Bcl9の異なるエピトープを認識する二つの抗体を用いた免疫組織化学的マッピングによるミャンマー国若年性発症肝細胞がんの特徴付け

B-cell lymphoma 9 (Bcl9) is the core component of Wnt/β-catenin signaling and overexpressed in nuclei of various tumors, including hepatocellular carcinoma (HCC). However, the extent of Bcl9 expression relative to HCC differentiation stage and its functional aspects are poorly understood. In this study, we examined the expression pattern of Bcl9 immunohistochemically, using two anti-Bcl9 antibodies; one was a conventional polyclonal-antibody (anti-Bcl9ABC) against amino acid no.800?900 of human-Bcl9, while the other (anti-Bcl9BIO) was against amino acid no.50?200, covering Pygopus-binding sites of Bcl9. Immunohistochemistry using anti-Bcl9BIO demonstrated distinctive staining in the cytoplasm, while the anti-Bcl9ABC signal was detected in both cytoplasm and nuclei of HCC cells, reflecting different states of Bcl9 function because Pygopus-binding to Bcl9 is essential to exert its function together with β-catenin in nucleus. Quantitative analysis revealed a significantly higher immunohistochemical-score by anti-Bcl9BIO in normal liver comparing various differentiation grades of HCC (P < 0.004), whereas no significant difference was noted with anti-Bcl9ABC. Interestingly, immunohistochemical-score of anti-Bcl9BIO in patients aged < 40 years was significantly lower than that of ? 40 years group (P < 0.01). The results indicated that anti-Bcl9BIO detected cytoplasmic Bcl9, which does not bind to Pygopus suggesting it could be a useful indicator for development of HCC in young Myanmar patients.長崎大学学位論文 学位記番号:博(医歯薬)甲第1129号 学位授与年月日:平成31年3月20日Author: Myat Thu Soe, Yasuaki Shibata, Myo Win Htun, Kuniko Abe, Kyaw Soe, Nay Win Than, Thann Lwin, Myat Phone Kyaw and Takehiko KojiCitation: Acta Histochemica et Cytochemica, 52(1), pp.9-17; 2019Nagasaki University (長崎大学)課程博

Improving local health through community health workers in Cambodia: challenges and solutions

Volunteer community health workers (CHWs) are an important link between the public health system and the community. The ‘Community Participation Policy for Health’ in Cambodia identifies CHWs as key to local health promotion and as a critical link between district health centres and the community. However, research on the challenges CHWs face and identifying what is required to optimise their performance is limited in the Cambodian context. This research explores the views of CHWs in rural Cambodia, on the challenges they face when implementing health initiatives

Designs and Codes

This talk contains a survey of some of the objects studied in design theory and coding theory, along with their interactions. The bibliography at the end includes books I have used and recommend

Palaeoenvironmental studies of the Middle Triassic uppermost Narrabeen Group, Sydney Basin: palaeoecological constraints with particular emphasis on trace fossil assemblages

