'She's like a daughter to me': insights into care, work and kinship from rural Russia

This article draws on ethnographic research into a state-funded homecare service in rural Russia. The article discusses intersections between care, work and kinship in the relationships between homecare workers and their elderly wards and explores the ways in which references to kinship, as a means of authenticating paid care and explaining its emotional content, reinforce public and private oppositions while doing little to relieve the tensions and conflicts of care work. The discussion brings together detailed empirical insights into local ideologies and practices as a way of generating new theoretical perspectives, which will be of relevance beyond the particular context of study

Excited States in Warm and Hot Dense Matter

Accurate modeling of warm and hot dense matter is challenging in part due to the multitude of excited states that must be considered. In thermal density functional theory, these excited states are averaged over to produce a single, averaged, thermal ground state. Here we present a variational framework and model that includes explicit excited states. In this framework an excited state is defined by a set of effective one-electron occupation factors and the corresponding energy is defined by the effective one-body energy with an exchange and correlation term. The variational framework is applied to an atom-in-plasma model (a generalization of the so-called average atom model). Comparisons with a density functional theory based average atom model generally reveal good agreement in the calculated pressure, but the new model also gives access to the excitation energies and charge state distributions

Loss of CLN7 results in depletion of soluble lysosomal proteins and impaired mTOR reactivation

Defects in the MFSD8 gene encoding the lysosomal membrane protein CLN7 lead to CLN7 disease, a neurodegenerative lysosomal storage disorder belonging to the group of neuronal ceroid lipofuscinoses (NCLs). Here we have performed a SILAC-based quantitative analysis of the lysosomal proteome using Cln7-deficient mouse embryonic fibroblasts (MEFs) from a Cln7 knockout (ko) mouse model. From 3335 different proteins identified, we detected 56 soluble lysosomal proteins and 29 highly abundant lysosomal membrane proteins. Quantification revealed that the amounts of 12 different soluble lysosomal proteins were significantly reduced in Cln7 ko MEFs compared with wild type controls. One of the most significantly depleted lysosomal proteins was Cln5 protein that underlies another distinct NCL disorder. Expression analyses showed that the mRNA expression, biosynthesis, intracellular sorting and proteolytic processing of Cln5 were not affected, whereas the depletion of mature Cln5 protein was due to increased proteolytic degradation by cysteine proteases in Cln7 ko lysosomes. Considering the similar phenotypes of CLN5 and CLN7 patients, our data suggest that depletion of CLN5 may play an important part in the pathogenesis of CLN7 disease. In addition, we found a defect in the ability of Cln7 ko MEFs to adapt to starvation conditions as shown by impaired mammalian target of rapamycin complex 1 reactivation, reduced autolysosome tubulation and increased perinuclear accumulation of autolysosomes compared to controls. In summary, depletion of multiple soluble lysosomal proteins suggest a critical role of CLN7 for lysosomal function, which may contribute to the pathogenesis and progression of CLN7 disease

The Influence of Magnetic Imperfections on the Low Temperature Properties of D-wave Superconductors

We consider the influence of planar ``magnetic" imperfections which destroy the local magnetic order, such as Zn impurities or $Cu^{2+}$ vacancies, on the low temperature properties of the cuprate superconductors. In the unitary limit, at low temperatures, for a $d_{x^2-y^2}$ pairing state such imperfections produce low energy quasiparticles with an anistropic spectrum in the vicinity of the nodes. We find that for the $La_{2-x}Sr_xCuO_4$ system, one is in the {\em quasi-one-dimensional} regime of quasiparticle scattering, discussed recently by Altshuler, Balatsky, and Rosengren, for impurity concentrations in excess of $\sim 0.16\%$ whereas YBCO$_7$ appears likely to be in the true 2D scattering regime for Zn concentrations less than $1.6\%$. We show the neutron scattering results of Mason et al. \cite{Aeppli} on $La_{1.86}Sr_{0.14}CuO_4$ provide strong evidence for ``dirty d-wave" superconductivity in their samples. We obtain simple expressions for the dynamic spin susceptibility and $^{63}Cu$ spin-lattice relaxation time, $^{63}T_1$, in the superconducting state.Comment: 10 pages; revtex; Los Alamos preprint LA-UR-94-53

Volcano dome dynamics at Mount St. Helens:Deformation and intermittent subsidence monitored by seismicity and camera imagery pixel offsets

