gruber Harry
- Gu Xuemin
- Guenther Garret
- Guerriero Jennifer
- Gugel Elena Gonzalez
- Guiducci Cristina
- Guirado Elizabeth
- Gulley James L.
- Gunatilaka Leslie A. A.
- Guo Jie
- Guo Zeng-qing
- Gupta Ravi
- Gupta Sachin
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- Gutierrez Andres A.
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- Guy Emily I.
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- Hellström Ann-Charlotte
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- Nagasaka Misako
- Nail Carmel
- Naing Aung
- Nair Nitya
- Nakamura Yusuke
- Nath Pulak R.
- Ndubaku Chudi
- Nechaev Sergey
- Neelapu Sattva S.
- Neely Jaclyn
- Nemunaitis John
- Neou Silinda
- Neubert Natalie J.
- Neves Rogerio
- Newcomb Eric
- Newman Jenna
- Ngo Lisa Y.
- Nguyen Andrew
- Nguyen Ngan
- Niazi Kayvan
- Nicholas Courtney
- Nicolette Charles
- Niederfellner Gerhard
- Nielsen Michael
- Noessner Elfriede
- Normant Emmanuel
- Novosiadly Ruslan
- Nuccitelli Richard
- Nutakki Ravi
- Obalapur Palakshi
- Obeid Joseph M.
- Obermajer NataĆĄa
- Ochyl Lukasz
- Odunsi Kunle
- Oft Martin
- Ogasawara Masahiro
- Ohr James
- Okada Hideho
- Okada Kaori
- Okeley Nicole M.
- Okubo Yoshiaki
- Olasz Judit
- Olson Walter
- Olson William
- Opyrchal Mateusz
- Ordentlich Peter
- Orecchioni Marco
- Ornatowski Wojciech
- Osada Toshihiro
- Ostrowski Michael C.
- Oswald Detlef
- Ota Shuichi
- Ott Patrick A.
- Ottoson Nadine
- Overwijk Willem W.
- Ovsepyan Armen
- Oyola Sandra
- OâConnor Rachel W.
- Pachynski Russell K.
- Pai Steven
- Pal Sumanta
- Palena Claudia
- Pall Georg
- Palmer Brent
- Palombella Vito J.
- Pan Alison
- Pan Wenjing
- Pandha Hardev
- Paneque Tomas
- Pant Shubham
- Papachristofilou Alexandros
- Papadopoulos Kyriakos P.
- Papot SĂ©bastien
- Paramithiotis Eustache
- Paris Mark
- Paris SĂ©bastien
- Park Ha-Ram
- Park Jae-Hyun
- Park Timothy
- Parlati Francesco
- Parsons Andrea J.
- Parviainen Suvi
- Pastan Ira
- Patel Manish
- Patel Shashank
- Paterson Alison M.
- Patil Ashwini
- Patnaik Amita
- Patterson Troy D.
- Paul Kiran
- Paul-Wetterberg Gabriella
- Paustian Christopher
- Peace Kaitlin M.
- Pei Jerry
- Pellom Samuel
- Peltonen Karita
- Pena Rhoneil
- Penny Sarah A.
- Peoples George E.
- Perez Myra
- Perna Serena
- Perry Kyle
- Persaud Krishnadatt
- Pesonen Sari
- Peterson Nichole
- Petit Robert
- Petricoin Emanuel
- Petroni Gina
- Petrylak Daniel P.
- Pferdekamper Anne Marie
- Pierobon Mariaelena
- Pike Luke
- Pilon-Thomas Shari
- Pinczewski Joel
- Pirson Romain
- Plachco Ana
- Pless Miklos
- Pollack Ian F.
- Pollock Emily
- Ponichtera Holly
- Ponte Jose
- Pope Hans
- Posner Marshall
- Postow Michael
- Pottier Agnes
- Poueymirou William
- Pourchet Aldo
- Pourdehnad Michael
- Pourzia Alexandra
- Powers Jay P.
- Pramoonjago Patcharin
- Prantner Andrew M.