"1990".Thesis (PhD)--Macquarie University, School of Earth Sciences, 1991.Bibliography: p. 596-630.PART 1. INTRODUCTION AND METHODOLOGY -- General introduction -- Methodology -- Classification of ichnofacies and lithofacies as used in the present study -- Definition of trace fossil zones (intervals, subintervals and levels) -- General classification of the palaeoenvironments and summary overview of the stratigraphic and geographic distribution of palaeoenvironments in the study area -- PART 2. SYSTEMATIC ICHNOTAXONOMY -- Large dwelling-burrows -- U-shaped burrows -- Vertical cylindrical burrows -- Thalassinoides, Ophiomorpha, Spongeliomorpha and turn-arounds -- Pellets and ovoid-shaped structures -- Bedding-parallel feeding and/or dwelling structures -- Dendritic feeding-burrows -- Rosette-shaped structures -- Escape-structures -- Tracks, trails and resting-traces -- Body fossils and root-penetration structures -- Miscellaneous traces -- PART 3. SYNTHESIS AND CONCLUSIONS -- Trace fossil assemblages (suites) in intervals IC to IF and their distribution in the study area -- Interpretation of the palaeoenvironmental affinities of the trace fossil zones and depositional setting of the study area -- Palaeogeographic synthesis and conclusions.The coastal exposures of the Triassic System in the Sydney Northshore area aggregate about 180 m in thickness and comprise the uppermost part of the Narrabeen Group (namely, in ascending stratigraphic order: the Bald Hill Claystone, the Garie Formation, and the Newport Formation, the latter divisible into Lower, Middle and Upper Members) and the overlying Hawkesbury Sandstone. With the exception of mainly allochthonous plant macrofossils and palynomorphs which occur sporadically and with varying abundance in the mudrock facies of these formations, environmentally-diagnostic body fossils are rare, and, where they occur, are nowhere unequivocally indicative of marine affinities. For this reasons, and because of the predominantly fluvial lithofacies characteristics exhibited by these formations throughout much of their stratigraphic extent and especially by their channel-form/channel-like sandstones lithosomes, most previous workers have interpreted these formations to be of fluvial or fluvio-lacustrine origin except possibly for several thin planar-and thinly-bedded fine-grained intervals encompassing the Garie and Newport Formations for which several lines of evidence, including lithofacies, equivocal palaeontological, and ichnological evidence, have prompted several workers to speculate a shallow- marine, possibility coastal lagoonal or estuarine origin. -- Although trace fossils occur in reasonable abundance at various stratigraphic levels within these uppermost Narrabeen Group rocks and particularly within the Newport Formation, they have hitherto received very little systematic study. A comprehensive study of this ichnofauna shows that it is relatively diverse, comprising almost 100 different ichnotaxa (including varietal categories) of predominantly invertebrate origin, and includes several new ichnogenera and ichnospecies among the more notable of which are: two large bioglyph-bearing dwelling-burrows of probable crustacean origin (Turimettichnus conaghani and T. webbyi) and one (Pytiniichnus trifurcatum) made either by a small reptile or an amphibian; a multi-stage spiral star-shaped feeding-trace (Helikospirichnus veeversi), probably made by a worm or worm-like deposit-feeder; several new species and varieties of Rhizocorallium (the first record of this ichnogenus in the Triassic of Australia); a new species and new variety of the saltatorial running vertebrate trackway Moodieichnus (an ichnogenus previously known only from the Late Permian of North America); and a new ichnogenus of vertical/steeply-inclined cylindrical branching dwelling-burrow (Barrenjoeichnus mitchelli). -- An alternating stratigraphic pattern of trace fossil abundance and diversity characterizes the upper Narrabeen Group strata in the Sydney Northshore area, and involves four relatively thin separate assemblage zones of relatively diverse ichnofauna and thicker intervening assemblage zones which lack ichnotaxo-nomic diversity. The assemblage zones of diverse trace fossils contain some elements in common to two or more zones, notably: Thalassinoides, Skolithos, Ophiomorpha, Chondrites, Rhizocorallium Palaeophycus, and Planolites, all of which are known to have unequivocal brackish- to shallow-marine palaeoecological affinities and which globally are characteristic of the Skolithos ichnofacies. Additionally, each of these four diverse assemblage zones is characterized by one or more particular index ichnogen-era which for convenience lend their name(s) to the zones as follows, in ascending stratigraphic order: Turimettichnus-Ophio-morpha assemblage zone; Skolithos-Diplocraterion assemblage zone; Helikospirichnus assemblage zone; and Rhizocorallium-Thalass inoides assemblage zone. The intervening ichnotaxonomically less-diverse and relatively impoverished assemblage zones are not similarly and separately named but are characterized by Barrenjoeichnus mitchelli and some species of Palaeophycus, Planolites and Skolithos as well as various plant-root petrification structures, all of which are here argued to have predominantly non-marine palaeoecological affinities. These latter assemblage zones can be referred to the Scoyenia-Teredolites ichnofacies. This stratigraphic pattern of alternating ichnologi-cally diverse and impoverished assemblage zones confirms the suggestions of previous workers (notably Bunny and Herbert, and Retallack) regarding the presence of brackish-/shallow-marine palaeoenvironmental influence in these Lower and Middle Triassic strata and allow for the first time the stratigraphic resolution of the marine strata into four marine tongues which are here named after their respective type localities. These are, in ascending order: The Turimetta Head Tongue (2 m to 3 m thick; extending from at least the middle part of the Bald Hill Clay-stone almost to the top of this formation); the St. Michaels Cave Tongue (4 m to 5 m thick; encompassing the Garie Formation and the lower part of the lower Member of the Newport Formation); the Bangalley Head Tongue (3 m to 5 m thick; extending from the uppermost part of the Lower Member into the lower part of the Middle Member of the Newport Formation); and the Palm Beach Tongue (3 m to 4 m thick; comprising the uppermost part of the Middle Member of the Newport Formation). The trace fossil assemblages in each of these marine tongues are indicative of a complex of brackish- to very shallow-marine low-energy palaeoenvi-ronments typical of modern coastal lagoons or estuaries and imply the presence of a protecting coeval topographic barrier of some kind to the east or southeast. This lagoon is herein called the Newport (Coastal) Lagoon and its development in the central-eastern part of the Sydney Basin coincides approximately with the geographic and depocentral axis of the basin which trends NW-SE and intersects the present coastline in the Sydney metropolitan area. The non-marine affinities of the impoverished and less-diverse trace fossil assemblages in the intervening and overlying strata are consistent with the fluvial/fluvio-lacustrine environmental interpretations of these thicker and predominantly sandstone-dominant intervals made by many other workers. Palaeocur-rent and petrographic data from these fluvial sediments show that the streams in which they formed debouched episodically into the Newport Lagoon variously from the northwest, west and southwest and were sourced variously from both the craton (Lachlan Fold Belt) to the southwest and the New England Orogen to the northeast.With the exception of evidence of short-lived brackish-marine conditions at the base of the Narrabeen Group in the northeastern Sydney Basin and in the top of the Ashfield Shale in the Wianamatta Group (above the Hawkesbury Sandstone) in the central part of the basin, the Triassic System of the basin is dominated by fluvial/fluvio-lacustrine sediments and the presently described marine tongues of the Newport Lagoon in the uppermost Narrabeen Group are the only other presently known record of marine conditions during the Triassic history of the basin. The development of the Newport Lagoon in the geographic and depocentral axis of the basin attests to the presence of a mild short-lived marine transgression in the latest Early and early Middle Triassic at the end of a period of declining piedmont clastic alluviation from the coeval New England Orogen to the northeast and immediately prior to the onset of a new phase of fluvial sedimentation sourced from the craton to the southwest and manifested by the deposition of the Middle Triassic Hawkesbury Sandstone.Mode of access: World Wide Web.xxxv, 630 p. ill., map

