517 research outputs found

    Analysis and Design of Silicon based Integrated Circuits for Radio Frequency Identification and Ranging Systems at 24GHz and 60GHz Frequency Bands

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    This scientific research work presents the analysis and design of radio frequency (RF) integrated circuits (ICs) designed for two cooperative RF identification (RFID) proof of concept systems. The first system concept is based on localizable and sensor-enabled superregenerative transponders (SRTs) interrogated using a 24GHz linear frequency modulated continuous wave (LFMCW) secondary radar. The second system concept focuses on low power components for a 60GHz continuous wave (CW) integrated single antenna frontend for interrogating close range passive backscatter transponders (PBTs). In the 24GHz localizable SRT based system, a LFMCW interrogating radar sends a RF chirp signal to interrogate SRTs based on custom superregenerative amplifier (SRA) ICs. The SRTs receive the chirp and transmit it back with phase coherent amplification. The distance to the SRTs are then estimated using the round trip time of flight method. Joint data transfer from the SRT to the interrogator is enabled by a novel SRA quench frequency shift keying (SQ-FSK) based low data rate simplex communication. The SRTs are also designed to be roll invariant using bandwidth enhanced microstrip patch antennas. Theoretical analysis is done to derive expressions as a function of system parameters including the minimum SRA gain required for attaining a defined range and equations for the maximum number of symbols that can be transmitted in data transfer mode. Analysis of the dependency of quench pulse characteristics during data transfer shows that the duty cycle has to be varied while keeping the on-time constant to reduce ranging errors. Also the worsening of ranging precision at longer distances is predicted based on the non-idealities resulting from LFMCWchirp quantization due to SRT characteristics and is corroborated by system level measurements. In order to prove the system concept and study the semiconductor technology dependent factors, variants of 24GHz SRA ICs are designed in a 130nm silicon germanium (SiGe) bipolar complementary metal oxide technology (BiCMOS) and a partially depleted silicon on insulator (SOI) technology. Among the SRA ICs designed, the SiGe-BiCMOS ICs feature a novel quench pulse shaping concept to simultaneously improve the output power and minimum detectable input power. A direct antenna drive SRA IC based on a novel stacked transistor cross-coupled oscillator topology employing this concept exhibit one of the best reported combinations of minimum detected input power level of −100 dBm and output power level of 5.6 dBm, post wirebonding. The SiGe stacked transistor with base feedback capacitance topology employed in this design is analyzed to derive parameters including the SRA loop gain for design optimization. Other theoretical contributions include the analysis of the novel integrated quench pulse shaping circuit and formulas derived for output voltage swing taking bondwire losses into account. Another SiGe design variant is the buffered antenna drive SRA IC having a measured minimum detected input power level better than −80 dBm, and an output power level greater than 3.2 dBm after wirebonding. The two inputs and outputs of this IC also enables the design of roll invariant SRTs. Laboratory based ranging experiments done to test the concepts and theoretical considerations show a maximum measured distance of 77m while transferring data at the rate of 0.5 symbols per second using SQ-FSK. For distances less than 10m, the characterized accuracy is better than 11 cm and the precision is better than 2.4 cm. The combination of the maximum range, precision and accuracy are one of the best reported among similar works in literature to the author’s knowledge. In the 60GHz close range CW