- Preillon Julie
- Presnell Scott
- Princiotta Michael
- Profusek Pam
- Puri Raj K.
- Qi Jin
- Qian Yingzhi
- Qiao Guanxi
- Qiao Na
- Qin Guozhong
- Qiu Xiaohong
- Quach Phi
- Quick Laura
- Quinn David I.
- Rabizadeh Shahrooz
- Rabolli Virginie
- Radfar Arash
- Radoja Sasa
- Radvanyi Laszlo
- Rae Chris S.
- Rafail Stavros
- Rafat Marjan
- Rahma Osama E.
- Rajopadhye Milind
- Rakhmilevich Alexander L.
- Ralph Christy
- Ramachandra Murali
- Ramachandra Raghuveer
- Ramalingam Suresh
- Ramchandren Radhakrishnan
- Ramos Kimberly
- Ranki Tuuli
- Rankin Erinn
- Rao Tharak
- Rapisuwon Suthee
- Ravindranathan Roshni
- Ray Chad
- Rebhun Robert
- Redchenko Irina
- Reeves Rebecca S.
- Reid-Schachter Gillian
- Reilley Matthew
- Reilly Christine
- Reiter Yoram
- Rekoske Brian
- Ren Xiubao
- Rennier Keith R.
- Renrick Ariana N.
- Repasky Elizabeth
- Reshef Ran
- Restifo Nicholas
- Ribas Antoni
- Richardson Jennifer H.
- Ridnour Lisa
- Rimoldi Donata
- Rinchai Darawan
- Rivas Sarai
- Rizell Magnus
- Roberts David D.
- Robinson William
- Rodriguez Anthony
- Rodriguez-Cruz Tania
- Roelands Jessica
- Roen Diana
- Rogers Connie J.
- Rose Jason
- Ross Merrick
- Rothwell William T.
- Rowlinson Scott
- Ruchko Sergey
- Ruth Nicola
- Ryan Kevin
- Saeed Abu Z.
- Saenger Yvonne M.
- Saims Dan
- Saito Takuro
- Salata Daria
- Salazar Rachel
- Saleh Rachidi
- Salerno Elise
- Samiulla Dodheri
- Sams Lillian
- Sanborn J. Zachary
- Sanborn Rachel E.
- Santo Gregg Espiritu
- Santos JoĂŁo
- Santos Patricia M.
- Sarnaik Amod A.
- Sasaki Eiji
- Saser Kate A.
- Sasikumar Pottayil
- Sathian Rekha
- Sato-Kaneko Fumi
- Saunthararajah Yogen
- Sausen Mark
- Savolt Akos
- Sawant Deepali
- Sayers Thomas J.
- Scales Stephanie
- Schad Sara
- Schaeffeler Elke
- Schaer David
- Scharping Nicole
- Scheel Birgit
- Schindler Ulrike
- Schlom Jeffrey
- Schlunegger Kyle
- Schluns Kimberly S.
- Schmidt Carl
- Schmidt Emmett
- Schmidt Manuel
- Schoenfeld Jonathan
- Schoenhals Jonathan
- Scholler Nathalie
- Scholz Alexander
- Schreiber Taylor H.
- Schroeder Andreas
- Schwab Matthias
- Schwartz Anthony L.
- Schwendeman Anna
- Scrivens Maria
- Sebastian Martin
- Sefrin Julian P.
- Segal Neil H.
- Seibel Tobias
- Senbabaoglu Yasin
- Senter Peter D.
- Senzer Neil
- Serpa Gregory
- Setiady Yulius
- Sette Alessandro
- Sevdali Maria
- Sexton Holly
- Seymour Len
- Sgarrella Francesco
- Shabanowitz Jeffrey
- Shafren Darren
- Shakya Reena
- Shamalov Katerina
- Shanker Anil
- Sharma Manish
- Sharma Meenu
- Sharma Naveen
- Sharma Padmanee
- Shayan Gulidanna
- Shea Sofia
- Shehade Hussein
- Sheikh Nadeem A.
