To what extent has Sustainable Intensification in England been achieved?

Agricultural intensification has significantly increased yields and fed growing populations across the planet, but has also led to considerable environmental degradation. In response an alternative process of ‘Sustainable Intensification’ (SI), whereby food production increases while environmental impacts are reduced, has been advocated as necessary, if not sufficient, for delivering food and environmental security. However, the extent to which SI has begun, the main drivers of SI, and the degree to which degradation is simply ‘offshored’ are uncertain. In this study we assess agroecosystem services in England and two contrasting sub-regions, majority-arable Eastern England and majority-pastoral South-Western England, since 1950 by analysing ecosystem service metrics and developing a simple system dynamics model. We find that rapid agricultural intensification drove significant environmental degradation in England in the early 1980s, but that most ecosystem services except farmland biodiversity began to recover after 2000, primarily due to reduced livestock and fertiliser usage decoupling from high yields. This partially follows the trajectory of an Environmental Kuznets Curve, with yields and GDP growth decoupling from environmental degradation above ~£17,000 per capita per annum. Together, these trends suggest that SI has begun in England. However, the lack of recovery in farmland biodiversity, and the reduction in UK food self-sufficiency resulting in some agricultural impacts being ‘offshored’, represent major negative trade-offs. Maintaining yields and restoring biodiversity while also addressing climate change, offshored degradation, and post-Brexit subsidy changes will require significant further SI in the future

Impact of saline irrigation and topical corticosteroids on the postsurgical sinonasal microbiota.

INTRODUCTION: Topical treatments with nasal saline irrigation, topical steroid sprays, or corticosteroid rinses can improve sinonasal symptoms in chronic rhinosinusitis (CRS). However, the impact of these therapies on commensals (Corynebacterium) and on biofilm pathogens associated with CRS (Staphylococcus aureus and Pseudomonas) is not well characterized. METHODS: Paired nasal and sinus swabs were collected endoscopically from 28 controls and 14 CRS patients with nasal polyposis (CRSwNP) who had not received systemic antibiotics or corticosteroids in the previous eight weeks. Total DNA from swab eluents were extracted and analyzed by 16S rRNA gene-based pyrosequencing. A total 359,077 reads were obtained and classified taxonomically. The association of use of topical therapies with sinonasal microbiota composition was assessed by factor and vector-fitting. The proportional abundances of sinonasal bacteria between topical therapy users and non-users were further compared by two-tailed Kolmogorov-Smirnov test among controls and among CRSwNP participants. RESULT: Nasal saline irrigation, with or without added budesonide, was not associated with significantly distinct sinonasal microbiota composition or significantly decreased Pseudomonas or S. aureus abundances among either controls or CRSwNP participants. Corynebacterium was slightly lower in controls that reported using saline irrigation than those who did not. No significant association was found between nasal saline irrigation and the proportional abundances of Pseudomonas, S. aureus, and Corynebacterium in CRSwNP participants. However, male CRSwNP patients were noted to have significantly higher Corynebacterium proportional abundances than their female counterparts. The use of topical steroid sprays was associated with a distinct microbiota in control subjects, characterized by higher proportional abundances of Dolosigranulum and Simonsiella and a lower proportional abundance of Campylobacter. CONCLUSION: Nasal saline irrigation is not associated with a distinct alteration in the proportional abundance of commensal bacteria or biofilm-forming pathogens in CRSwNP patients. However, use of topical intranasal corticosteroid sprays in control subjects is associated with a distinct sinonasal microbiota