interrogator based system, the RF frontend transmits a continuous wave signal through the transmit path of a quasi circulator (QC) interfaced to an antenna to interrogate a PBT. The backscatter is received using the same antenna interfaced to the QC. The received signal is then amplified and downconverted for further processing. To prove this concept, two optimized QC ICs and a downconversion mixer IC are designed in a 22nm fully depleted SOI technology. The first QC is the transmission lines based QC which consumes a power of 5.4mW, operates at a frequency range from 56GHz to 64GHz and occupies an area of 0.49mm2. The transmit path loss is 5.7 dB, receive path gain is 2 dB and the tunable transmit path to receive path isolation is between 20 dB and 32 dB. The second QC is based on lumped elements, and operates in a relatively narrow bandwidth from 59.6GHz to 61.5GHz, has a gain of 8.5 dB and provides a tunable isolation better than 20 dB between the transmit and receive paths. This QC design also occupies a small area of 0.34mm² while consuming 13.2mW power. The downconversion is realized using a novel folded switching stage down conversion mixer (FSSDM) topology optimized to achieve one of the best reported combination of maximum voltage conversion gain of 21.5 dB, a factor of 2.5 higher than reported state-of-the-art results, and low power consumption of 5.25mW. The design also employs a unique back-gate tunable intermediate frequency output stage using which a gain tuning range of 5.5 dB is attained. Theoretical analysis of the FSSDM topology is performed and equations for the RF input stage transconductance, bandwidth, voltage conversion gain and gain tuning are derived. A feasibility study for the components of the 60GHz integrated single antenna interrogator frontend is also performed using PBTs to prove the system design concept.:1 Introduction 1 1.1 Motivation and Related Work . . . . . . . . . . . . . . . . . . . . . 1 1.2 Scope and Functional Specifications . . . . . . . . . . . . . . . . . 4 1.3 Objectives and Structure . . . . . . . . . . . . . . . . . . . . . . . . 5 2 Features and Fundamentals of RFIDs and Superregenerative Amplifiers 9 2.1 RFID Transponder Technology . . . . . . . . . . . . . . . . . . . . 9 2.1.1 Chipless RFID Transponders . . . . . . . . . . . . . . . . . 10 2.1.2 Semiconductor based RFID Transponders . . . . . . . . . . 11 2.1.2.1 Passive Transponders . . . . . . . . . . . . . . . . 11 2.1.2.2 Active Transponders . . . . . . . . . . . . . . . . . 13 2.2 RFID Interrogator Architectures . . . . . . . . . . . . . . . . . . . 18 2.2.1 Interferometer based Interrogator . . . . . . . . . . . . . . . 19 2.2.2 Ultra-wideband Interrogator . . . . . . . . . . . . . . . . . . 20 2.2.3 Continuous Wave Interrogators . . . . . . . . . . . . . . . . 21 2.3 Coupling Dependent Range and Operating Frequencies . . . . . . . 25 2.4 RFID Ranging Techniques . . . . . . . . . . . . . . . . . . . . . . . 28 2.4.0.1 Received Signal Strength based Ranging . . . . . 28 2.4.0.2 Phase based Ranging . . . . . . . . . . . . . . . . 30 2.4.0.3 Time based Ranging . . . . . . . . . . . . . . . . . 30 2.5 Architecture Selection for Proof of Concept Systems . . . . . . . . 32 2.6 Superregenerative Amplifier (SRA) . . . . . . . . . . . . . . . . . . 35 2.6.1 Fundamentals . . . . . . . . . . . . . . . . . . . . . . . . . . 35 2.6.2 Modes of Operation . . . . . . . . . . . . . . . . . . . . . . 42 2.6.3 Frequency Domain Characteristics . . . . . . . . . . . . . . 45 2.7 Semiconductor Technologies for RFIC Design . . . . . . . . . . . . 48 2.7.1 Silicon Germanium BiCMOS . . . . . . . . . . . . . . . . . 48 2.7.2 Silicon-on-Insulator . . . . . . . . . . . . . . . . . . . . . . . 48 3 24GHz Superregenerative Transponder based Identification and Rang- ing System 51 3.1 System Design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 51 3.1.1 SRT Identification and Ranging . . . . . . . . . . . . . . . . 