- Shekarian Tala
- Shepard Dale
- Sherry Lorcan
- Shi Feng
- Shi Jian
- Shih Vincent FS
- Shimizu Atsushi
- Shrestha Yashaswi
- Shrivastav Shruti
- Shuman Stewart
- Shuster Alexandr
- Shwonek Peter
- Sidney John
- Siebenaler Kristen
- Silk Ann
- Silk Ann W.
- Silva John
- Simmons John
- Simoes Ines
- Sims Jennifer S.
- Singh Manisha
- Singson Victoria
- Siurala Mikko
- Sivado Eva
- Sivan Ayelet
- Sjöberg Madeleine
- Skaletskaya Anna
- Skoble Justin
- Slansky Jill
- Slingluff Craig L.
- Slomovitz Brian M.
- Smith Ernest
- Smith Jill
- Smith Kelly
- Smith Leia
- Smolkin Mark E.
- Snook Adam E.
- Snzol Mario
- Sokolove Jeremy
- Solowiej Jim
- Somanchi Srinivas
- Sondel Paul M.
- Soneson Charlotte
- Song Xiao-Tong
- Sotayo Alaba
- Sotirovska Natalija
- Spada Filomena
- Speers Ellen
- Speiser Daniel E.
- Spektor Alexander
- Spranger Stefani
- Spurgeon Stephen
- Squalls Olivia
- Srirangam Jay
- Srivastava Raghvendra
- Staab Mary Jane
- Stack Edward
- Staelens Ludovicus
- Starzynska Teresa
- Steadman Lora
- Stefano Pierini
- Steggerda Susanne
- Stein Paul L.
- Stelow Edward B.
- Sternby Malin
- SternJohn Julius
- Stewart Al
- Stock Wendy
- Stone Geoffrey W.
- Stosnach Claudia
- Straub Tobias
- Straus Jane
- Streiner Nicole
- StÄhle Magnus
- Su Yu-Lin
- Sudarshan Naremaddepalli
- Sugarbaker David
- Sukari Ammar
- Sultan Hussein
- Sun Shaoli
- Sundararaman Srividya
- Sung Leonard
- Suresh Rahul
- Surguladze David
- Suryawanshi Satyendra
- Suzuki Akiko
- Suzuki Ryuji
- Sweis Randy F.
- Taback Bret
- Tagliaferri Mary
- Talbert Erin
- Tallarico John
- Tan Joanne B. L.
- Tan Joanne BL
- Tan Wei
- Tan Yann Chong
- Tanaka Maki
- Tang Chad
- Tannir Nizar M.
- Taylor Allison
- Taylor Matthew
- Tcherepanova Irina
- ter Meulen Jan
- Terabe Masaki
- Termini James
- Tetzlaff Michael
- Tewary Poonam
- Thakurta Anjan
- Thayer Matt
- Theodoraki Marie-Nicole
- Thimme Robert
- Thomas Portia
- Thomas Remy
- Thomas Vincent
- Thompson John A.
- Thounaojam Menaka
- Thurston Gavin
- Tighe Rober
- Tilahun Ashenafi
- Tillé Laure
- Timmerman John
- Tipton Kimberly A.
- Tognon Christina E.
- Tomai Mark A.
- Toms Anne
- Torno Sebold
- Torrey Heather
- Torti Vince
- Toth Laszlo
- Trager James B.
- Trappey Alfred F.
- Trivedi Sumita
- Truesdell Peter
- Tsang Kwong
- Tsang Kwong Y.
- Tsaparikos Konstantinos
- Tsouko Efrosini
- Tsujikawa Takahiro
- Tuck David
- Tumang Joseph
- Turbitt William J.
- Turk Andrew T.
- Tyner Jeffery W.
- TĂ€htinen Siri
- Uecker Darrin
- Ugel Stefano
- Uhlik Mark
- Ujhelyi Mihaly
- Ullenhag Gustav
- Unfricht Darryn
- Ungerleider Richard
- Urban Julie
- Valsesia-Wittmann Sandrine
- Van der Meijs Pien
- van Vugt Marianne
- van Zutphen Mariëlle
- Vanamee Eva
- Vanderslice Peter
- VanderVeen Laurie
- Vanpouille-Box Claire I.