Des Heiligen Und Neuen Jerusalems ... Theil : Darinnen das Edelste Kleinod/ Als der Einige Glaub- und Lebensweg Rechtschaffender Christen/ ... Mit vielen Glaubens-Artickeln/ sam[m]t deren Kupffer-Bildern/ ...

in unterschiedlichen Abhandlungen vorgestellet und gezeiget/ ... Von ... Andreas Than[n]/ von Georgenberg ...Das Heilige Jerusalem durch den Glaub und Lebensweg Zu erlangenErschienen T. 1 (1680) bis T. 2 (1681

"Arcadias and Avalons: Reframing Real Estate, Radicalism, and Race in the Cooperative Commonwealth of Los Angeles, 1893 - 1929"

Metropolitan Los Angeles grew dramatically during an era when a culture of cooperation enabled a broad dialogue among ideological systems that throughout most of the twentieth century would remain in violent opposition. Cooperation manifested in a location where scholars rarely search for it: in the relationship between utopian literature and real estate development that prevailed between 1893 and 1929. This study analyzes the ways that utopian concepts became useful to the capitalist enterprises promoted by boosters and builders, along with socialist developers attempting to materialize a new social order. While most analytical approaches to this subject emphasize the separation and isolation of utopian movements and colonies from the mainstream, “Arcadias and Avalons” questions the definition of mainstream and expands the category of utopian colony. Drawing on research in cultural studies, literary criticism, intellectual history, and urban planning, I argue that the substance and form of Los Angeles drew from an Anglo-Saxon imaginary that promised every white man a house and a job and nurtured social movements to advocate for every issue except solving the race problem. Utopia demanded racial homogeneity, and this became an important and persistent intellectual principle that contoured Los Angeles community planning during its most crucial period of material and metaphysical development

Mein Eberharts von || der Thann/ Stadthalters zu Coburg/|| warhafftiger/ gegründter ... gegen=||bericht/ vnd ableinung/ auff den abdruck/ so in || der Fürstlichen Sechsischen Cantzley zu || Weymar Namen/ hieuor ausgangen/|| der Theologen zu Jhena domals ge=||gebenen abschied betreffende/|| Geschehen/ Anno/|| 1563.|| ... ||

Vorlageform des Erscheinungsvermerks: M.D.LXVI.||[Eisleben: Andreas Petri

Unicum Ovile Catholicum, Oder Der Einige Catholische Schafstall : Wie solcher nach seinem Notis ... von denen Falschen und Ketzerischen zuerkennen und zu unterscheiden

in einer Revocations-Predigt ... Anno 1688. ... In der Pfarr-Kirchen/ der Königl. freyen Stadt Leutschau/ in Ober-Ungarn gehalten ... vom Autore, Andrea Thann der Zeit Licent.Vorlageform d. Erscheinungsvermerks: Tyrnau/ Gedruckt von Johann Adam Friedl: Im Jahr 1693

Das Rumicin

Volume: 31Start Page: 26End Page: 3