51 3.1.2 Power Link Analysis . . . . . . . . . . . . . . . . . . . . . . 55 3.1.3 Non-idealities . . . . . . . . . . . . . . . . . . . . . . . . . . 59 3.1.4 SRA Quench Frequency Shift Keying for data transfer . . . 61 3.1.5 Knowledge Gained . . . . . . . . . . . . . . . . . . . . . . . 63 3.2 RFIC Designs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 64 3.2.1 Low Power Direct Antenna Drive CMOS SRA IC . . . . . . 66 3.2.1.1 Circuit analysis and design . . . . . . . . . . . . . 66 3.2.1.2 Characterization . . . . . . . . . . . . . . . . . . . 69 3.2.2 Direct Antenna Drive SiGe SRA ICs . . . . . . . . . . . . . 71 3.2.2.1 Stacked Transistor Cross-coupled Quenchable Oscillator . . . . . . . . . . . . . . . . . . . . . . . . 72 3.2.2.1.1 Resonator . . . . . . . . . . . . . . . . . . 72 3.2.2.1.2 Output Network . . . . . . . . . . . . . . 75 3.2.2.1.3 Stacked Transistor Cross-coupled Pair and Loop Gain . . . . . . . . . . . . . . . . . 77 3.2.2.2 Quench Waveform Design . . . . . . . . . . . . . . 85 3.2.2.3 Characterization . . . . . . . . . . . . . . . . . . . 89 3.2.3 Antenna Diversity SiGe SRA IC with Integrated Quench Pulse Shaping . . . . . . . . . . . . . . . . . . . . . . . . . . 91 3.2.3.1 Circuit Analysis and Design . . . . . . . . . . . . 91 3.2.3.1.1 Crosscoupled Pair and Sampling Current 94 3.2.3.1.2 Common Base Input Stage . . . . . . . . 95 3.2.3.1.3 Cascode Output Stage . . . . . . . . . . . 96 3.2.3.1.4 Quench Pulse Shaping Circuit . . . . . . 96 3.2.3.1.5 Power Gain . . . . . . . . . . . . . . . . . 99 3.2.3.2 Characterization . . . . . . . . . . . . . . . . . . . 102 3.2.4 Knowledge Gained . . . . . . . . . . . . . . . . . . . . . . . 103 3.3 Proof of Principle System Implementation . . . . . . . . . . . . . . 106 3.3.1 Superregenerative Transponders . . . . . . . . . . . . . . . 106 3.3.1.1 Bandwidth Enhanced Microstrip Patch Antennas 108 3.3.2 FMCW Radar Interrogator . . . . . . . . . . . . . . . . . . 114 3.3.3 Chirp Z-transform Based Data Analysis . . . . . . . . . . . 116 4 60GHz Single Antenna RFID Interrogator based Identification System 121 4.1 System Design . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 121 4.2 RFIC Designs . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 125 4.2.1 Quasi-circulator ICs . . . . . . . . . . . . . . . . . . . . . . 125 4.2.1.1 Transmission Lines based Quasi-Circulator IC . . 126 4.2.1.2 Lumped Elements WPD based Quasi-Circulator . 130 4.2.1.3 Characterization . . . . . . . . . . . . . . . . . . . 134 4.2.1.4 Knowledge Gained . . . . . . . . . . . . . . . . . . 135 4.2.2 Folded Switching Stage Downconversion Mixer IC . . . . . 138 4.2.2.1 FSSDM Circuit Design . . . . . . . . . . . . . . . 138 4.2.2.2 Cascode Transconductance Stage . . . . . . . . . . 138 4.2.2.3 Folded Switching Stage with LC DC Feed . . . . . 142 4.2.2.4 LO Balun . . . . . . . . . . . . . . . . . . . . . . . 145 4.2.2.5 Backgate Tunable IF Stage and Offset Correction 146 4.2.2.6 Voltage Conversion Gain . . . . . . . . . . . . . . 147 4.2.2.7 Characterization . . . . . . . . . . . . . . . . . . . 150 4.2.2.8 Knowledge Gained . . . . . . . . . . . . . . . . . . 151 4.3 Proof of Principle System Implementation . . . . . . . . . . . . . . 154 5 Experimental Tests 157 5.1 24GHz System . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 157 5.1.1 Ranging Experiments . . . . . . . . . . . . . . . . . . . . . 157 5.1.2 Roll Invariance Experiments . . . . . . . . . . . . . . . . . . 158 5.1.3 Joint Ranging and Data Transfer Experiments . . . . . . . 158 5.2 60GHz System Detection Experiments . . . . . . . . . . . . . . . . 165 6 Summary and Future Work 167 Appendices 171 A Derivation of Parameters for CB Amplifier with Base Feedback Capac- itance 173 B Definitions 177 C 24GHz Experiment Setups 179 D 60 GHz Experiment Setups 183 References 185 List of Original Publications 203 List of Abbreviations 207 List of Symbols 213 List of Figures 215 List of Tables 223 Curriculum Vitae 22