- VanVlasselaer Peter
- Varhegyi Nikole
- Vasilakos John P.
- Vaske Charles
- Vassilev Lotta
- Velcheti Vamsidhar
- Velculescu Victor
- Verma Amita
- Vetto John
- Vianden Christina
- Vietsch Eveline E.
- Vignali Dario
- Vogel Katharina
- Volkmuth Wayne
- Volz Barbara
- vonEbyen Rie
- Vreeland Timothy J.
- Vu Tuyen
- Wada Hiroshi
- Wagtmann Nicolai
- Waldman Michelle
- Waldman Scott A.
- Waller John
- Wallraven Gladice
- Walsh Richard
- Walters Ian B.
- Wang Ena
- Wang Hongjie
- Wang Ping
- Wang Shangzi
- Wang Weiyi
- Wang Ximi K.
- Wang Yi
- Wang Ziming
- Ward Stephen T.
- Waugh Katherine
- Weber Amy
- Wehler Thomas
- Wei Spencer
- Weichselbaum Ralph R.
- Weiner David
- Weiner Louis M.
- Weinstein Gregory
- Weiss Christian
- Welden Scott
- Wellstein Anton
- Welsh James
- Wennerberg Erik
- Wenthe Jessica
- Werner Lauryn R.
- West Brian
- West James
- Wheatley Courtney
- Whetstone Ryan
- White James
- White-Stern Ashley
- Whiteside Melinda
- Whiting Chan C.
- Wicha Max S.
- Wieckowski Eva
- Wijeratne Kithsiri
- Wilhite Tyler
- Wilkinson Robert W.
- Williams Matthew
- Williamson Kevin
- Willingham Stephen
- Wilson James M.
- Wilson Nicholas
- Winters Kevin
- Withers Sita
- Wittig Burghardt
- Wolchok Jedd D.
- Wolfreys Alison
- Won Haejung
- Wong Chihunt
- Wong Deborah J.
- Wong Gabriel
- Wong Kenneth R.
- Wong Michael KK
- Wood Laura
- Woodside Darren G.
- Workman Creg
- Wu Bill X.
- Wu Dongyun
- Wu Jennifer
- Wu Yeting
- Wyant Timothy
- Wythes Martin
- Xi Biao
- Xia Leiming
- Xia Yang
- Xiang Bo
- Xiao Christine
- Xiao Hong
- Xiao Zhilan
- Xu Chun-wei
- Xu Chunxiao
- Xu Guifen
- Xu Xiaomei
- Xu Xin
- Xu Ya-Ming
- Xu Yitong
- Yadav Mahesh
- Yagiz Kader
- Yamashiro Darrell J.
- Yan Jian
- Yang Chou
- Yang Ning
- Yang Zane
- Yano Hiroshi
- Yao Shiyin
- Ye Yun-bin
- Yin Catherine
- YlösmÀki Erkko
- Young Gregory
- Young Kristina
- Young Rob
- Young Steve W.
- Youssoufian Hagop
- Yu Huakui
- Yu Ling
- Yu Naichen
- Zafar Sadia
- Zalevsky Jonathan
- Zappasodi Roberta
- Zauderer Maurice
- Zeh Herbert
- Zelenetz Andrew D.
- Zeng Weiping
- Zeng Xue
- Zha Yuanyuan
- Zhang Danhui
- Zhang Jing
- Zhang Ping
- Zhang Qifang
- Zhang Shannon S.