The surface deformation field measured at volcanic domes provides insights into the effects of magmatic processes, gravity-and gas-driven processes, and the development and distribution of internal dome structures. Here we study short-term dome deformation associated with earthquakes at Mount St. Helens, recorded by a permanent optical camera and seismic monitoring network. We use Digital Image Correlation (DIC) to compute the displacement field between successive images and compare the results to the occurrence and characteristics of seismic events during a 6 week period of dome growth in 2006. The results reveal that dome growth at Mount St. Helens was repeatedly interrupted by short-term meter-scale downward displacements at the dome surface, which were associated in time with low-frequency, large-magnitude seismic events followed by a tremor-like signal. The tremor was only recorded by the seismic stations closest to the dome. We find a correlation between the magnitudes of the camera-derived displacements and the spectral amplitudes of the associated tremor. We use the DIC results from two cameras and a high-resolution topographic model to derive full 3-D displacement maps, which reveals internal dome structures and the effect of the seismic activity on daily surface velocities. We postulate that the tremor is recording the gravity-driven response of the upper dome due to mechanical collapse or depressurization and fault-controlled slumping. Our results highlight the different scales and structural expressions during growth and disintegration of lava domes and the relationships between seismic and deformation signals

Health Literacy and Medication Adherence Among Patients Treated in a Free Health Clinic: A Pilot Study

Background: A patient’s health literacy is not routinely assessed during visits with a health care provider. Since low health literacy is a risk factor for poor health outcomes, assessing health literacy should be considered as part of the standard medical workup. Objectives: To evaluate the health literacy levels and medication adherence of patients treated by pharmacists in both the general medicine and the chronic care clinics at an urban free health clinic. Methods: Eligible patients from the free health clinic completed the Rapid Estimate of Adult Literacy in Medicine (REALM), a health literacy measurement tool, during their clinic visit in 2011. Medication adherence was self-reported by the patients. Results: A total of 100 patients participated (mean age = 48). The majority of participants were female (56%) and white (55%). Most (64%) of the patients scored at a high school reading level according to REALM. Only 21% of participants read at a seventh- to eighth-grade level. Overall medication adherence rate was 73%. Forgetting to take medication was the most popular reason given for nonadherence. Conclusion: Disease state and adherence were significantly related in patients with HIV/AIDS and hypertension. Patient’s ethnicity was significantly associated with literacy levels (P < .05). Although patients’ literacy levels were not significantly associated with self-reported adherence in this population, availability of a patient’s baseline health literacy level as a part of the medical record may help clinicians to individualize their interaction based on the patient’s health literacy level in order to achieve better health outcomes, including improved medication adherence, especially for underserved populations

Anhydrous Ammonia or Liquid Supplement Treatment of Wheat Straw: Demonstration Results

The effect of anhydrous ammonia or liquid supplement treatment of wheat straw was evaluated by field demonstration in response to the drought of 1989. Ammoniation of wheat straw increased estimated TDN content by 7.8 percentage points and crude protein by 7 percentage points in comparison with untreated straw. Adding a liquid protein supplement to wheat straw increased estimated TDN content by 1.5 percentage points and crude protein by .6 percentage points. Ammoniation increased the quality of wheat straw to a level comparable to prairie hay. Based on nutrient analysis, the ammoniation procedure was more effective in improving the quality of wheat straw than addition of liquid supplement

Interplane magnetic coupling effects in the multilattice compound Y_2Ba_4Cu_7O_{15}

We investigate the interplane magnetic coupling of the multilattice compound Y_2Ba_4Cu_7O_{15} by means of a bilayer Hubbard model with inequivalent planes. We evaluate the spin response, effective interaction and the intra- and interplane spin-spin relaxation times within the fluctuation exchange approximation. We show that strong in-plane antiferromagnetic fluctuations are responsible for a magnetic coupling between the planes, which in turns leads to a tendency of the fluctuation in the two planes to equalize. This equalization effect grows whit increasing in-plane antiferromagnetic fluctuations, i. e., with decreasing temperature and decreasing doping, while it is completely absent when the in-layer correlation length becomes of the order of one lattice spacing. Our results provide a good qualitative description of NMR and NQR experiments in Y_2Ba_4Cu_7O_{15}.Comment: Final version, to appear. in Phys. Rev. B (Rapid Communications), sched. Jan. 9