    Machine Learning Techniques for Lung Cancer Risk Prediction using Text Dataset

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    The early symptoms of lung cancer, a serious threat to human health, are comparable to those of the common cold and bronchitis. Clinical professionals can use machine learning techniques to customize screening and prevention strategies to the unique needs of each patient, potentially saving lives and enhancing patient care. Researchers must identify linked clinical and demographic variables from patient records and further pre-process and prepare the dataset for training a machine-learning model in order to properly predict the development of lung cancer. The goal of the study is to develop a precise and understandable machine learning (ML) model for early lung cancer prediction utilizing demographic and clinical variables, as well as to contribute to the growing field of medical research ML application that may improve healthcare outcomes. In order to create the most effective and precise predictive model, machine learning techniques like Logistic Regression, Decision Tree, Random Forest, Support Vector Machine, K-Nearest Neighbor (KNN), and Naive Bayes were utilized in this article

    COVID-19 associated mucormycosis during the second wave of pandemic in South India

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    Background: The incidence of mucormycosis has risen more rapidly during the second wave compared with the first wave of COVID-19 in India. As with the other parts of the country, our state also experience surge of mucormycosis cases among COVID-19 patients admitted in our hospitals. The surge of COVID-19 associated mucormycosis (CAM) which was new for the whole medical community with no prior experience.  In this context a prospective descriptive study was conducted.Methods: The study was done at a public sector tertiary care hospital in Kerala, South India from April to June 2021 prospectively.Results: During our study period of three months total 40 cases were reported with diagnosis of mucormycosis. Sex wise 29 (72.5%) were males and 11 (27.5%) were females. The mean age was 55.8+16 years. Thirty three (83%) cases were confirmed to be CAM by real time reverse transcriptase polymerase chain reaction (RTPCR) test. Thirty one (79%) of them have got associated risk factor diabetes mellitus. Twenty six (65%) had undergone steroid treatment. Other associated risk factors were hypoxia 10 (25%), zinc supplement 30 (75%), steam inhalation 14 (35%), and intensive care unit (ICU) admission 6 (15%). All the cases were rhino orbito cerebral type. Majority 26 (65%) received medical and surgical treatment. The outcome wise 16 (40%) patients were discharged after cure and case fatality rate was 4 (10%).Conclusions: In our study CAM was highly associated with increasing age above 50, diabetes, steroid use and zinc supplementation. The health care workers and patients should be made aware of the importance of glycemic control, over use of steroids

    Quantification of Maceration Changes using Post Mortem MRI in Fetuses

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    BACKGROUND: Post mortem imaging is playing an increasingly important role in perinatal autopsy, and correct interpretation of imaging changes is paramount. This is particularly important following intra-uterine fetal death, where there may be fetal maceration. The aim of this study was to investigate whether any changes seen on a whole body fetal post mortem magnetic resonance imaging (PMMR) correspond to maceration at conventional autopsy. METHODS: We performed pre-autopsy PMMR in 75 fetuses using a 1.5 Tesla Siemens Avanto MR scanner (Erlangen, Germany). PMMR images were reported blinded to the clinical history and autopsy data using a numerical severity scale (0 = no maceration changes to 2 = severe maceration changes) for 6 different visceral organs (total 12). The degree of maceration at autopsy was categorized according to severity on a numerical scale (1 = no maceration to 4 = severe maceration). We also generated quantitative maps to measure the liver and lung T2. RESULTS: The mean PMMR maceration score correlated well with the autopsy maceration score (R(2) = 0.93). A PMMR score of ≥4.5 had a sensitivity of 91%, specificity of 64%, for detecting moderate or severe maceration at autopsy. Liver and lung T2 were increased in fetuses with maceration scores of 3-4 in comparison to those with 1-2 (liver p = 0.03, lung p = 0.02). CONCLUSIONS: There was a good correlation between PMMR maceration score and the extent of maceration seen at conventional autopsy. This score may be useful in interpretation of fetal PMMR