- Zhang Theresa
- Zhang Winter
- Zhang Yanping
- Zhao Fei
- Zhao Leyna
- Zhao Xingli
- Zheng Lianxing
- Zheng Wenxin
- Zheng Xianxian
- Zheng Yi
- Zhong Hong
- Zhou Li
- Zhou Xiangjun
- Zippelius Alfred
- Zloza Andrew
- Zou Jun
- Zuba-Surma Ewa
- Zubkova Olga
- Zureikat Amer
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 03/01/2017
- Field of study
Evaluation of a quality improvement intervention to reduce anastomotic leak following right colectomy (EAGLE): pragmatic, batched stepped-wedge, cluster-randomized trial in 64 countries
- Author
- Aarts Frits
- Ababneh Hazim
- Abad-Motos Ane
- Abaidalla Ahmed
- Abbakar Malaz
- Abd El Aal Ahmed
- Abd-Errazik Mohammad Ahmad
- Abdalradiy Abdalrahmman G
- Abdelkhalek Mohamed
- Abdelkhalek Mostafa
- Abdellatif Ahmed
- Abdellatif Mohamed
- Abdelsaid Kirolas
- Abdou Khaled
- Abdulfatah Mustapha
- Abdullah Mohammad Amer
- Abdullahi Mustapha Miko Mohammed
- AbellĂĄn Antonio Melero
- Abeysinghe Nayana
- Abiyere Henry
- Achimas-Cadariu Patriciu Andrei
- Adakaya Sıla
- Adam Nicolas
- Adams Benita
- Adams Ferdinand
- Adegboye Kazeem
- Adeyeye Ademola
- Adra Lama
- Adu-Poku Patricia
- Afuwape Oludolapo
- Afzal Ameer
- Afzal Muhammad Farooq
- Agapov Mihail
- Agara Daniel
- Aggarwal Manisha
- Agger Erika
- Aghadi Ifeanyi Kene
- Ahmed Amjed Yassir
- Ahmed Haleemasahdia
- Ahmed Khalil
- Ahmed Manar
- Ahmed Masood
- Ahmed Safia
- Ahn Hong Min
- Aibe Raquel
- Aigner Felix
- Aissat Abdenour
- Aitbaeva Arai
- Akay Omer
- Akbar Ali
- Akbas Ahmet
- Akere Abidemi
- Akesen Selcan
- Akgun Erhan
- Akhtar Naseem
- Akın Emrah
- Akova Elif
- Aktas Serhat
- Akçay Ăzlem
- Al Masri Mahmoud
- Al-Alnsi Ahmed
- Al-Hutheifi Roqia'A
- Al-Jarrah Amar
- Al-Naggar Hamza
- Al-Shehari Mohammed
- Alamin Nadeen
- Alawi Raneen
- Alawlaqi Dina
- Alawneh Fade
- Alberola Maria José
- Albers Michael
- Alcolea Natalia GonzĂĄlez
- Aleem Muhammad
- Alegre InĂȘs
- Alegre Javier Martinez
- Alexandre Flavia
- Alexandrescu Corina
- Alexnder Abelevich
- Alexopoulou Kalliopi
- Alfonso Beatriz AmorĂłs
- Ali Ahmed
- Ali Che Saniati Che
- Ali Danish
- Ali Madeeha
- Ali Mahmoud Abdelwahab
- Ali Manhal Hashim
- Ali Noura Al
- Alikhanli Jhale
- Aliyeva Zumrud
- Aliyu Mohammed
- Aljawder Hasan
- Allen Kate
- Almahmeed Ebrahim
- Alonso Alfredo
- Alonso Javier Etreros
- Alsamneh Muneer
- Alsayadi Ramzi
- Altinel Yuksel
- Altintoprak Fatih
- Altomare Donato F
- Alvarenga Isabella
- Alvarez Laura Jimenez
- Alvarez-Bautista Francisco Emmanuel
- Alvarez-DĂez Marcos
- Alves Brenda Chayanny
- Amadigwe Rita
- Amado Andreia
- Amado FabĂola
- Amador Cristina GarcĂa
- Amanullah Nazli
- Amaral HĂ©lida Aline Tomacheski
- Amaral Luis
- Amin-Tai Hizami
- Aminu Bashiru
- Amir Ahmad Suhaimi
- Ammar Ahmed Siddique
- Ammar Mona Ahmed
- Ammendola Michele
- Ammerata Giorgio
- Amorim Edgar
- Ancans Guntis
- Anderson Tom
- Andrade Diogo
- Andrejevic Predrag
- AndrĂ©s Beatriz DĂaz San
- Anestiadou Elissavet
