On a Coccidium (\u3ci\u3eKlossiella muris\u3c/i\u3e, gen. et spec. nov.) Parasitic in the Renal Epithelium of the Mouse

In 1889, Smith published a preliminary description of a polysporous coccidium found in the epithelium of the convoluted tubules of the mouse\u27s kidney. Several stages of the parasite were seen but the scantiness of the material left many gaps in the life-cycle. During investigations recently made to determine the mode of transmission of the Sarcosporidium of the mouse, Smith found a considerable number of gray mice, caught in the animal room connected with this laboratory, whose kidneys were abundantly invaded by this coccidium. This favorable opportunity of examining more thoroughly into the life-history of this sporozoon was utilized, and, as a result, we are able to add materially to the knowledge of this cell parasite. In the following pages some details given in the first paper will be repeated to avoid obscurity in the descriptions as well as to aid those to whom the first paper is inaccessible. Thus far we have found only adult mice infected. The invaded kidneys are a trifle enlarged and the surface is faintly uneven. The most characteristic feature is a very delicate mottling of the whole surface with minute, barely visible, grayish specks. This appearance of the kidneys may be considered almost diagnostic of the presence of the parasite

Urban wind power and the private sector : community benefits, social acceptance and public engagement

Given the ambitious government targets for renewable energy generation in the UK, there has been a push by government and industry towards various types and scales of Renewable Energy Technologies (RETs). This paper explores the implications of commercial urban wind projects for local communities, drawing on a case study of proposals by ASDA to construct wind turbines in two semi-urban locations in the UK. The paper argues that community responses to the proposals were complex and varied and could not adequately be encapsulated by 'nimby' (not in my back yard) assignations. It concludes that while ASDA followed a process of consulting local people, this process highlighted the problems of the 'business as usual' approach to public engagement employed by ASDA, and assumptions made about public acceptance of RETs

The Nonlinear Debye-Onsager Relaxation Effect in Weakly Ionized Plasmas

A weakly ionized plasma under the influence of a strong electric field is considered. Supposing a local Maxwellian distribution for the electron momenta the plasma is described by hydrodynamic equations for the pair distribution functions. These equations are solved and the relaxation field is calculated for an arbitrary field strength. It is found that the relaxation effect becomes lower with increasing strength of the electrical field.Comment: 4 pages, 1 figur

Endocytosis Occurs Independently Of Annexin-Vi In Human A431 Cells

Annexin VI is one of a family of calcium-dependent phospholipid-binding proteins. Although the function of this protein is not known, various physiological roles have been proposed, including a role in the budding of clathrin-coated pits (Lin et al., 1992. Cell. 70:283-291.). In this study we have investigated a possible endocytotic role for annexin VI in intact cells, using the human squamous carcinoma cell line A431, and report that these cells do not express endogenous annexin VI, as judged by Western and Northern blotting and PCR/Southern blotting. To examine whether endocytosis might in some way be either facilitated or inhibited by the presence of annexin VI, a series of A431 clones were isolated in which annexin VI expression was achieved by stable transfection. These cells expressed annexin VI at similar levels to other human cell types. Using assays for endocytosis and recycling of the transferrin receptor, we report that each of these cellular processes occurs with identical kinetics in both transfected and wild-type A431 cells. In addition, purified annexin VI failed to support the scission of coated pits in permeabilized A431 cells. We conclude that annexin VI is not an essential component of the endocytic pathway, and that in A431 cells, annexin VI fails to exert any influence on internalization and recycling of the transferrin receptor

Risk factors for dating violence versus cohabiting violence : results from the third generation of the Cambridge Study in Delinquent Development

BACKGROUND: Dating violence is an important problem. Evidence suggests that women are more likely to perpetrate dating violence. AIMS: The present study investigates the prevalence of dating violence compared with cohabiting violence in a community sample of men and women and assesses to what extent child and adolescent explanatory factors predict this behaviour. A secondary aim is to construct a risk score for dating violence based on the strongest risk factors. METHODS: The Cambridge Study in Delinquent Development is a prospective longitudinal survey of 411 men (generation 2) born in the 1950s in an inner London area. Most recently, their sons and daughters [generation 3 (G3)] have been interviewed regarding their perpetration of dating and cohabiting violence, utilising the Conflict Tactics Scale. Risk factors were measured in four domains (family, parental, socio-economic and individual). RESULTS: A larger proportion of women than men perpetrated at least one act of violence towards their dating partner (36.4 vs 21.7%). There was a similar pattern for cohabiting violence (39.6 vs 21.4%). A number of risk factors were significantly associated with the perpetration of dating violence. For G3 women, these included a convicted father, parental conflict, large family size and poor housing. For G3 men, these included having a young father or mother, separation from the father before age 16, early school leaving, frequent truancy and having a criminal conviction. A risk score for both men and women, based on 10 risk factors, significantly predicted dating violence. CONCLUSION: Risk factors from four domains were important in predicting dating violence, but they were different for G3 men and women. It may be important to consider different risk factors and different risk assessments for male compared with female perpetration of dating violence. Early identification and interventions are recommended

A longitudinal analysis of the criminal careers of IPV offender subtypes : results from a prospective survey of males

Using data from the Cambridge Study in Delinquent Development, a prospective longitudinal survey of more than 400 males in the United Kingdom followed from age 8 years to age 48 years, we investigated the role of Cluster B personality traits and the association with violent offending groups based on a typology theory of male intimate partner violence (IPV) perpetrators: those who committed family-only violence and the generally violent offender. We also considered whether offending/violent groups could be predicted using risk factors measured in childhood, adolescence, and adulthood. Our findings suggest that those men who are violent both within and outside the home (the generally violent men) are distinguished from those who are involved in IPV within the home only. The differences appear to be more in degree than in kind. We discuss these findings in relation to the idea of specific interventions and policy