    Molecular dynamics in amorphous ergocalciferol

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    While developing new pharmaceutical products based on drug substances in their amorphous form, the molecular mobility of amorphous active ingredients have to be characterized in detail. The molecular mobility in the supercooled liquid and glassy states of ergocalciferol is studied using broadband dielectric spectroscopy over wide frequency and temperature ranges. Dielectric studies revealed a number of relaxation process of different molecular origi

    Post-mortem magnetic resonance imaging in fetuses, newborns and children

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    My thesis explores the feasibility and utility of whole body post-mortem magnetic resonance (MR) imaging as an alternative for conventional autopsy in fetuses, newborns and children. The thesis starts with a systematic review of the existing literature on post-mortem MR imaging to identify the knowledge gaps. This is followed by the development of an effective recruitment model and a comparative study on the accuracy of less invasive autopsy by post-mortem MR imaging with conventional autopsy in 200 fetuses, newborns and children. The cause of death was accurately identified in more than 90% of cases by less invasive autopsy, following a hospital death, unexplained stillbirth or an unexpected death under HM Coronial investigation. Post-mortem MR imaging of the brain had a very high negative predictive value for excluding major neuropathological lesions; opening of the head can be avoided if post-mortem MR imaging of the brain is normal. High-resolution, 3D post-mortem cardiac MR imaging accurately detected structural heart diseases in larger fetuses, newborns and children. However, the accuracy of post-mortem lung MR imaging was poor; renal lesions required histological examination for definitive diagnosis. Furthermore, post-mortem MR imaging cannot differentiate between the normal death process and ante-mortem hypoxic brain injury due to the changes in T1 and T2 relaxometry values occurring after death. The diagnostic utility and image quality at 1.5 Tesla MR imaging was poor in smaller fetuses, however high field MR imaging at 9.4 Tesla provided satisfactory MR images in this sub group. In addition, visceral organ weights were accurately estimated from post-mortem MR data sets and anatomical models of these organs reconstructed by rapid prototyping. My thesis concludes by demonstrating the proof of principle of MR guided percutaneous biopsy in a piglet model. In summary, less invasive autopsy by post-mortem MR imaging may be a satisfactory alternative to conventional autopsy; however accurate methods of percutaneous tissue sampling need to be developed and validated for adequate histological examination of visceral organs, particularly lungs, kidneys and heart

    Relaxation dynamics of amorphous dibucaine using dielectric studies

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    Using broadband dielectric spectroscopy the molecular mobility of dibucaine is investigated in the supercooled liquid and gassy states, over a wide temperature range for some test frequencies. Above the glass transition temperature T-g, the presence of structural alpha- relaxation peak was observed due to the cooperative motions of the molecule and upon cooling frozen kinetically to form the glass. The secondary relaxation process was perceivable below T-g due to localized motions. The peak loss frequency of alpha-relaxation process shows non-Arrhenius behavior and obeys Vogel-Fulcher-Tammann equation over the measured temperature range whereas the beta- process shows Arrhenius behavior