- Ang Chin Wee
- Angelo Franceschi
- Anokhin Evgeny
- Anoldo Pietro
- Antakia Ramez
- Anton Majd
- Antonelli Serena
- Antropoli Carmine
- Anula Rocio
- Anwar Jamal
- Anyadike Florence
- Apostolakidou Magda
- Apostolidi Eirini
- Aprea Giovanni
- Arabadzhiev Angel
- Arakawa Satoshi
- Arauz Jazmin
- Aravindan U
- Aremu Abdurrahman
- Aremu Isiaka
- Argawy Osama
- Arican Can
- Arida Zahed Abu
- Armellin Claudia
- Arnaoutoglou Eleni
- Arreguy-Borges Kanthya
- Artigot Mariano
- Arturi Alessandro
- Arulappan Nirupama
- Arya Shobhit
- Arynov Ardak
- Asaad Peter
- Asano Yukio
- Ascari Francesca
- Asgarov Mohsum
- Ashmawy Soad
- Aslam Muhammad Imran
- Assimakopoulou Elena
- Assis Ana
- Astilleta Romina
- Atanasov Boyko
- Atendido Tiffany
- Athanasakis Elias
- Atici Semra Demirli
- Avellaneda Nicholas
- Avellaneda Nicolas
- Avseren Goksu
- Awead Marwa
- Ayandipo Omobolaji
- Aybar Engin
- Aydin Funda
- Aydin Gaye
- Ayoub Kusay
- Aytac Erman
- Aytaç Erman
- Azevedo Jose
- Azevedo Patricia
- Azhar Najia
- Aziz Gowhar
- Azman Zairul Azwan Mohd
- AĆkar Ahmet
- Babatunde Olanrewaju
- Badawi Marwa
- Baek Jeong-Heum
- Baez Noelia FernĂĄndez
- Baeza-Murcia Melody
- Bagnardi Francesco
- Baharom Salahudin
- Baik Seung Hyuk
- Baimakhanov Abylai
- Bains Lovenish
- Baker Aleksandra
- Bakmaz Bernarda
- Bala Abubakar Muhammad
- Balaban Vladimir
- Balalis Dimitrios
- Balasubramaniam Dinesh
- Balathayalan Yathev
- Baldi Claudio
- Balestri Riccardo
- Balfour James
- Ballah Abubakar
- Ballian Nikiforos
- Balooshi Iman Al
- Baloyiannis Ioannis
- Bamford Richard
- Bandar Mahdi Al
- Banham Gail
- Bannoud Mohammad Hassan
- Baptista Victor
- Baral Jörg
- Barbalace Nicolas
- Barbato Giuseppe
- Barbosa Anderson
- Bareka Metaxia
- Baris Baver
- Barradas Renato
- Barreda Sara Castillo
- Barrena-Blazquez Silvestra
- Barton Jess
- Bartosiak Katarzyna
- Bashilkina Olga
- Bashir Mohammed
- Basile Raffaele
- Basnyat Pradeep
- Batool Sana
- Bautista Wilson Manuel SĂĄnchez
- Bayhan ZĂŒlfĂŒ
- Bayo José Manuel Muros
- BayĂłn Raquel Ălvaro
- Baños Pedro Antonio Parra
- Beard David
- Bedzhanyan Arkady
- Behilil Chakib
- Bekele Kebebe
- Belarmino Armin
- Belay Million
- Belev Nikolay
- Bellato Vittoria
- BeltrĂĄn de Heredia Juan
- Belvedere Angela
- Benetti Emilio
- Benetti Sara
- Bengueddach Aicha
- Benjelloun El Bachir
- Benkabbou Amine
- Bennett James
- Bensafir Salim
- Bergamini Carlo
- Bernotaite Vlada
- Beron Reinaldo Isaacs
- Bethune Robert
- Bezede Cosmin
- Beznosenko Andriy
- Bhangu Aneel
- Bhargava Aman
- Bhat Rama Rani Krishna
- Bianchi Romina
- Bianco Francesco
- Bigoni Irene
- Binetti Margherita
- Bintintan Vasile
- Biondi Alberto
- Biondo Santino Antonio
- Bisgin Tayfun
- Bisheet George
- Bissett Ian
- Biswas Jyotirmoy
- Blackwell Sue
- Blanco Pablo
- Blanco Raquel RĂos
- Blanco-Colino Ruth
- Blasco Laura Fraile
- Blazquez-Martin Alma
- Bobadilla Billy Jimenez
- Bocancia Raluca
- Boccia Giuseppe
- Bogatikov Alexander