    Coupling of Caged Molecule Dynamics to JG β-Relaxation: I

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    The paper (Sibik, J.; Elliott, S. R.; Zeitler, J. A. J. Phys. Chem. Lett. 2014, 5, 1968-1972) used terahertz time-domain spectroscopy (THz-TDS) to study the dynamics of the polyalcohols, glycerol, threitol, xylitol, and sorbitol, at temperatures from below to above the glass transition temperature Tg. On heating the glasses, they observed the dielectric losses, ε″(ν) at ν = 1 THz, increase monotonically with temperature and change dependence at two temperatures, first deep in the glassy state at TTHz = 0.65Tg and second at Tg. The effects at both temperatures are most prominent in sorbitol but become progressively weaker in the order of xylitol and threitol, and the sub-Tg change was not observed in glycerol. They suggested this feature originates from the high-frequency tail of the Johari-Goldstein (JG) β-relaxation, and the temperature region near 0.65Tg is the universal region for the secondary glass transition due to the JG β-relaxation. In this paper, we first use isothermal dielectric relaxation data at frequencies below 106 Hz to locate the "second glass transition" temperature Tβ at which the JG β-relaxation time βJG reaches 100 s. The value of Tβ is close to TTHz = 0.65Tg for sorbitol (0.63Tg) and xylitol (0.65Tg), but Tβ is 0.74Tg for threitol and 0.83Tg for glycerol. Notwithstanding, the larger values of Tβ of glycerol are consistent with the THz-TDS data. Next, we identify the dynamic process probed by THz-TDS as the caged molecule dynamics, showing up in susceptibility spectra as nearly constant loss (NCL). The caged molecule dynamics regime is terminated by the onset of the primitive relaxation of the coupling model, which is the precursor of the JG β-relaxation. From this relation, established is the connection of the magnitude and temperature dependence of the NCL and those of βJG. This connection explains the monotonic increase of NCL with temperature and change to a stronger dependence after crossing Tβ giving rise to the sub-Tg behavior of ε″(ν) observed in experiment. Beyond the polyalcohols, we present new dielectric relaxation measurements of flufenamic acid and recall dielectric, NMR, and calorimetric data of indomethacin. The data of these two pharmaceuticals enables us to determine the value of Tβ = 0.67Tg for flufenamic acid and Tβ = 0.58Tg or Tβ = 0.62Tg for indomethacin, which can be compared with experimental values of TTHz from THz-TDS measurements when they become available. We point out that the sub-Tg change of NCL at Tβ found by THz-TDS can be observed by other high frequency spectroscopy including neutron scattering, light scattering, Brillouin scattering, and inelastic X-ray scattering. An example from neutron scattering is cited. All the findings demonstrate the connection of all processes in the evolution of dynamics ending at the structural α-relaxation. © 2015 American Chemical Society

    Revealing the rich dynamics of glass-forming systems by modification of composition and change of thermodynamic conditions

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    Secondary relaxations have been classified into two types, depending on whether they are related to the structural alpha-relaxation in properties or not. Those secondary relaxations that are related to the a-relaxation may have fundamental importance, and are called the Johari–Goldstein (JG) ß-relaxations. Two polar molecular glass-formers, one flexible and another rigid, dissolved in apolar host with higher glass transition temperature are studied by broadband dielectric spectroscopy at ambient and elevated pressure. The neat flexible glassformer diethylphthalate (DEP) has a resolved secondary relaxation which, unlike the a-relaxation, is insensitive to pressure and hence is not the JG ß-relaxation. In the solution, the JG ß-relaxation of DEP shows up in experiment and its relaxation time tß is pressure and temperature dependent like ta. The result supports the universal presence of the JG ß-relaxation in all glass-formers, and the separation between ta and tß is determined by intermolecular interaction. The rigid glass-former is cyano-benzene (CNBz) and its secondary relaxation involves the entire molecule is necessarily the JG ß-relaxation. The dielectric relaxation spectra obtained at a number of combinations of pressure and temperature at constant ta show not only unchanged is the frequency dispersion of the a-relaxation but also tß. The remarkable results indicate that the JG ß-relaxation bears a strong connection to the alpha-relaxation, and the two relaxations are inseparablewhen considering the dynamics of glass-forming systems. Experimentally, tau_alpha has been found to be a function of the product variables, T/rho^gamma, where rho is the density and gamma is a material constant. From the invariance of the ratio, tau_alphaa/tau_ß, to change of thermodynamic conditions seen in our experiment as well in other systems, it follows that tß is also a function of T/rho^gamma, with the same gamma at least approximately. Since the JG ß-relaxation is the precursor of the a-relaxation, causality implies that the T/rho^gamma-dependence originates from the JG ß-relaxation and is passed on to the alpha-relaxation
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