- Bolanle Olajide Edward
- Bomfa-Barbosa Alysson
- Bompou Effrosyni
- Bonardello Michela
- Bonci Eduard-Alexandru
- Bordom Daniel Osei
- Borges Filipe
- Borghi Felice
- Boschiero Matheus Negri
- Bose Bodhisattva
- Bouchagier Konstantinos
- Boudjenan-Serradj Nabil
- Boudoux Sabrina
- Bourazani Maria
- Boyce Stephen
- Bozbiyik Osman
- Bracale Umberto
- Brachini Gioia
- Bradulskis Saulius
- Brainsa Eneida
- Brandström Gustav
- Braumille Markus
- Bravo Ana Minaya
- Bravo Raquel
- Bredikhin Mikhail
- Brito Noelia
- Bruni Andrea
- Buccianti Piero
- Buchs Nicolas
- Buchwald Pamela
- Budnikova Ina
- BudrikienÄ Rima
- Buey Lourdes
- Buijs Louis
- Buleje Jorge Alejandro Benavides
- Burlov Nikita
- Butt Anam
- Byshetty Rajendar
- Bywater Edward
- Bzikha Ilham
- BĂĄnky BalĂĄzs
- BĂŠlum Jens Kristian
- Caballero-Delgado Javier
- Cabrera Claudia
- Cafranga EstĂbaliz GutiĂ©rrez
- Cagnazzo Federica
- Calabria Mariangela
- Calabro' Marcello
- Caliendo Domenico
- Calin Camelia
- Caliskan Cemil
- Callan Rory
- Callari Cosimo
- Caltea Mihaela
- Calvo Almudena Castro
- Camacho Amparo
- Cammarata Francesco
- Campanati Renato
- Campanelli Michela
- Campbell Marion
- Canals LucĂa Otazu
- Canda Aras Emre
- Cano-Matias Auxiliadora
- Cao Victor Hugo Bruno
- Capolupo Gabriella Teresa
- Cappiello Antonio
- Capuano Marianna
- Capusan Alina
- Carannante Filippo
- Carbone Ludovico
- Cardelli Stefano
- Carden Claire
- Cardoso Diogo
- Caricato Marco
- Carlin Patricia Saez
- Carlini Massimo
- Carlos Sandra
- Carneros Virginia Jimenez
- Carosso Fabio
- Caroço Teresa Vieira
- Carpelan Anu
- Carpenter Holly
- Carrascosa-Morales Irene
- Carrie Augusto
- Carrizo Claudia
- Carta Giuseppina
- Carvalho Alexandre
- Carvello Michele
- Casanova Daniel
- Cascais Raquel
- Cassia Gabriela
- Castaldi Antonio
- Castaño Renata
- Castiglioni Simone
- Castillo Enrique Roca
- Castro Marta Cuartero
- Catalano Pablo
- Cato Liam
- Caz Esra
- Cebolla Elena Sagarra
- Cecchini Ilaria
- CeldrĂĄn Rebeca GonzĂĄlez
- Celik Hale Kefeli
- Ceretti Andrea Pisani
- Ceron Silvia Ferrer
- Cervellera Maurizio
- Cervone Carmela
- Chacko Anil
- Chandrasinghe Pramodh
- Charakopoulou Alexandra
- Chardalias Leonidas
- Chaturvedi Arun
- Chatzikomnitsa Paraskevi
- Chaudhari Abhishek
- Chaudhry Sanjay
- Chawla Tabish
- Chee Corissa
- Chen Nevin
- Cheng Kuang I
- Chiarugi Massimo
- Chisthi Meer
- Chitnis Abhishek
- Chitul Andrei
- Chmielewski Gaspard
- Cholewa Hanna
- Chornet Marta RosellĂł
- Chowdhary Manish
- Chowdhury Sharfuddin
- Chowdhury Sharfuddin M
- Chowdri Nisar
- Christensen Peter
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Chua Lorna
- Chubukova Natlia
- Chung Jun Seong
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- Yew Chor Kuan
- Yılmaz GĂŒlseren
- Yilmazlar Tuncay
- YiÄit Direnç
- Yoldas Tayfun
- Yonekura Hiroshi
- Yorkmui Liu
- Yoshino Kenji
- Younes Lina
- Young Trudi
- Yule Michael
- Yusoff Zakiah Mohd
- Zaari Fatimazahraa
- Zabiyaka Mikhail
- ZadroĆŒna Monika
- Zafar Madiha
- Zagaynov Eugeny
- Zaidi Syed-Nadeem
- Zaimis Tilemachos
- Zain Wan Zainira Wan
- Zainy Rhendra Hardy Mohamad
- Zakaria Andee Dzulkarnaen
- Zakaria Maheen
- Zakaria Zaidi
- Zamudio-Bautista Jorge Luis
- Zanc Loredana
- Zanoni Andrea
- Zanus Giacomo
- Zapparoli Alessandro
- Zappone Anna
- Zarzava Eirini
- Zatari Dirar
- Zawadzki Marek
- Zayakov Georgi
- Zaycev Andrey
- Zazo Aya
- Zazo Rama
- Zdravkovic Maja
- Zengin Abdullah KaÄan
- Zeringa Georgia
- Zimmerman David D E
- Zuhdy Mohammad
- Zvirych Vitalii
- Zywicka Ewa
- Ălvarez-Llano Laura
- Ăngelo Miguel Duarte
- ĂSullivan Sara Nuñez
- Ăzçelik Mehmet Faik
- Äoza Ivo
- Ćanlı Ahmet Necati
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Background
Anastomotic leak affects 8 per cent of patients after right colectomy with a 10-fold increased risk of postoperative death. The EAGLE study aimed to develop and test whether an international, standardized quality improvement intervention could reduce anastomotic leaks.
Methods
The internationally intended protocol, iteratively co-developed by a multistage Delphi process, comprised an online educational module introducing risk stratification, an intraoperative checklist, and harmonized surgical techniques. Clusters (hospital teams) were randomized to one of three arms with varied sequences of intervention/data collection by a derived stepped-wedge batch design (at least 18 hospital teams per batch). Patients were blinded to the study allocation. Low- and middle-income country enrolment was encouraged. The primary outcome (assessed by intention to treat) was anastomotic leak rate, and subgroup analyses by module completion (at least 80 per cent of surgeons, high engagement; less than 50 per cent, low engagement) were preplanned.
Results
A total 355 hospital teams registered, with 332 from 64 countries (39.2 per cent low and middle income) included in the final analysis. The online modules were completed by half of the surgeons (2143 of 4411). The primary analysis included 3039 of the 3268 patients recruited (206 patients had no anastomosis and 23 were lost to follow-up), with anastomotic leaks arising before and after the intervention in 10.1 and 9.6 per cent respectively (adjusted OR 0.87, 95 per cent c.i. 0.59 to 1.30; P = 0.498). The proportion of surgeons completing the educational modules was an influence: the leak rate decreased from 12.2 per cent (61 of 500) before intervention to 5.1 per cent (24 of 473) after intervention in high-engagement centres (adjusted OR 0.36, 0.20 to 0.64; P < 0.001), but this was not observed in low-engagement hospitals (8.3 per cent (59 of 714) and 13.8 per cent (61 of 443) respectively; adjusted OR 2.09, 1.31 to 3.31).
Conclusion
Completion of globally available digital training by engaged teams can alter anastomotic leak rates. Registration number: NCT04270721 (http://www.clinicaltrials.gov)